Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Cornelia Jäkel, Frank Bergmann, Reka Toth, Yassen Assenov, Daniel van der Duin, Oliver Strobel, Thomas Hank, Günter Klöppel, Craig Dorrell, Markus Grompe, Joshua Moss, Yuval Dor, Peter Schirmacher, Christoph Plass, Odilia Popanda, Peter Schmezer

ABSTRACT

Pancreatic acinar cell carcinoma (ACC) is an aggressive exocrine tumor with largely unknown biology. Here, to identify potential targets for personalized treatment, we perform integrative genome-wide and epigenome-wide analyses. The results show frequently aberrant DNA methylation, abundant chromosomal amplifications and deletions, and mutational signatures suggesting defective DNA repair. In contrast to pancreatic ductal adenocarcinoma, no recurrent point mutations are detected. The tumor suppressors ID3, ARID1A, APC, and CDKN2A are frequently impaired also on the protein level and thus potentially affect ACC tumorigenesis. Consequently, this work identifies promising therapeutic targets in ACC for drugs recently approved for precision cancer therapy. More... »

PAGES

1323

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-017-01118-x

DOI

http://dx.doi.org/10.1038/s41467-017-01118-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092462781

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29109526


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Acinar Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Pancreatic Ductal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle Checkpoints", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Aberrations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epigenesis, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Dosage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Tumor Suppressor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genomic Instability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatic Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "J\u00e4kel", 
        "givenName": "Cornelia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bergmann", 
        "givenName": "Frank", 
        "id": "sg:person.0634166371.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634166371.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Toth", 
        "givenName": "Reka", 
        "id": "sg:person.01173475271.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173475271.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Assenov", 
        "givenName": "Yassen", 
        "id": "sg:person.01111011364.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111011364.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van der Duin", 
        "givenName": "Daniel", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Department of General and Visceral Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Strobel", 
        "givenName": "Oliver", 
        "id": "sg:person.0703632143.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703632143.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Department of General and Visceral Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hank", 
        "givenName": "Thomas", 
        "id": "sg:person.01301160042.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301160042.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Technical University Munich", 
          "id": "https://www.grid.ac/institutes/grid.6936.a", 
          "name": [
            "Institute of Pathology, Technical University Munich, Trogerstr. 18, 81675, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kl\u00f6ppel", 
        "givenName": "G\u00fcnter", 
        "id": "sg:person.016522011357.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016522011357.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oregon Health & Science University", 
          "id": "https://www.grid.ac/institutes/grid.5288.7", 
          "name": [
            "Department of Pediatrics, Pap\u00e9 Family Pediatric Research Institute, Oregon Stem Cell Center, Oregon Health and Science University, 97239, Portland, OR, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dorrell", 
        "givenName": "Craig", 
        "id": "sg:person.01005370346.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005370346.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oregon Health & Science University", 
          "id": "https://www.grid.ac/institutes/grid.5288.7", 
          "name": [
            "Department of Pediatrics, Pap\u00e9 Family Pediatric Research Institute, Oregon Stem Cell Center, Oregon Health and Science University, 97239, Portland, OR, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grompe", 
        "givenName": "Markus", 
        "id": "sg:person.01126164604.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126164604.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hebrew University of Jerusalem", 
          "id": "https://www.grid.ac/institutes/grid.9619.7", 
          "name": [
            "Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 9112102, Jerusalem, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moss", 
        "givenName": "Joshua", 
        "id": "sg:person.0742634710.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742634710.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hebrew University of Jerusalem", 
          "id": "https://www.grid.ac/institutes/grid.9619.7", 
          "name": [
            "Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 9112102, Jerusalem, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dor", 
        "givenName": "Yuval", 
        "id": "sg:person.01054565053.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054565053.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schirmacher", 
        "givenName": "Peter", 
        "id": "sg:person.01072556301.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072556301.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Plass", 
        "givenName": "Christoph", 
        "id": "sg:person.01047735151.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047735151.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Popanda", 
        "givenName": "Odilia", 
        "id": "sg:person.01276635117.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276635117.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schmezer", 
        "givenName": "Peter", 
        "id": "sg:person.01241754775.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241754775.08"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/ijc.25668", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002419013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-13-3608", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002973964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-014-1657-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003365152", 
          "https://doi.org/10.1007/s00428-014-1657-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms13837", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004182927", 
          "https://doi.org/10.1038/ncomms13837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrdp.2016.22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004400801", 
          "https://doi.org/10.1038/nrdp.2016.22"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2011.83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004833868", 
          "https://doi.org/10.1038/modpathol.2011.83"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2014-15-2-r30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005027341", 
          "https://doi.org/10.1186/gb-2014-15-2-r30"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg3554", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006119577", 
          "https://doi.org/10.1038/nrg3554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-014-1562-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006373292", 
          "https://doi.org/10.1007/s00428-014-1562-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.039131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007064314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11378", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007597995", 
          "https://doi.org/10.1038/nature11378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-14-0849", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007785415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aag0299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008264056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12920-014-0064-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008675542", 
          "https://doi.org/10.1186/s12920-014-0064-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12920-014-0064-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008675542", 
          "https://doi.org/10.1186/s12920-014-0064-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12920-014-0064-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008675542", 
          "https://doi.org/10.1186/s12920-014-0064-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.1983.tb02277.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011252567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.1983.tb02277.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011252567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.4310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012406526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.2011-0231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013891624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1608277113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019140346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.2092", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020237833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3480", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021263328", 
          "https://doi.org/10.1038/nm.3480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021761707", 
          "https://doi.org/10.1038/nature12213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpa.0000000000000328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023333844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpa.0000000000000328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023333844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e318263209d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023733574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e318263209d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023733574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e318263209d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023733574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.amjsurg.2010.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023928043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.surg.2008.03.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026574952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkv1123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027301575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature14169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027837321", 
          "https://doi.org/10.1038/nature14169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11547", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029387548", 
          "https://doi.org/10.1038/nature11547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11605-008-0577-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030535219", 
          "https://doi.org/10.1007/s11605-008-0577-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2016.26", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031060512", 
          "https://doi.org/10.1038/nrclinonc.2016.26"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep08829", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031072563", 
          "https://doi.org/10.1038/srep08829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature16965", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031075239", 
          "https://doi.org/10.1038/nature16965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032452653", 
          "https://doi.org/10.1038/nm.3799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-011-2283-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033000687", 
          "https://doi.org/10.1007/s00125-011-2283-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-011-2283-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033000687", 
          "https://doi.org/10.1007/s00125-011-2283-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms9971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033106726", 
          "https://doi.org/10.1038/ncomms9971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2012-13-10-r84", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033852568", 
          "https://doi.org/10.1186/gb-2012-13-10-r84"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2764", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033967678", 
          "https://doi.org/10.1038/ng.2764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btv408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034757148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/bts680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034923242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1235122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035954369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1478-3231.2005.01069.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036066431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1478-3231.2005.01069.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036066431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2011-12-4-r41", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036416165", 
          "https://doi.org/10.1186/gb-2011-12-4-r41"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd4233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038992417", 
          "https://doi.org/10.1038/nrd4233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2008.211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039987283", 
          "https://doi.org/10.1038/nprot.2008.211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13059-016-0893-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041278818", 
          "https://doi.org/10.1186/s13059-016-0893-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.614", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041845966", 
          "https://doi.org/10.1038/onc.2010.614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-13-0349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041987136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)64917-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042056769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btt684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042068352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btt684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042068352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1519286113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044437485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1541-7786.mcr-10-0535", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045412121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047065106", 
          "https://doi.org/10.1038/nature12146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-13-86", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047392734", 
          "https://doi.org/10.1186/1471-2105-13-86"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-13-86", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047392734", 
          "https://doi.org/10.1186/1471-2105-13-86"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0041361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047981654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkv1268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049566161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050004918", 
          "https://doi.org/10.1038/nature12477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-4146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050476862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1054/bjoc.2000.1567", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050912740", 
          "https://doi.org/10.1054/bjoc.2000.1567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.semdp.2014.08.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051281664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.3764", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051450199", 
          "https://doi.org/10.1038/ng.3764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.3764", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051450199", 
          "https://doi.org/10.1038/ng.3764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btg412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051607942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-0175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052274588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.3115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052944075", 
          "https://doi.org/10.1038/nmeth.3115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/106652702761034136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059204960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082775289", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature21063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083822538", 
          "https://doi.org/10.1038/nature21063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature21063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083822538", 
          "https://doi.org/10.1038/nature21063"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "Pancreatic acinar cell carcinoma (ACC) is an aggressive exocrine tumor with largely unknown biology. Here, to identify potential targets for personalized treatment, we perform integrative genome-wide and epigenome-wide analyses. The results show frequently aberrant DNA methylation, abundant chromosomal amplifications and deletions, and mutational signatures suggesting defective DNA repair. In contrast to pancreatic ductal adenocarcinoma, no recurrent point mutations are detected. The tumor suppressors ID3, ARID1A, APC, and CDKN2A are frequently impaired also on the protein level and thus potentially affect ACC tumorigenesis. Consequently, this work identifies promising therapeutic targets in ACC for drugs recently approved for precision cancer therapy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41467-017-01118-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1043282", 
        "issn": [
          "2041-1723"
        ], 
        "name": "Nature Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability", 
    "pagination": "1323", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ac3d969652aac4952099ec1cd6a4330b7fdf8be3f437e56a237f09f1ee941cb2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29109526"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101528555"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41467-017-01118-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1092462781"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41467-017-01118-x", 
      "https://app.dimensions.ai/details/publication/pub.1092462781"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:28", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000577.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41467-017-01118-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41467-017-01118-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41467-017-01118-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41467-017-01118-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41467-017-01118-x'


 

This table displays all metadata directly associated to this object as RDF triples.

462 TRIPLES      21 PREDICATES      106 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41467-017-01118-x schema:about N0c525d967b90492098cf062f4c053108
2 N161033194a8e45f5a647020776cd29c8
3 N326a1252a39740118547fd67ad8461d0
4 N37626957c17c46349c8485bdb38b525f
5 N3f919acacf8545bfb0819af6e1815ba8
6 N4f31915b5809497e83c008b50bfdea46
7 Nbb542921b4ef40e6b83d682449a5b7af
8 Nd0c513b85087476a82ecc121c20f66ee
9 Nd2a415ac84c94221a23759cb4d5048d6
10 Nd3751af158454f9498804b4b22ec4a2b
11 Nfe34ce8e195c488d9c8ce4df40f16f77
12 anzsrc-for:11
13 anzsrc-for:1112
14 schema:author Ne766e8b25d264eaaa4a27f6148d71aeb
15 schema:citation sg:pub.10.1007/s00125-011-2283-5
16 sg:pub.10.1007/s00428-014-1562-1
17 sg:pub.10.1007/s00428-014-1657-8
18 sg:pub.10.1007/s11605-008-0577-9
19 sg:pub.10.1038/modpathol.2011.83
20 sg:pub.10.1038/nature11378
21 sg:pub.10.1038/nature11547
22 sg:pub.10.1038/nature12146
23 sg:pub.10.1038/nature12213
24 sg:pub.10.1038/nature12477
25 sg:pub.10.1038/nature14169
26 sg:pub.10.1038/nature16965
27 sg:pub.10.1038/nature21063
28 sg:pub.10.1038/ncomms13837
29 sg:pub.10.1038/ncomms9971
30 sg:pub.10.1038/ng.2764
31 sg:pub.10.1038/ng.3764
32 sg:pub.10.1038/nm.3480
33 sg:pub.10.1038/nm.3799
34 sg:pub.10.1038/nmeth.3115
35 sg:pub.10.1038/nprot.2008.211
36 sg:pub.10.1038/nrclinonc.2016.26
37 sg:pub.10.1038/nrd4233
38 sg:pub.10.1038/nrdp.2016.22
39 sg:pub.10.1038/nrg3554
40 sg:pub.10.1038/onc.2010.614
41 sg:pub.10.1038/srep08829
42 sg:pub.10.1054/bjoc.2000.1567
43 sg:pub.10.1186/1471-2105-13-86
44 sg:pub.10.1186/gb-2011-12-4-r41
45 sg:pub.10.1186/gb-2012-13-10-r84
46 sg:pub.10.1186/gb-2014-15-2-r30
47 sg:pub.10.1186/s12920-014-0064-y
48 sg:pub.10.1186/s13059-016-0893-4
49 https://app.dimensions.ai/details/publication/pub.1082775289
50 https://doi.org/10.1002/ijc.25668
51 https://doi.org/10.1002/path.4310
52 https://doi.org/10.1016/j.amjsurg.2010.06.004
53 https://doi.org/10.1016/j.surg.2008.03.006
54 https://doi.org/10.1016/s0002-9440(10)64917-6
55 https://doi.org/10.1053/j.semdp.2014.08.003
56 https://doi.org/10.1073/pnas.1519286113
57 https://doi.org/10.1073/pnas.1608277113
58 https://doi.org/10.1089/106652702761034136
59 https://doi.org/10.1093/bioinformatics/btg412
60 https://doi.org/10.1093/bioinformatics/bts680
61 https://doi.org/10.1093/bioinformatics/btt684
62 https://doi.org/10.1093/bioinformatics/btv408
63 https://doi.org/10.1093/nar/gkv1123
64 https://doi.org/10.1093/nar/gkv1268
65 https://doi.org/10.1097/mpa.0000000000000328
66 https://doi.org/10.1097/pas.0b013e318263209d
67 https://doi.org/10.1111/j.1365-2559.1983.tb02277.x
68 https://doi.org/10.1111/j.1478-3231.2005.01069.x
69 https://doi.org/10.1126/science.1235122
70 https://doi.org/10.1126/science.aag0299
71 https://doi.org/10.1158/0008-5472.can-04-4146
72 https://doi.org/10.1158/0008-5472.can-07-0175
73 https://doi.org/10.1158/0008-5472.can-13-3608
74 https://doi.org/10.1158/1541-7786.mcr-10-0535
75 https://doi.org/10.1158/2159-8290.cd-13-0349
76 https://doi.org/10.1158/2159-8290.cd-14-0849
77 https://doi.org/10.1242/jcs.039131
78 https://doi.org/10.1371/journal.pone.0041361
79 https://doi.org/10.1634/theoncologist.2011-0231
80 https://doi.org/10.18632/oncotarget.2092
81 schema:datePublished 2017-12
82 schema:datePublishedReg 2017-12-01
83 schema:description Pancreatic acinar cell carcinoma (ACC) is an aggressive exocrine tumor with largely unknown biology. Here, to identify potential targets for personalized treatment, we perform integrative genome-wide and epigenome-wide analyses. The results show frequently aberrant DNA methylation, abundant chromosomal amplifications and deletions, and mutational signatures suggesting defective DNA repair. In contrast to pancreatic ductal adenocarcinoma, no recurrent point mutations are detected. The tumor suppressors ID3, ARID1A, APC, and CDKN2A are frequently impaired also on the protein level and thus potentially affect ACC tumorigenesis. Consequently, this work identifies promising therapeutic targets in ACC for drugs recently approved for precision cancer therapy.
84 schema:genre research_article
85 schema:inLanguage en
86 schema:isAccessibleForFree true
87 schema:isPartOf N5b056e10e4754abeaf7fb23c3a674c9e
88 Ncee476066994446c8f8dfa31301e80dd
89 sg:journal.1043282
90 schema:name Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability
91 schema:pagination 1323
92 schema:productId N397fc7ef746f467b8802a7e7fb1d81ae
93 N3ec6cf2d631941cdbb6ec04b7033cd9f
94 N7fc31eea81e045c3b9a1b76b7e12241a
95 N83e64bddd3514ca990818fe08c1703d8
96 N9ac7d65c0c65436a83e7d43e61a9f3e3
97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092462781
98 https://doi.org/10.1038/s41467-017-01118-x
99 schema:sdDatePublished 2019-04-10T13:28
100 schema:sdLicense https://scigraph.springernature.com/explorer/license/
101 schema:sdPublisher Nbdd21728c8764a5f810e8d053e983632
102 schema:url https://www.nature.com/articles/s41467-017-01118-x
103 sgo:license sg:explorer/license/
104 sgo:sdDataset articles
105 rdf:type schema:ScholarlyArticle
106 N0099721499c04331b813e3bdcd49da28 rdf:first sg:person.016522011357.98
107 rdf:rest N871d57dbf29e40fc91c5d0ab7235c3eb
108 N0c525d967b90492098cf062f4c053108 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Mutation
110 rdf:type schema:DefinedTerm
111 N161033194a8e45f5a647020776cd29c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Pancreatic Neoplasms
113 rdf:type schema:DefinedTerm
114 N1ef1d6817a8e443497c975ba3763437c rdf:first sg:person.01126164604.61
115 rdf:rest Nf24cf2971d914f7184586314d3b29630
116 N231308d77c354cb6814715c9f45e33a1 rdf:first sg:person.01241754775.08
117 rdf:rest rdf:nil
118 N2f32c75e73034a10bb6a71dae306f781 rdf:first sg:person.0703632143.41
119 rdf:rest Nfa0726f427bd41debf5d31872c64efaf
120 N31185efabbe5470f8c9254e9b9fac885 rdf:first sg:person.01054565053.26
121 rdf:rest Nefb4e39055834668ab029a478ac09efa
122 N326a1252a39740118547fd67ad8461d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Genomic Instability
124 rdf:type schema:DefinedTerm
125 N37626957c17c46349c8485bdb38b525f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Carcinoma, Acinar Cell
127 rdf:type schema:DefinedTerm
128 N3849ebfb313a45128c97c19f7dd9e197 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
129 schema:familyName van der Duin
130 schema:givenName Daniel
131 rdf:type schema:Person
132 N397fc7ef746f467b8802a7e7fb1d81ae schema:name nlm_unique_id
133 schema:value 101528555
134 rdf:type schema:PropertyValue
135 N3ec6cf2d631941cdbb6ec04b7033cd9f schema:name dimensions_id
136 schema:value pub.1092462781
137 rdf:type schema:PropertyValue
138 N3f919acacf8545bfb0819af6e1815ba8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Cell Cycle Checkpoints
140 rdf:type schema:DefinedTerm
141 N4f31915b5809497e83c008b50bfdea46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Epigenesis, Genetic
143 rdf:type schema:DefinedTerm
144 N5b056e10e4754abeaf7fb23c3a674c9e schema:volumeNumber 8
145 rdf:type schema:PublicationVolume
146 N5e58841ddcf24f608515f1130b52b187 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
147 schema:familyName Jäkel
148 schema:givenName Cornelia
149 rdf:type schema:Person
150 N65845ddf67f442d6ba472d6b013c8160 rdf:first sg:person.01047735151.14
151 rdf:rest Nf40d1ef1c01e4a0084391a6433d3f2b2
152 N7fc31eea81e045c3b9a1b76b7e12241a schema:name pubmed_id
153 schema:value 29109526
154 rdf:type schema:PropertyValue
155 N83e64bddd3514ca990818fe08c1703d8 schema:name readcube_id
156 schema:value ac3d969652aac4952099ec1cd6a4330b7fdf8be3f437e56a237f09f1ee941cb2
157 rdf:type schema:PropertyValue
158 N851fc8005d99429784228fe8cf6dbfbb rdf:first N3849ebfb313a45128c97c19f7dd9e197
159 rdf:rest N2f32c75e73034a10bb6a71dae306f781
160 N871d57dbf29e40fc91c5d0ab7235c3eb rdf:first sg:person.01005370346.81
161 rdf:rest N1ef1d6817a8e443497c975ba3763437c
162 N8d464f7c259b43e3a4fe4bdc9ef9fbcb rdf:first sg:person.01111011364.01
163 rdf:rest N851fc8005d99429784228fe8cf6dbfbb
164 N9ac7d65c0c65436a83e7d43e61a9f3e3 schema:name doi
165 schema:value 10.1038/s41467-017-01118-x
166 rdf:type schema:PropertyValue
167 N9d4dc063051b4570832d616404a45e51 rdf:first sg:person.01173475271.57
168 rdf:rest N8d464f7c259b43e3a4fe4bdc9ef9fbcb
169 Na077c92853e84302adc9955ee13576b2 schema:name Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany
170 rdf:type schema:Organization
171 Nb00dbcf75fe1474f96b228893d7598c3 rdf:first sg:person.0634166371.10
172 rdf:rest N9d4dc063051b4570832d616404a45e51
173 Nbb542921b4ef40e6b83d682449a5b7af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Humans
175 rdf:type schema:DefinedTerm
176 Nbdd21728c8764a5f810e8d053e983632 schema:name Springer Nature - SN SciGraph project
177 rdf:type schema:Organization
178 Ncee476066994446c8f8dfa31301e80dd schema:issueNumber 1
179 rdf:type schema:PublicationIssue
180 Nd0c513b85087476a82ecc121c20f66ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Chromosome Aberrations
182 rdf:type schema:DefinedTerm
183 Nd2a415ac84c94221a23759cb4d5048d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Gene Dosage
185 rdf:type schema:DefinedTerm
186 Nd3751af158454f9498804b4b22ec4a2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Genes, Tumor Suppressor
188 rdf:type schema:DefinedTerm
189 Ne69e8b67dfc1492bad880fa5dcb77dfc schema:name Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany
190 rdf:type schema:Organization
191 Ne766e8b25d264eaaa4a27f6148d71aeb rdf:first N5e58841ddcf24f608515f1130b52b187
192 rdf:rest Nb00dbcf75fe1474f96b228893d7598c3
193 Nefb4e39055834668ab029a478ac09efa rdf:first sg:person.01072556301.62
194 rdf:rest N65845ddf67f442d6ba472d6b013c8160
195 Nf24cf2971d914f7184586314d3b29630 rdf:first sg:person.0742634710.98
196 rdf:rest N31185efabbe5470f8c9254e9b9fac885
197 Nf40d1ef1c01e4a0084391a6433d3f2b2 rdf:first sg:person.01276635117.74
198 rdf:rest N231308d77c354cb6814715c9f45e33a1
199 Nfa0726f427bd41debf5d31872c64efaf rdf:first sg:person.01301160042.50
200 rdf:rest N0099721499c04331b813e3bdcd49da28
201 Nfe34ce8e195c488d9c8ce4df40f16f77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Carcinoma, Pancreatic Ductal
203 rdf:type schema:DefinedTerm
204 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
205 schema:name Medical and Health Sciences
206 rdf:type schema:DefinedTerm
207 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
208 schema:name Oncology and Carcinogenesis
209 rdf:type schema:DefinedTerm
210 sg:journal.1043282 schema:issn 2041-1723
211 schema:name Nature Communications
212 rdf:type schema:Periodical
213 sg:person.01005370346.81 schema:affiliation https://www.grid.ac/institutes/grid.5288.7
214 schema:familyName Dorrell
215 schema:givenName Craig
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005370346.81
217 rdf:type schema:Person
218 sg:person.01047735151.14 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
219 schema:familyName Plass
220 schema:givenName Christoph
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047735151.14
222 rdf:type schema:Person
223 sg:person.01054565053.26 schema:affiliation https://www.grid.ac/institutes/grid.9619.7
224 schema:familyName Dor
225 schema:givenName Yuval
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054565053.26
227 rdf:type schema:Person
228 sg:person.01072556301.62 schema:affiliation Ne69e8b67dfc1492bad880fa5dcb77dfc
229 schema:familyName Schirmacher
230 schema:givenName Peter
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072556301.62
232 rdf:type schema:Person
233 sg:person.01111011364.01 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
234 schema:familyName Assenov
235 schema:givenName Yassen
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111011364.01
237 rdf:type schema:Person
238 sg:person.01126164604.61 schema:affiliation https://www.grid.ac/institutes/grid.5288.7
239 schema:familyName Grompe
240 schema:givenName Markus
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126164604.61
242 rdf:type schema:Person
243 sg:person.01173475271.57 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
244 schema:familyName Toth
245 schema:givenName Reka
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173475271.57
247 rdf:type schema:Person
248 sg:person.01241754775.08 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
249 schema:familyName Schmezer
250 schema:givenName Peter
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241754775.08
252 rdf:type schema:Person
253 sg:person.01276635117.74 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
254 schema:familyName Popanda
255 schema:givenName Odilia
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276635117.74
257 rdf:type schema:Person
258 sg:person.01301160042.50 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
259 schema:familyName Hank
260 schema:givenName Thomas
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301160042.50
262 rdf:type schema:Person
263 sg:person.016522011357.98 schema:affiliation https://www.grid.ac/institutes/grid.6936.a
264 schema:familyName Klöppel
265 schema:givenName Günter
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016522011357.98
267 rdf:type schema:Person
268 sg:person.0634166371.10 schema:affiliation Na077c92853e84302adc9955ee13576b2
269 schema:familyName Bergmann
270 schema:givenName Frank
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634166371.10
272 rdf:type schema:Person
273 sg:person.0703632143.41 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
274 schema:familyName Strobel
275 schema:givenName Oliver
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703632143.41
277 rdf:type schema:Person
278 sg:person.0742634710.98 schema:affiliation https://www.grid.ac/institutes/grid.9619.7
279 schema:familyName Moss
280 schema:givenName Joshua
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742634710.98
282 rdf:type schema:Person
283 sg:pub.10.1007/s00125-011-2283-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033000687
284 https://doi.org/10.1007/s00125-011-2283-5
285 rdf:type schema:CreativeWork
286 sg:pub.10.1007/s00428-014-1562-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006373292
287 https://doi.org/10.1007/s00428-014-1562-1
288 rdf:type schema:CreativeWork
289 sg:pub.10.1007/s00428-014-1657-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003365152
290 https://doi.org/10.1007/s00428-014-1657-8
291 rdf:type schema:CreativeWork
292 sg:pub.10.1007/s11605-008-0577-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030535219
293 https://doi.org/10.1007/s11605-008-0577-9
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/modpathol.2011.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004833868
296 https://doi.org/10.1038/modpathol.2011.83
297 rdf:type schema:CreativeWork
298 sg:pub.10.1038/nature11378 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007597995
299 https://doi.org/10.1038/nature11378
300 rdf:type schema:CreativeWork
301 sg:pub.10.1038/nature11547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029387548
302 https://doi.org/10.1038/nature11547
303 rdf:type schema:CreativeWork
304 sg:pub.10.1038/nature12146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047065106
305 https://doi.org/10.1038/nature12146
306 rdf:type schema:CreativeWork
307 sg:pub.10.1038/nature12213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021761707
308 https://doi.org/10.1038/nature12213
309 rdf:type schema:CreativeWork
310 sg:pub.10.1038/nature12477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050004918
311 https://doi.org/10.1038/nature12477
312 rdf:type schema:CreativeWork
313 sg:pub.10.1038/nature14169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027837321
314 https://doi.org/10.1038/nature14169
315 rdf:type schema:CreativeWork
316 sg:pub.10.1038/nature16965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031075239
317 https://doi.org/10.1038/nature16965
318 rdf:type schema:CreativeWork
319 sg:pub.10.1038/nature21063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083822538
320 https://doi.org/10.1038/nature21063
321 rdf:type schema:CreativeWork
322 sg:pub.10.1038/ncomms13837 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004182927
323 https://doi.org/10.1038/ncomms13837
324 rdf:type schema:CreativeWork
325 sg:pub.10.1038/ncomms9971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033106726
326 https://doi.org/10.1038/ncomms9971
327 rdf:type schema:CreativeWork
328 sg:pub.10.1038/ng.2764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033967678
329 https://doi.org/10.1038/ng.2764
330 rdf:type schema:CreativeWork
331 sg:pub.10.1038/ng.3764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051450199
332 https://doi.org/10.1038/ng.3764
333 rdf:type schema:CreativeWork
334 sg:pub.10.1038/nm.3480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021263328
335 https://doi.org/10.1038/nm.3480
336 rdf:type schema:CreativeWork
337 sg:pub.10.1038/nm.3799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032452653
338 https://doi.org/10.1038/nm.3799
339 rdf:type schema:CreativeWork
340 sg:pub.10.1038/nmeth.3115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052944075
341 https://doi.org/10.1038/nmeth.3115
342 rdf:type schema:CreativeWork
343 sg:pub.10.1038/nprot.2008.211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039987283
344 https://doi.org/10.1038/nprot.2008.211
345 rdf:type schema:CreativeWork
346 sg:pub.10.1038/nrclinonc.2016.26 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031060512
347 https://doi.org/10.1038/nrclinonc.2016.26
348 rdf:type schema:CreativeWork
349 sg:pub.10.1038/nrd4233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038992417
350 https://doi.org/10.1038/nrd4233
351 rdf:type schema:CreativeWork
352 sg:pub.10.1038/nrdp.2016.22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004400801
353 https://doi.org/10.1038/nrdp.2016.22
354 rdf:type schema:CreativeWork
355 sg:pub.10.1038/nrg3554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006119577
356 https://doi.org/10.1038/nrg3554
357 rdf:type schema:CreativeWork
358 sg:pub.10.1038/onc.2010.614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041845966
359 https://doi.org/10.1038/onc.2010.614
360 rdf:type schema:CreativeWork
361 sg:pub.10.1038/srep08829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031072563
362 https://doi.org/10.1038/srep08829
363 rdf:type schema:CreativeWork
364 sg:pub.10.1054/bjoc.2000.1567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050912740
365 https://doi.org/10.1054/bjoc.2000.1567
366 rdf:type schema:CreativeWork
367 sg:pub.10.1186/1471-2105-13-86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047392734
368 https://doi.org/10.1186/1471-2105-13-86
369 rdf:type schema:CreativeWork
370 sg:pub.10.1186/gb-2011-12-4-r41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036416165
371 https://doi.org/10.1186/gb-2011-12-4-r41
372 rdf:type schema:CreativeWork
373 sg:pub.10.1186/gb-2012-13-10-r84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033852568
374 https://doi.org/10.1186/gb-2012-13-10-r84
375 rdf:type schema:CreativeWork
376 sg:pub.10.1186/gb-2014-15-2-r30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005027341
377 https://doi.org/10.1186/gb-2014-15-2-r30
378 rdf:type schema:CreativeWork
379 sg:pub.10.1186/s12920-014-0064-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1008675542
380 https://doi.org/10.1186/s12920-014-0064-y
381 rdf:type schema:CreativeWork
382 sg:pub.10.1186/s13059-016-0893-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041278818
383 https://doi.org/10.1186/s13059-016-0893-4
384 rdf:type schema:CreativeWork
385 https://app.dimensions.ai/details/publication/pub.1082775289 schema:CreativeWork
386 https://doi.org/10.1002/ijc.25668 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002419013
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1002/path.4310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012406526
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1016/j.amjsurg.2010.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023928043
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1016/j.surg.2008.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026574952
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1016/s0002-9440(10)64917-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042056769
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1053/j.semdp.2014.08.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051281664
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1073/pnas.1519286113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044437485
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1073/pnas.1608277113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019140346
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1089/106652702761034136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059204960
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1093/bioinformatics/btg412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051607942
405 rdf:type schema:CreativeWork
406 https://doi.org/10.1093/bioinformatics/bts680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034923242
407 rdf:type schema:CreativeWork
408 https://doi.org/10.1093/bioinformatics/btt684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042068352
409 rdf:type schema:CreativeWork
410 https://doi.org/10.1093/bioinformatics/btv408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034757148
411 rdf:type schema:CreativeWork
412 https://doi.org/10.1093/nar/gkv1123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027301575
413 rdf:type schema:CreativeWork
414 https://doi.org/10.1093/nar/gkv1268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049566161
415 rdf:type schema:CreativeWork
416 https://doi.org/10.1097/mpa.0000000000000328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023333844
417 rdf:type schema:CreativeWork
418 https://doi.org/10.1097/pas.0b013e318263209d schema:sameAs https://app.dimensions.ai/details/publication/pub.1023733574
419 rdf:type schema:CreativeWork
420 https://doi.org/10.1111/j.1365-2559.1983.tb02277.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011252567
421 rdf:type schema:CreativeWork
422 https://doi.org/10.1111/j.1478-3231.2005.01069.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036066431
423 rdf:type schema:CreativeWork
424 https://doi.org/10.1126/science.1235122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035954369
425 rdf:type schema:CreativeWork
426 https://doi.org/10.1126/science.aag0299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008264056
427 rdf:type schema:CreativeWork
428 https://doi.org/10.1158/0008-5472.can-04-4146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050476862
429 rdf:type schema:CreativeWork
430 https://doi.org/10.1158/0008-5472.can-07-0175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052274588
431 rdf:type schema:CreativeWork
432 https://doi.org/10.1158/0008-5472.can-13-3608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002973964
433 rdf:type schema:CreativeWork
434 https://doi.org/10.1158/1541-7786.mcr-10-0535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045412121
435 rdf:type schema:CreativeWork
436 https://doi.org/10.1158/2159-8290.cd-13-0349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041987136
437 rdf:type schema:CreativeWork
438 https://doi.org/10.1158/2159-8290.cd-14-0849 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007785415
439 rdf:type schema:CreativeWork
440 https://doi.org/10.1242/jcs.039131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007064314
441 rdf:type schema:CreativeWork
442 https://doi.org/10.1371/journal.pone.0041361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047981654
443 rdf:type schema:CreativeWork
444 https://doi.org/10.1634/theoncologist.2011-0231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013891624
445 rdf:type schema:CreativeWork
446 https://doi.org/10.18632/oncotarget.2092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020237833
447 rdf:type schema:CreativeWork
448 https://www.grid.ac/institutes/grid.5253.1 schema:alternateName University Hospital Heidelberg
449 schema:name Department of General and Visceral Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
450 rdf:type schema:Organization
451 https://www.grid.ac/institutes/grid.5288.7 schema:alternateName Oregon Health & Science University
452 schema:name Department of Pediatrics, Papé Family Pediatric Research Institute, Oregon Stem Cell Center, Oregon Health and Science University, 97239, Portland, OR, USA
453 rdf:type schema:Organization
454 https://www.grid.ac/institutes/grid.6936.a schema:alternateName Technical University Munich
455 schema:name Institute of Pathology, Technical University Munich, Trogerstr. 18, 81675, Munich, Germany
456 rdf:type schema:Organization
457 https://www.grid.ac/institutes/grid.7497.d schema:alternateName German Cancer Research Center
458 schema:name Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
459 rdf:type schema:Organization
460 https://www.grid.ac/institutes/grid.9619.7 schema:alternateName Hebrew University of Jerusalem
461 schema:name Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, 9112102, Jerusalem, Israel
462 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...