Differential effects of N-acetylcysteine on retinal degeneration in two mouse models of normal tension glaucoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-02

AUTHORS

Hiroki Sano, Kazuhiko Namekata, Atsuko Kimura, Hiroshi Shitara, Xiaoli Guo, Chikako Harada, Yoshinori Mitamura, Takayuki Harada

ABSTRACT

N-acetylcysteine (NAC) is widely used as a mucolytic agent and as an antidote to paracetamol overdose. NAC serves as a precursor of cysteine and stimulates the synthesis of glutathione in neural cells. Suppressing oxidative stress in the retina may be an effective therapeutic strategy for glaucoma, a chronic neurodegenerative disease of the retinal ganglion cells (RGCs) and optic nerves. Here we examined the therapeutic potential of NAC in two mouse models of normal tension glaucoma, in which excitatory amino-acid carrier 1 (EAAC1) or glutamate/aspartate transporter (GLAST) gene was deleted. EAAC1 is expressed in retinal neurons including RGCs, whereas GLAST is mainly expressed in Müller glial cells. Intraperitoneal administration of NAC prevented RGC degeneration and visual impairment in EAAC1-deficient (knockout; KO) mice, but not in GLAST KO mice. In EAAC1 KO mice, oxidative stress and autophagy were suppressed with increased glutathione levels by NAC treatment. Our findings suggest a possibility that systemic administration of NAC may be available for some types of glaucoma patients. More... »

PAGES

75

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41419-019-1365-z

    DOI

    http://dx.doi.org/10.1038/s41419-019-1365-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111676674

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30692515


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