Potassium channel activity controls breast cancer metastasis by affecting β-catenin signaling View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-03

AUTHORS

Eun-Kyoung Breuer, Daniela Fukushiro-Lopes, Annika Dalheim, Miranda Burnette, Jeremiah Zartman, Simon Kaja, Claire Wells, Loredana Campo, Kimberly J. Curtis, Ricardo Romero-Moreno, Laurie E. Littlepage, Glen L. Niebur, Kent Hoskins, Michael I. Nishimura, Saverio Gentile

ABSTRACT

Potassium ion channels are critical in the regulation of cell motility. The acquisition of cell motility is an essential parameter of cancer metastasis. However, the role of K+ channels in cancer metastasis has been poorly studied. High expression of the hG1 gene, which encodes for Kv11.1 channel associates with good prognosis in estrogen receptor-negative breast cancer (BC). We evaluated the efficacy of the Kv11.1 activator NS1643 in arresting metastasis in a triple negative breast cancer (TNBC) mouse model. NS1643 significantly reduces the metastatic spread of breast tumors in vivo by inhibiting cell motility, reprogramming epithelial-mesenchymal transition via attenuation of Wnt/β-catenin signaling and suppressing cancer cell stemness. Our findings provide important information regarding the clinical relevance of potassium ion channel expression in breast tumors and the mechanisms by which potassium channel activity can modulate tumor biology. Findings suggest that Kv11.1 activators may represent a novel therapeutic approach for the treatment of metastatic estrogen receptor-negative BC. Ion channels are critical factor for cell motility but little is known about their role in metastasis. Stimulation of the Kv11.1 channel suppress the metastatic phenotype in TNBC. This work could represent a paradigm-shifting approach to reducing mortality by targeting a pathway that is central to the development of metastases. More... »

PAGES

180

References to SciGraph publications

  • 2005-04. Wnt signalling in stem cells and cancer in NATURE
  • 2010-12. Key signaling nodes in mammary gland development and cancer: β-catenin in BREAST CANCER RESEARCH
  • 2014-01. Prognostic significance of NANOG and KLF4 for breast cancer in BREAST CANCER
  • 2013-06. Potassium channel activation inhibits proliferation of breast cancer cells by activating a senescence program in CELL DEATH & DISEASE
  • 2014-05. The pluripotency factor nanog promotes breast cancer tumorigenesis and metastasis in ONCOGENE
  • 2015. Border Cell Migration: A Model System for Live Imaging and Genetic Analysis of Collective Cell Movement in DROSOPHILA OOGENESIS
  • 2017-12. The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer in MOLECULAR CANCER
  • 2017-04. Oxidation of KCNB1 potassium channels triggers apoptotic integrin signaling in the brain in CELL DEATH & DISEASE
  • 2011-12. Activation of β-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters in BMC CANCER
  • 2012-03. Sox2 expression in breast tumours and activation in breast cancer stem cells in ONCOGENE
  • 2018-12. hERG1 channel expression associates with molecular subtypes and prognosis in breast cancer in CANCER CELL INTERNATIONAL
  • 2013-04. PAK4 kinase activity and somatic mutation promote carcinoma cell motility and influence inhibitor sensitivity in ONCOGENE
  • 2014-11. Characterization of novel markers of senescence and their prognostic potential in cancer in CELL DEATH & DISEASE
  • 2007-09. Modeling Migration and Metastasis in Drosophila in JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
  • 2015-09. Distinct EMT programs control normal mammary stem cells and tumour-initiating cells in NATURE
  • 2009-06. Differential expression of potassium ion channels in human renal cell carcinoma in GERIATRIC NEPHROLOGY AND UROLOGY
  • 2014-06. Anthracycline-Induced Cardiotoxicity: A Review of Pathophysiology, Diagnosis, and Treatment in CURRENT TREATMENT OPTIONS IN CARDIOVASCULAR MEDICINE
  • 2015-04. Mechanical Stimulation of Bone Marrow In Situ Induces Bone Formation in Trabecular Explants in ANNALS OF BIOMEDICAL ENGINEERING
  • 2016-12. miRpower: a web-tool to validate survival-associated miRNAs utilizing expression data from 2178 breast cancer patients in BREAST CANCER RESEARCH AND TREATMENT
  • 2010-06. Epithelial-Mesenchymal Transition (EMT) in Tumor-Initiating Cells and Its Clinical Implications in Breast Cancer in JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
  • 2016-10. hERG1 potassium channel in cancer cells: a tool to reprogram immortality in EUROPEAN BIOPHYSICS JOURNAL
  • 2015-01. Primary Cilia Exist in a Small Fraction of Cells in Trabecular Bone and Marrow in CALCIFIED TISSUE INTERNATIONAL
  • 2016-12. POU5F1/Oct-4 expression in breast cancer tissue is significantly associated with non-sentinel lymph node metastasis in BMC CANCER
  • 2013-09. Synthetic lethal metabolic targeting of cellular senescence in cancer therapy in NATURE
  • 2010-03. ERα signaling through slug regulates E-cadherin and EMT in ONCOGENE
  • 2017-07-27. The metastatic suppressor NDRG1 inhibits EMT, migration and invasion through interaction and promotion of caveolin-1 ubiquitylation in human colorectal cancer cells in ONCOGENE
  • 2011-08. Novel roles for hERG K+ channels in cell proliferation and apoptosis in CELL DEATH & DISEASE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41419-019-1429-0

    DOI

    http://dx.doi.org/10.1038/s41419-019-1429-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112285943

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30792401


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