Nuclear ErbB2 represses DEPTOR transcription to inhibit autophagy in breast cancer cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-04-14

AUTHORS

Yanli Bi, Longyuan Gong, Pengyuan Liu, Xiufang Xiong, Yongchao Zhao

ABSTRACT

ErbB2, a classical receptor tyrosine kinase, is frequently overexpressed in breast cancer cells. Although the role of ErbB2 in the transmission of extracellular signals to intracellular matrix has been widely studied, the functions of nuclear ErbB2 remain largely elusive. Here, we report a novel function of nuclear ErbB2 in repressing the transcription of DEPTOR, a direct inhibitor of mTOR. Nuclear ErbB2 directly binds to the consensus binding sequence in the DEPTOR promoter to repress its transcription. The kinase activity of ErbB2 is required for its nuclear translocation and transcriptional repression of DEPTOR. Moreover, the repressed DEPTOR by nuclear ErbB2 inhibits the induction of autophagy by activating mTORC1. Thus, our study reveals a novel mechanism for autophagy regulation by functional ErbB2, which translocates to the nucleus and acts as a transcriptional regulator to suppress DEPTOR transcription, leading to activation of the PI3K/AKT/mTOR pathway to inhibit autophagy. More... »

PAGES

397

References to SciGraph publications

  • 2013-04-07. Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation in NATURE MEDICINE
  • 2015-07-27. Stat3 regulates ErbB-2 expression and co-opts ErbB-2 nuclear function to induce miR-21 expression, PDCD4 downregulation and breast cancer metastasis in ONCOGENE
  • 2016-09-05. DEPTOR is a direct NOTCH1 target that promotes cell proliferation and survival in T-cell leukemia in ONCOGENE
  • 2018-11-13. Ribosomal protein S27-like regulates autophagy via the β-TrCP-DEPTOR-mTORC1 axis in CELL DEATH & DISEASE
  • 2000-12-09. Molecular mechanisms underlying ErbB2/HER2 action in breast cancer in ONCOGENE
  • 2010-12-15. mTOR: from growth signal integration to cancer, diabetes and ageing in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2019-08-13. The cross talk of two family members of β-TrCP in the regulation of cell autophagy and growth in CELL DEATH & DIFFERENTIATION
  • 2012-04-20. Nuclear functions and subcellular trafficking mechanisms of the epidermal growth factor receptor family in CELL & BIOSCIENCE
  • 2019-01-17. Nuclear ErbB-2: a Novel Therapeutic Target in ErbB-2-Positive Breast Cancer? in DISCOVER ONCOLOGY
  • 2012-09-06. Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis in CELL DEATH & DISEASE
  • 2004-07-29. New targets for therapy in breast cancer: Small molecule tyrosine kinase inhibitors in BREAST CANCER RESEARCH
  • 2012-02-22. Clinical relevance of ErbB-2/HER2 nuclear expression in breast cancer in BMC CANCER
  • 2012-07-12. The ERBB network: at last, cancer therapy meets systems biology in NATURE REVIEWS CANCER
  • 2014-09-01. Targeting ErbB-2 nuclear localization and function inhibits breast cancer growth and overcomes trastuzumab resistance in ONCOGENE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41419-021-03686-9

    DOI

    http://dx.doi.org/10.1038/s41419-021-03686-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1137190020

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33854045


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Autophagy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Breast Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Proliferation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intracellular Signaling Peptides and Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phosphatidylinositol 3-Kinases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptor, ErbB-2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China", 
              "id": "http://www.grid.ac/institutes/grid.13402.34", 
              "name": [
                "Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China", 
                "Zhejiang Provincial Key Laboratory of Pancreatic Disease, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China", 
                "Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bi", 
            "givenName": "Yanli", 
            "id": "sg:person.012112135346.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012112135346.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China", 
              "id": "http://www.grid.ac/institutes/grid.13402.34", 
              "name": [
                "Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China", 
                "Zhejiang Provincial Key Laboratory of Pancreatic Disease, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China", 
                "Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gong", 
            "givenName": "Longyuan", 
            "id": "sg:person.07553766144.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07553766144.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China", 
              "id": "http://www.grid.ac/institutes/grid.13402.34", 
              "name": [
                "Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liu", 
            "givenName": "Pengyuan", 
            "id": "sg:person.0624616710.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624616710.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China", 
              "id": "http://www.grid.ac/institutes/grid.13402.34", 
              "name": [
                "Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China", 
                "Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Xiong", 
            "givenName": "Xiufang", 
            "id": "sg:person.01110467571.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110467571.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Center, Zhejiang University, Hangzhou, China", 
              "id": "http://www.grid.ac/institutes/grid.13402.34", 
              "name": [
                "Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China", 
                "Zhejiang Provincial Key Laboratory of Pancreatic Disease, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China", 
                "Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China", 
                "Cancer Center, Zhejiang University, Hangzhou, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhao", 
            "givenName": "Yongchao", 
            "id": "sg:person.01304472406.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304472406.33"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nm.3144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051517024", 
              "https://doi.org/10.1038/nm.3144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3309", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013979828", 
              "https://doi.org/10.1038/nrc3309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm3025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025226207", 
              "https://doi.org/10.1038/nrm3025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2016.275", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051890848", 
              "https://doi.org/10.1038/onc.2016.275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2015.281", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000830870", 
              "https://doi.org/10.1038/onc.2015.281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203973", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039053742", 
              "https://doi.org/10.1038/sj.onc.1203973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41419-018-1168-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1109815836", 
              "https://doi.org/10.1038/s41419-018-1168-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2014.272", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050309476", 
              "https://doi.org/10.1038/onc.2014.272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12672-018-0356-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111492358", 
              "https://doi.org/10.1007/s12672-018-0356-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-12-74", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042375407", 
              "https://doi.org/10.1186/1471-2407-12-74"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2045-3701-2-13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005175327", 
              "https://doi.org/10.1186/2045-3701-2-13"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cddis.2012.125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017459370", 
              "https://doi.org/10.1038/cddis.2012.125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr919", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018227977", 
              "https://doi.org/10.1186/bcr919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41418-019-0402-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1120290071", 
              "https://doi.org/10.1038/s41418-019-0402-x"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2021-04-14", 
        "datePublishedReg": "2021-04-14", 
        "description": "ErbB2, a classical receptor tyrosine kinase, is frequently overexpressed in breast cancer cells. Although the role of ErbB2 in the transmission of extracellular signals to intracellular matrix has been widely studied, the functions of nuclear ErbB2 remain largely elusive. Here, we report a novel function of nuclear ErbB2 in repressing the transcription of DEPTOR, a direct inhibitor of mTOR. Nuclear ErbB2 directly binds to the consensus binding sequence in the DEPTOR promoter to repress its transcription. The kinase activity of ErbB2 is required for its nuclear translocation and transcriptional repression of DEPTOR. Moreover, the repressed DEPTOR by nuclear ErbB2 inhibits the induction of autophagy by activating mTORC1. Thus, our study reveals a novel mechanism for autophagy regulation by functional ErbB2, which translocates to the nucleus and acts as a transcriptional regulator to suppress DEPTOR transcription, leading to activation of the PI3K/AKT/mTOR pathway to inhibit autophagy.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41419-021-03686-9", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.8351544", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.8891021", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1042939", 
            "issn": [
              "2041-4889"
            ], 
            "name": "Cell Death & Disease", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "12"
          }
        ], 
        "keywords": [
          "classical receptor tyrosine kinase", 
          "breast cancer cells", 
          "receptor tyrosine kinases", 
          "cancer cells", 
          "induction of autophagy", 
          "PI3K/AKT/mTOR pathway", 
          "transcriptional repression", 
          "AKT/mTOR pathway", 
          "transcriptional regulators", 
          "role of ErbB2", 
          "functional ErbB2", 
          "extracellular signals", 
          "novel function", 
          "autophagy regulation", 
          "kinase activity", 
          "tyrosine kinase", 
          "transcription", 
          "DEPTOR", 
          "nuclear translocation", 
          "novel mechanism", 
          "mTOR pathway", 
          "ErbB2", 
          "direct inhibitor", 
          "cells", 
          "repression", 
          "kinase", 
          "promoter", 
          "autophagy", 
          "regulator", 
          "mTOR", 
          "translocation", 
          "regulation", 
          "pathway", 
          "sequence", 
          "activation", 
          "inhibits", 
          "induction", 
          "inhibitors", 
          "function", 
          "nucleus", 
          "mechanism", 
          "role", 
          "activity", 
          "signals", 
          "study", 
          "transmission", 
          "matrix", 
          "consensus"
        ], 
        "name": "Nuclear ErbB2 represses DEPTOR transcription to inhibit autophagy in breast cancer cells", 
        "pagination": "397", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1137190020"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41419-021-03686-9"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "33854045"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41419-021-03686-9", 
          "https://app.dimensions.ai/details/publication/pub.1137190020"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-10-01T06:48", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_893.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41419-021-03686-9"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41419-021-03686-9'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41419-021-03686-9'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41419-021-03686-9'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41419-021-03686-9'


     

    This table displays all metadata directly associated to this object as RDF triples.

    234 TRIPLES      21 PREDICATES      95 URIs      73 LITERALS      15 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41419-021-03686-9 schema:about N131c106c8add494fadbf21f46b3fbf21
    2 N1a8173189ca54886a82a1c2a52254db8
    3 N80b37a6461264925b55c089e52a9c980
    4 N84c2675a2af04ad7817f7727664fb558
    5 Nbd98ecf9441f4a5d831ac04c435d75d9
    6 Nec2e8e89aae54847b5c1f751ad81cf9d
    7 Nec725d0447ac461886d4b3ac21922eeb
    8 Neccdd3e412644f128d98b67ec5e2492b
    9 anzsrc-for:06
    10 anzsrc-for:0601
    11 schema:author N12d139769ef64d6780791bb703bd0e00
    12 schema:citation sg:pub.10.1007/s12672-018-0356-3
    13 sg:pub.10.1038/cddis.2012.125
    14 sg:pub.10.1038/nm.3144
    15 sg:pub.10.1038/nrc3309
    16 sg:pub.10.1038/nrm3025
    17 sg:pub.10.1038/onc.2014.272
    18 sg:pub.10.1038/onc.2015.281
    19 sg:pub.10.1038/onc.2016.275
    20 sg:pub.10.1038/s41418-019-0402-x
    21 sg:pub.10.1038/s41419-018-1168-7
    22 sg:pub.10.1038/sj.onc.1203973
    23 sg:pub.10.1186/1471-2407-12-74
    24 sg:pub.10.1186/2045-3701-2-13
    25 sg:pub.10.1186/bcr919
    26 schema:datePublished 2021-04-14
    27 schema:datePublishedReg 2021-04-14
    28 schema:description ErbB2, a classical receptor tyrosine kinase, is frequently overexpressed in breast cancer cells. Although the role of ErbB2 in the transmission of extracellular signals to intracellular matrix has been widely studied, the functions of nuclear ErbB2 remain largely elusive. Here, we report a novel function of nuclear ErbB2 in repressing the transcription of DEPTOR, a direct inhibitor of mTOR. Nuclear ErbB2 directly binds to the consensus binding sequence in the DEPTOR promoter to repress its transcription. The kinase activity of ErbB2 is required for its nuclear translocation and transcriptional repression of DEPTOR. Moreover, the repressed DEPTOR by nuclear ErbB2 inhibits the induction of autophagy by activating mTORC1. Thus, our study reveals a novel mechanism for autophagy regulation by functional ErbB2, which translocates to the nucleus and acts as a transcriptional regulator to suppress DEPTOR transcription, leading to activation of the PI3K/AKT/mTOR pathway to inhibit autophagy.
    29 schema:genre article
    30 schema:isAccessibleForFree true
    31 schema:isPartOf N1d83dbc720da462681da127ab92d64a3
    32 N800f35a61ef1421caad9474002ceceaa
    33 sg:journal.1042939
    34 schema:keywords AKT/mTOR pathway
    35 DEPTOR
    36 ErbB2
    37 PI3K/AKT/mTOR pathway
    38 activation
    39 activity
    40 autophagy
    41 autophagy regulation
    42 breast cancer cells
    43 cancer cells
    44 cells
    45 classical receptor tyrosine kinase
    46 consensus
    47 direct inhibitor
    48 extracellular signals
    49 function
    50 functional ErbB2
    51 induction
    52 induction of autophagy
    53 inhibitors
    54 inhibits
    55 kinase
    56 kinase activity
    57 mTOR
    58 mTOR pathway
    59 matrix
    60 mechanism
    61 novel function
    62 novel mechanism
    63 nuclear translocation
    64 nucleus
    65 pathway
    66 promoter
    67 receptor tyrosine kinases
    68 regulation
    69 regulator
    70 repression
    71 role
    72 role of ErbB2
    73 sequence
    74 signals
    75 study
    76 transcription
    77 transcriptional regulators
    78 transcriptional repression
    79 translocation
    80 transmission
    81 tyrosine kinase
    82 schema:name Nuclear ErbB2 represses DEPTOR transcription to inhibit autophagy in breast cancer cells
    83 schema:pagination 397
    84 schema:productId N166a0a2591c8415faf73abe9e9a097f6
    85 N64da21ee3e6f4f228114476be84df14f
    86 Nf65ad689e16c4dd5a98b3221f4e21e92
    87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1137190020
    88 https://doi.org/10.1038/s41419-021-03686-9
    89 schema:sdDatePublished 2022-10-01T06:48
    90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    91 schema:sdPublisher Nb9d9eda41afb4d71b7c637434086e3b6
    92 schema:url https://doi.org/10.1038/s41419-021-03686-9
    93 sgo:license sg:explorer/license/
    94 sgo:sdDataset articles
    95 rdf:type schema:ScholarlyArticle
    96 N12d139769ef64d6780791bb703bd0e00 rdf:first sg:person.012112135346.39
    97 rdf:rest Nc2c2fbec8eee41888b3034030bbd9a5a
    98 N131c106c8add494fadbf21f46b3fbf21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    99 schema:name Cell Proliferation
    100 rdf:type schema:DefinedTerm
    101 N166a0a2591c8415faf73abe9e9a097f6 schema:name dimensions_id
    102 schema:value pub.1137190020
    103 rdf:type schema:PropertyValue
    104 N1a8173189ca54886a82a1c2a52254db8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    105 schema:name Signal Transduction
    106 rdf:type schema:DefinedTerm
    107 N1d83dbc720da462681da127ab92d64a3 schema:issueNumber 4
    108 rdf:type schema:PublicationIssue
    109 N4a45698a3b6342e9ad728e3f97423033 rdf:first sg:person.01304472406.33
    110 rdf:rest rdf:nil
    111 N542453d919c34727ad8439d33270625c rdf:first sg:person.01110467571.75
    112 rdf:rest N4a45698a3b6342e9ad728e3f97423033
    113 N62c327f50d8c416b976342cd2d26145f rdf:first sg:person.0624616710.11
    114 rdf:rest N542453d919c34727ad8439d33270625c
    115 N64da21ee3e6f4f228114476be84df14f schema:name doi
    116 schema:value 10.1038/s41419-021-03686-9
    117 rdf:type schema:PropertyValue
    118 N800f35a61ef1421caad9474002ceceaa schema:volumeNumber 12
    119 rdf:type schema:PublicationVolume
    120 N80b37a6461264925b55c089e52a9c980 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Receptor, ErbB-2
    122 rdf:type schema:DefinedTerm
    123 N84c2675a2af04ad7817f7727664fb558 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Breast Neoplasms
    125 rdf:type schema:DefinedTerm
    126 Nb9d9eda41afb4d71b7c637434086e3b6 schema:name Springer Nature - SN SciGraph project
    127 rdf:type schema:Organization
    128 Nbd98ecf9441f4a5d831ac04c435d75d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Phosphatidylinositol 3-Kinases
    130 rdf:type schema:DefinedTerm
    131 Nc2c2fbec8eee41888b3034030bbd9a5a rdf:first sg:person.07553766144.18
    132 rdf:rest N62c327f50d8c416b976342cd2d26145f
    133 Nec2e8e89aae54847b5c1f751ad81cf9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Autophagy
    135 rdf:type schema:DefinedTerm
    136 Nec725d0447ac461886d4b3ac21922eeb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Humans
    138 rdf:type schema:DefinedTerm
    139 Neccdd3e412644f128d98b67ec5e2492b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Intracellular Signaling Peptides and Proteins
    141 rdf:type schema:DefinedTerm
    142 Nf65ad689e16c4dd5a98b3221f4e21e92 schema:name pubmed_id
    143 schema:value 33854045
    144 rdf:type schema:PropertyValue
    145 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    146 schema:name Biological Sciences
    147 rdf:type schema:DefinedTerm
    148 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    149 schema:name Biochemistry and Cell Biology
    150 rdf:type schema:DefinedTerm
    151 sg:grant.8351544 http://pending.schema.org/fundedItem sg:pub.10.1038/s41419-021-03686-9
    152 rdf:type schema:MonetaryGrant
    153 sg:grant.8891021 http://pending.schema.org/fundedItem sg:pub.10.1038/s41419-021-03686-9
    154 rdf:type schema:MonetaryGrant
    155 sg:journal.1042939 schema:issn 2041-4889
    156 schema:name Cell Death & Disease
    157 schema:publisher Springer Nature
    158 rdf:type schema:Periodical
    159 sg:person.01110467571.75 schema:affiliation grid-institutes:grid.13402.34
    160 schema:familyName Xiong
    161 schema:givenName Xiufang
    162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110467571.75
    163 rdf:type schema:Person
    164 sg:person.012112135346.39 schema:affiliation grid-institutes:grid.13402.34
    165 schema:familyName Bi
    166 schema:givenName Yanli
    167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012112135346.39
    168 rdf:type schema:Person
    169 sg:person.01304472406.33 schema:affiliation grid-institutes:grid.13402.34
    170 schema:familyName Zhao
    171 schema:givenName Yongchao
    172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304472406.33
    173 rdf:type schema:Person
    174 sg:person.0624616710.11 schema:affiliation grid-institutes:grid.13402.34
    175 schema:familyName Liu
    176 schema:givenName Pengyuan
    177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624616710.11
    178 rdf:type schema:Person
    179 sg:person.07553766144.18 schema:affiliation grid-institutes:grid.13402.34
    180 schema:familyName Gong
    181 schema:givenName Longyuan
    182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07553766144.18
    183 rdf:type schema:Person
    184 sg:pub.10.1007/s12672-018-0356-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111492358
    185 https://doi.org/10.1007/s12672-018-0356-3
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1038/cddis.2012.125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017459370
    188 https://doi.org/10.1038/cddis.2012.125
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1038/nm.3144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051517024
    191 https://doi.org/10.1038/nm.3144
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1038/nrc3309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013979828
    194 https://doi.org/10.1038/nrc3309
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/nrm3025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025226207
    197 https://doi.org/10.1038/nrm3025
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/onc.2014.272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050309476
    200 https://doi.org/10.1038/onc.2014.272
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/onc.2015.281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000830870
    203 https://doi.org/10.1038/onc.2015.281
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/onc.2016.275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051890848
    206 https://doi.org/10.1038/onc.2016.275
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1038/s41418-019-0402-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1120290071
    209 https://doi.org/10.1038/s41418-019-0402-x
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1038/s41419-018-1168-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1109815836
    212 https://doi.org/10.1038/s41419-018-1168-7
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1038/sj.onc.1203973 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039053742
    215 https://doi.org/10.1038/sj.onc.1203973
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1186/1471-2407-12-74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042375407
    218 https://doi.org/10.1186/1471-2407-12-74
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1186/2045-3701-2-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005175327
    221 https://doi.org/10.1186/2045-3701-2-13
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1186/bcr919 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018227977
    224 https://doi.org/10.1186/bcr919
    225 rdf:type schema:CreativeWork
    226 grid-institutes:grid.13402.34 schema:alternateName Cancer Center, Zhejiang University, Hangzhou, China
    227 Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    228 Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
    229 schema:name Cancer Center, Zhejiang University, Hangzhou, China
    230 Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    231 Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    232 Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China
    233 Zhejiang Provincial Key Laboratory of Pancreatic Disease, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    234 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...