Prevalence of pharmacogenomic variants in 100 pharmacogenes among Southeast Asian populations under the collaboration of the Southeast Asian Pharmacogenomics Research ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-02-04

AUTHORS

Chakkaphan Runcharoen, Koya Fukunaga, Insee Sensorn, Nareenart Iemwimangsa, Sommon Klumsathian, Hang Tong, Nam Sy Vo, Ly Le, Tin Maung Hlaing, Myo Thant, Shamsul Mohd Zain, Zahurin Mohamed, Yuh-Fen Pung, Francis Capule, Jose Nevado, Catherine Lynn Silao, Zeina N. Al-Mahayri, Bassam R. Ali, Rika Yuliwulandari, Kinasih Prayuni, Hilyatuz Zahroh, Dzul Azri Mohamed Noor, Phonepadith Xangsayarath, Dalouny Xayavong, Sengchanh Kounnavong, Somphou Sayasone, Zoe Kordou, Ioannis Liopetas, Athina Tsikrika, Evangelia-Eirini Tsermpini, Maria Koromina, Christina Mitropoulou, George P. Patrinos, Aumpika Kesornsit, Angkana Charoenyingwattana, Sukanya Wattanapokayakit, Surakameth Mahasirimongkol, Taisei Mushiroda, Wasun Chantratita

ABSTRACT

Pharmacogenomics can enhance the outcome of treatment by adopting pharmacogenomic testing to maximize drug efficacy and lower the risk of serious adverse events. Next-generation sequencing (NGS) is a cost-effective technology for genotyping several pharmacogenomic loci at once, thereby increasing publicly available data. A panel of 100 pharmacogenes among Southeast Asian (SEA) populations was resequenced using the NGS platform under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm). Here, we present the frequencies of pharmacogenomic variants and the comparison of these pharmacogenomic variants among different SEA populations and other populations used as controls. We investigated the different types of pharmacogenomic variants, especially those that may have a functional impact. Our results provide substantial genetic variations at 100 pharmacogenomic loci among SEA populations that may contribute to interpopulation variability in drug response phenotypes. Correspondingly, this study provides basic information for further pharmacogenomic investigations in SEA populations. More... »

PAGES

7

Journal

TITLE

Human Genome Variation

ISSUE

1

VOLUME

8

Author Affiliations

  • Center for Medical Genomics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • Laboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
  • School of Biotechnology, International University, Vietnam National University, Ho Chi Minh City, Vietnam
  • Vingroup Big Data Institute, Hanoi, Vietnam
  • Defence Services Medical Academy, Mingalardon, Myanmar
  • Defence Services Medical Research Centre, Nay Pyi Taw, Myanmar
  • Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • Department of Biomedical Sciences, University of Nottingham (Malaysia Campus), Selangor, Malaysia
  • Department of Pharmacy, College of Pharmacy, University of the Philippines Manila, Manila, Philippines
  • Institute of Human Genetics, National Institutes of Health, University of the Philippines Manila, Manila, Philippines
  • Department of Pediatrics, Philippine General Hospital and College of Medicine, University of the Philippines Manila, Manila, Philippines
  • Department of Pathology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
  • Department of Pathology and Department of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
  • Genetic Research Center, YARSI Research Institute, YARSI University, Jakarta, Indonesia
  • School of Pharmaceutical Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia
  • National Center for Laboratory and Epidemiology (NCLE), Vientiane, Lao PDR
  • Lao Tropical and Public Health Institute, Vientiane, Lao PDR
  • University of Patras, School of Health Sciences, Department of Pharmacy, Laboratory of Pharmacogenomics and Individualised Therapy, Patras, Greece
  • The Golden Helix Foundation, London, UK
  • Graduate Program in Molecular Medicine, Faculty of Science, Mahidol University, Bangkok, Thailand
  • Division of Genomic Medicine and Innovation Support, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41439-021-00135-z

    DOI

    http://dx.doi.org/10.1038/s41439-021-00135-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1135110689

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33542200


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