Multicolor lineage tracing reveals clonal architecture and dynamics in colon cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Sebastian Lamprecht, Eva Marina Schmidt, Cristina Blaj, Heiko Hermeking, Andreas Jung, Thomas Kirchner, David Horst

ABSTRACT

Colon cancers are composed of phenotypically heterogeneous tumor cell subpopulations with variable expression of putative stem cell and differentiation antigens. While in normal colonic mucosa, clonal repopulation occurs along differentiation gradients from crypt base toward crypt apex, the clonal architecture of colon cancer and the relevance of tumor cell subpopulations for clonal outgrowth are poorly understood. Using a multicolor lineage tracing approach in colon cancer xenografts that reflect primary colon cancer architecture, we here demonstrate that clonal outgrowth is mainly driven by tumor cells located at the leading tumor edge with clonal axis formation toward the tumor center. While our findings are compatible with lineage outgrowth in a cancer stem cell model, they suggest that in colorectal cancer tumor cell position may be more important for clonal outgrowth than tumor cell phenotype. More... »

PAGES

1406

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-017-00976-9

DOI

http://dx.doi.org/10.1038/s41467-017-00976-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092558467

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29127276


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