Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion View Full Text


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Article Info

DATE

2020-09-29

AUTHORS

Hyeon Gyu Seo, Han Byeol Kim, Ji Young Yoon, Tae Hyun Kweon, Yun Soo Park, Jingu Kang, Jinwoo Jung, SeongJin Son, Eugene C. Yi, Tae Ho Lee, Won Ho Yang, Jin Won Cho

ABSTRACT

O-GlcNAc transferase (OGT) is an enzyme that catalyzes the O-GlcNAc modification of nucleocytoplasmic proteins and is highly expressed in many types of cancer. However, the mechanism regulating its expression in cancer cells is not well understood. This study shows that OGT is a substrate of the E3 ubiquitin ligase X-linked inhibitor of apoptosis (XIAP) which plays an important role in cancer pathogenesis. Although LSD2 histone demethylase has already been reported as an E3 ubiquitin ligase in lung cancer cells, we identified XIAP as the main E3 ubiquitin ligase in colon cancer cells. Interestingly, OGT catalyzes the O-GlcNAc modification of XIAP at serine 406 and this modification is required for the E3 ubiquitin ligase activity of XIAP toward specifically OGT. Moreover, O-GlcNAcylation of XIAP suppresses colon cancer cell growth and invasion by promoting the proteasomal degradation of OGT. Therefore, our findings regarding the reciprocal regulation of OGT and XIAP provide a novel molecular mechanism for controlling cancer growth and invasion regulated by OGT and O-GlcNAc modification. More... »

PAGES

815

References to SciGraph publications

  • 2005-12-02. Targeting XIAP for the treatment of malignancy in CELL DEATH & DIFFERENTIATION
  • 2009-11. Building ubiquitin chains: E2 enzymes at work in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2009-07-10. XIAP as a ubiquitin ligase in cellular signaling in CELL DEATH & DIFFERENTIATION
  • 2014-06-20. Cancer Metabolism: Cross Talk Between Signaling and O-GlcNAcylation in CANCER GENOMICS AND PROTEOMICS
  • 2008-10-19. IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis in NATURE CELL BIOLOGY
  • 2013-12-26. Ubiquitination of Rac1 by Inhibitors of Apoptosis (IAPs) in RAS SIGNALING
  • 2006-09-10. Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability in NATURE CELL BIOLOGY
  • 2016-05-25. Proteogenomics connects somatic mutations to signalling in breast cancer in NATURE
  • 2011-08-18. O-GlcNAc signalling: implications for cancer cell biology in NATURE REVIEWS CANCER
  • 2016-06-27. O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway in ONCOGENE
  • 2011-05-13. Gene expression of O-GlcNAc cycling enzymes in human breast cancers in CLINICAL AND EXPERIMENTAL MEDICINE
  • 2008-11-16. X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility in NATURE CELL BIOLOGY
  • 2010-03-01. Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1 in ONCOGENE
  • 2017-06-29. Ubiquitin-dependent regulation of Cdc42 by XIAP in CELL DEATH & DISEASE
  • 2017-05-05. The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis in NATURE COMMUNICATIONS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41419-020-02999-5

    DOI

    http://dx.doi.org/10.1038/s41419-020-02999-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1131258418

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/32994395


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