Planar polarized Rab35 functions as an oscillatory ratchet during cell intercalation in the Drosophila epithelium View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-09-07

AUTHORS

Cayla E. Jewett, Timothy E. Vanderleest, Hui Miao, Yi Xie, Roopa Madhu, Dinah Loerke, J. Todd Blankenship

ABSTRACT

The coordination between membrane trafficking and actomyosin networks is essential to the regulation of cell and tissue shape. Here, we examine Rab protein distributions during Drosophila epithelial tissue remodeling and show that Rab35 is dynamically planar polarized. Rab35 compartments are enriched at contractile interfaces of intercalating cells and provide the first evidence of interfacial monopolarity. When Rab35 function is disrupted, apical area oscillations still occur and contractile steps are observed. However, contractions are followed by reversals and interfaces fail to shorten, demonstrating that Rab35 functions as a ratchet ensuring unidirectional movement. Although actomyosin forces have been thought to drive interface contraction, initiation of Rab35 compartments does not require Myosin II function. However, Rab35 compartments do not terminate and continue to grow into large elongated structures following actomyosin disruption. Finally, Rab35 represents a common contractile cell-shaping mechanism, as mesoderm invagination fails in Rab35 compromised embryos and Rab35 localizes to constricting surfaces.Various stages of tissue morphogenesis involve the contraction of epithelial surfaces. Here, the authors identify the Rab GTPase Rab35 as an essential component of this contractile process, which functions as a membrane ratchet to ensure unidirectional movement of intercalating cells. More... »

PAGES

476

References to SciGraph publications

  • 2008-11-23. Pulsed contractions of an actin–myosin network drive apical constriction in NATURE
  • 2011-06-26. Rab35 GTPase and OCRL phosphatase remodel lipids and F-actin for successful cytokinesis in NATURE CELL BIOLOGY
  • 2008-11-02. Nature and anisotropy of cortical forces orienting Drosophila tissue morphogenesis in NATURE CELL BIOLOGY
  • 2017-02-23. Oxidation of F-actin controls the terminal steps of cytokinesis in NATURE COMMUNICATIONS
  • 2015-07-27. A self-organized biomechanical network drives shape changes during tissue morphogenesis in NATURE
  • 2005-08-14. Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway in NATURE GENETICS
  • 2008-07-20. Robust single particle tracking in live cell time-lapse sequences in NATURE METHODS
  • 2010-11-10. Planar polarized actomyosin contractile flows control epithelial junction remodelling in NATURE
  • 2012-11-11. Vertebrate kidney tubules elongate using a planar cell polarity–dependent, rosette-based mechanism of convergent extension in NATURE GENETICS
  • 2004-06. Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation in NATURE
  • 2013-07-07. Apical domain polarization localizes actin-myosin activity to drive ratchet-like apical constriction in NATURE CELL BIOLOGY
  • 2011-04-24. Spatial regulation of Dia and Myosin-II by RhoGEF2 controls initiation of E-cadherin endocytosis during epithelial morphogenesis in NATURE CELL BIOLOGY
  • 2012-03-11. Whacked and Rab35 polarize dynein motor complex-dependent seamless tube growth in NATURE CELL BIOLOGY
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1038/s41467-017-00553-0

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    http://dx.doi.org/10.1038/s41467-017-00553-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1091465435

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28883443


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