Structural basis of ethnic-specific variants of PAX4 associated with type 2 diabetes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-07-05

AUTHORS

Jun Hosoe, Ken Suzuki, Fuyuki Miya, Takashi Kato, Tatsuhiko Tsunoda, Yukinori Okada, Momoko Horikoshi, Nobuhiro Shojima, Toshimasa Yamauchi, Takashi Kadowaki

ABSTRACT

Recently, we conducted genome-wide association studies of type 2 diabetes (T2D) in a Japanese population, which identified 20 novel T2D loci that were not associated with T2D in Europeans. Moreover, nine novel missense risk variants, such as those of PAX4, were not rare in the Japanese population, but rare in Europeans. We report in silico structural analysis of ethnic-specific variants of PAX4, which suggests the pathogenic effect of these variants. More... »

PAGES

25

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41439-021-00156-8

DOI

http://dx.doi.org/10.1038/s41439-021-00156-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1139364033

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34226521


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