Vitamin D status in irritable bowel syndrome and the impact of supplementation on symptoms: what do we know and what ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-01-25

AUTHORS

Claire E. Williams, Elizabeth A. Williams, Bernard M. Corfe

ABSTRACT

BackgroundLow vitamin D status is associated with risk of colorectal cancer and has been implicated in inflammatory bowel disease. Irritable bowel syndrome (IBS) is a chronic, relapsing, functional bowel disorder. A nascent literature suggests a role for vitamin D in IBS, but this has not been collated or critiqued. To date, seven studies have been published: four observational studies and three randomised controlled trials (RCTs). All observational studies reported that a substantial proportion of the IBS population was vitamin D deficient. Two intervention studies reported improvement in IBS symptom severity scores and quality of life (QoL) with vitamin D supplementation.There are limited data around the role of vitamin D in IBS.ConclusionsThe available evidence suggests that low vitamin D status is common among the IBS population and merits assessment and rectification for general health reasons alone. An inverse correlation between serum vitamin D and IBS symptom severity is suggested and vitamin D interventions may benefit symptoms. However, the available RCTs do not provide strong, generalisable evidence; larger and adequately powered interventions are needed to establish a case for therapeutic application of vitamin D in IBS. More... »

PAGES

1358-1363

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41430-017-0064-z

DOI

http://dx.doi.org/10.1038/s41430-017-0064-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100512178

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29367731


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