High central blood pressure is associated with incident cardiovascular events in treated hypertensives: the ABC-J II Study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-08-02

AUTHORS

Kazuo Eguchi, Hiroshi Miyashita, Tsuneo Takenaka, Yasuharu Tabara, Hirofumi Tomiyama, Yasuaki Dohi, Junichiro Hashimoto, Takayoshi Ohkubo, Yuko Ohta, Yoshitaka Hirooka, Katsuhiko Kohara, Sadayoshi Ito, Yuhei Kawano, Kenji Sunagawa, Hiromichi Suzuki, Yutaka Imai, Kazuomi Kario, Kenji Takazawa, Akira Yamashina, Kazuyuki Shimada, the ABC-J II Investigator Group

ABSTRACT

It is not established whether central blood pressure (BP) evaluated by a radial pulse wave analysis is useful to predict cardiovascular prognoses. We tested the hypothesis that central BP predicts future cardiovascular events in treated hypertensive subjects. We conducted a multicenter, observational cohort study of 3566 hypertensives being treated with antihypertensive medications at 27 institutions in Japan. We performed the radial pulse wave analyses using applanation tonometry in all subjects. The primary outcome was the incidence of any of the following: stroke, myocardial infarction (MI), sudden cardiac death, and acute aortic dissection. The mean age of the subjects was 66.0 ± 10.9 years, and 50.6% were male. The mean brachial SBP and central SBP were 138 ± 18 mm Hg and 128 ± 19 mm Hg, respectively. When the central SBP was divided into quintiles, the number of events was least in the 2nd quintile, and we set it as the reference. In the Cox regression analysis adjusting for age, sex, body mass index, creatinine, diabetes, use of β-blocker, and history of MI/stroke, the patients in the 3rd (hazard ratio (HR) 3.55, 95% confidence interval 1.29–9.78, p = 0.014), 4th (HR 4.12, 95% CI 1.53–11.10, p = 0.005), and 5th quintiles (HR 2.87, 95% CI 1.01–8.18, p = 0.048) had a significantly higher incidence of cardiovascular events compared to the 2nd quintile. The results were essentially unchanged when brachial DBP was additionally adjusted. In conclusion, in treated hypertensives, high central SBP was associated with worse cardiovascular outcomes. More... »

PAGES

947-956

References to SciGraph publications

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  • Journal

    TITLE

    Hypertension Research

    ISSUE

    11

    VOLUME

    41

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41440-018-0075-8

    DOI

    http://dx.doi.org/10.1038/s41440-018-0075-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1105950654

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30072732


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