Engineered production of kitasetalic acid, a new tetrahydro-β-carboline with the ability to suppress glucose-regulated protein synthesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-10

AUTHORS

Shohei Ueda, Shigeru Kitani, Takushi Namba, Masayoshi Arai, Haruo Ikeda, Takuya Nihira

ABSTRACT

β-Carboline alkaloids and related compounds show a broad spectrum of biological activities. We previously identified new members of the β-carboline alkaloid family by using an engineered Kitasatospora setae strain and a heterologous Streptomyces host expressing the plausible biosynthetic genes, including the hypothetical gene kse_70640 (kslB). Here, we elucidated the chemical structure of a new tetrahydro-β-carboline compound (named kitasetalic acid) that appeared in a heterologous Streptomyces host expressing the kslB gene alone. Kitasetalic acid suppressed the expression of glucose-regulated protein 78 (GRP78) without inducing cell death. This is the first report to show that a tetrahydro-β-carboline compound regulates the expression of the GRP78 protein in cancer cell lines. More... »

PAGES

854-861

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41429-018-0074-7

DOI

http://dx.doi.org/10.1038/s41429-018-0074-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105306045

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29973681


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