Protoporphyrin IX is a dual inhibitor of p53/MDM2 and p53/MDM4 interactions and induces apoptosis in B-cell chronic lymphocytic leukemia cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-12

AUTHORS

Liren Jiang, Natasha Malik, Pilar Acedo, Joanna Zawacka-Pankau

ABSTRACT

p53 is a tumor suppressor, which belongs to the p53 family of proteins. The family consists of p53, p63 and p73 proteins, which share similar structure and function. Activation of wild-type p53 or TAp73 in tumors leads to tumor regression, and small molecules restoring the p53 pathway are in clinical development. Protoporphyrin IX (PpIX), a metabolite of aminolevulinic acid, is a clinically approved drug applied in photodynamic diagnosis and therapy. PpIX induces p53-dependent and TAp73-dependent apoptosis and inhibits TAp73/MDM2 and TAp73/MDM4 interactions. Here we demonstrate that PpIX is a dual inhibitor of p53/MDM2 and p53/MDM4 interactions and activates apoptosis in B-cell chronic lymphocytic leukemia cells without illumination and without affecting normal cells. PpIX stabilizes p53 and TAp73 proteins, induces p53-downstream apoptotic targets and provokes cancer cell death at doses non-toxic to normal cells. Our findings open up new opportunities for repurposing PpIX for treating lymphoblastic leukemia with wild-type TP53. More... »

PAGES

77

References to SciGraph publications

  • 2012. The Fluorescent Two-Hybrid (F2H) Assay for Direct Analysis of Protein–Protein Interactions in Living Cells in TWO HYBRID TECHNOLOGIES
  • 2012-08. MDM4 is a key therapeutic target in cutaneous melanoma in NATURE MEDICINE
  • 2018-12. The effect of N-acetyl-l-cysteine (NAC) on liver toxicity and clinical outcome after hematopoietic stem cell transplantation in SCIENTIFIC REPORTS
  • 2017-12-15. Targeting mutant p53 for efficient cancer therapy in NATURE REVIEWS CANCER
  • 2013-02. MDM2, MDMX and p53 in oncogenesis and cancer therapy in NATURE REVIEWS CANCER
  • 2018-12. Reactivation of TAp73 tumor suppressor by protoporphyrin IX, a metabolite of aminolevulinic acid, induces apoptosis in TP53-deficient cancer cells in CELL DIVISION
  • 2014-10. JNK–NQO1 axis drives TAp73-mediated tumor suppression upon oxidative and proteasomal stress in CELL DEATH & DISEASE
  • 2019-01-17. The RANK–RANKL axis: an opportunity for drug repurposing in cancer? in CLINICAL AND TRANSLATIONAL ONCOLOGY
  • 2013-10. APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase in CELL DEATH & DISEASE
  • 2018-05. APR-246 reactivates mutant p53 by targeting cysteines 124 and 277 in CELL DEATH & DISEASE
  • 2014-04. ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis in CELL DEATH & DIFFERENTIATION
  • 1997-04. Pharmacokinetic Optimisation of Cancer Chemotherapy in CLINICAL PHARMACOKINETICS
  • 2010-11-25. Selective activation of p53-mediated tumour suppression in high-grade tumours in NATURE
  • 2015-06. APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cells in CELL DEATH & DISEASE
  • 2015-01. IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41420-019-0157-7

    DOI

    http://dx.doi.org/10.1038/s41420-019-0157-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112675667

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30886745


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