Adeno-associated virus neutralising antibodies in type 1 diabetes mellitus. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-08

AUTHORS

Slawomir Andrzejewski, Aparna Murali, Charmaine Ramlogan-Steel, Katie P Edwards, Nathan Efron, Jason C Steel, Christopher J Layton

ABSTRACT

Recombinant Adeno-associated viruses (AAVs) are an attractive vector for gene therapy delivery which may be blocked by AAV neutralising antibodies (NAbs). As Type 1 Diabetes (T1DM) is an endocrine disease of immunological origin, it is likely that NAb profiles are altered in the disease. In this study NAb to AAV2, AAV5, AAV6, and AAV8 in 72 subjects with T1DM and 45 non-diabetic patients were measured over a 4-year follow-up period. AAV2 NAb titres were significantly lower in non-diabetic subjects (P = 0.036). The T1DM group had more AAV8 NAb activity at baseline (P = 0.019), whilst after 4 years follow-up the T1DM group displayed developed increased AAV 5 (P = 0.03), 6 (P = 0.03) and 8 (P = 0.002) activity relative to the control group, however, overall AAV5 and 8 NAb levels were very low in patients <40. AAV NAb titre activity and prevalence generally appears higher in T1DM, however, low levels of AAV 5 and 8, particular in younger adult age groups at which T1DM can be targeted, could make these attractive vectors to target the disease. More... »

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41434-019-0076-5

    DOI

    http://dx.doi.org/10.1038/s41434-019-0076-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113300759

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30962537


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