S1PR1 regulates the switch of two angiogenic modes by VE-cadherin phosphorylation in breast cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-03

AUTHORS

Shuang Liu, Chunsheng Ni, Danfang Zhang, Huizhi Sun, Xueyi Dong, Na Che, Xiaohui Liang, Chen Chen, Fang Liu, Jingru Bai, Xian Lin, Xiulan Zhao, Baocun Sun

ABSTRACT

Angiogenesis in solid tumors is divided into two modes: endothelium-dependent vessel (EDV) and vasculogenic mimicry (VM). Sphingosine-1-phosphate receptor 1 (S1PR1) plays a vital role on EDV in a variety of human tumors. However, the relationship between S1PR1 and VM is not clear. The aim of this study is to investigate S1PR1 on the regulation of EDV and mimicry formation in breast cancer. Here we show that S1PR1 phosphorylates the complex of VE-cadherin to regulate the switch of EDV and mimicry formation. Suppression of S1PR1 impairs EDV, but contributes to the generation of VM, invasion, and metastasis in vivo and vitro. By inhibiting RhoA activation, the S1PR1/VE-cadherin signaling is blocked. S1PR1 controls VE-cadherin expression and EDV via RhoA activation. Moreover, the low expression of S1PR1 correlates with VM and poor prognosis in breast cancer patient. The results show that S1PR1 regulated RhoA activation to accelerate VE-cadherin phosphorylation (Y731), leading to increased EDV and reduced VM in breast cancer. S1PR1 may provide a new thinking direction for antiangiogenic therapy for patients with breast cancer. More... »

PAGES

200

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41419-019-1411-x

DOI

http://dx.doi.org/10.1038/s41419-019-1411-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112395732

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30814488


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41419-019-1411-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41419-019-1411-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41419-019-1411-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41419-019-1411-x'


 

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287 Department of Pathology, Tianjin Medical University, Tianjin, China
288 rdf:type schema:Organization
 




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