Development of patient “profiles” to tailor counseling for incidental genomic sequencing results View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-08

AUTHORS

Chloe Mighton, Lindsay Carlsson, Marc Clausen, Selina Casalino, Salma Shickh, Laura McCuaig, Esha Joshi, Seema Panchal, Tracy Graham, Melyssa Aronson, Carolyn Piccinin, Laura Winter-Paquette, Kara Semotiuk, Justin Lorentz, Talia Mancuso, Karen Ott, Yael Silberman, Christine Elser, Andrea Eisen, Raymond H. Kim, Jordan Lerner-Ellis, June C. Carroll, Emily Glogowski, Kasmintan Schrader, Yvonne Bombard

ABSTRACT

Guidelines recommend that providers engage patients in shared decision-making about receiving incidental results (IR) prior to genomic sequencing (GS), but this can be time-consuming, given the myriad of IR and variation in patients' preferences. We aimed to develop patient profiles to inform pre-test counseling for IR. We conducted semi-structured interviews with participants as a part of a randomized trial of the GenomicsADvISER.com, a decision aid for selecting IR. Interviews explored factors participants considered when deliberating over learning IR. Interviews were analyzed by thematic analysis and constant comparison. Participants were mostly female (28/31) and about half of them were over the age of 50 (16/31). We identified five patient profiles that reflect common contextual factors, attitudes, concerns, and perceived utility of IR. Information Enthusiasts self-identified as "planners" and valued learning most or all IR to enable planning and disease prevention because "knowledge is power". Concerned Individuals defined themselves as "anxious," and were reluctant to learn IR, anticipating negative psychological impacts from IR. Contemplators were discerning about the value and limitations of IR, weighing health benefits with the impacts of not being able to "un-know" information. Individuals of Advanced Life Stage did not consider IR relevant for themselves and primarily considered their implications for family members. Reassurance Seekers were reassured by previous negative genetic test results which shaped their expectations for receiving no IR: "hopefully [GS will] be negative, too. And then I can rest easy". These profiles could inform targeted counseling for IR by providing a framework to address common values, concerns. and misconceptions. More... »

PAGES

1-10

References to SciGraph publications

  • 2013-11. Recommendations for returning genomic incidental findings? We need to talk! in GENETICS IN MEDICINE
  • 2013-11. Return of incidental findings in genomic medicine: measuring what patients value—development of an instrument to measure preferences for information from next-generation testing (IMPRINT) in GENETICS IN MEDICINE
  • 2011-06. Deploying whole genome sequencing in clinical practice and public health: Meeting the challenge one bin at a time in GENETICS IN MEDICINE
  • 2013-03. Intentions to receive individual results from whole-genome sequencing among participants in the ClinSeq study in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2017-05. Choices for return of primary and secondary genomic research results of 790 members of families with Mendelian disease in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2018-10. Operationalizing the Reciprocal Engagement Model of Genetic Counseling Practice: a Framework for the Scalable Delivery of Genomic Counseling and Testing in JOURNAL OF GENETIC COUNSELING
  • 2013-02. Focusing on Patient Needs and Preferences May Improve Genetic Counseling for Colorectal Cancer in JOURNAL OF GENETIC COUNSELING
  • 2018-07. The Genomics ADvISER: development and usability testing of a decision aid for the selection of incidental sequencing results in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2015-09. Purposeful Sampling for Qualitative Data Collection and Analysis in Mixed Method Implementation Research in ADMINISTRATION AND POLICY IN MENTAL HEALTH AND MENTAL HEALTH SERVICES RESEARCH
  • 2017-02. Recommendations for reporting of secondary findings in clinical exome and genome sequencing, 2016 update (ACMG SF v2.0): a policy statement of the American College of Medical Genetics and Genomics in GENETICS IN MEDICINE
  • 2013-06. Whole-genome sequencing in health care in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2019-01. Psychosocial and behavioral outcomes of genomic testing in cancer: a systematic review in EUROPEAN JOURNAL OF HUMAN GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41431-019-0352-2

    DOI

    http://dx.doi.org/10.1038/s41431-019-0352-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112606885

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30846854


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1701", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Psychology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/17", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Psychology and Cognitive Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "St. Michael's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.415502.7", 
              "name": [
                "University of Toronto, Toronto, ON, Canada", 
                "St. Michael\u2019s Hospital, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mighton", 
            "givenName": "Chloe", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Health Network", 
              "id": "https://www.grid.ac/institutes/grid.231844.8", 
              "name": [
                "University Health Network, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carlsson", 
            "givenName": "Lindsay", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "St. Michael's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.415502.7", 
              "name": [
                "St. Michael\u2019s Hospital, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Clausen", 
            "givenName": "Marc", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "St. Michael's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.415502.7", 
              "name": [
                "St. Michael\u2019s Hospital, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Casalino", 
            "givenName": "Selina", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "St. Michael's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.415502.7", 
              "name": [
                "University of Toronto, Toronto, ON, Canada", 
                "St. Michael\u2019s Hospital, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shickh", 
            "givenName": "Salma", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "St. Michael's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.415502.7", 
              "name": [
                "University of Toronto, Toronto, ON, Canada", 
                "St. Michael\u2019s Hospital, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McCuaig", 
            "givenName": "Laura", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "St. Michael's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.415502.7", 
              "name": [
                "University of Toronto, Toronto, ON, Canada", 
                "St. Michael\u2019s Hospital, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Joshi", 
            "givenName": "Esha", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mount Sinai Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416166.2", 
              "name": [
                "Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Panchal", 
            "givenName": "Seema", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sunnybrook Health Science Centre", 
              "id": "https://www.grid.ac/institutes/grid.413104.3", 
              "name": [
                "Sunnybrook Health Sciences Centre, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Graham", 
            "givenName": "Tracy", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mount Sinai Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416166.2", 
              "name": [
                "University of Toronto, Toronto, ON, Canada", 
                "Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aronson", 
            "givenName": "Melyssa", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mount Sinai Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416166.2", 
              "name": [
                "Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Piccinin", 
            "givenName": "Carolyn", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mount Sinai Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416166.2", 
              "name": [
                "University of Toronto, Toronto, ON, Canada", 
                "Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Winter-Paquette", 
            "givenName": "Laura", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mount Sinai Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416166.2", 
              "name": [
                "University of Toronto, Toronto, ON, Canada", 
                "Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Semotiuk", 
            "givenName": "Kara", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sunnybrook Health Science Centre", 
              "id": "https://www.grid.ac/institutes/grid.413104.3", 
              "name": [
                "Sunnybrook Health Sciences Centre, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lorentz", 
            "givenName": "Justin", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sunnybrook Health Science Centre", 
              "id": "https://www.grid.ac/institutes/grid.413104.3", 
              "name": [
                "Sunnybrook Health Sciences Centre, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mancuso", 
            "givenName": "Talia", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sunnybrook Health Science Centre", 
              "id": "https://www.grid.ac/institutes/grid.413104.3", 
              "name": [
                "Sunnybrook Health Sciences Centre, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ott", 
            "givenName": "Karen", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sunnybrook Health Science Centre", 
              "id": "https://www.grid.ac/institutes/grid.413104.3", 
              "name": [
                "Sunnybrook Health Sciences Centre, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Silberman", 
            "givenName": "Yael", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Health Network", 
              "id": "https://www.grid.ac/institutes/grid.231844.8", 
              "name": [
                "University Health Network, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Elser", 
            "givenName": "Christine", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sunnybrook Health Science Centre", 
              "id": "https://www.grid.ac/institutes/grid.413104.3", 
              "name": [
                "Sunnybrook Health Sciences Centre, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Eisen", 
            "givenName": "Andrea", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital for Sick Children", 
              "id": "https://www.grid.ac/institutes/grid.42327.30", 
              "name": [
                "University Health Network, Toronto, ON, Canada", 
                "Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada", 
                "The Hospital for Sick Children, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim", 
            "givenName": "Raymond H.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mount Sinai Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416166.2", 
              "name": [
                "University of Toronto, Toronto, ON, Canada", 
                "Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lerner-Ellis", 
            "givenName": "Jordan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mount Sinai Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416166.2", 
              "name": [
                "University of Toronto, Toronto, ON, Canada", 
                "Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carroll", 
            "givenName": "June C.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "OPKO Health (United States)", 
              "id": "https://www.grid.ac/institutes/grid.428467.b", 
              "name": [
                "GeneDx, Gaithersburg, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Glogowski", 
            "givenName": "Emily", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "BC Cancer Agency", 
              "id": "https://www.grid.ac/institutes/grid.248762.d", 
              "name": [
                "BC Cancer Agency, Vancouver, BC, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schrader", 
            "givenName": "Kasmintan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "St. Michael's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.415502.7", 
              "name": [
                "University of Toronto, Toronto, ON, Canada", 
                "St. Michael\u2019s Hospital, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bombard", 
            "givenName": "Yvonne", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1159/000226595", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003087032"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/cge.12430", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004453410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijmedinf.2011.03.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007478699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jmedgenet-2015-103144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008349559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0132690", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014263922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/cge.12597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026437927"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10488-013-0528-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026865872", 
              "https://doi.org/10.1007/s10488-013-0528-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jbi.2014.09.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028409161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10897-012-9519-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035406411", 
              "https://doi.org/10.1007/s10897-012-9519-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1097/gim.0b013e318220aaba", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037100196", 
              "https://doi.org/10.1097/gim.0b013e318220aaba"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1097/gim.0b013e318220aaba", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037100196", 
              "https://doi.org/10.1097/gim.0b013e318220aaba"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/gim.2016.190", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038769083", 
              "https://doi.org/10.1038/gim.2016.190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/gim.2016.190", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038769083", 
              "https://doi.org/10.1038/gim.2016.190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/gim.2016.190", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038769083", 
              "https://doi.org/10.1038/gim.2016.190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/pme.15.45", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043972037"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.a.35554", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045817053"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2648.1997.t01-25-00999.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048797744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejhg.2013.46", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048957454", 
              "https://doi.org/10.1038/ejhg.2013.46"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/gim.2013.113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050190818", 
              "https://doi.org/10.1038/gim.2013.113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/gim.2013.63", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050654944", 
              "https://doi.org/10.1038/gim.2013.63"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejhg.2012.179", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052109817", 
              "https://doi.org/10.1038/ejhg.2012.179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7748/nr.13.4.84.s4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073924531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejhg.2017.21", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084127986", 
              "https://doi.org/10.1038/ejhg.2017.21"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijmedinf.2017.10.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092180678"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10897-018-0230-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101106498", 
              "https://doi.org/10.1007/s10897-018-0230-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10897-018-0230-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101106498", 
              "https://doi.org/10.1007/s10897-018-0230-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmjopen-2018-021876", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103654650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmjopen-2018-021876", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103654650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41431-018-0144-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103668136", 
              "https://doi.org/10.1038/s41431-018-0144-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41431-018-0144-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103668136", 
              "https://doi.org/10.1038/s41431-018-0144-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41431-018-0144-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103668136", 
              "https://doi.org/10.1038/s41431-018-0144-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pec.2018.08.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106003056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41431-018-0257-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106908919", 
              "https://doi.org/10.1038/s41431-018-0257-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41431-018-0257-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106908919", 
              "https://doi.org/10.1038/s41431-018-0257-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41431-018-0257-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106908919", 
              "https://doi.org/10.1038/s41431-018-0257-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pon.4887", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106916055"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/cancers10110435", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1109888694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/cancers10110435", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1109888694"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-03-08", 
        "datePublishedReg": "2019-03-08", 
        "description": "Guidelines recommend that\u00a0providers engage patients in shared decision-making about receiving incidental results (IR) prior to genomic sequencing (GS), but this can be time-consuming, given the myriad of IR and variation in patients' preferences. We aimed to develop patient profiles to inform pre-test counseling for IR. We conducted semi-structured interviews with participants as a part of a randomized trial of the GenomicsADvISER.com, a decision aid for selecting IR. Interviews explored factors participants considered when deliberating over learning IR. Interviews were analyzed by thematic analysis and constant comparison. Participants were mostly female (28/31) and about half of them were over the age of 50 (16/31). We identified five patient profiles that reflect common contextual factors, attitudes, concerns, and perceived utility of IR. Information Enthusiasts self-identified as \"planners\" and valued learning most or\u00a0all IR to enable planning and disease prevention because \"knowledge is power\". Concerned Individuals defined themselves as \"anxious,\"\u00a0and were reluctant to learn IR, anticipating negative psychological impacts from IR. Contemplators were discerning about the value and limitations of IR, weighing health benefits with the impacts of not being able to \"un-know\" information. Individuals of Advanced Life Stage did not consider IR relevant for themselves and\u00a0primarily considered their implications for family members. Reassurance Seekers were reassured by previous negative genetic test results which shaped their expectations for receiving no IR: \"hopefully [GS will] be negative, too. And then I can rest easy\". These profiles could inform targeted counseling for IR by providing a framework to address common values, concerns. and misconceptions.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41431-019-0352-2", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1103410", 
            "issn": [
              "1018-4813", 
              "1476-5438"
            ], 
            "name": "European Journal of Human Genetics", 
            "type": "Periodical"
          }
        ], 
        "name": "Development of patient \u201cprofiles\u201d to tailor counseling for incidental genomic sequencing results", 
        "pagination": "1-10", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "f384f72e09e8d2059694653cc875a48f7ea0453d2e2d1300dd42c02cbea001b1"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30846854"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9302235"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41431-019-0352-2"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1112606885"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41431-019-0352-2", 
          "https://app.dimensions.ai/details/publication/pub.1112606885"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T11:18", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000354_0000000354/records_11701_00000002.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41431-019-0352-2"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41431-019-0352-2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41431-019-0352-2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41431-019-0352-2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41431-019-0352-2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    324 TRIPLES      21 PREDICATES      54 URIs      18 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41431-019-0352-2 schema:about anzsrc-for:17
    2 anzsrc-for:1701
    3 schema:author N77ec028aedf241a9b7c3b7adc3b71726
    4 schema:citation sg:pub.10.1007/s10488-013-0528-y
    5 sg:pub.10.1007/s10897-012-9519-5
    6 sg:pub.10.1007/s10897-018-0230-z
    7 sg:pub.10.1038/ejhg.2012.179
    8 sg:pub.10.1038/ejhg.2013.46
    9 sg:pub.10.1038/ejhg.2017.21
    10 sg:pub.10.1038/gim.2013.113
    11 sg:pub.10.1038/gim.2013.63
    12 sg:pub.10.1038/gim.2016.190
    13 sg:pub.10.1038/s41431-018-0144-0
    14 sg:pub.10.1038/s41431-018-0257-5
    15 sg:pub.10.1097/gim.0b013e318220aaba
    16 https://doi.org/10.1002/ajmg.a.35554
    17 https://doi.org/10.1002/pon.4887
    18 https://doi.org/10.1016/j.ijmedinf.2011.03.006
    19 https://doi.org/10.1016/j.ijmedinf.2017.10.006
    20 https://doi.org/10.1016/j.jbi.2014.09.004
    21 https://doi.org/10.1016/j.pec.2018.08.004
    22 https://doi.org/10.1046/j.1365-2648.1997.t01-25-00999.x
    23 https://doi.org/10.1111/cge.12430
    24 https://doi.org/10.1111/cge.12597
    25 https://doi.org/10.1136/bmjopen-2018-021876
    26 https://doi.org/10.1136/jmedgenet-2015-103144
    27 https://doi.org/10.1159/000226595
    28 https://doi.org/10.1371/journal.pone.0132690
    29 https://doi.org/10.2217/pme.15.45
    30 https://doi.org/10.3390/cancers10110435
    31 https://doi.org/10.7748/nr.13.4.84.s4
    32 schema:datePublished 2019-03-08
    33 schema:datePublishedReg 2019-03-08
    34 schema:description Guidelines recommend that providers engage patients in shared decision-making about receiving incidental results (IR) prior to genomic sequencing (GS), but this can be time-consuming, given the myriad of IR and variation in patients' preferences. We aimed to develop patient profiles to inform pre-test counseling for IR. We conducted semi-structured interviews with participants as a part of a randomized trial of the GenomicsADvISER.com, a decision aid for selecting IR. Interviews explored factors participants considered when deliberating over learning IR. Interviews were analyzed by thematic analysis and constant comparison. Participants were mostly female (28/31) and about half of them were over the age of 50 (16/31). We identified five patient profiles that reflect common contextual factors, attitudes, concerns, and perceived utility of IR. Information Enthusiasts self-identified as "planners" and valued learning most or all IR to enable planning and disease prevention because "knowledge is power". Concerned Individuals defined themselves as "anxious," and were reluctant to learn IR, anticipating negative psychological impacts from IR. Contemplators were discerning about the value and limitations of IR, weighing health benefits with the impacts of not being able to "un-know" information. Individuals of Advanced Life Stage did not consider IR relevant for themselves and primarily considered their implications for family members. Reassurance Seekers were reassured by previous negative genetic test results which shaped their expectations for receiving no IR: "hopefully [GS will] be negative, too. And then I can rest easy". These profiles could inform targeted counseling for IR by providing a framework to address common values, concerns. and misconceptions.
    35 schema:genre research_article
    36 schema:inLanguage en
    37 schema:isAccessibleForFree false
    38 schema:isPartOf sg:journal.1103410
    39 schema:name Development of patient “profiles” to tailor counseling for incidental genomic sequencing results
    40 schema:pagination 1-10
    41 schema:productId N2c6ef8adb65d49bdb21841a6a3b0b6c6
    42 N339eebfc221f43c5b4d9577fa52f7d22
    43 Nb0bde3ef01924e52ace15a6818e80655
    44 Ne09d676d5f3f4885b3b89553083c67eb
    45 Nf846d884638f459d9baa578a13466b3c
    46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112606885
    47 https://doi.org/10.1038/s41431-019-0352-2
    48 schema:sdDatePublished 2019-04-11T11:18
    49 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    50 schema:sdPublisher N600f67726efd4135b95c2def38f5eabf
    51 schema:url https://www.nature.com/articles/s41431-019-0352-2
    52 sgo:license sg:explorer/license/
    53 sgo:sdDataset articles
    54 rdf:type schema:ScholarlyArticle
    55 N03791896f911472dae0eb88ba3577e2e rdf:first N3094b48b35134da39047b4b5a1ea22dc
    56 rdf:rest N3e95aa6267614a0fa0b2d3f3ef739013
    57 N07053520ba904a17b0ebd708c8f467ae rdf:first Na707ffd344e54d19a4283bb21a39c509
    58 rdf:rest N71d2f93660f642b69bc6e6535bc0481a
    59 N076ed68a08284f7ca7e4441f35e7e031 rdf:first Na37314a50c824467b52763ecd1a108a4
    60 rdf:rest Nf4c70fb9c93b4cf7b74d0ae957b84fe4
    61 N13f84440c2e142838098362101e1dcc2 schema:affiliation https://www.grid.ac/institutes/grid.415502.7
    62 schema:familyName Bombard
    63 schema:givenName Yvonne
    64 rdf:type schema:Person
    65 N21a6ea954b8945758749310de8f7af77 schema:affiliation https://www.grid.ac/institutes/grid.415502.7
    66 schema:familyName McCuaig
    67 schema:givenName Laura
    68 rdf:type schema:Person
    69 N25ae3ac817bd45a68a08a5a18fcbb4f3 rdf:first N290675ff5f8d407f8294e897ea46411f
    70 rdf:rest N03791896f911472dae0eb88ba3577e2e
    71 N290675ff5f8d407f8294e897ea46411f schema:affiliation https://www.grid.ac/institutes/grid.231844.8
    72 schema:familyName Carlsson
    73 schema:givenName Lindsay
    74 rdf:type schema:Person
    75 N2c6ef8adb65d49bdb21841a6a3b0b6c6 schema:name pubmed_id
    76 schema:value 30846854
    77 rdf:type schema:PropertyValue
    78 N2f2d42f5de5344e9bc90d161478d2b4a rdf:first Nc73e2b84b0c24cb589a40a98e38e8f84
    79 rdf:rest N30d3166c44ac4cff9c8d8de3662672d6
    80 N3094b48b35134da39047b4b5a1ea22dc schema:affiliation https://www.grid.ac/institutes/grid.415502.7
    81 schema:familyName Clausen
    82 schema:givenName Marc
    83 rdf:type schema:Person
    84 N30d3166c44ac4cff9c8d8de3662672d6 rdf:first N6bbea247f2be4d6c9f4ec79cfff15d70
    85 rdf:rest Nf437fa57d0df4cf9a3ccf90764f3aa65
    86 N3234aa927cc04770951912a2ddb2aecb schema:affiliation https://www.grid.ac/institutes/grid.413104.3
    87 schema:familyName Eisen
    88 schema:givenName Andrea
    89 rdf:type schema:Person
    90 N339eebfc221f43c5b4d9577fa52f7d22 schema:name readcube_id
    91 schema:value f384f72e09e8d2059694653cc875a48f7ea0453d2e2d1300dd42c02cbea001b1
    92 rdf:type schema:PropertyValue
    93 N3e95aa6267614a0fa0b2d3f3ef739013 rdf:first N938740614fb64b648c641c352d8d7527
    94 rdf:rest N6a0324ab396e4f2ea5dd6cf19e917c4e
    95 N44ee9cadd8f24e5db2ca3039054fc3fc schema:affiliation https://www.grid.ac/institutes/grid.413104.3
    96 schema:familyName Lorentz
    97 schema:givenName Justin
    98 rdf:type schema:Person
    99 N492d2fd2860a409aa6db52ba108b3d03 rdf:first Ncb1afebae5d9458b9bdc96455a22f41a
    100 rdf:rest N60e0fcff761b4dbd91379ef3f9660d88
    101 N579b18d598c1443ab4256738d0659afe schema:affiliation https://www.grid.ac/institutes/grid.231844.8
    102 schema:familyName Elser
    103 schema:givenName Christine
    104 rdf:type schema:Person
    105 N600f67726efd4135b95c2def38f5eabf schema:name Springer Nature - SN SciGraph project
    106 rdf:type schema:Organization
    107 N60e0fcff761b4dbd91379ef3f9660d88 rdf:first Naf5464930cbb4f24afa8e5bceda8630f
    108 rdf:rest Ne40a1e34d3e94469a0ecb3c14e2ac2aa
    109 N63e9015d617b4bde842b8074804fe940 schema:affiliation https://www.grid.ac/institutes/grid.416166.2
    110 schema:familyName Panchal
    111 schema:givenName Seema
    112 rdf:type schema:Person
    113 N6a0324ab396e4f2ea5dd6cf19e917c4e rdf:first N6cec1a896b5f4475b71cb918af7417dc
    114 rdf:rest N933dac7b89e246b497f48560d2374507
    115 N6bbea247f2be4d6c9f4ec79cfff15d70 schema:affiliation https://www.grid.ac/institutes/grid.416166.2
    116 schema:familyName Lerner-Ellis
    117 schema:givenName Jordan
    118 rdf:type schema:Person
    119 N6cec1a896b5f4475b71cb918af7417dc schema:affiliation https://www.grid.ac/institutes/grid.415502.7
    120 schema:familyName Shickh
    121 schema:givenName Salma
    122 rdf:type schema:Person
    123 N71d2f93660f642b69bc6e6535bc0481a rdf:first N13f84440c2e142838098362101e1dcc2
    124 rdf:rest rdf:nil
    125 N766de8a0dd54482cb8eefd5ed776e25a rdf:first N8aef823a103d479888d3401aae7c316d
    126 rdf:rest N87f42e63de8447a9ac717f583864f2fe
    127 N77ec028aedf241a9b7c3b7adc3b71726 rdf:first N8847e0bcbd04440c99cae34db159081c
    128 rdf:rest N25ae3ac817bd45a68a08a5a18fcbb4f3
    129 N7d0114632e4947c5a48ca608b1e2d7a0 rdf:first Nacfea055ba6249fab05aec7965527455
    130 rdf:rest N492d2fd2860a409aa6db52ba108b3d03
    131 N87f42e63de8447a9ac717f583864f2fe rdf:first N63e9015d617b4bde842b8074804fe940
    132 rdf:rest Neebf8e84deac46edb1d3b96c545671dc
    133 N8847e0bcbd04440c99cae34db159081c schema:affiliation https://www.grid.ac/institutes/grid.415502.7
    134 schema:familyName Mighton
    135 schema:givenName Chloe
    136 rdf:type schema:Person
    137 N8aef823a103d479888d3401aae7c316d schema:affiliation https://www.grid.ac/institutes/grid.415502.7
    138 schema:familyName Joshi
    139 schema:givenName Esha
    140 rdf:type schema:Person
    141 N933dac7b89e246b497f48560d2374507 rdf:first N21a6ea954b8945758749310de8f7af77
    142 rdf:rest N766de8a0dd54482cb8eefd5ed776e25a
    143 N938740614fb64b648c641c352d8d7527 schema:affiliation https://www.grid.ac/institutes/grid.415502.7
    144 schema:familyName Casalino
    145 schema:givenName Selina
    146 rdf:type schema:Person
    147 Na37314a50c824467b52763ecd1a108a4 schema:affiliation https://www.grid.ac/institutes/grid.413104.3
    148 schema:familyName Ott
    149 schema:givenName Karen
    150 rdf:type schema:Person
    151 Na707ffd344e54d19a4283bb21a39c509 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
    152 schema:familyName Schrader
    153 schema:givenName Kasmintan
    154 rdf:type schema:Person
    155 Nacfea055ba6249fab05aec7965527455 schema:affiliation https://www.grid.ac/institutes/grid.416166.2
    156 schema:familyName Aronson
    157 schema:givenName Melyssa
    158 rdf:type schema:Person
    159 Naf5464930cbb4f24afa8e5bceda8630f schema:affiliation https://www.grid.ac/institutes/grid.416166.2
    160 schema:familyName Winter-Paquette
    161 schema:givenName Laura
    162 rdf:type schema:Person
    163 Nb0bde3ef01924e52ace15a6818e80655 schema:name doi
    164 schema:value 10.1038/s41431-019-0352-2
    165 rdf:type schema:PropertyValue
    166 Nb8439d647b78406bb965d94a5c02ceb7 rdf:first Nf56840aa6d9548eab49ed77a30a9340a
    167 rdf:rest N07053520ba904a17b0ebd708c8f467ae
    168 Nc4505a6c34b04fd99f918c31b40cade9 schema:affiliation https://www.grid.ac/institutes/grid.416166.2
    169 schema:familyName Carroll
    170 schema:givenName June C.
    171 rdf:type schema:Person
    172 Nc73e2b84b0c24cb589a40a98e38e8f84 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
    173 schema:familyName Kim
    174 schema:givenName Raymond H.
    175 rdf:type schema:Person
    176 Nc898f79dfc464ba7982bdc7f43576bc3 schema:affiliation https://www.grid.ac/institutes/grid.413104.3
    177 schema:familyName Mancuso
    178 schema:givenName Talia
    179 rdf:type schema:Person
    180 Ncb1afebae5d9458b9bdc96455a22f41a schema:affiliation https://www.grid.ac/institutes/grid.416166.2
    181 schema:familyName Piccinin
    182 schema:givenName Carolyn
    183 rdf:type schema:Person
    184 Ncccbd1046aaf4f62a9ce5334ea443323 rdf:first N3234aa927cc04770951912a2ddb2aecb
    185 rdf:rest N2f2d42f5de5344e9bc90d161478d2b4a
    186 Nd53f05f70e2d4bb2ab4037ea493d1a92 schema:affiliation https://www.grid.ac/institutes/grid.416166.2
    187 schema:familyName Semotiuk
    188 schema:givenName Kara
    189 rdf:type schema:Person
    190 Ndacbc295712346538ba769f34f091f89 schema:affiliation https://www.grid.ac/institutes/grid.413104.3
    191 schema:familyName Graham
    192 schema:givenName Tracy
    193 rdf:type schema:Person
    194 Ne09d676d5f3f4885b3b89553083c67eb schema:name nlm_unique_id
    195 schema:value 9302235
    196 rdf:type schema:PropertyValue
    197 Ne40a1e34d3e94469a0ecb3c14e2ac2aa rdf:first Nd53f05f70e2d4bb2ab4037ea493d1a92
    198 rdf:rest Nfa0c91ba24db4593a2695cfd7295c665
    199 Ne5e03cf522a44ad0aa5308b5069e1772 schema:affiliation https://www.grid.ac/institutes/grid.413104.3
    200 schema:familyName Silberman
    201 schema:givenName Yael
    202 rdf:type schema:Person
    203 Neebf8e84deac46edb1d3b96c545671dc rdf:first Ndacbc295712346538ba769f34f091f89
    204 rdf:rest N7d0114632e4947c5a48ca608b1e2d7a0
    205 Nf36321c4c5764d56984d2c4e5be665c7 rdf:first N579b18d598c1443ab4256738d0659afe
    206 rdf:rest Ncccbd1046aaf4f62a9ce5334ea443323
    207 Nf437fa57d0df4cf9a3ccf90764f3aa65 rdf:first Nc4505a6c34b04fd99f918c31b40cade9
    208 rdf:rest Nb8439d647b78406bb965d94a5c02ceb7
    209 Nf4c70fb9c93b4cf7b74d0ae957b84fe4 rdf:first Ne5e03cf522a44ad0aa5308b5069e1772
    210 rdf:rest Nf36321c4c5764d56984d2c4e5be665c7
    211 Nf56840aa6d9548eab49ed77a30a9340a schema:affiliation https://www.grid.ac/institutes/grid.428467.b
    212 schema:familyName Glogowski
    213 schema:givenName Emily
    214 rdf:type schema:Person
    215 Nf7b50df258ec4b229c278eb20bd76db1 rdf:first Nc898f79dfc464ba7982bdc7f43576bc3
    216 rdf:rest N076ed68a08284f7ca7e4441f35e7e031
    217 Nf846d884638f459d9baa578a13466b3c schema:name dimensions_id
    218 schema:value pub.1112606885
    219 rdf:type schema:PropertyValue
    220 Nfa0c91ba24db4593a2695cfd7295c665 rdf:first N44ee9cadd8f24e5db2ca3039054fc3fc
    221 rdf:rest Nf7b50df258ec4b229c278eb20bd76db1
    222 anzsrc-for:17 schema:inDefinedTermSet anzsrc-for:
    223 schema:name Psychology and Cognitive Sciences
    224 rdf:type schema:DefinedTerm
    225 anzsrc-for:1701 schema:inDefinedTermSet anzsrc-for:
    226 schema:name Psychology
    227 rdf:type schema:DefinedTerm
    228 sg:journal.1103410 schema:issn 1018-4813
    229 1476-5438
    230 schema:name European Journal of Human Genetics
    231 rdf:type schema:Periodical
    232 sg:pub.10.1007/s10488-013-0528-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1026865872
    233 https://doi.org/10.1007/s10488-013-0528-y
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1007/s10897-012-9519-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035406411
    236 https://doi.org/10.1007/s10897-012-9519-5
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1007/s10897-018-0230-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1101106498
    239 https://doi.org/10.1007/s10897-018-0230-z
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1038/ejhg.2012.179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052109817
    242 https://doi.org/10.1038/ejhg.2012.179
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/ejhg.2013.46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048957454
    245 https://doi.org/10.1038/ejhg.2013.46
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1038/ejhg.2017.21 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084127986
    248 https://doi.org/10.1038/ejhg.2017.21
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1038/gim.2013.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050190818
    251 https://doi.org/10.1038/gim.2013.113
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/gim.2013.63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050654944
    254 https://doi.org/10.1038/gim.2013.63
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/gim.2016.190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038769083
    257 https://doi.org/10.1038/gim.2016.190
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/s41431-018-0144-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103668136
    260 https://doi.org/10.1038/s41431-018-0144-0
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/s41431-018-0257-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106908919
    263 https://doi.org/10.1038/s41431-018-0257-5
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1097/gim.0b013e318220aaba schema:sameAs https://app.dimensions.ai/details/publication/pub.1037100196
    266 https://doi.org/10.1097/gim.0b013e318220aaba
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1002/ajmg.a.35554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045817053
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1002/pon.4887 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106916055
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1016/j.ijmedinf.2011.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007478699
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1016/j.ijmedinf.2017.10.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092180678
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1016/j.jbi.2014.09.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028409161
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/j.pec.2018.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106003056
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1046/j.1365-2648.1997.t01-25-00999.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048797744
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1111/cge.12430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004453410
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1111/cge.12597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026437927
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1136/bmjopen-2018-021876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103654650
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1136/jmedgenet-2015-103144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008349559
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1159/000226595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003087032
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1371/journal.pone.0132690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014263922
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.2217/pme.15.45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043972037
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.3390/cancers10110435 schema:sameAs https://app.dimensions.ai/details/publication/pub.1109888694
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.7748/nr.13.4.84.s4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073924531
    299 rdf:type schema:CreativeWork
    300 https://www.grid.ac/institutes/grid.231844.8 schema:alternateName University Health Network
    301 schema:name University Health Network, Toronto, ON, Canada
    302 rdf:type schema:Organization
    303 https://www.grid.ac/institutes/grid.248762.d schema:alternateName BC Cancer Agency
    304 schema:name BC Cancer Agency, Vancouver, BC, Canada
    305 rdf:type schema:Organization
    306 https://www.grid.ac/institutes/grid.413104.3 schema:alternateName Sunnybrook Health Science Centre
    307 schema:name Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    308 rdf:type schema:Organization
    309 https://www.grid.ac/institutes/grid.415502.7 schema:alternateName St. Michael's Hospital
    310 schema:name St. Michael’s Hospital, Toronto, ON, Canada
    311 University of Toronto, Toronto, ON, Canada
    312 rdf:type schema:Organization
    313 https://www.grid.ac/institutes/grid.416166.2 schema:alternateName Mount Sinai Hospital
    314 schema:name Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada
    315 University of Toronto, Toronto, ON, Canada
    316 rdf:type schema:Organization
    317 https://www.grid.ac/institutes/grid.42327.30 schema:alternateName Hospital for Sick Children
    318 schema:name Mount Sinai Hospital, Sinai Health System, Toronto, ON, Canada
    319 The Hospital for Sick Children, Toronto, ON, Canada
    320 University Health Network, Toronto, ON, Canada
    321 rdf:type schema:Organization
    322 https://www.grid.ac/institutes/grid.428467.b schema:alternateName OPKO Health (United States)
    323 schema:name GeneDx, Gaithersburg, MD, USA
    324 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...