ER stress sensor, glucose regulatory protein 78 (GRP78) regulates redox status in pancreatic cancer thereby maintaining “stemness” View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-02

AUTHORS

Patricia Dauer, Nikita S. Sharma, Vineet K. Gupta, Brittany Durden, Roey Hadad, Santanu Banerjee, Vikas Dudeja, Ashok Saluja, Sulagna Banerjee

ABSTRACT

Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) signaling have been shown to be dysregulated in multiple cancer types. Glucose regulatory protein 78 (GRP78), the master regulator of the UPR, plays a role in proliferation, invasion, and metastasis in cancer. Cancer stem cells (CSCs) make up a crucial component of the tumor heterogeneity in pancreatic cancer, as well as other cancers. "Stemness" in pancreatic cancer defines a population of cells within the tumor that have increased therapeutic resistance as well as survival advantage. In the current study, we investigated how GRP78 was responsible for maintaining "stemness" in pancreatic cancer thereby contributing to its aggressive biology. We determined that GRP78 downregulation decreased clonogenicity and self-renewal properties in pancreatic cancer cell lines in vitro. In vivo studies resulted in delayed tumor initiation frequency, as well as smaller tumor volume in the shGRP78 groups. Additionally, downregulation of GRP78 resulted in dysregulated fatty acid metabolism in pancreatic tumors as well as the cells. Further, our results showed that shGRP78 dysregulates multiple transcriptomic and proteomic pathways that involve DNA damage, oxidative stress, and cell death, that were reversed upon treatment with a ROS inhibitor, N-acetylcysteine. This study thus demonstrates for the first time that the heightened UPR in pancreatic cancer may be responsible for maintenance of the "stemness" properties in these cells that are attributed to aggressive properties like chemoresistance and metastasis. More... »

PAGES

132

References to SciGraph publications

  • 2017-11. Doxycycline induces apoptosis via ER stress selectively to cells with a cancer stem cell-like properties: importance of stem cell plasticity in ONCOGENESIS
  • 2017-08-28. Endoplasmic reticulum stress signaling and chemotherapy resistance in solid cancers in ONCOGENESIS
  • 2018-01. MiR-770 suppresses the chemo-resistance and metastasis of triple negative breast cancer via direct targeting of STMN1 in CELL DEATH & DISEASE
  • 2010-12. Elimination of head and neck cancer initiating cells through targeting glucose regulated protein78 signaling in MOLECULAR CANCER
  • 2017-06. Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells in CELL RESEARCH
  • 2014-04. Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential in NATURE REVIEWS CANCER
  • 2003-03. Long-term Results of Partial Pancreaticoduodenectomy for Ductal Adenocarcinoma of the Pancreatic Head: 25-Year Experience in WORLD JOURNAL OF SURGERY
  • 2004-10. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells in NATURE
  • 2018-05. Metabolic features of cancer stem cells: the emerging role of lipid metabolism in ONCOGENE
  • 2000-01. Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions in BREAST CANCER RESEARCH AND TREATMENT
  • 2015-12. Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer in SCIENTIFIC REPORTS
  • 2017-11-30. Knockdown of IRE1α inhibits colonic tumorigenesis through decreasing β-catenin and IRE1α targeting suppresses colon cancer cells in ONCOGENE
  • 2011-07. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis in NATURE
  • 2018-12. When fats commit crimes: fatty acid metabolism, cancer stemness and therapeutic resistance in CANCER COMMUNICATIONS
  • 2004-12. The role of the unfolded protein response in tumour development: friend or foe? in NATURE REVIEWS CANCER
  • 2008-07. Exploring the role of cancer stem cells in radioresistance in NATURE REVIEWS CANCER
  • 2011-11. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41419-019-1408-5

    DOI

    http://dx.doi.org/10.1038/s41419-019-1408-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112067762

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30755605


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Miami", 
              "id": "https://www.grid.ac/institutes/grid.26790.3a", 
              "name": [
                "Department of Pharmacology, University of Minnesota, 55455, Minneapolis, MN, USA", 
                "Department of Surgery, University of Miami, Miami, FL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dauer", 
            "givenName": "Patricia", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Miami", 
              "id": "https://www.grid.ac/institutes/grid.26790.3a", 
              "name": [
                "Department of Surgery, University of Miami, Miami, FL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sharma", 
            "givenName": "Nikita S.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sylvester Comprehensive Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.419791.3", 
              "name": [
                "Department of Surgery, University of Miami, Miami, FL, USA", 
                "Sylvester Comprehensive Cancer Center, Miami, FL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gupta", 
            "givenName": "Vineet K.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Miami", 
              "id": "https://www.grid.ac/institutes/grid.26790.3a", 
              "name": [
                "Department of Surgery, University of Miami, Miami, FL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Durden", 
            "givenName": "Brittany", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Miami", 
              "id": "https://www.grid.ac/institutes/grid.26790.3a", 
              "name": [
                "Department of Surgery, University of Miami, Miami, FL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hadad", 
            "givenName": "Roey", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sylvester Comprehensive Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.419791.3", 
              "name": [
                "Department of Surgery, University of Miami, Miami, FL, USA", 
                "Sylvester Comprehensive Cancer Center, Miami, FL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Banerjee", 
            "givenName": "Santanu", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sylvester Comprehensive Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.419791.3", 
              "name": [
                "Department of Surgery, University of Miami, Miami, FL, USA", 
                "Sylvester Comprehensive Cancer Center, Miami, FL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dudeja", 
            "givenName": "Vikas", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sylvester Comprehensive Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.419791.3", 
              "name": [
                "Department of Surgery, University of Miami, Miami, FL, USA", 
                "Sylvester Comprehensive Cancer Center, Miami, FL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Saluja", 
            "givenName": "Ashok", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sylvester Comprehensive Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.419791.3", 
              "name": [
                "Department of Surgery, University of Miami, Miami, FL, USA", 
                "Sylvester Comprehensive Cancer Center, Miami, FL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Banerjee", 
            "givenName": "Sulagna", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1080/13651820600803981", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001134680"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3701", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004259192", 
              "https://doi.org/10.1038/nrc3701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.10838", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005039757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2011.07.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005422638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.sla.0000143248.71964.29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006102220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.sla.0000143248.71964.29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006102220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-4598-9-283", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007747413", 
              "https://doi.org/10.1186/1476-4598-9-283"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10189", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011803417", 
              "https://doi.org/10.1038/nature10189"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.9833", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013131061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.201110131", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013591595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2492", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013664882", 
              "https://doi.org/10.1038/nm.2492"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00268-002-6659-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017160480", 
              "https://doi.org/10.1007/s00268-002-6659-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1006332011207", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017605970", 
              "https://doi.org/10.1023/a:1006332011207"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep16067", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019391624", 
              "https://doi.org/10.1038/srep16067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-14-1490", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020203395"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0039047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020473957"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cca.2005.07.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020965329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cca.2005.07.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020965329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archsurg.138.12.1316", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021465604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.2795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022537747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.2795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022537747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpgi.00466.2013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022843430"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.02.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023540354"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bjs.4484", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024648330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026944005", 
              "https://doi.org/10.1038/nrc1505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026944005", 
              "https://doi.org/10.1038/nrc1505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tcb.2014.06.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029778168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ol.2013.1753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029790347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ol.2013.1753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029790347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-13-2947", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030935513"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archsurg.139.7.718", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030965849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pai.0b013e3182434113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031286706"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pai.0b013e3182434113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031286706"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2012/841362", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032799798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jprot.2016.10.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032862465"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dmm.011338", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039898158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2016.06.056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041948770"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2016.06.056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041948770"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.00779-06", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042990573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0079541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045946485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02989", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046218320", 
              "https://doi.org/10.1038/nature02989"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02989", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046218320", 
              "https://doi.org/10.1038/nature02989"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pan.2016.12.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047679758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.2004.047191", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047741076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa032295", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048680038"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.3228", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050711742"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.3228", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050711742"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.trecan.2016.03.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051550508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2419", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053441127", 
              "https://doi.org/10.1038/nrc2419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/pr100039d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056291963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-15-2616", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063215995"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-15-0774", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063226423"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2017.41", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084127943", 
              "https://doi.org/10.1038/cr.2017.41"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-16-3062", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091246507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2017.284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091280868", 
              "https://doi.org/10.1038/onc.2017.284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/oncsis.2017.72", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091372052", 
              "https://doi.org/10.1038/oncsis.2017.72"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7150/oncm.22477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092032617"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41389-017-0009-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092959396", 
              "https://doi.org/10.1038/s41389-017-0009-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41419-017-0030-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100315489", 
              "https://doi.org/10.1038/s41419-017-0030-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41388-018-0141-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101019948", 
              "https://doi.org/10.1038/s41388-018-0141-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41388-018-0141-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101019948", 
              "https://doi.org/10.1038/s41388-018-0141-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1878-0261.12322", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103846851"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1878-0261.12322", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103846851"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40880-018-0317-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105472119", 
              "https://doi.org/10.1186/s40880-018-0317-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.canlet.2018.09.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107341130"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-02", 
        "datePublishedReg": "2019-02-01", 
        "description": "Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) signaling have been shown to be dysregulated in multiple cancer types. Glucose regulatory protein 78 (GRP78), the master regulator of the UPR, plays a role in proliferation, invasion, and metastasis in cancer. Cancer stem cells (CSCs) make up a crucial component of the tumor heterogeneity in pancreatic cancer, as well as other cancers. \"Stemness\" in pancreatic cancer defines a population of cells within the tumor that have increased therapeutic resistance as well as survival advantage. In the current study, we investigated how GRP78 was responsible for maintaining \"stemness\" in pancreatic cancer thereby contributing to its aggressive biology. We determined that GRP78 downregulation decreased clonogenicity and self-renewal properties in pancreatic cancer cell lines in vitro. In vivo studies resulted in delayed tumor initiation frequency, as well as smaller tumor volume in the shGRP78 groups. Additionally, downregulation of GRP78 resulted in dysregulated fatty acid metabolism in pancreatic tumors as well as the cells. Further, our results showed that shGRP78 dysregulates multiple transcriptomic and proteomic pathways that involve DNA damage, oxidative stress, and cell death, that were reversed upon treatment with a ROS inhibitor, N-acetylcysteine. This study thus demonstrates for the first time that the heightened UPR in pancreatic cancer may be responsible for maintenance of the \"stemness\" properties in these cells that are attributed to aggressive properties like chemoresistance and metastasis.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41419-019-1408-5", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2479063", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3536746", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2482122", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1042939", 
            "issn": [
              "2041-4889"
            ], 
            "name": "Cell Death & Disease", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "10"
          }
        ], 
        "name": "ER stress sensor, glucose regulatory protein 78 (GRP78) regulates redox status in pancreatic cancer thereby maintaining \u201cstemness\u201d", 
        "pagination": "132", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "79a1d04e7ab73ef644e2b1e19604f97c11e195254beec05c88c7f622a37dcf55"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30755605"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101524092"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41419-019-1408-5"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1112067762"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41419-019-1408-5", 
          "https://app.dimensions.ai/details/publication/pub.1112067762"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T09:04", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000335_0000000335/records_125259_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41419-019-1408-5"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41419-019-1408-5'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41419-019-1408-5'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41419-019-1408-5'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41419-019-1408-5'


     

    This table displays all metadata directly associated to this object as RDF triples.

    305 TRIPLES      21 PREDICATES      83 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41419-019-1408-5 schema:about anzsrc-for:11
    2 anzsrc-for:1112
    3 schema:author N30bd341c79224ee59d2e328b019992f3
    4 schema:citation sg:pub.10.1007/s00268-002-6659-z
    5 sg:pub.10.1023/a:1006332011207
    6 sg:pub.10.1038/cr.2017.41
    7 sg:pub.10.1038/nature02989
    8 sg:pub.10.1038/nature10189
    9 sg:pub.10.1038/nm.2492
    10 sg:pub.10.1038/nrc1505
    11 sg:pub.10.1038/nrc2419
    12 sg:pub.10.1038/nrc3701
    13 sg:pub.10.1038/onc.2017.284
    14 sg:pub.10.1038/oncsis.2017.72
    15 sg:pub.10.1038/s41388-018-0141-3
    16 sg:pub.10.1038/s41389-017-0009-3
    17 sg:pub.10.1038/s41419-017-0030-7
    18 sg:pub.10.1038/srep16067
    19 sg:pub.10.1186/1476-4598-9-283
    20 sg:pub.10.1186/s40880-018-0317-9
    21 https://doi.org/10.1001/archsurg.138.12.1316
    22 https://doi.org/10.1001/archsurg.139.7.718
    23 https://doi.org/10.1002/1878-0261.12322
    24 https://doi.org/10.1002/bjs.4484
    25 https://doi.org/10.1002/path.2795
    26 https://doi.org/10.1016/j.canlet.2018.09.028
    27 https://doi.org/10.1016/j.cca.2005.07.016
    28 https://doi.org/10.1016/j.cell.2011.02.013
    29 https://doi.org/10.1016/j.cell.2016.06.056
    30 https://doi.org/10.1016/j.jprot.2016.10.002
    31 https://doi.org/10.1016/j.pan.2016.12.010
    32 https://doi.org/10.1016/j.stem.2011.07.016
    33 https://doi.org/10.1016/j.tcb.2014.06.001
    34 https://doi.org/10.1016/j.trecan.2016.03.007
    35 https://doi.org/10.1021/pr100039d
    36 https://doi.org/10.1056/nejmoa032295
    37 https://doi.org/10.1080/13651820600803981
    38 https://doi.org/10.1083/jcb.201110131
    39 https://doi.org/10.1097/01.sla.0000143248.71964.29
    40 https://doi.org/10.1097/pai.0b013e3182434113
    41 https://doi.org/10.1128/mcb.00779-06
    42 https://doi.org/10.1136/gut.2004.047191
    43 https://doi.org/10.1152/ajpgi.00466.2013
    44 https://doi.org/10.1155/2012/841362
    45 https://doi.org/10.1158/0008-5472.can-15-2616
    46 https://doi.org/10.1158/0008-5472.can-16-3062
    47 https://doi.org/10.1158/1078-0432.ccr-13-2947
    48 https://doi.org/10.1158/1535-7163.mct-15-0774
    49 https://doi.org/10.1158/2159-8290.cd-14-1490
    50 https://doi.org/10.1242/dmm.011338
    51 https://doi.org/10.1371/journal.pone.0039047
    52 https://doi.org/10.1371/journal.pone.0079541
    53 https://doi.org/10.18632/oncotarget.10838
    54 https://doi.org/10.18632/oncotarget.3228
    55 https://doi.org/10.18632/oncotarget.9833
    56 https://doi.org/10.3892/ol.2013.1753
    57 https://doi.org/10.7150/oncm.22477
    58 schema:datePublished 2019-02
    59 schema:datePublishedReg 2019-02-01
    60 schema:description Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) signaling have been shown to be dysregulated in multiple cancer types. Glucose regulatory protein 78 (GRP78), the master regulator of the UPR, plays a role in proliferation, invasion, and metastasis in cancer. Cancer stem cells (CSCs) make up a crucial component of the tumor heterogeneity in pancreatic cancer, as well as other cancers. "Stemness" in pancreatic cancer defines a population of cells within the tumor that have increased therapeutic resistance as well as survival advantage. In the current study, we investigated how GRP78 was responsible for maintaining "stemness" in pancreatic cancer thereby contributing to its aggressive biology. We determined that GRP78 downregulation decreased clonogenicity and self-renewal properties in pancreatic cancer cell lines in vitro. In vivo studies resulted in delayed tumor initiation frequency, as well as smaller tumor volume in the shGRP78 groups. Additionally, downregulation of GRP78 resulted in dysregulated fatty acid metabolism in pancreatic tumors as well as the cells. Further, our results showed that shGRP78 dysregulates multiple transcriptomic and proteomic pathways that involve DNA damage, oxidative stress, and cell death, that were reversed upon treatment with a ROS inhibitor, N-acetylcysteine. This study thus demonstrates for the first time that the heightened UPR in pancreatic cancer may be responsible for maintenance of the "stemness" properties in these cells that are attributed to aggressive properties like chemoresistance and metastasis.
    61 schema:genre research_article
    62 schema:inLanguage en
    63 schema:isAccessibleForFree true
    64 schema:isPartOf N0cde93dfddb14f8f9b69db7e9480ad10
    65 N94fd20592aa244d18c2f22a7fa2323a7
    66 sg:journal.1042939
    67 schema:name ER stress sensor, glucose regulatory protein 78 (GRP78) regulates redox status in pancreatic cancer thereby maintaining “stemness”
    68 schema:pagination 132
    69 schema:productId N02a539ec449b4ae2aba714f1772b1ede
    70 N86e6574fb28442499f8a4e9dab9337b2
    71 N90b5a2517aa04e6f8a6fc62138d26436
    72 Na66a346154544e379f878fafaea92ba4
    73 Nc6d300bafac24a6ca2d18c611c8940e7
    74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112067762
    75 https://doi.org/10.1038/s41419-019-1408-5
    76 schema:sdDatePublished 2019-04-11T09:04
    77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    78 schema:sdPublisher Nf9061675ee594c14bd8c12bcfdfb82f1
    79 schema:url https://www.nature.com/articles/s41419-019-1408-5
    80 sgo:license sg:explorer/license/
    81 sgo:sdDataset articles
    82 rdf:type schema:ScholarlyArticle
    83 N02a539ec449b4ae2aba714f1772b1ede schema:name pubmed_id
    84 schema:value 30755605
    85 rdf:type schema:PropertyValue
    86 N05b6638553104e40a12c6b3fc0ad6566 rdf:first N6c89ccfcc189432f9e03dbbfb0b1fae8
    87 rdf:rest Ne4a2a266bae7413fa6f958f288d236ad
    88 N068bb3dc177a4e34af6c9e26f959b2b2 schema:affiliation https://www.grid.ac/institutes/grid.26790.3a
    89 schema:familyName Dauer
    90 schema:givenName Patricia
    91 rdf:type schema:Person
    92 N0cde93dfddb14f8f9b69db7e9480ad10 schema:issueNumber 2
    93 rdf:type schema:PublicationIssue
    94 N15c52137c2a3449392517ebb6ddb5991 schema:affiliation https://www.grid.ac/institutes/grid.419791.3
    95 schema:familyName Banerjee
    96 schema:givenName Sulagna
    97 rdf:type schema:Person
    98 N15e3dca826b4407a8431ebd475cae183 schema:affiliation https://www.grid.ac/institutes/grid.26790.3a
    99 schema:familyName Hadad
    100 schema:givenName Roey
    101 rdf:type schema:Person
    102 N1c9007b2f54f4aab80ccc4422f80efde rdf:first N247833de82dc43e5a15a11fa6f27737b
    103 rdf:rest N313665034db9427c9ccc812c32da5790
    104 N247833de82dc43e5a15a11fa6f27737b schema:affiliation https://www.grid.ac/institutes/grid.419791.3
    105 schema:familyName Gupta
    106 schema:givenName Vineet K.
    107 rdf:type schema:Person
    108 N30bd341c79224ee59d2e328b019992f3 rdf:first N068bb3dc177a4e34af6c9e26f959b2b2
    109 rdf:rest N477e0f6231d14c35937822614d2d9a19
    110 N313665034db9427c9ccc812c32da5790 rdf:first N85147a86198e431eb188673b350d2dad
    111 rdf:rest N36040c40fc004994a7bebcc104bbba69
    112 N36040c40fc004994a7bebcc104bbba69 rdf:first N15e3dca826b4407a8431ebd475cae183
    113 rdf:rest N4068280ea3c849459fc95ff613ccd79f
    114 N3f5cc1d2540b464cab63f2e7ecaed7b6 rdf:first N15c52137c2a3449392517ebb6ddb5991
    115 rdf:rest rdf:nil
    116 N4068280ea3c849459fc95ff613ccd79f rdf:first Nc1027863ca3a4f6e82a27060e69542d9
    117 rdf:rest N05b6638553104e40a12c6b3fc0ad6566
    118 N477e0f6231d14c35937822614d2d9a19 rdf:first N6c6a5f1840b14882a464d997d46e0f30
    119 rdf:rest N1c9007b2f54f4aab80ccc4422f80efde
    120 N5eaee3c544f840a485ef8de5b8a51041 schema:affiliation https://www.grid.ac/institutes/grid.419791.3
    121 schema:familyName Saluja
    122 schema:givenName Ashok
    123 rdf:type schema:Person
    124 N6c6a5f1840b14882a464d997d46e0f30 schema:affiliation https://www.grid.ac/institutes/grid.26790.3a
    125 schema:familyName Sharma
    126 schema:givenName Nikita S.
    127 rdf:type schema:Person
    128 N6c89ccfcc189432f9e03dbbfb0b1fae8 schema:affiliation https://www.grid.ac/institutes/grid.419791.3
    129 schema:familyName Dudeja
    130 schema:givenName Vikas
    131 rdf:type schema:Person
    132 N85147a86198e431eb188673b350d2dad schema:affiliation https://www.grid.ac/institutes/grid.26790.3a
    133 schema:familyName Durden
    134 schema:givenName Brittany
    135 rdf:type schema:Person
    136 N86e6574fb28442499f8a4e9dab9337b2 schema:name doi
    137 schema:value 10.1038/s41419-019-1408-5
    138 rdf:type schema:PropertyValue
    139 N90b5a2517aa04e6f8a6fc62138d26436 schema:name dimensions_id
    140 schema:value pub.1112067762
    141 rdf:type schema:PropertyValue
    142 N94fd20592aa244d18c2f22a7fa2323a7 schema:volumeNumber 10
    143 rdf:type schema:PublicationVolume
    144 Na66a346154544e379f878fafaea92ba4 schema:name nlm_unique_id
    145 schema:value 101524092
    146 rdf:type schema:PropertyValue
    147 Nc1027863ca3a4f6e82a27060e69542d9 schema:affiliation https://www.grid.ac/institutes/grid.419791.3
    148 schema:familyName Banerjee
    149 schema:givenName Santanu
    150 rdf:type schema:Person
    151 Nc6d300bafac24a6ca2d18c611c8940e7 schema:name readcube_id
    152 schema:value 79a1d04e7ab73ef644e2b1e19604f97c11e195254beec05c88c7f622a37dcf55
    153 rdf:type schema:PropertyValue
    154 Ne4a2a266bae7413fa6f958f288d236ad rdf:first N5eaee3c544f840a485ef8de5b8a51041
    155 rdf:rest N3f5cc1d2540b464cab63f2e7ecaed7b6
    156 Nf9061675ee594c14bd8c12bcfdfb82f1 schema:name Springer Nature - SN SciGraph project
    157 rdf:type schema:Organization
    158 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    159 schema:name Medical and Health Sciences
    160 rdf:type schema:DefinedTerm
    161 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    162 schema:name Oncology and Carcinogenesis
    163 rdf:type schema:DefinedTerm
    164 sg:grant.2479063 http://pending.schema.org/fundedItem sg:pub.10.1038/s41419-019-1408-5
    165 rdf:type schema:MonetaryGrant
    166 sg:grant.2482122 http://pending.schema.org/fundedItem sg:pub.10.1038/s41419-019-1408-5
    167 rdf:type schema:MonetaryGrant
    168 sg:grant.3536746 http://pending.schema.org/fundedItem sg:pub.10.1038/s41419-019-1408-5
    169 rdf:type schema:MonetaryGrant
    170 sg:journal.1042939 schema:issn 2041-4889
    171 schema:name Cell Death & Disease
    172 rdf:type schema:Periodical
    173 sg:pub.10.1007/s00268-002-6659-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1017160480
    174 https://doi.org/10.1007/s00268-002-6659-z
    175 rdf:type schema:CreativeWork
    176 sg:pub.10.1023/a:1006332011207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017605970
    177 https://doi.org/10.1023/a:1006332011207
    178 rdf:type schema:CreativeWork
    179 sg:pub.10.1038/cr.2017.41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084127943
    180 https://doi.org/10.1038/cr.2017.41
    181 rdf:type schema:CreativeWork
    182 sg:pub.10.1038/nature02989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046218320
    183 https://doi.org/10.1038/nature02989
    184 rdf:type schema:CreativeWork
    185 sg:pub.10.1038/nature10189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011803417
    186 https://doi.org/10.1038/nature10189
    187 rdf:type schema:CreativeWork
    188 sg:pub.10.1038/nm.2492 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013664882
    189 https://doi.org/10.1038/nm.2492
    190 rdf:type schema:CreativeWork
    191 sg:pub.10.1038/nrc1505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026944005
    192 https://doi.org/10.1038/nrc1505
    193 rdf:type schema:CreativeWork
    194 sg:pub.10.1038/nrc2419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053441127
    195 https://doi.org/10.1038/nrc2419
    196 rdf:type schema:CreativeWork
    197 sg:pub.10.1038/nrc3701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004259192
    198 https://doi.org/10.1038/nrc3701
    199 rdf:type schema:CreativeWork
    200 sg:pub.10.1038/onc.2017.284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091280868
    201 https://doi.org/10.1038/onc.2017.284
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1038/oncsis.2017.72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091372052
    204 https://doi.org/10.1038/oncsis.2017.72
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1038/s41388-018-0141-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101019948
    207 https://doi.org/10.1038/s41388-018-0141-3
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1038/s41389-017-0009-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092959396
    210 https://doi.org/10.1038/s41389-017-0009-3
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1038/s41419-017-0030-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100315489
    213 https://doi.org/10.1038/s41419-017-0030-7
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1038/srep16067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019391624
    216 https://doi.org/10.1038/srep16067
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1186/1476-4598-9-283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007747413
    219 https://doi.org/10.1186/1476-4598-9-283
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1186/s40880-018-0317-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105472119
    222 https://doi.org/10.1186/s40880-018-0317-9
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1001/archsurg.138.12.1316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021465604
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1001/archsurg.139.7.718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030965849
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1002/1878-0261.12322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103846851
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1002/bjs.4484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024648330
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1002/path.2795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022537747
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1016/j.canlet.2018.09.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107341130
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1016/j.cca.2005.07.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020965329
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1016/j.cell.2011.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023540354
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1016/j.cell.2016.06.056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041948770
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1016/j.jprot.2016.10.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032862465
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1016/j.pan.2016.12.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047679758
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1016/j.stem.2011.07.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005422638
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1016/j.tcb.2014.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029778168
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1016/j.trecan.2016.03.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051550508
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1021/pr100039d schema:sameAs https://app.dimensions.ai/details/publication/pub.1056291963
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1056/nejmoa032295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048680038
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1080/13651820600803981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001134680
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1083/jcb.201110131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013591595
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1097/01.sla.0000143248.71964.29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006102220
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1097/pai.0b013e3182434113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031286706
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1128/mcb.00779-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042990573
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1136/gut.2004.047191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047741076
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1152/ajpgi.00466.2013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022843430
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1155/2012/841362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032799798
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1158/0008-5472.can-15-2616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063215995
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1158/0008-5472.can-16-3062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091246507
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1158/1078-0432.ccr-13-2947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030935513
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1158/1535-7163.mct-15-0774 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063226423
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1158/2159-8290.cd-14-1490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020203395
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1242/dmm.011338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039898158
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1371/journal.pone.0039047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020473957
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1371/journal.pone.0079541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045946485
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.18632/oncotarget.10838 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005039757
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.18632/oncotarget.3228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050711742
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.18632/oncotarget.9833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013131061
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.3892/ol.2013.1753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029790347
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.7150/oncm.22477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092032617
    297 rdf:type schema:CreativeWork
    298 https://www.grid.ac/institutes/grid.26790.3a schema:alternateName University of Miami
    299 schema:name Department of Pharmacology, University of Minnesota, 55455, Minneapolis, MN, USA
    300 Department of Surgery, University of Miami, Miami, FL, USA
    301 rdf:type schema:Organization
    302 https://www.grid.ac/institutes/grid.419791.3 schema:alternateName Sylvester Comprehensive Cancer Center
    303 schema:name Department of Surgery, University of Miami, Miami, FL, USA
    304 Sylvester Comprehensive Cancer Center, Miami, FL, USA
    305 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...