Relationship between age and surgical success after trabeculectomy with adjunctive mitomycin C View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-08

AUTHORS

Thi Kieu Hau Hoang, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park

ABSTRACT

PURPOSE: To investigate whether there is any effect of age on bleb morphology and surgical success after trabeculectomy with adjunctive Mitomycin C (MMC). METHODS: A total 143 eyes of 123 patients were divided into two groups: group 1 ( ≤ 60 years old, n = 85) and group 2 ( > 60 years old, n = 58). Kaplan-Meier survival curve analysis was used to assess long-term surgical success according to "complete success" (intraocular pressure (IOP) reduction ≥ 30% without medications) and "qualified success" criteria (IOP reduction ≥ 30%, with or without medications) between the two groups. Cox proportional hazard models were used to examine the factors associated with surgical success. Bleb morphology was evaluated by height, extent and vascularity at postoperative 1 month, 3 months, 6 months, and 12 months. RESULTS: The younger-age group (group 1) showed significantly better results, in terms of both complete success and qualified success, than did the older-age group (group 2) (p < 0.001 and p = 0.01, respectively). Age and preoperative anti-glaucoma medications were the factors related to complete success (p = 0.001). Also, there were significant differences in height, extent and vascularity of bleb between the two groups (p = 0.038, p = 0.002 and p = 0.006, respectively). CONCLUSION: The long-term surgical outcome after trabeculectomy with MMC was better in the younger-age group than in the older-age group. Specifically, the younger-age group showed a more prominent and more localized bleb with less vascularity. More... »

PAGES

1321-1328

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41433-018-0071-x

DOI

http://dx.doi.org/10.1038/s41433-018-0071-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101760968

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29581522


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59 schema:description PURPOSE: To investigate whether there is any effect of age on bleb morphology and surgical success after trabeculectomy with adjunctive Mitomycin C (MMC). METHODS: A total 143 eyes of 123 patients were divided into two groups: group 1 ( ≤ 60 years old, n = 85) and group 2 ( > 60 years old, n = 58). Kaplan-Meier survival curve analysis was used to assess long-term surgical success according to "complete success" (intraocular pressure (IOP) reduction ≥ 30% without medications) and "qualified success" criteria (IOP reduction ≥ 30%, with or without medications) between the two groups. Cox proportional hazard models were used to examine the factors associated with surgical success. Bleb morphology was evaluated by height, extent and vascularity at postoperative 1 month, 3 months, 6 months, and 12 months. RESULTS: The younger-age group (group 1) showed significantly better results, in terms of both complete success and qualified success, than did the older-age group (group 2) (p < 0.001 and p = 0.01, respectively). Age and preoperative anti-glaucoma medications were the factors related to complete success (p = 0.001). Also, there were significant differences in height, extent and vascularity of bleb between the two groups (p = 0.038, p = 0.002 and p = 0.006, respectively). CONCLUSION: The long-term surgical outcome after trabeculectomy with MMC was better in the younger-age group than in the older-age group. Specifically, the younger-age group showed a more prominent and more localized bleb with less vascularity.
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