Cyclic helix B peptide ameliorates acute myocardial infarction in mice by inhibiting apoptosis and inflammatory responses View Full Text


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Article Info

DATE

2019-12

AUTHORS

Cheng Yang, Chao Zhang, Jianguo Jia, Lingyan Wang, Weitao Zhang, Jiawei Li, Ming Xu, Ruiming Rong, Tongyu Zhu

ABSTRACT

Cyclic helix B peptide (CHBP) is a peptide derivant of erythropoietin with powerful tissue-protective efficacies in a variety of organ injuries, but without erythropoietic effect. However, the role of CHBP in acute myocardial infarction (AMI) and related mechanisms are not studied yet. In this study, we found in a murine AMI model that the administration of CHBP could ameliorate cardiac injury, increase the survival rate, inhibit cardiomyocyte apoptosis, improve cardiac function and remodeling, and reduce the expression of inflammatory cytokines in the serum and kidney tissue both at 24 h and 8 weeks following AMI. This study suggests that CHBP has the potential to be used as an effective drug in the treatment of AMI. More... »

PAGES

78

References to SciGraph publications

  • 2011-09. A Nonerythropoietic Peptide that Mimics the 3D Structure of Erythropoietin Reduces Organ Injury/Dysfunction and Inflammation in Experimental Hemorrhagic Shock in MOLECULAR MEDICINE
  • 2017-12. A novel cytoprotective peptide protects mesenchymal stem cells against mitochondrial dysfunction and apoptosis induced by starvation via Nrf2/Sirt3/FoxO3a pathway in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2017-06. The Protective Effects of Helix B Surface Peptide on Experimental Acute Liver Injury Induced by Carbon Tetrachloride in DIGESTIVE DISEASES AND SCIENCES
  • 2015-11. A novel cyclic helix B peptide inhibits dendritic cell maturation during amelioration of acute kidney graft rejection through Jak-2/STAT3/SOCS1 in CELL DEATH & DISEASE
  • 2011-03. A Small Nonerythropoietic Helix B Surface Peptide Based upon Erythropoietin Structure Is Cardioprotective against Ischemic Myocardial Damage in MOLECULAR MEDICINE
  • 2016-11. Proteome Analysis of Renoprotection Mediated by a Novel Cyclic Helix B Peptide in Acute Kidney Injury in SCIENTIFIC REPORTS
  • 2012-04. Delayed Administration of Pyroglutamate Helix B Surface Peptide (pHBSP), a Novel Nonerythropoietic Analog of Erythropoietin, Attenuates Acute Kidney Injury in MOLECULAR MEDICINE
  • 2018-12. TRPM7 in CHBP-induced renoprotection upon ischemia reperfusion-related injury in SCIENTIFIC REPORTS
  • 2015-12. Cyclic helix B peptide inhibits ischemia reperfusion-induced renal fibrosis via the PI3K/Akt/FoxO3a pathway in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2013-08. What is the Role of Erythropoietin in Acute Myocardial Infarct? Bridging the Gap Between Experimental Models and Clinical Trials in CARDIOVASCULAR DRUGS AND THERAPY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41420-019-0161-y

    DOI

    http://dx.doi.org/10.1038/s41420-019-0161-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112853774

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30911412


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