A new clinical screening strategy and prevalence estimation for glucokinase variant-induced diabetes in an adult Chinese population View Full Text


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Article Info

DATE

2019-04

AUTHORS

Yumin Ma, Xueyao Han, Xianghai Zhou, Yufeng Li, Siqian Gong, Simin Zhang, Xiaoling Cai, Lingli Zhou, Yingying Luo, Meng Li, Wei Liu, Xiuying Zhang, Qian Ren, Linong Ji

ABSTRACT

PURPOSE: To estimate the prevalence of glucokinase variant-induced diabetes (GCK-DM) in a general population and to establish a clinical strategy for identifying GCK-DM from type 2 diabetes (T2DM). METHODS: A population-based study of diabetes in a rural region of Beijing, China, was conducted using two-stage stratified random cluster sampling. The glucokinase exons were sequenced in patients with diabetes. RESULTS: A total of 3345 subjects, including 545 patients with diabetes, participated in this study. Seven patients with GCK-DM were identified. The estimated prevalence rates of GCK-DM were 0.21% and 1.3% in the whole population and the diabetic patients, respectively. In the newly diagnosed diabetic patients (New-DM), a triglyceride cutoff ≤1.43 mmol/L (126.55 mg/dl) could discriminate GCK-DM from T2DM with 100% sensitivity and 68.4% specificity. Its effectiveness was confirmed in an additional 134 early-onset young patients with T2DM and mild hyperglycemia. A clinical criterion based on triglyceride and mild hyperglycemia could differentiate GCK-DM from T2DM in New-DM and was shown to be effective in identifying GCK-DM from 559 early-onset young patients with T2DM in the hospital. CONCLUSIONS: The prevalence of GCK-DM is approximately 1.3% in the Chinese population with diabetes, and the new clinical screening strategy is helpful for identifying GCK-DM. More... »

PAGES

939-947

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41436-018-0282-3

    DOI

    http://dx.doi.org/10.1038/s41436-018-0282-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1107129343

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30245511


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