Emerging role of FBXO22 in carcinogenesis View Full Text


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Article Info

DATE

2020-07-27

AUTHORS

Jiangting Cheng, Min Lin, Man Chu, Longyuan Gong, Yanli Bi, Yongchao Zhao

ABSTRACT

The F-box protein 22 (FBXO22), one of F-box proteins, has been identified to be critically involved in carcinogenesis. FBXO22 promotes proliferation in breast cancer and lung cancer, but suppresses migration and metastasis. FBXO22 exerts oncogenetic functions via promoting the ubiquitination and degradation of its substrates, including KDM4A, KDM4B, methylated p53, p21, KLF4, LKB1, Snail, CD147, Bach1, PTEN, and HDM2. FBXO22 is also regulated by several regulatory factors such as p53, miR-155, SNHG14, and circ_0006282. In this review, we summarize the regulatory factors and downstream targets of FBXO22 in cancers, discuss its functions in tumorigenesis, and further highlight the alteration of FBXO22 expression in a variety of human malignancies. Finally, we provide novel insights for future perspectives on targeting FBXO22 as a promising strategy for cancer therapy. More... »

PAGES

66

References to SciGraph publications

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  • 2020-04-06. FBXO22 degrades nuclear PTEN to promote tumorigenesis in NATURE COMMUNICATIONS
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