Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Michelle L. Krishnan, Juliette Van Steenwinckel, Anne-Laure Schang, Jun Yan, Johanna Arnadottir, Tifenn Le Charpentier, Zsolt Csaba, Pascal Dournaud, Sara Cipriani, Constance Auvynet, Luigi Titomanlio, Julien Pansiot, Gareth Ball, James P. Boardman, Andrew J. Walley, Alka Saxena, Ghazala Mirza, Bobbi Fleiss, A. David Edwards, Enrico Petretto, Pierre Gressens

ABSTRACT

Preterm birth places infants in an adverse environment that leads to abnormal brain development and cerebral injury through a poorly understood mechanism known to involve neuroinflammation. In this study, we integrate human and mouse molecular and neuroimaging data to investigate the role of microglia in preterm white matter damage. Using a mouse model where encephalopathy of prematurity is induced by systemic interleukin-1β administration, we undertake gene network analysis of the microglial transcriptomic response to injury, extend this by analysis of protein-protein interactions, transcription factors and human brain gene expression, and translate findings to living infants using imaging genomics. We show that DLG4 (PSD95) protein is synthesised by microglia in immature mouse and human, developmentally regulated, and modulated by inflammation; DLG4 is a hub protein in the microglial inflammatory response; and genetic variation in DLG4 is associated with structural differences in the preterm infant brain. DLG4 is thus apparently involved in brain development and impacts inter-individual susceptibility to injury after preterm birth.Inflammation mediated by microglia plays a key role in brain injury associated with preterm birth, but little is known about the microglial response in preterm infants. Here, the authors integrate molecular and imaging data from animal models and preterm infants, and find that microglial expression of DLG4 plays a role. More... »

PAGES

428

References to SciGraph publications

  • 2016-12. Decreased neuroinflammation correlates to higher vagus nerve activity fluctuations in near-term ovine fetuses: a case for the afferent cholinergic anti-inflammatory pathway? in JOURNAL OF NEUROINFLAMMATION
  • 2017-04. Posttranslational Modifications Regulate the Postsynaptic Localization of PSD-95 in MOLECULAR NEUROBIOLOGY
  • 2007-12. Composition Profiler: a tool for discovery and visualization of amino acid composition differences in BMC BIOINFORMATICS
  • 2013-06. Progress toward treatments for synaptic defects in autism in NATURE MEDICINE
  • 2015-12. Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus in NATURE COMMUNICATIONS
  • 2013-12. The microglial sensome revealed by direct RNA sequencing in NATURE NEUROSCIENCE
  • 2015-08. Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders in NATURE REVIEWS GENETICS
  • 2014-12. Predicting disease associations via biological network analysis in BMC BIOINFORMATICS
  • 2007-12. From correlation to causation networks: a simple approximate learning algorithm and its application to high-dimensional plant gene expression data in BMC SYSTEMS BIOLOGY
  • 2016-12. Modulatory effects of vagal stimulation on neurophysiological parameters and the cellular immune response in the rat brain during systemic inflammation in INTENSIVE CARE MEDICINE EXPERIMENTAL
  • 2003. Interleukin 1 (IL-1) Induces the Activation of Stat3 in TISSUE ENGINEERING, STEM CELLS, AND GENE THERAPIES
  • 2014-04-02. Transcriptional landscape of the prenatal human brain in NATURE
  • 2014-03. The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia in JOURNAL OF MOLECULAR MEDICINE
  • 2009-12. Disease candidate gene identification and prioritization using protein interaction networks in BMC BIOINFORMATICS
  • 2016-09. Estrogen ameliorates microglial activation by inhibiting the Kir2.1 inward-rectifier K+ channel in SCIENTIFIC REPORTS
  • 2015-06. Understanding multicellular function and disease with human tissue-specific networks in NATURE GENETICS
  • 2014-02. Glutamatergic Postsynaptic Density Protein Dysfunctions in Synaptic Plasticity and Dendritic Spines Morphology: Relevance to Schizophrenia and Other Behavioral Disorders Pathophysiology, and Implications for Novel Therapeutic Approaches in MOLECULAR NEUROBIOLOGY
  • 2017-01. Expression of Kir4.1 and Kir5.1 inwardly rectifying potassium channels in oligodendrocytes, the myelinating cells of the CNS in BRAIN STRUCTURE AND FUNCTION
  • 2015-12. Efficient Test and Visualization of Multi-Set Intersections in SCIENTIFIC REPORTS
  • 2011-10. Temporal dynamics and genetic control of transcription in the human prefrontal cortex in NATURE
  • 2014-03. Intermittent or sustained systemic inflammation and the preterm brain in PEDIATRIC RESEARCH
  • 2012-12. The vagus nerve and the inflammatory reflex—linking immunity and metabolism in NATURE REVIEWS ENDOCRINOLOGY
  • 2012-03. PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2 in NATURE NEUROSCIENCE
  • 2012-09. An anatomically comprehensive atlas of the adult human brain transcriptome in NATURE
  • 2001-05. Lethality and centrality in protein networks in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41467-017-00422-w

    DOI

    http://dx.doi.org/10.1038/s41467-017-00422-w

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1091449486

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28874660


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