Combination therapy for erectile dysfunction involving a PDE5 inhibitor and alprostadil View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-10

AUTHORS

I. Moncada, J. Martinez-Salamanca, E. Ruiz-Castañe, J. Romero

ABSTRACT

The phosphodiesterase-5 inhibitors (PDE5Is) are the first-line treatment option for men with erectile dysfunction (ED), with alprostadil considered a second-line choice. Consideration has to be given to patients who fail these treatments and what their options are. This review evaluates the data on the combination of a PDE5I with alprostadil in patients who have previously failed therapy with either drug. A PubMed search was conducted and identified nine publications relating to combination treatment with alprostadil as intracavernosal, intraurethral or topical application. The results indicate that with all three formulations the combination therapy resulted in an improved outcome compared with either of the drugs as monotherapy. This was demonstrated by the increased total International Index of Erectile Function (IIEF) scores as well as IIEF erectile function domain scores. This finding was also valid for patients with post-prostatectomy ED. The associated side effects of the combined treatment did not result in treatment discontinuation. These findings suggest that combination therapy with a PDE5I and alprostadil might be considered a treatment option in patients who have previously had a poor response to either drug. More... »

PAGES

203-208

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41443-018-0046-2

DOI

http://dx.doi.org/10.1038/s41443-018-0046-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105853938

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30050072


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