Signalling strength determines proapoptotic functions of STING View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-09-05

AUTHORS

Muhammet F. Gulen, Ute Koch, Simone M. Haag, Fabian Schuler, Lionel Apetoh, Andreas Villunger, Freddy Radtke, Andrea Ablasser

ABSTRACT

Mammalian cells use cytosolic nucleic acid receptors to detect pathogens and other stress signals. In innate immune cells the presence of cytosolic DNA is sensed by the cGAS–STING signalling pathway, which initiates a gene expression programme linked to cellular activation and cytokine production. Whether the outcome of the STING response varies between distinct cell types remains largely unknown. Here we show that T cells exhibit an intensified STING response, which leads to the expression of a distinct set of genes and results in the induction of apoptosis. Of note, this proapoptotic STING response is still functional in cancerous T cells and delivery of small molecule STING agonists prevents in vivo growth of T-cell-derived tumours independent of its adjuvant activity. Our results demonstrate how the magnitude of STING signalling can shape distinct effector responses, which may permit for cell type-adjusted behaviours towards endogenous or exogenous insults. More... »

PAGES

427

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-017-00573-w

DOI

http://dx.doi.org/10.1038/s41467-017-00573-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091449498

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28874664


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