Association of blood pressure with estimates of 24-h urinary sodium and potassium excretion from repeated single-spot urine samples View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-12-06

AUTHORS

Trang Thi Minh Nguyen, Katsuyuki Miura, Sachiko Tanaka-Mizuno, Taichiro Tanaka, Yasuyuki Nakamura, Akira Fujiyoshi, Aya Kadota, Junko Tamaki, Toru Takebayashi, Tomonori Okamura, Hirotsugu Ueshima

ABSTRACT

While the association between 24-h urinary sodium and potassium excretion with blood pressure is well established, the relationships of these ions to spot urine measurements are unclear. Our purpose is to assess the association between blood pressure and the estimated 24-h sodium and potassium excretion from repeated single-spot urine samples. Spot urine and blood pressure were collected annually during a 5-year period from 4360 Japanese workers with ages ranging from 19 to 55 years. Estimates of 24-h sodium and potassium excretion were based on Tanaka's formula. Overall, a single standard deviation increase in the estimated sodium excretion (36.5 mmol/day) was associated with a 1.3 mmHg higher systolic blood pressure and a 0.8 mmHg higher diastolic blood pressure (P < 0.001). A single standard deviation increase in estimated potassium excretion (8.9 mmol/day) was associated with a 1.1 mmHg lower systolic blood pressure and a 0.7 mmHg lower diastolic blood pressure (P < 0.001). As a combined measure of the excretion of both electrolytes, the estimated 24-h sodium-to-potassium ratio was positively associated with both blood pressures (P < 0.001). Associations of blood pressure with sodium and the sodium-to-potassium ratio increased with age and were stronger in men compared to women. Associations with potassium and the sodium-to-potassium ratio were stronger in individuals who were overweight. The findings provide evidence for an association between blood pressure and the estimated 24-h sodium and potassium excretion from repeated single-spot urine samples. As convenient measures of dietary intake for each electrolyte, repeated spot urine samples may be useful for assessing hypertension risk, especially in men, older individuals, and overweight individuals. More... »

PAGES

1-8

References to SciGraph publications

  • 2017-07. Diurnal variation of urinary sodium-to-potassium ratio in free-living Japanese individuals in HYPERTENSION RESEARCH
  • 2016-05. Four to seven random casual urine specimens are sufficient to estimate 24-h urinary sodium/potassium ratio in individuals with high blood pressure in JOURNAL OF HUMAN HYPERTENSION
  • 2004-07. The High-risk and Population Strategy for Occupational Health Promotion (HIPOP-OHP) study: study design and cardiovascular risk factors at the baseline survey in JOURNAL OF HUMAN HYPERTENSION
  • 2002-02. A simple method to estimate populational 24-h urinary sodium and potassium excretion using a casual urine specimen in JOURNAL OF HUMAN HYPERTENSION
  • 2004-07. Methodological issues for a large-scale intervention trial of lifestyle modification: Interim assessment of the high-risk and population strategy for occupational health promotion (HIPOP-OHP) study in ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
  • 2017-08. Relationships between urinary electrolytes excretion and central hemodynamics, and arterial stiffness in hypertensive patients in HYPERTENSION RESEARCH
  • 2010-03. Association between a-adducin gene polymorphism (Gly460Trp) and genetic predisposition to salt sensitivity: a meta-analysis in JOURNAL OF APPLIED GENETICS
  • 2014-08. Six random specimens of daytime casual urine on different days are sufficient to estimate daily sodium/potassium ratio in comparison to 7-day 24-h urine collections in HYPERTENSION RESEARCH
  • 1999-11. Trends in blood pressure and urinary sodium and potassium excretion in Japan: reinvestigation in the 8th year after the Intersalt Study in JOURNAL OF HUMAN HYPERTENSION
  • 2003. Salt Sensitivity of Japanese from the Viewpoint of Gene Polymorphism in HYPERTENSION RESEARCH
  • 2003-09. INTERMAP: the dietary data—process and quality control in JOURNAL OF HUMAN HYPERTENSION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41440-018-0152-z

    DOI

    http://dx.doi.org/10.1038/s41440-018-0152-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1110401067

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30523292


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical Physiology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Shiga University of Medical Science", 
              "id": "https://www.grid.ac/institutes/grid.410827.8", 
              "name": [
                "Department of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam", 
                "Department of Public Health, Shiga University of Medical Science, Otsu, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nguyen", 
            "givenName": "Trang Thi Minh", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Shiga University of Medical Science", 
              "id": "https://www.grid.ac/institutes/grid.410827.8", 
              "name": [
                "Department of Public Health, Shiga University of Medical Science, Otsu, Japan", 
                "Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Miura", 
            "givenName": "Katsuyuki", 
            "id": "sg:person.016117126742.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016117126742.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Shiga University of Medical Science", 
              "id": "https://www.grid.ac/institutes/grid.410827.8", 
              "name": [
                "Department of Medical Statistics, Shiga University of Medical Science, Otsu, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tanaka-Mizuno", 
            "givenName": "Sachiko", 
            "id": "sg:person.01050630721.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050630721.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Toho University", 
              "id": "https://www.grid.ac/institutes/grid.265050.4", 
              "name": [
                "Health Care Center, Toho University, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tanaka", 
            "givenName": "Taichiro", 
            "id": "sg:person.01304313507.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304313507.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ryukoku University", 
              "id": "https://www.grid.ac/institutes/grid.440926.d", 
              "name": [
                "Department of Food Science and Human Nutrition, Ryukoku University, Otsu, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakamura", 
            "givenName": "Yasuyuki", 
            "id": "sg:person.012451435004.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012451435004.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Shiga University of Medical Science", 
              "id": "https://www.grid.ac/institutes/grid.410827.8", 
              "name": [
                "Department of Public Health, Shiga University of Medical Science, Otsu, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fujiyoshi", 
            "givenName": "Akira", 
            "id": "sg:person.01316736544.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316736544.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Shiga University of Medical Science", 
              "id": "https://www.grid.ac/institutes/grid.410827.8", 
              "name": [
                "Department of Public Health, Shiga University of Medical Science, Otsu, Japan", 
                "Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kadota", 
            "givenName": "Aya", 
            "id": "sg:person.0755674244.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755674244.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Hygiene and Public Health, Osaka Medical University, Takatsuki, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tamaki", 
            "givenName": "Junko", 
            "id": "sg:person.0762667770.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762667770.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Keio University", 
              "id": "https://www.grid.ac/institutes/grid.26091.3c", 
              "name": [
                "Department of Preventive Medicine and Public Health, Keio University, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takebayashi", 
            "givenName": "Toru", 
            "id": "sg:person.01344616774.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344616774.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Keio University", 
              "id": "https://www.grid.ac/institutes/grid.26091.3c", 
              "name": [
                "Department of Preventive Medicine and Public Health, Keio University, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Okamura", 
            "givenName": "Tomonori", 
            "id": "sg:person.01103472645.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103472645.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Shiga University of Medical Science", 
              "id": "https://www.grid.ac/institutes/grid.410827.8", 
              "name": [
                "Department of Public Health, Shiga University of Medical Science, Otsu, Japan", 
                "Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ueshima", 
            "givenName": "Hirotsugu", 
            "id": "sg:person.013726456617.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013726456617.18"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/sj.jhh.1001307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006149433", 
              "https://doi.org/10.1038/sj.jhh.1001307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.jhh.1001307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006149433", 
              "https://doi.org/10.1038/sj.jhh.1001307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.f1326", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010843344"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.f1325", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011869866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.289.19.2560", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013958161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.jhh.1001680", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014299294", 
              "https://doi.org/10.1038/sj.jhh.1001680"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.jhh.1001680", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014299294", 
              "https://doi.org/10.1038/sj.jhh.1001680"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf03195715", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016466588", 
              "https://doi.org/10.1007/bf03195715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf03195715", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016466588", 
              "https://doi.org/10.1007/bf03195715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/jch.12658", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016607366"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/cir.0b013e31820d0793", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016664764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02898092", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020620006", 
              "https://doi.org/10.1007/bf02898092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02898092", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020620006", 
              "https://doi.org/10.1007/bf02898092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/cir.0000000000000015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021623201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/cir.0000000000000015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021623201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.jhh.1000915", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022687109", 
              "https://doi.org/10.1038/sj.jhh.1000915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.jhh.1000915", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022687109", 
              "https://doi.org/10.1038/sj.jhh.1000915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.hyp.33.1.18", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024829200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm200101043440101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027778040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/hr.2014.76", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027983768", 
              "https://doi.org/10.1038/hr.2014.76"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/hr.2014.76", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027983768", 
              "https://doi.org/10.1038/hr.2014.76"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1291/hypres.26.521", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028511156", 
              "https://doi.org/10.1291/hypres.26.521"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.hyp.22.4.502", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032026672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.hyp.17.1_suppl.i102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032973637"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-nutr-071714-034322", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037043877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/jhh.2015.84", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039708015", 
              "https://doi.org/10.1038/jhh.2015.84"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1249/01.mss.0000078924.61453.fb", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041095568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1249/01.mss.0000078924.61453.fb", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041095568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1249/01.mss.0000078924.61453.fb", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041095568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/aje/kwt066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041872859"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1620/tjem.158.269", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043022542"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.jhh.1001604", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044320796", 
              "https://doi.org/10.1038/sj.jhh.1001604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.jhh.1001604", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044320796", 
              "https://doi.org/10.1038/sj.jhh.1001604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2215/cjn.02060311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044550671"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.f1378", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046106182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/hjh.0000000000000122", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051707213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/hjh.0000000000000122", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051707213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1304127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051915754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nut.2007.09.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052588233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ije/dyv313", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059676618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ije/dyw287", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059676854"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/hr.2016.187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074207105", 
              "https://doi.org/10.1038/hr.2016.187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079218374", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079396334", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079791914", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/oxfordjournals.aje.a117100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082682298"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/hr.2017.29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084128104", 
              "https://doi.org/10.1038/hr.2017.29"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-12-06", 
        "datePublishedReg": "2018-12-06", 
        "description": "While the association between 24-h urinary sodium and potassium excretion with blood pressure is well established, the relationships of these ions to spot urine measurements are unclear. Our purpose is to assess the association between blood pressure and the estimated 24-h sodium and potassium excretion from repeated single-spot urine samples. Spot urine and blood pressure were collected annually during a 5-year period from 4360 Japanese workers with ages ranging from 19 to 55 years. Estimates of 24-h sodium and potassium excretion were based on Tanaka's formula. Overall, a single standard deviation increase in the estimated sodium excretion (36.5\u2009mmol/day) was associated with a 1.3\u2009mmHg higher systolic blood pressure and a 0.8\u2009mmHg higher diastolic blood pressure (P\u2009<\u20090.001). A single standard deviation increase in estimated potassium excretion (8.9\u2009mmol/day) was associated with a 1.1\u2009mmHg lower systolic blood pressure and a 0.7\u2009mmHg lower diastolic blood pressure (P\u2009<\u20090.001). As a combined measure of the excretion of both electrolytes, the estimated 24-h sodium-to-potassium ratio was positively associated with both blood pressures (P\u2009<\u20090.001). Associations of blood pressure with sodium and the sodium-to-potassium ratio increased with age and were stronger in men compared to women. Associations with potassium and the sodium-to-potassium ratio were stronger in individuals who were overweight. The findings provide evidence for an association between blood pressure and the estimated 24-h sodium and potassium excretion from repeated single-spot urine samples. As convenient measures of dietary intake for each electrolyte, repeated spot urine samples may be useful for assessing hypertension risk, especially in men, older individuals, and overweight individuals.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41440-018-0152-z", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1313717", 
            "issn": [
              "0916-9636", 
              "1348-4214"
            ], 
            "name": "Hypertension Research", 
            "type": "Periodical"
          }
        ], 
        "name": "Association of blood pressure with estimates of 24-h urinary sodium and potassium excretion from repeated single-spot urine samples", 
        "pagination": "1-8", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "a3d0c19e2842a4bd28cf689fc725169e3b29c6b3b709421958efd393d0c37f93"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30523292"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9307690"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41440-018-0152-z"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1110401067"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41440-018-0152-z", 
          "https://app.dimensions.ai/details/publication/pub.1110401067"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T08:30", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000309_0000000309/records_106256_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41440-018-0152-z"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41440-018-0152-z'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41440-018-0152-z'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41440-018-0152-z'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41440-018-0152-z'


     

    This table displays all metadata directly associated to this object as RDF triples.

    262 TRIPLES      21 PREDICATES      62 URIs      18 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41440-018-0152-z schema:about anzsrc-for:11
    2 anzsrc-for:1116
    3 schema:author N647afa0e20244b26ad4e7da50a409191
    4 schema:citation sg:pub.10.1007/bf02898092
    5 sg:pub.10.1007/bf03195715
    6 sg:pub.10.1038/hr.2014.76
    7 sg:pub.10.1038/hr.2016.187
    8 sg:pub.10.1038/hr.2017.29
    9 sg:pub.10.1038/jhh.2015.84
    10 sg:pub.10.1038/sj.jhh.1000915
    11 sg:pub.10.1038/sj.jhh.1001307
    12 sg:pub.10.1038/sj.jhh.1001604
    13 sg:pub.10.1038/sj.jhh.1001680
    14 sg:pub.10.1291/hypres.26.521
    15 https://app.dimensions.ai/details/publication/pub.1079218374
    16 https://app.dimensions.ai/details/publication/pub.1079396334
    17 https://app.dimensions.ai/details/publication/pub.1079791914
    18 https://doi.org/10.1001/jama.289.19.2560
    19 https://doi.org/10.1016/j.nut.2007.09.001
    20 https://doi.org/10.1056/nejm200101043440101
    21 https://doi.org/10.1056/nejmoa1304127
    22 https://doi.org/10.1093/aje/kwt066
    23 https://doi.org/10.1093/ije/dyv313
    24 https://doi.org/10.1093/ije/dyw287
    25 https://doi.org/10.1093/oxfordjournals.aje.a117100
    26 https://doi.org/10.1097/hjh.0000000000000122
    27 https://doi.org/10.1111/jch.12658
    28 https://doi.org/10.1136/bmj.f1325
    29 https://doi.org/10.1136/bmj.f1326
    30 https://doi.org/10.1136/bmj.f1378
    31 https://doi.org/10.1146/annurev-nutr-071714-034322
    32 https://doi.org/10.1161/01.hyp.17.1_suppl.i102
    33 https://doi.org/10.1161/01.hyp.22.4.502
    34 https://doi.org/10.1161/01.hyp.33.1.18
    35 https://doi.org/10.1161/cir.0000000000000015
    36 https://doi.org/10.1161/cir.0b013e31820d0793
    37 https://doi.org/10.1249/01.mss.0000078924.61453.fb
    38 https://doi.org/10.1620/tjem.158.269
    39 https://doi.org/10.2215/cjn.02060311
    40 schema:datePublished 2018-12-06
    41 schema:datePublishedReg 2018-12-06
    42 schema:description While the association between 24-h urinary sodium and potassium excretion with blood pressure is well established, the relationships of these ions to spot urine measurements are unclear. Our purpose is to assess the association between blood pressure and the estimated 24-h sodium and potassium excretion from repeated single-spot urine samples. Spot urine and blood pressure were collected annually during a 5-year period from 4360 Japanese workers with ages ranging from 19 to 55 years. Estimates of 24-h sodium and potassium excretion were based on Tanaka's formula. Overall, a single standard deviation increase in the estimated sodium excretion (36.5 mmol/day) was associated with a 1.3 mmHg higher systolic blood pressure and a 0.8 mmHg higher diastolic blood pressure (P < 0.001). A single standard deviation increase in estimated potassium excretion (8.9 mmol/day) was associated with a 1.1 mmHg lower systolic blood pressure and a 0.7 mmHg lower diastolic blood pressure (P < 0.001). As a combined measure of the excretion of both electrolytes, the estimated 24-h sodium-to-potassium ratio was positively associated with both blood pressures (P < 0.001). Associations of blood pressure with sodium and the sodium-to-potassium ratio increased with age and were stronger in men compared to women. Associations with potassium and the sodium-to-potassium ratio were stronger in individuals who were overweight. The findings provide evidence for an association between blood pressure and the estimated 24-h sodium and potassium excretion from repeated single-spot urine samples. As convenient measures of dietary intake for each electrolyte, repeated spot urine samples may be useful for assessing hypertension risk, especially in men, older individuals, and overweight individuals.
    43 schema:genre research_article
    44 schema:inLanguage en
    45 schema:isAccessibleForFree false
    46 schema:isPartOf sg:journal.1313717
    47 schema:name Association of blood pressure with estimates of 24-h urinary sodium and potassium excretion from repeated single-spot urine samples
    48 schema:pagination 1-8
    49 schema:productId N82a5e7afd3db4494bbf60bb870b9ad52
    50 N950e110f60b54a07b29c85ae2bb4a883
    51 N97938f8daa6748c1947e9225602a23de
    52 Nb17f6503f06147988ca6ccb2d8585773
    53 Nd13268e102ae4d66b7576c109265f3ef
    54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110401067
    55 https://doi.org/10.1038/s41440-018-0152-z
    56 schema:sdDatePublished 2019-04-11T08:30
    57 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    58 schema:sdPublisher Nfa16ae12b12145f29b8f710469c75b26
    59 schema:url https://www.nature.com/articles/s41440-018-0152-z
    60 sgo:license sg:explorer/license/
    61 sgo:sdDataset articles
    62 rdf:type schema:ScholarlyArticle
    63 N06522f2127064319923e01f3828fabff rdf:first sg:person.01316736544.12
    64 rdf:rest N29cb95c6689544018f7afc25728aaad4
    65 N0732fd1be5494d088eca8dfbb47a5df1 schema:name Department of Hygiene and Public Health, Osaka Medical University, Takatsuki, Japan
    66 rdf:type schema:Organization
    67 N0d8d927c8cee46388c26d8833bad606e rdf:first sg:person.01103472645.54
    68 rdf:rest N6e1cf8648c864b9a8be5429b9df227c7
    69 N27ea60b7cb354f768def6f410fb7edd6 rdf:first sg:person.012451435004.39
    70 rdf:rest N06522f2127064319923e01f3828fabff
    71 N29cb95c6689544018f7afc25728aaad4 rdf:first sg:person.0755674244.04
    72 rdf:rest Nadfa9f5d487342e394bc3f6c23fce3c0
    73 N3ec9275aab474461a499dac042c2a15e rdf:first sg:person.01344616774.70
    74 rdf:rest N0d8d927c8cee46388c26d8833bad606e
    75 N56a03eff248c481599799e6ab500608d rdf:first sg:person.016117126742.38
    76 rdf:rest Nee0ef7de20e3443f8878f875213f1ffa
    77 N647afa0e20244b26ad4e7da50a409191 rdf:first Nba406cbb7db148ba90a44ad622bfc66f
    78 rdf:rest N56a03eff248c481599799e6ab500608d
    79 N6e1cf8648c864b9a8be5429b9df227c7 rdf:first sg:person.013726456617.18
    80 rdf:rest rdf:nil
    81 N82a5e7afd3db4494bbf60bb870b9ad52 schema:name pubmed_id
    82 schema:value 30523292
    83 rdf:type schema:PropertyValue
    84 N950e110f60b54a07b29c85ae2bb4a883 schema:name dimensions_id
    85 schema:value pub.1110401067
    86 rdf:type schema:PropertyValue
    87 N97938f8daa6748c1947e9225602a23de schema:name doi
    88 schema:value 10.1038/s41440-018-0152-z
    89 rdf:type schema:PropertyValue
    90 N9c5e0d7a1f73456cb4b34caf9049750e rdf:first sg:person.01304313507.20
    91 rdf:rest N27ea60b7cb354f768def6f410fb7edd6
    92 Nadfa9f5d487342e394bc3f6c23fce3c0 rdf:first sg:person.0762667770.00
    93 rdf:rest N3ec9275aab474461a499dac042c2a15e
    94 Nb17f6503f06147988ca6ccb2d8585773 schema:name readcube_id
    95 schema:value a3d0c19e2842a4bd28cf689fc725169e3b29c6b3b709421958efd393d0c37f93
    96 rdf:type schema:PropertyValue
    97 Nba406cbb7db148ba90a44ad622bfc66f schema:affiliation https://www.grid.ac/institutes/grid.410827.8
    98 schema:familyName Nguyen
    99 schema:givenName Trang Thi Minh
    100 rdf:type schema:Person
    101 Nd13268e102ae4d66b7576c109265f3ef schema:name nlm_unique_id
    102 schema:value 9307690
    103 rdf:type schema:PropertyValue
    104 Nee0ef7de20e3443f8878f875213f1ffa rdf:first sg:person.01050630721.17
    105 rdf:rest N9c5e0d7a1f73456cb4b34caf9049750e
    106 Nfa16ae12b12145f29b8f710469c75b26 schema:name Springer Nature - SN SciGraph project
    107 rdf:type schema:Organization
    108 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    109 schema:name Medical and Health Sciences
    110 rdf:type schema:DefinedTerm
    111 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
    112 schema:name Medical Physiology
    113 rdf:type schema:DefinedTerm
    114 sg:journal.1313717 schema:issn 0916-9636
    115 1348-4214
    116 schema:name Hypertension Research
    117 rdf:type schema:Periodical
    118 sg:person.01050630721.17 schema:affiliation https://www.grid.ac/institutes/grid.410827.8
    119 schema:familyName Tanaka-Mizuno
    120 schema:givenName Sachiko
    121 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050630721.17
    122 rdf:type schema:Person
    123 sg:person.01103472645.54 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
    124 schema:familyName Okamura
    125 schema:givenName Tomonori
    126 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103472645.54
    127 rdf:type schema:Person
    128 sg:person.012451435004.39 schema:affiliation https://www.grid.ac/institutes/grid.440926.d
    129 schema:familyName Nakamura
    130 schema:givenName Yasuyuki
    131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012451435004.39
    132 rdf:type schema:Person
    133 sg:person.01304313507.20 schema:affiliation https://www.grid.ac/institutes/grid.265050.4
    134 schema:familyName Tanaka
    135 schema:givenName Taichiro
    136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304313507.20
    137 rdf:type schema:Person
    138 sg:person.01316736544.12 schema:affiliation https://www.grid.ac/institutes/grid.410827.8
    139 schema:familyName Fujiyoshi
    140 schema:givenName Akira
    141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316736544.12
    142 rdf:type schema:Person
    143 sg:person.01344616774.70 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
    144 schema:familyName Takebayashi
    145 schema:givenName Toru
    146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344616774.70
    147 rdf:type schema:Person
    148 sg:person.013726456617.18 schema:affiliation https://www.grid.ac/institutes/grid.410827.8
    149 schema:familyName Ueshima
    150 schema:givenName Hirotsugu
    151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013726456617.18
    152 rdf:type schema:Person
    153 sg:person.016117126742.38 schema:affiliation https://www.grid.ac/institutes/grid.410827.8
    154 schema:familyName Miura
    155 schema:givenName Katsuyuki
    156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016117126742.38
    157 rdf:type schema:Person
    158 sg:person.0755674244.04 schema:affiliation https://www.grid.ac/institutes/grid.410827.8
    159 schema:familyName Kadota
    160 schema:givenName Aya
    161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755674244.04
    162 rdf:type schema:Person
    163 sg:person.0762667770.00 schema:affiliation N0732fd1be5494d088eca8dfbb47a5df1
    164 schema:familyName Tamaki
    165 schema:givenName Junko
    166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762667770.00
    167 rdf:type schema:Person
    168 sg:pub.10.1007/bf02898092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020620006
    169 https://doi.org/10.1007/bf02898092
    170 rdf:type schema:CreativeWork
    171 sg:pub.10.1007/bf03195715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016466588
    172 https://doi.org/10.1007/bf03195715
    173 rdf:type schema:CreativeWork
    174 sg:pub.10.1038/hr.2014.76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027983768
    175 https://doi.org/10.1038/hr.2014.76
    176 rdf:type schema:CreativeWork
    177 sg:pub.10.1038/hr.2016.187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074207105
    178 https://doi.org/10.1038/hr.2016.187
    179 rdf:type schema:CreativeWork
    180 sg:pub.10.1038/hr.2017.29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084128104
    181 https://doi.org/10.1038/hr.2017.29
    182 rdf:type schema:CreativeWork
    183 sg:pub.10.1038/jhh.2015.84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039708015
    184 https://doi.org/10.1038/jhh.2015.84
    185 rdf:type schema:CreativeWork
    186 sg:pub.10.1038/sj.jhh.1000915 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022687109
    187 https://doi.org/10.1038/sj.jhh.1000915
    188 rdf:type schema:CreativeWork
    189 sg:pub.10.1038/sj.jhh.1001307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006149433
    190 https://doi.org/10.1038/sj.jhh.1001307
    191 rdf:type schema:CreativeWork
    192 sg:pub.10.1038/sj.jhh.1001604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044320796
    193 https://doi.org/10.1038/sj.jhh.1001604
    194 rdf:type schema:CreativeWork
    195 sg:pub.10.1038/sj.jhh.1001680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014299294
    196 https://doi.org/10.1038/sj.jhh.1001680
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1291/hypres.26.521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028511156
    199 https://doi.org/10.1291/hypres.26.521
    200 rdf:type schema:CreativeWork
    201 https://app.dimensions.ai/details/publication/pub.1079218374 schema:CreativeWork
    202 https://app.dimensions.ai/details/publication/pub.1079396334 schema:CreativeWork
    203 https://app.dimensions.ai/details/publication/pub.1079791914 schema:CreativeWork
    204 https://doi.org/10.1001/jama.289.19.2560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013958161
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.1016/j.nut.2007.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052588233
    207 rdf:type schema:CreativeWork
    208 https://doi.org/10.1056/nejm200101043440101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027778040
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.1056/nejmoa1304127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051915754
    211 rdf:type schema:CreativeWork
    212 https://doi.org/10.1093/aje/kwt066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041872859
    213 rdf:type schema:CreativeWork
    214 https://doi.org/10.1093/ije/dyv313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059676618
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.1093/ije/dyw287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059676854
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1093/oxfordjournals.aje.a117100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082682298
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1097/hjh.0000000000000122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051707213
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1111/jch.12658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016607366
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1136/bmj.f1325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011869866
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1136/bmj.f1326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010843344
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1136/bmj.f1378 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046106182
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1146/annurev-nutr-071714-034322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037043877
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1161/01.hyp.17.1_suppl.i102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032973637
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1161/01.hyp.22.4.502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032026672
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1161/01.hyp.33.1.18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024829200
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1161/cir.0000000000000015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021623201
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1161/cir.0b013e31820d0793 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016664764
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1249/01.mss.0000078924.61453.fb schema:sameAs https://app.dimensions.ai/details/publication/pub.1041095568
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1620/tjem.158.269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043022542
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.2215/cjn.02060311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044550671
    247 rdf:type schema:CreativeWork
    248 https://www.grid.ac/institutes/grid.26091.3c schema:alternateName Keio University
    249 schema:name Department of Preventive Medicine and Public Health, Keio University, Tokyo, Japan
    250 rdf:type schema:Organization
    251 https://www.grid.ac/institutes/grid.265050.4 schema:alternateName Toho University
    252 schema:name Health Care Center, Toho University, Tokyo, Japan
    253 rdf:type schema:Organization
    254 https://www.grid.ac/institutes/grid.410827.8 schema:alternateName Shiga University of Medical Science
    255 schema:name Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Japan
    256 Department of Medical Statistics, Shiga University of Medical Science, Otsu, Japan
    257 Department of Public Health, Shiga University of Medical Science, Otsu, Japan
    258 Department of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam
    259 rdf:type schema:Organization
    260 https://www.grid.ac/institutes/grid.440926.d schema:alternateName Ryukoku University
    261 schema:name Department of Food Science and Human Nutrition, Ryukoku University, Otsu, Japan
    262 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...