Variable repeats in the eukaryotic polyubiquitin gene ubi4 modulate proteostasis and stress survival View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Rita Gemayel, Yudi Yang, Maria C. Dzialo, Jacek Kominek, Jakob Vowinckel, Veerle Saels, Leen Van Huffel, Elisa van der Zande, Markus Ralser, Jan Steensels, Karin Voordeckers, Kevin J. Verstrepen

ABSTRACT

Ubiquitin conjugation signals for selective protein degradation by the proteasome. In eukaryotes, ubiquitin is encoded both as a monomeric ubiquitin unit fused to a ribosomal gene and as multiple ubiquitin units in tandem. The polyubiquitin gene is a unique, highly conserved open reading frame composed solely of tandem repeats, yet it is still unclear why cells utilize this unusual gene structure. Using the Saccharomyces cerevisiae UBI4 gene, we show that this multi-unit structure allows cells to rapidly produce large amounts of ubiquitin needed to respond to sudden stress. The number of ubiquitin units encoded by UBI4 influences cellular survival and the rate of ubiquitin-proteasome system (UPS)-mediated proteolysis following heat stress. Interestingly, the optimal number of repeats varies under different types of stress indicating that natural variation in repeat numbers may optimize the chance for survival. Our results demonstrate how a variable polycistronic transcript provides an evolutionary alternative for gene copy number variation.Eukaryotic cells rely on the ubiquitin-proteasome system for selective degradation of proteins, a process vital to organismal fitness. Here the authors show that the number of repeats in the polyubiquitin gene is evolutionarily unstable within and between yeast species, and that this variability may tune the cell's capacity to respond to sudden environmental perturbations. More... »

PAGES

397

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41467-017-00533-4

DOI

http://dx.doi.org/10.1038/s41467-017-00533-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091344459

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28855501


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