Cost of cancer diagnosis using next-generation sequencing targeted gene panels in routine practice: a nationwide French study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-01-24

AUTHORS

Patricia Marino, Rajae Touzani, Lionel Perrier, Etienne Rouleau, Dede Sika Kossi, Zou Zhaomin, Nathanaël Charrier, Nicolas Goardon, Claude Preudhomme, Isabelle Durand-Zaleski, Isabelle Borget, Sandrine Baffert, On behalf of NGSEco Group:

ABSTRACT

It is currently unclear if next-generation sequencing (NGS) technologies can be implemented in the diagnosis setting at an affordable cost. The aim of this study was to measure the total cost of performing NGS in clinical practice in France, in both germline and somatic cancer genetics.The study was performed on 15 French representative cancer molecular genetics laboratories performing NGS panels’ tests. The production cost was estimated using a micro-costing method with resources consumed collected in situ in each laboratory from a healthcare provider perspective. In addition, we used a top–down methodology for specific post-sequencing steps including bioinformatics, technical validation, and biological validation. Additional non-specific costs were also included. Costs were detailed per step of the process (from the pre-analytical phase to delivery of results), and per cost driver (consumables, staff, equipment, maintenance, overheads). Sensitivity analyses were performed.The mean total cost of NGS for targeted gene panels was estimated to 607€ (±207) in somatic genetics and 550€ (±140) in germline oncogenetic analysis. Consumables were the highest cost driver of the sequencing process. The sensitivity analysis showed that a 25% reduction of consumables resulted in a 15% decrease in total NGS cost in somatic genetics, and 13% in germline analysis. Additional costs accounted for 30–32% of the total NGS costs.Beyond cost assessment considerations, the diffusion of NGS technologies will raise questions about their efficiency when compared to more targeted approaches, and their added value in a context of routine diagnosis. More... »

PAGES

314-323

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41431-017-0081-3

DOI

http://dx.doi.org/10.1038/s41431-017-0081-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100586547

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29367707


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25 schema:description It is currently unclear if next-generation sequencing (NGS) technologies can be implemented in the diagnosis setting at an affordable cost. The aim of this study was to measure the total cost of performing NGS in clinical practice in France, in both germline and somatic cancer genetics.The study was performed on 15 French representative cancer molecular genetics laboratories performing NGS panels’ tests. The production cost was estimated using a micro-costing method with resources consumed collected in situ in each laboratory from a healthcare provider perspective. In addition, we used a top–down methodology for specific post-sequencing steps including bioinformatics, technical validation, and biological validation. Additional non-specific costs were also included. Costs were detailed per step of the process (from the pre-analytical phase to delivery of results), and per cost driver (consumables, staff, equipment, maintenance, overheads). Sensitivity analyses were performed.The mean total cost of NGS for targeted gene panels was estimated to 607€ (±207) in somatic genetics and 550€ (±140) in germline oncogenetic analysis. Consumables were the highest cost driver of the sequencing process. The sensitivity analysis showed that a 25% reduction of consumables resulted in a 15% decrease in total NGS cost in somatic genetics, and 13% in germline analysis. Additional costs accounted for 30–32% of the total NGS costs.Beyond cost assessment considerations, the diffusion of NGS technologies will raise questions about their efficiency when compared to more targeted approaches, and their added value in a context of routine diagnosis.
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32 French study
33 NGS
34 NGS costs
35 NGS panel
36 NGS technologies
37 addition
38 additional cost
39 affordable cost
40 aim
41 analysis
42 approach
43 assessment considerations
44 bioinformatics
45 biological validation
46 cancer diagnosis
47 cancer genetics
48 clinical practice
49 consideration
50 consumables
51 context
52 cost
53 cost drivers
54 costing method
55 decrease
56 diagnosis
57 diffusion
58 drivers
59 efficiency
60 gene panel
61 genetics
62 genetics laboratories
63 germline
64 germline analysis
65 healthcare provider perspective
66 high cost drivers
67 laboratory
68 mean total cost
69 method
70 methodology
71 molecular genetics laboratory
72 nationwide French study
73 next-generation sequencing
74 next-generation sequencing technologies
75 panel
76 perspective
77 practice
78 process
79 production costs
80 provider perspectives
81 questions
82 reduction
83 reduction of consumables
84 resources
85 routine diagnosis
86 routine practice
87 sensitivity analysis
88 sequencing
89 sequencing process
90 sequencing technologies
91 situ
92 somatic cancer genetics
93 somatic genetics
94 step
95 study
96 targeted gene panel
97 technical validation
98 technology
99 test
100 total cost
101 validation
102 values
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