Annexin A1-suppressed autophagy promotes nasopharyngeal carcinoma cell invasion and metastasis by PI3K/AKT signaling activation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Jin-Feng Zhu, Wei Huang, Hong-Mei Yi, Ta Xiao, Jiao-Yang Li, Juan Feng, Hong Yi, Shan-Shan Lu, Xin-Hui Li, Rou-Huang Lu, Qiu-Yan He, Zhi-Qiang Xiao

ABSTRACT

Annexin A1 (ANXA1) is dysregulated in the various tumors. However, the role and mechanism of ANXA1 in the cancers are poorly understood. In this study, we first showed a clinically positive correlation between ANXA1 and autophagy-associated protein SQSTM1 expression in nasopharyngeal carcinoma (NPC) and ANXA1-regulating SQSTM1 expression through autophagy, and further demonstrated that ANXA1 inhibited BECN1 and ATG5-dependent autophagy in the NPC cells. Using phospho-kinase antibody array to identify signaling through which ANXA1 regulated NPC cell autophagy, we found that ANXA1-suppressed autophagy was associated with PI3K/AKT signaling activation. We also showed that ANXA1 expression was significantly increased in the NPCs with metastasis relative to NPCs without metastasis and positively correlated with lymphonode and distant metastasis; high ANXA1 expression in the NPC cells promoted in vitro tumor cell migration and invasion and in vivo metastasis. Lastly, we showed that inhibition of autophagy restored the ability of tumor cell migration and invasion, epithelial-mesenchymal transition (EMT)-like alterations and in vivo metastasis in the ANXA1 knockdown NPC cells with autophagy activation; ANXA1-suppresed autophagy induced EMT-like alterations possibly by inhibiting autophagy-mediated degradation of Snail. Our data suggest that ANXA1-suppressed autophagy promotes NPC cell migration, invasion and metastasis by activating PI3K/AKT signaling pathway, highlighting that the activation of autophagy may inhibit metastasis of NPC with high ANXA1 expression. More... »

PAGES

1154

References to SciGraph publications

  • 2017-03. Autophagy in cancer metastasis in ONCOGENE
  • 2017-06-01. MiR-125b regulates proliferation and apoptosis of nasopharyngeal carcinoma by targeting A20/NF-κB signaling pathway in CELL DEATH & DISEASE
  • 2013-10. IBP-mediated suppression of autophagy promotes growth and metastasis of breast cancer cells via activating mTORC2/Akt/FOXO3a signaling pathway in CELL DEATH & DISEASE
  • 2008-02. Autophagy fights disease through cellular self-digestion in NATURE
  • 2014-12. Role of intracellular and extracellular annexin A1 in migration and invasion of human pancreatic carcinoma cells in BMC CANCER
  • 2008-11. Tissue microarray analysis reveals strong clinical evidence for a close association between loss of annexin A1 expression and nodal metastasis in gastric cancer in CLINICAL & EXPERIMENTAL METASTASIS
  • 2014-08. The genomic landscape of nasopharyngeal carcinoma in NATURE GENETICS
  • 2016-12. Autophagy and epithelial–mesenchymal transition: an intricate interplay in cancer in CELL DEATH & DISEASE
  • 2011-07. Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-κB: implication in breast cancer metastasis in ONCOGENE
  • 2008-11. MicroRNA-196a targets annexin A1: a microRNA-mediated mechanism of annexin A1 downregulation in cancers in ONCOGENE
  • 2015-09. Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation in CELL DEATH & DISEASE
  • 2014-10. Annexin A1 in primary tumors promotes melanoma dissemination in CLINICAL & EXPERIMENTAL METASTASIS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41419-018-1204-7

    DOI

    http://dx.doi.org/10.1038/s41419-018-1204-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1110029144

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30459351


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Xinjiang Medical University", 
              "id": "https://www.grid.ac/institutes/grid.13394.3c", 
              "name": [
                "Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China", 
                "Department of Gastrointestinal Surgery, The Affiliated Cancer Hospital of Xinjiang Medical University, 830011, Urumqi, Xinjiang, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhu", 
            "givenName": "Jin-Feng", 
            "id": "sg:person.01005410161.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005410161.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Huang", 
            "givenName": "Wei", 
            "id": "sg:person.01167121070.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167121070.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yi", 
            "givenName": "Hong-Mei", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Chinese Academy of Medical Sciences Dermatology Hospital", 
              "id": "https://www.grid.ac/institutes/grid.477246.4", 
              "name": [
                "Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China", 
                "Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 210042, Nanjing, Jiangsu, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Xiao", 
            "givenName": "Ta", 
            "id": "sg:person.0623046361.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623046361.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Jiao-Yang", 
            "id": "sg:person.01264705561.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264705561.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Feng", 
            "givenName": "Juan", 
            "id": "sg:person.01236065161.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236065161.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yi", 
            "givenName": "Hong", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lu", 
            "givenName": "Shan-Shan", 
            "id": "sg:person.01304200361.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304200361.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Xin-Hui", 
            "id": "sg:person.0647060602.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647060602.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lu", 
            "givenName": "Rou-Huang", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China", 
                "Department of Pathology, Xiangya Hospital, Central South University, 410078, Changsha, Hunan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "He", 
            "givenName": "Qiu-Yan", 
            "id": "sg:person.0731200572.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731200572.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Xiao", 
            "givenName": "Zhi-Qiang", 
            "id": "sg:person.01161655572.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161655572.57"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.bbrc.2011.03.067", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004144610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cddis.2013.380", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005874361", 
              "https://doi.org/10.1038/cddis.2013.380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.06-7464rev", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005983697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-11-3832", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011164602"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cib.20076", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011178890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.emboj.7600759", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011375545"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biocel.2013.06.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011597788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0913360107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013100355"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2016.333", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016852310", 
              "https://doi.org/10.1038/onc.2016.333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.11.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017006433"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cddis.2016.415", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017539003", 
              "https://doi.org/10.1038/cddis.2016.415"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.9067", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018759292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.9067", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018759292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2008.256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018867661", 
              "https://doi.org/10.1038/onc.2008.256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2011.28", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019674334", 
              "https://doi.org/10.1038/onc.2011.28"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-06-0483", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022651658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023238440", 
              "https://doi.org/10.1038/ng.3006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023238440", 
              "https://doi.org/10.1038/ng.3006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cddis.2015.249", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024031512", 
              "https://doi.org/10.1038/cddis.2015.249"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.09-154096", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024708852"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06639", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025718085", 
              "https://doi.org/10.1038/nature06639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.3847", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027337218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.3847", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027337218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.4725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027693032"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2013.12.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027948350"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-8049(11)70179-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028233425"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-8049(11)70179-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028233425"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10585-014-9665-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028496312", 
              "https://doi.org/10.1007/s10585-014-9665-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ceb.2009.10.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028544009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.86.9.3428", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035959126"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1535-6108(04)00119-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037144537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.5674", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037645367"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1247/csf.23.33", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037831603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-14-961", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043605288", 
              "https://doi.org/10.1186/1471-2407-14-961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10585-008-9178-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044271150", 
              "https://doi.org/10.1007/s10585-008-9178-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10585-008-9178-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044271150", 
              "https://doi.org/10.1007/s10585-008-9178-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2005/108490", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045863143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0360-3016(92)90740-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046372717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/19.21.5720", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049092516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-15-2996", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063225279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci33700", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063417073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/mmr.2014.2656", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071522058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/mmr.2014.2656", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071522058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/mmr.2014.2656", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071522058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/15384101.2014.987619", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072288262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/auto.26398", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072289861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/auto.29961", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072290093"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/auto.3424", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072290121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/auto.6.3.11303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072290671"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/auto.7.2.14074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072290977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5301/jbm.5000046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072752816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5301/jbm.5000046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072752816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083105210", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cddis.2017.211", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085729320", 
              "https://doi.org/10.1038/cddis.2017.211"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cddis.2017.211", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085729320", 
              "https://doi.org/10.1038/cddis.2017.211"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/15548627.2018.1450020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104382282"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-12", 
        "datePublishedReg": "2018-12-01", 
        "description": "Annexin A1 (ANXA1) is dysregulated in the various tumors. However, the role and mechanism of ANXA1 in the cancers are poorly understood. In this study, we first showed a clinically positive correlation between ANXA1 and autophagy-associated protein SQSTM1 expression in nasopharyngeal carcinoma (NPC) and ANXA1-regulating SQSTM1 expression through autophagy, and further demonstrated that ANXA1 inhibited BECN1 and ATG5-dependent autophagy in the NPC cells. Using phospho-kinase antibody array to identify signaling through which ANXA1 regulated NPC cell autophagy, we found that ANXA1-suppressed autophagy was associated with PI3K/AKT signaling activation. We also showed that ANXA1 expression was significantly increased in the NPCs with metastasis relative to NPCs without metastasis and positively correlated with lymphonode and distant metastasis; high ANXA1 expression in the NPC cells promoted in vitro tumor cell migration and invasion and in vivo metastasis. Lastly, we showed that inhibition of autophagy restored the ability of tumor cell migration and invasion, epithelial-mesenchymal transition (EMT)-like alterations and in vivo metastasis in the ANXA1 knockdown NPC cells with autophagy activation; ANXA1-suppresed autophagy induced EMT-like alterations possibly by inhibiting autophagy-mediated degradation of Snail. Our data suggest that ANXA1-suppressed autophagy promotes NPC cell migration, invasion and metastasis by activating PI3K/AKT signaling pathway, highlighting that the activation of autophagy may inhibit metastasis of NPC with high ANXA1 expression.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41419-018-1204-7", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1042939", 
            "issn": [
              "2041-4889"
            ], 
            "name": "Cell Death & Disease", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "12", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "Annexin A1-suppressed autophagy promotes nasopharyngeal carcinoma cell invasion and metastasis by PI3K/AKT signaling activation", 
        "pagination": "1154", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "2c5c09fe6038ce4f60fb1d45704e61cfed2beec351a6032d1ff11352efa93cd2"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30459351"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101524092"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41419-018-1204-7"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1110029144"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41419-018-1204-7", 
          "https://app.dimensions.ai/details/publication/pub.1110029144"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T08:11", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000269_0000000269/records_56813_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41419-018-1204-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-1204-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-1204-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-1204-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-1204-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    320 TRIPLES      21 PREDICATES      76 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41419-018-1204-7 schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 schema:author N9d7bed96c6114acf8c9f5783db0a0cc8
    4 schema:citation sg:pub.10.1007/s10585-008-9178-y
    5 sg:pub.10.1007/s10585-014-9665-2
    6 sg:pub.10.1038/cddis.2013.380
    7 sg:pub.10.1038/cddis.2015.249
    8 sg:pub.10.1038/cddis.2016.415
    9 sg:pub.10.1038/cddis.2017.211
    10 sg:pub.10.1038/nature06639
    11 sg:pub.10.1038/ng.3006
    12 sg:pub.10.1038/onc.2008.256
    13 sg:pub.10.1038/onc.2011.28
    14 sg:pub.10.1038/onc.2016.333
    15 sg:pub.10.1186/1471-2407-14-961
    16 https://app.dimensions.ai/details/publication/pub.1083105210
    17 https://doi.org/10.1016/0360-3016(92)90740-9
    18 https://doi.org/10.1016/j.bbrc.2011.03.067
    19 https://doi.org/10.1016/j.biocel.2013.06.020
    20 https://doi.org/10.1016/j.ceb.2009.10.008
    21 https://doi.org/10.1016/j.cell.2009.11.007
    22 https://doi.org/10.1016/j.molcel.2013.12.014
    23 https://doi.org/10.1016/s0959-8049(11)70179-4
    24 https://doi.org/10.1016/s1535-6108(04)00119-9
    25 https://doi.org/10.1038/sj.emboj.7600759
    26 https://doi.org/10.1073/pnas.0913360107
    27 https://doi.org/10.1073/pnas.86.9.3428
    28 https://doi.org/10.1080/15548627.2018.1450020
    29 https://doi.org/10.1093/emboj/19.21.5720
    30 https://doi.org/10.1096/fj.06-7464rev
    31 https://doi.org/10.1096/fj.09-154096
    32 https://doi.org/10.1155/2005/108490
    33 https://doi.org/10.1158/0008-5472.can-11-3832
    34 https://doi.org/10.1158/1078-0432.ccr-06-0483
    35 https://doi.org/10.1158/1078-0432.ccr-15-2996
    36 https://doi.org/10.1172/jci33700
    37 https://doi.org/10.1247/csf.23.33
    38 https://doi.org/10.18632/oncotarget.3847
    39 https://doi.org/10.18632/oncotarget.4725
    40 https://doi.org/10.18632/oncotarget.5674
    41 https://doi.org/10.18632/oncotarget.9067
    42 https://doi.org/10.3892/mmr.2014.2656
    43 https://doi.org/10.4161/15384101.2014.987619
    44 https://doi.org/10.4161/auto.26398
    45 https://doi.org/10.4161/auto.29961
    46 https://doi.org/10.4161/auto.3424
    47 https://doi.org/10.4161/auto.6.3.11303
    48 https://doi.org/10.4161/auto.7.2.14074
    49 https://doi.org/10.4161/cib.20076
    50 https://doi.org/10.5301/jbm.5000046
    51 schema:datePublished 2018-12
    52 schema:datePublishedReg 2018-12-01
    53 schema:description Annexin A1 (ANXA1) is dysregulated in the various tumors. However, the role and mechanism of ANXA1 in the cancers are poorly understood. In this study, we first showed a clinically positive correlation between ANXA1 and autophagy-associated protein SQSTM1 expression in nasopharyngeal carcinoma (NPC) and ANXA1-regulating SQSTM1 expression through autophagy, and further demonstrated that ANXA1 inhibited BECN1 and ATG5-dependent autophagy in the NPC cells. Using phospho-kinase antibody array to identify signaling through which ANXA1 regulated NPC cell autophagy, we found that ANXA1-suppressed autophagy was associated with PI3K/AKT signaling activation. We also showed that ANXA1 expression was significantly increased in the NPCs with metastasis relative to NPCs without metastasis and positively correlated with lymphonode and distant metastasis; high ANXA1 expression in the NPC cells promoted in vitro tumor cell migration and invasion and in vivo metastasis. Lastly, we showed that inhibition of autophagy restored the ability of tumor cell migration and invasion, epithelial-mesenchymal transition (EMT)-like alterations and in vivo metastasis in the ANXA1 knockdown NPC cells with autophagy activation; ANXA1-suppresed autophagy induced EMT-like alterations possibly by inhibiting autophagy-mediated degradation of Snail. Our data suggest that ANXA1-suppressed autophagy promotes NPC cell migration, invasion and metastasis by activating PI3K/AKT signaling pathway, highlighting that the activation of autophagy may inhibit metastasis of NPC with high ANXA1 expression.
    54 schema:genre research_article
    55 schema:inLanguage en
    56 schema:isAccessibleForFree true
    57 schema:isPartOf N9c70a974af104da3996d366abe889c06
    58 Nbb5d3c380ab84fc7b912ba2f01fb5074
    59 sg:journal.1042939
    60 schema:name Annexin A1-suppressed autophagy promotes nasopharyngeal carcinoma cell invasion and metastasis by PI3K/AKT signaling activation
    61 schema:pagination 1154
    62 schema:productId N05f7ca54613b46e281a84f3a2a534707
    63 N921a23c0f9d64993ac8965663cd92a89
    64 N93a37ffa17684ca0985ad22665f66d71
    65 Nc9b75d044110417ab501bd810f547042
    66 Nef4654fec88445d8ac240d4a1a6df8eb
    67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110029144
    68 https://doi.org/10.1038/s41419-018-1204-7
    69 schema:sdDatePublished 2019-04-11T08:11
    70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    71 schema:sdPublisher Nb6c817e63838470e8b8128a43ebb1b46
    72 schema:url https://www.nature.com/articles/s41419-018-1204-7
    73 sgo:license sg:explorer/license/
    74 sgo:sdDataset articles
    75 rdf:type schema:ScholarlyArticle
    76 N05f7ca54613b46e281a84f3a2a534707 schema:name readcube_id
    77 schema:value 2c5c09fe6038ce4f60fb1d45704e61cfed2beec351a6032d1ff11352efa93cd2
    78 rdf:type schema:PropertyValue
    79 N1bc80bf5d17146b79f6bf7d8e5431bd3 rdf:first sg:person.01161655572.57
    80 rdf:rest rdf:nil
    81 N1f33a8bbd4014466a2f4b21c7762ae3c rdf:first Nd625893400974b5b85f60c190449ce0f
    82 rdf:rest N607006106cca417792056c13b0808298
    83 N210cb51cf19248508ef3c23dd71bb85c schema:name Department of Pathology, Xiangya Hospital, Central South University, 410078, Changsha, Hunan, China
    84 Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China
    85 rdf:type schema:Organization
    86 N2a4aa78fdcd04297a8e37d6a2057c3d8 rdf:first N49793904b6884414abe4c890f7540a2c
    87 rdf:rest N3778cbcd9246418ebd745a43926fda47
    88 N3778cbcd9246418ebd745a43926fda47 rdf:first sg:person.01304200361.39
    89 rdf:rest Nf0e036c4805949ffa82b430f382e8bfa
    90 N401a5b924b9f492189c31f7420d45f84 schema:name Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China
    91 rdf:type schema:Organization
    92 N49793904b6884414abe4c890f7540a2c schema:affiliation Ne13d0203252142a682bea3117bcae0ac
    93 schema:familyName Yi
    94 schema:givenName Hong
    95 rdf:type schema:Person
    96 N4e3414e0479c4234a1a7bf59697345cc schema:name Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China
    97 rdf:type schema:Organization
    98 N569ec72b57e14f6fac9731b20b94d23d rdf:first sg:person.01167121070.60
    99 rdf:rest N1f33a8bbd4014466a2f4b21c7762ae3c
    100 N607006106cca417792056c13b0808298 rdf:first sg:person.0623046361.31
    101 rdf:rest N69c7c4630df04ad1b54fa6fa30053d07
    102 N6847d8d0af3645e98d5df7c279bd511d schema:name Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China
    103 rdf:type schema:Organization
    104 N69c7c4630df04ad1b54fa6fa30053d07 rdf:first sg:person.01264705561.71
    105 rdf:rest Nbe388c3e52e94a059f0259c7a791f1f8
    106 N7518cb6aa7a14b3193e81cbac6046dc5 schema:name Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China
    107 rdf:type schema:Organization
    108 N78dca8a361b44d1da64ae35492076919 schema:name Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China
    109 rdf:type schema:Organization
    110 N921a23c0f9d64993ac8965663cd92a89 schema:name dimensions_id
    111 schema:value pub.1110029144
    112 rdf:type schema:PropertyValue
    113 N93a37ffa17684ca0985ad22665f66d71 schema:name nlm_unique_id
    114 schema:value 101524092
    115 rdf:type schema:PropertyValue
    116 N9c70a974af104da3996d366abe889c06 schema:volumeNumber 9
    117 rdf:type schema:PublicationVolume
    118 N9d7bed96c6114acf8c9f5783db0a0cc8 rdf:first sg:person.01005410161.01
    119 rdf:rest N569ec72b57e14f6fac9731b20b94d23d
    120 Nb691fc8801134e339499700ad837d27a schema:affiliation N78dca8a361b44d1da64ae35492076919
    121 schema:familyName Lu
    122 schema:givenName Rou-Huang
    123 rdf:type schema:Person
    124 Nb6c817e63838470e8b8128a43ebb1b46 schema:name Springer Nature - SN SciGraph project
    125 rdf:type schema:Organization
    126 Nbb5d3c380ab84fc7b912ba2f01fb5074 schema:issueNumber 12
    127 rdf:type schema:PublicationIssue
    128 Nbe388c3e52e94a059f0259c7a791f1f8 rdf:first sg:person.01236065161.69
    129 rdf:rest N2a4aa78fdcd04297a8e37d6a2057c3d8
    130 Nc29735c5894340769979d67c519ac798 schema:name Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China
    131 rdf:type schema:Organization
    132 Nc94b1e6e5ed54eafad22ff70d201dbe6 schema:name Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China
    133 rdf:type schema:Organization
    134 Nc9b75d044110417ab501bd810f547042 schema:name pubmed_id
    135 schema:value 30459351
    136 rdf:type schema:PropertyValue
    137 Nca7e5c46323e4a78bc78c79a3d31061d rdf:first Nb691fc8801134e339499700ad837d27a
    138 rdf:rest Ndc42fb93f4b24429a94943e65a38c512
    139 Nce98462d62c14f90b7df65aca831a895 schema:name Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China
    140 rdf:type schema:Organization
    141 Nd625893400974b5b85f60c190449ce0f schema:affiliation Nc94b1e6e5ed54eafad22ff70d201dbe6
    142 schema:familyName Yi
    143 schema:givenName Hong-Mei
    144 rdf:type schema:Person
    145 Ndc42fb93f4b24429a94943e65a38c512 rdf:first sg:person.0731200572.29
    146 rdf:rest N1bc80bf5d17146b79f6bf7d8e5431bd3
    147 Ne13d0203252142a682bea3117bcae0ac schema:name Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China
    148 rdf:type schema:Organization
    149 Nef4654fec88445d8ac240d4a1a6df8eb schema:name doi
    150 schema:value 10.1038/s41419-018-1204-7
    151 rdf:type schema:PropertyValue
    152 Nf0e036c4805949ffa82b430f382e8bfa rdf:first sg:person.0647060602.60
    153 rdf:rest Nca7e5c46323e4a78bc78c79a3d31061d
    154 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    155 schema:name Biological Sciences
    156 rdf:type schema:DefinedTerm
    157 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    158 schema:name Biochemistry and Cell Biology
    159 rdf:type schema:DefinedTerm
    160 sg:journal.1042939 schema:issn 2041-4889
    161 schema:name Cell Death & Disease
    162 rdf:type schema:Periodical
    163 sg:person.01005410161.01 schema:affiliation https://www.grid.ac/institutes/grid.13394.3c
    164 schema:familyName Zhu
    165 schema:givenName Jin-Feng
    166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005410161.01
    167 rdf:type schema:Person
    168 sg:person.01161655572.57 schema:affiliation Nce98462d62c14f90b7df65aca831a895
    169 schema:familyName Xiao
    170 schema:givenName Zhi-Qiang
    171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161655572.57
    172 rdf:type schema:Person
    173 sg:person.01167121070.60 schema:affiliation N4e3414e0479c4234a1a7bf59697345cc
    174 schema:familyName Huang
    175 schema:givenName Wei
    176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167121070.60
    177 rdf:type schema:Person
    178 sg:person.01236065161.69 schema:affiliation Nc29735c5894340769979d67c519ac798
    179 schema:familyName Feng
    180 schema:givenName Juan
    181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236065161.69
    182 rdf:type schema:Person
    183 sg:person.01264705561.71 schema:affiliation N6847d8d0af3645e98d5df7c279bd511d
    184 schema:familyName Li
    185 schema:givenName Jiao-Yang
    186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264705561.71
    187 rdf:type schema:Person
    188 sg:person.01304200361.39 schema:affiliation N7518cb6aa7a14b3193e81cbac6046dc5
    189 schema:familyName Lu
    190 schema:givenName Shan-Shan
    191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304200361.39
    192 rdf:type schema:Person
    193 sg:person.0623046361.31 schema:affiliation https://www.grid.ac/institutes/grid.477246.4
    194 schema:familyName Xiao
    195 schema:givenName Ta
    196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623046361.31
    197 rdf:type schema:Person
    198 sg:person.0647060602.60 schema:affiliation N401a5b924b9f492189c31f7420d45f84
    199 schema:familyName Li
    200 schema:givenName Xin-Hui
    201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647060602.60
    202 rdf:type schema:Person
    203 sg:person.0731200572.29 schema:affiliation N210cb51cf19248508ef3c23dd71bb85c
    204 schema:familyName He
    205 schema:givenName Qiu-Yan
    206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731200572.29
    207 rdf:type schema:Person
    208 sg:pub.10.1007/s10585-008-9178-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1044271150
    209 https://doi.org/10.1007/s10585-008-9178-y
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1007/s10585-014-9665-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028496312
    212 https://doi.org/10.1007/s10585-014-9665-2
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1038/cddis.2013.380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005874361
    215 https://doi.org/10.1038/cddis.2013.380
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1038/cddis.2015.249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024031512
    218 https://doi.org/10.1038/cddis.2015.249
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1038/cddis.2016.415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017539003
    221 https://doi.org/10.1038/cddis.2016.415
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1038/cddis.2017.211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085729320
    224 https://doi.org/10.1038/cddis.2017.211
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1038/nature06639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025718085
    227 https://doi.org/10.1038/nature06639
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1038/ng.3006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023238440
    230 https://doi.org/10.1038/ng.3006
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/onc.2008.256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018867661
    233 https://doi.org/10.1038/onc.2008.256
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1038/onc.2011.28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019674334
    236 https://doi.org/10.1038/onc.2011.28
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1038/onc.2016.333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016852310
    239 https://doi.org/10.1038/onc.2016.333
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1186/1471-2407-14-961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043605288
    242 https://doi.org/10.1186/1471-2407-14-961
    243 rdf:type schema:CreativeWork
    244 https://app.dimensions.ai/details/publication/pub.1083105210 schema:CreativeWork
    245 https://doi.org/10.1016/0360-3016(92)90740-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046372717
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1016/j.bbrc.2011.03.067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004144610
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1016/j.biocel.2013.06.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011597788
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1016/j.ceb.2009.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028544009
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1016/j.cell.2009.11.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017006433
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1016/j.molcel.2013.12.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027948350
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1016/s0959-8049(11)70179-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028233425
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1016/s1535-6108(04)00119-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037144537
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1038/sj.emboj.7600759 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011375545
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1073/pnas.0913360107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013100355
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1073/pnas.86.9.3428 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035959126
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1080/15548627.2018.1450020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104382282
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1093/emboj/19.21.5720 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049092516
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1096/fj.06-7464rev schema:sameAs https://app.dimensions.ai/details/publication/pub.1005983697
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1096/fj.09-154096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024708852
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1155/2005/108490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045863143
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1158/0008-5472.can-11-3832 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011164602
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1158/1078-0432.ccr-06-0483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022651658
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1158/1078-0432.ccr-15-2996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063225279
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1172/jci33700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063417073
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1247/csf.23.33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037831603
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.18632/oncotarget.3847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027337218
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.18632/oncotarget.4725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027693032
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.18632/oncotarget.5674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037645367
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.18632/oncotarget.9067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018759292
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.3892/mmr.2014.2656 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071522058
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.4161/15384101.2014.987619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072288262
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.4161/auto.26398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072289861
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.4161/auto.29961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072290093
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.4161/auto.3424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072290121
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.4161/auto.6.3.11303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072290671
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.4161/auto.7.2.14074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072290977
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.4161/cib.20076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011178890
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.5301/jbm.5000046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072752816
    312 rdf:type schema:CreativeWork
    313 https://www.grid.ac/institutes/grid.13394.3c schema:alternateName Xinjiang Medical University
    314 schema:name Department of Gastrointestinal Surgery, The Affiliated Cancer Hospital of Xinjiang Medical University, 830011, Urumqi, Xinjiang, China
    315 Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China
    316 rdf:type schema:Organization
    317 https://www.grid.ac/institutes/grid.477246.4 schema:alternateName Chinese Academy of Medical Sciences Dermatology Hospital
    318 schema:name Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 210042, Nanjing, Jiangsu, China
    319 Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China
    320 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...