27 years of prenatal diagnosis for Huntington disease in the United Kingdom View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-12-14

AUTHORS

Raul E. Piña-Aguilar, Sheila A. Simpson, Abdulrahman Alshatti, Angus Clarke, David Craufurd, Huw Dorkins, Karen Doye, Nayana Lahiri, Alison Lashwood, Colleen Lynch, Claire Miller, Sally Morton, Mary O’Driscoll, Oliver W. Quarrell, Daniela Rae, Mark Strong, Charlotte Tomlinson, Peter Turnpenny, Zosia Miedzybrodzka

ABSTRACT

PURPOSE: There is little long-term, population-based data on uptake of prenatal diagnosis for Huntington disease (HD), a late-onset autosomal dominant neurodegenerative disorder, and the effect of the availability of preimplantation genetic diagnosis (PGD) on families' decisions about conventional prenatal diagnosis is not known. We report trends in prenatal diagnosis and preimplantation diagnosis for HD in the United Kingdom since services commenced. METHODS: Long-term UK-wide prospective case record-based service evaluation in 23 UK Regional Genetic Centres 1988-2015, and four UK PGD centers 2002-2015. RESULTS: From 1988 to 2015, 479 prenatal diagnoses were performed in the UK for HD. An exclusion approach was used in 150 (31%). The annual rate of HD prenatal diagnosis has remained around 18 (3.5/million) over 27 years, despite a steady increase in the use of PGD for HD since 2002. CONCLUSION: Although increasing number of couples are choosing either direct or exclusion PGD to prevent HD in their offspring, both direct and exclusion prenatal diagnosis remain important options in a health system where both PGD and prenatal diagnosis are state funded. At-risk couples should be informed of all options available to them, preferably prepregnancy. More... »

PAGES

1-5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41436-018-0367-z

DOI

http://dx.doi.org/10.1038/s41436-018-0367-z

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https://app.dimensions.ai/details/publication/pub.1110559583

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30546084


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23 schema:description PURPOSE: There is little long-term, population-based data on uptake of prenatal diagnosis for Huntington disease (HD), a late-onset autosomal dominant neurodegenerative disorder, and the effect of the availability of preimplantation genetic diagnosis (PGD) on families' decisions about conventional prenatal diagnosis is not known. We report trends in prenatal diagnosis and preimplantation diagnosis for HD in the United Kingdom since services commenced. METHODS: Long-term UK-wide prospective case record-based service evaluation in 23 UK Regional Genetic Centres 1988-2015, and four UK PGD centers 2002-2015. RESULTS: From 1988 to 2015, 479 prenatal diagnoses were performed in the UK for HD. An exclusion approach was used in 150 (31%). The annual rate of HD prenatal diagnosis has remained around 18 (3.5/million) over 27 years, despite a steady increase in the use of PGD for HD since 2002. CONCLUSION: Although increasing number of couples are choosing either direct or exclusion PGD to prevent HD in their offspring, both direct and exclusion prenatal diagnosis remain important options in a health system where both PGD and prenatal diagnosis are state funded. At-risk couples should be informed of all options available to them, preferably prepregnancy.
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