Screening for long noncoding RNAs associated with oral squamous cell carcinoma reveals the potentially oncogenic actions of DLEU1 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-08-01

AUTHORS

Koyo Nishiyama, Reo Maruyama, Takeshi Niinuma, Masahiro Kai, Hiroshi Kitajima, Mutsumi Toyota, Yui Hatanaka, Tomohiro Igarashi, Jun-ichi Kobayashi, Kazuhiro Ogi, Hironari Dehari, Akihiro Miyazaki, Akira Yorozu, Eiichiro Yamamoto, Masashi Idogawa, Yasushi Sasaki, Tamotsu Sugai, Takashi Tokino, Hiroyoshi Hiratsuka, Hiromu Suzuki

ABSTRACT

Recent studies have shown that long noncoding RNAs (lncRNAs) have pivotal roles in human malignancies, although their significance in oral squamous cell carcinoma (OSCC) is not fully understood. In the present study, we identified lncRNAs functionally associated with OSCC. By analyzing RNA-seq datasets obtained from primary head and neck squamous cell carcinoma (HNSCC), we identified 15 lncRNAs aberrantly expressed in cancer tissues. We then validated their expression in 18 OSCC cell lines using qRT-PCR and identified 6 lncRNAs frequently overexpressed in OSCC. Among those, we found that knocking down DLEU1 (deleted in lymphocytic leukemia 1) strongly suppressed OSCC cell proliferation. DLEU1 knockdown also suppressed migration, invasion, and xenograft formation by OSCC cells, which is suggestive of its oncogenic functionality. Microarray analysis revealed that DLEU1 knockdown significantly affects expression of a number of cancer-related genes in OSCC cells, including HAS3, CD44, and TP63, suggesting that DLEU1 regulates HA-CD44 signaling. Expression of DLEU1 was elevated in 71% of primary OSCC tissues, and high DLEU1 expression was associated with shorter overall survival of HNSCC patients. These data suggest that elevated DLEU1 expression contributes to OSCC development, and that DLEU1 may be a useful therapeutic target in OSCC. More... »

PAGES

826

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41419-018-0893-2

DOI

http://dx.doi.org/10.1038/s41419-018-0893-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105940437

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30069008


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Squamous Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kaplan-Meier Estimate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Nude", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mouth Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA Interference", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Long Noncoding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Small Interfering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Oral Surgery, Sapporo Medical University School of Medicine, S1, W16, 060-8543, Chuo-ku, Sapporo, Japan", 
            "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishiyama", 
        "givenName": "Koyo", 
        "id": "sg:person.010567305302.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010567305302.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Project for Cancer Epigenomics, Cancer Institute, Japanese Foundation for Cancer Research, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410807.a", 
          "name": [
            "Project for Cancer Epigenomics, Cancer Institute, Japanese Foundation for Cancer Research, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maruyama", 
        "givenName": "Reo", 
        "id": "sg:person.0774207002.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774207002.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Niinuma", 
        "givenName": "Takeshi", 
        "id": "sg:person.0765245215.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765245215.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kai", 
        "givenName": "Masahiro", 
        "id": "sg:person.0747516413.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747516413.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kitajima", 
        "givenName": "Hiroshi", 
        "id": "sg:person.01025415023.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025415023.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Toyota", 
        "givenName": "Mutsumi", 
        "id": "sg:person.010336230435.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010336230435.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Oral Surgery, Sapporo Medical University School of Medicine, S1, W16, 060-8543, Chuo-ku, Sapporo, Japan", 
            "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hatanaka", 
        "givenName": "Yui", 
        "id": "sg:person.016164640770.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016164640770.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oral Surgery, Sapporo Medical University School of Medicine, S1, W16, 060-8543, Chuo-ku, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Oral Surgery, Sapporo Medical University School of Medicine, S1, W16, 060-8543, Chuo-ku, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Igarashi", 
        "givenName": "Tomohiro", 
        "id": "sg:person.01107207063.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107207063.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oral Surgery, Sapporo Medical University School of Medicine, S1, W16, 060-8543, Chuo-ku, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Oral Surgery, Sapporo Medical University School of Medicine, S1, W16, 060-8543, Chuo-ku, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kobayashi", 
        "givenName": "Jun-ichi", 
        "id": "sg:person.0673122305.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673122305.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oral Surgery, Sapporo Medical University School of Medicine, S1, W16, 060-8543, Chuo-ku, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Oral Surgery, Sapporo Medical University School of Medicine, S1, W16, 060-8543, Chuo-ku, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ogi", 
        "givenName": "Kazuhiro", 
        "id": "sg:person.01371470771.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371470771.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oral Surgery, Sapporo Medical University School of Medicine, S1, W16, 060-8543, Chuo-ku, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Oral Surgery, Sapporo Medical University School of Medicine, S1, W16, 060-8543, Chuo-ku, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dehari", 
        "givenName": "Hironari", 
        "id": "sg:person.01365772160.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365772160.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oral Surgery, Sapporo Medical University School of Medicine, S1, W16, 060-8543, Chuo-ku, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Oral Surgery, Sapporo Medical University School of Medicine, S1, W16, 060-8543, Chuo-ku, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyazaki", 
        "givenName": "Akihiro", 
        "id": "sg:person.01317656760.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317656760.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yorozu", 
        "givenName": "Akira", 
        "id": "sg:person.012451140051.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012451140051.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamamoto", 
        "givenName": "Eiichiro", 
        "id": "sg:person.01064102140.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064102140.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Genome Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Medical Genome Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Idogawa", 
        "givenName": "Masashi", 
        "id": "sg:person.0770307061.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770307061.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Genome Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Medical Genome Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sasaki", 
        "givenName": "Yasushi", 
        "id": "sg:person.013060476532.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013060476532.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Diagnostic Pathology, School of Medicine, Iwate Medical University, Morioka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411790.a", 
          "name": [
            "Department of Molecular Diagnostic Pathology, School of Medicine, Iwate Medical University, Morioka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sugai", 
        "givenName": "Tamotsu", 
        "id": "sg:person.01372162736.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372162736.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Genome Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Medical Genome Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tokino", 
        "givenName": "Takashi", 
        "id": "sg:person.01272777202.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272777202.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oral Surgery, Sapporo Medical University School of Medicine, S1, W16, 060-8543, Chuo-ku, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Oral Surgery, Sapporo Medical University School of Medicine, S1, W16, 060-8543, Chuo-ku, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hiratsuka", 
        "givenName": "Hiroyoshi", 
        "id": "sg:person.01073043060.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073043060.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263171.0", 
          "name": [
            "Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suzuki", 
        "givenName": "Hiromu", 
        "id": "sg:person.014315602124.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014315602124.12"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature08975", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017276958", 
          "https://doi.org/10.1038/nature08975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm3679", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037346264", 
          "https://doi.org/10.1038/nrm3679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2402551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037392906", 
          "https://doi.org/10.1038/sj.leu.2402551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003047559", 
          "https://doi.org/10.1038/nature11233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023030962", 
          "https://doi.org/10.1038/nrc1391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms13616", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049727598", 
          "https://doi.org/10.1038/ncomms13616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001074134", 
          "https://doi.org/10.1038/sj.onc.1201643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-014-3012-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043385509", 
          "https://doi.org/10.1007/s10549-014-3012-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004110360", 
          "https://doi.org/10.1038/sj.bjc.6601124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2012.244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028358194", 
          "https://doi.org/10.1038/bmt.2012.244"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-08-01", 
    "datePublishedReg": "2018-08-01", 
    "description": "Recent studies have shown that long noncoding RNAs (lncRNAs) have pivotal roles in human malignancies, although their significance in oral squamous cell carcinoma (OSCC) is not fully understood. In the present study, we identified lncRNAs functionally associated with OSCC. By analyzing RNA-seq datasets obtained from primary head and neck squamous cell carcinoma (HNSCC), we identified 15 lncRNAs aberrantly expressed in cancer tissues. We then validated their expression in 18 OSCC cell lines using qRT-PCR and identified 6 lncRNAs frequently overexpressed in OSCC. Among those, we found that knocking down DLEU1 (deleted in lymphocytic leukemia 1) strongly suppressed OSCC cell proliferation. DLEU1 knockdown also suppressed migration, invasion, and xenograft formation by OSCC cells, which is suggestive of its oncogenic functionality. Microarray analysis revealed that DLEU1 knockdown significantly affects expression of a number of cancer-related genes in OSCC cells, including HAS3, CD44, and TP63, suggesting that DLEU1 regulates HA-CD44 signaling. Expression of DLEU1 was elevated in 71% of primary OSCC tissues, and high DLEU1 expression was associated with shorter overall survival of HNSCC patients. These data suggest that elevated DLEU1 expression contributes to OSCC development, and that DLEU1 may be a useful therapeutic target in OSCC.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41419-018-0893-2", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5914246", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5924165", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6534209", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5866127", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7534779", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7544004", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6834244", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6834866", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5912178", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5882866", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7542050", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1042939", 
        "issn": [
          "2041-4889"
        ], 
        "name": "Cell Death & Disease", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "keywords": [
      "oral squamous cell carcinoma", 
      "squamous cell carcinoma", 
      "cell carcinoma", 
      "OSCC cells", 
      "DLEU1 expression", 
      "neck squamous cell carcinoma", 
      "DLEU1 knockdown", 
      "HA-CD44 signaling", 
      "expression of DLEU1", 
      "shorter overall survival", 
      "OSCC cell lines", 
      "OSCC cell proliferation", 
      "useful therapeutic target", 
      "primary OSCC tissues", 
      "overall survival", 
      "HNSCC patients", 
      "OSCC tissues", 
      "primary head", 
      "cancer-related genes", 
      "therapeutic target", 
      "cancer tissues", 
      "xenograft formation", 
      "human malignancies", 
      "carcinoma", 
      "oncogenic action", 
      "qRT-PCR", 
      "cell proliferation", 
      "oncogenic functionality", 
      "cell lines", 
      "microarray analysis", 
      "DLEU1", 
      "present study", 
      "pivotal role", 
      "lncRNAs", 
      "Recent studies", 
      "expression", 
      "knockdown", 
      "tissue", 
      "cells", 
      "patients", 
      "malignancy", 
      "CD44", 
      "RNA", 
      "survival", 
      "RNA-seq datasets", 
      "invasion", 
      "proliferation", 
      "TP63", 
      "study", 
      "HAS3", 
      "signaling", 
      "head", 
      "target", 
      "significance", 
      "genes", 
      "role", 
      "action", 
      "migration", 
      "data", 
      "development", 
      "lines", 
      "number", 
      "analysis", 
      "formation", 
      "functionality", 
      "dataset"
    ], 
    "name": "Screening for long noncoding RNAs associated with oral squamous cell carcinoma reveals the potentially oncogenic actions of DLEU1", 
    "pagination": "826", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1105940437"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41419-018-0893-2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30069008"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41419-018-0893-2", 
      "https://app.dimensions.ai/details/publication/pub.1105940437"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T21:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_785.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41419-018-0893-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0893-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0893-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0893-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0893-2'


 

This table displays all metadata directly associated to this object as RDF triples.

395 TRIPLES      21 PREDICATES      117 URIs      99 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41419-018-0893-2 schema:about N067ca57540ae40708e471a8ac27ae468
2 N10223543df99499ea5d65cb0a4d68029
3 N29352757a3324487a0b6bf22f2a305b3
4 N40a5ecb5557f4e2cba61d7158d1832e1
5 N45430ef02b4e4a2e8483300511dde22e
6 N50fa7653f4f844308b84e58d7ce35641
7 N702291bc865444e9b36985de6367d73e
8 N74788301296940d592f9f340482f0165
9 N79cddcbde1df44fba038c5388993f4c9
10 N7c51973df2194a49a1976cd2a3e521e8
11 N7cc3f414417f4b9099b90c3f85036e48
12 N7d469c0162984af7a802ee6e8c587504
13 N803ed268f435440bb07a6467d3b95f1f
14 Nc62a6d8a6880460b8506d72134d7c849
15 Ne1ef4d2640da4b09b07da8f42c63ff0c
16 Nffbe74a9e2624af5bcc6bf7dff8edce4
17 anzsrc-for:11
18 anzsrc-for:1112
19 schema:author N200c1aaa4cd246ba8592d401d3af1ca8
20 schema:citation sg:pub.10.1007/s10549-014-3012-9
21 sg:pub.10.1038/bmt.2012.244
22 sg:pub.10.1038/nature08975
23 sg:pub.10.1038/nature11233
24 sg:pub.10.1038/ncomms13616
25 sg:pub.10.1038/nrc1391
26 sg:pub.10.1038/nrm3679
27 sg:pub.10.1038/sj.bjc.6601124
28 sg:pub.10.1038/sj.leu.2402551
29 sg:pub.10.1038/sj.onc.1201643
30 schema:datePublished 2018-08-01
31 schema:datePublishedReg 2018-08-01
32 schema:description Recent studies have shown that long noncoding RNAs (lncRNAs) have pivotal roles in human malignancies, although their significance in oral squamous cell carcinoma (OSCC) is not fully understood. In the present study, we identified lncRNAs functionally associated with OSCC. By analyzing RNA-seq datasets obtained from primary head and neck squamous cell carcinoma (HNSCC), we identified 15 lncRNAs aberrantly expressed in cancer tissues. We then validated their expression in 18 OSCC cell lines using qRT-PCR and identified 6 lncRNAs frequently overexpressed in OSCC. Among those, we found that knocking down DLEU1 (deleted in lymphocytic leukemia 1) strongly suppressed OSCC cell proliferation. DLEU1 knockdown also suppressed migration, invasion, and xenograft formation by OSCC cells, which is suggestive of its oncogenic functionality. Microarray analysis revealed that DLEU1 knockdown significantly affects expression of a number of cancer-related genes in OSCC cells, including HAS3, CD44, and TP63, suggesting that DLEU1 regulates HA-CD44 signaling. Expression of DLEU1 was elevated in 71% of primary OSCC tissues, and high DLEU1 expression was associated with shorter overall survival of HNSCC patients. These data suggest that elevated DLEU1 expression contributes to OSCC development, and that DLEU1 may be a useful therapeutic target in OSCC.
33 schema:genre article
34 schema:isAccessibleForFree true
35 schema:isPartOf N5951f07a565448b6b166fb377b55b1e2
36 Nc0aa10d902c84a61b420c0ad5bce21bf
37 sg:journal.1042939
38 schema:keywords CD44
39 DLEU1
40 DLEU1 expression
41 DLEU1 knockdown
42 HA-CD44 signaling
43 HAS3
44 HNSCC patients
45 OSCC cell lines
46 OSCC cell proliferation
47 OSCC cells
48 OSCC tissues
49 RNA
50 RNA-seq datasets
51 Recent studies
52 TP63
53 action
54 analysis
55 cancer tissues
56 cancer-related genes
57 carcinoma
58 cell carcinoma
59 cell lines
60 cell proliferation
61 cells
62 data
63 dataset
64 development
65 expression
66 expression of DLEU1
67 formation
68 functionality
69 genes
70 head
71 human malignancies
72 invasion
73 knockdown
74 lines
75 lncRNAs
76 malignancy
77 microarray analysis
78 migration
79 neck squamous cell carcinoma
80 number
81 oncogenic action
82 oncogenic functionality
83 oral squamous cell carcinoma
84 overall survival
85 patients
86 pivotal role
87 present study
88 primary OSCC tissues
89 primary head
90 proliferation
91 qRT-PCR
92 role
93 shorter overall survival
94 signaling
95 significance
96 squamous cell carcinoma
97 study
98 survival
99 target
100 therapeutic target
101 tissue
102 useful therapeutic target
103 xenograft formation
104 schema:name Screening for long noncoding RNAs associated with oral squamous cell carcinoma reveals the potentially oncogenic actions of DLEU1
105 schema:pagination 826
106 schema:productId N5a397a55cfd5410c8f83aa4acbe9909f
107 Na7af003b03a34fe6bb8c01936a605912
108 Nb5d82c53c0d94ce38939ed41733c0a60
109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105940437
110 https://doi.org/10.1038/s41419-018-0893-2
111 schema:sdDatePublished 2022-11-24T21:03
112 schema:sdLicense https://scigraph.springernature.com/explorer/license/
113 schema:sdPublisher Ndf2d848012954669b7fc6369e8a4e9ac
114 schema:url https://doi.org/10.1038/s41419-018-0893-2
115 sgo:license sg:explorer/license/
116 sgo:sdDataset articles
117 rdf:type schema:ScholarlyArticle
118 N067ca57540ae40708e471a8ac27ae468 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Cell Movement
120 rdf:type schema:DefinedTerm
121 N10223543df99499ea5d65cb0a4d68029 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name RNA Interference
123 rdf:type schema:DefinedTerm
124 N12450d9948f641cc94c9b9b6e4ee90d4 rdf:first sg:person.01107207063.29
125 rdf:rest N8a8c20a29f334051a823c54ce06fd407
126 N200c1aaa4cd246ba8592d401d3af1ca8 rdf:first sg:person.010567305302.71
127 rdf:rest N71b637f6e1444d0da9cc2a2ea64f7113
128 N20afc91f4c484c77ac7b720da535b1b4 rdf:first sg:person.0770307061.79
129 rdf:rest N64083e9c16954dc591bb6923cbd86f60
130 N29352757a3324487a0b6bf22f2a305b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Carcinoma, Squamous Cell
132 rdf:type schema:DefinedTerm
133 N29f08429a8074bc18375e225adc6cf09 rdf:first sg:person.016164640770.95
134 rdf:rest N12450d9948f641cc94c9b9b6e4ee90d4
135 N3318c2e46a39490ab264e776e408ed7d rdf:first sg:person.012451140051.65
136 rdf:rest N9268819fe451406dad555b28327a2a3b
137 N40a5ecb5557f4e2cba61d7158d1832e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name RNA, Small Interfering
139 rdf:type schema:DefinedTerm
140 N4481baf7b6c54637b8539c52261d826d rdf:first sg:person.01025415023.42
141 rdf:rest Nfd9ae10beec94b55b22ca8214d36c83d
142 N45430ef02b4e4a2e8483300511dde22e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Tumor Suppressor Proteins
144 rdf:type schema:DefinedTerm
145 N50fa7653f4f844308b84e58d7ce35641 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Cell Proliferation
147 rdf:type schema:DefinedTerm
148 N5446da4d07294577b638086a27a6458f rdf:first sg:person.01073043060.92
149 rdf:rest Nfd3adafff7bc4493a6d4800f23fcf5df
150 N5951f07a565448b6b166fb377b55b1e2 schema:volumeNumber 9
151 rdf:type schema:PublicationVolume
152 N5a397a55cfd5410c8f83aa4acbe9909f schema:name dimensions_id
153 schema:value pub.1105940437
154 rdf:type schema:PropertyValue
155 N64083e9c16954dc591bb6923cbd86f60 rdf:first sg:person.013060476532.17
156 rdf:rest N7c0e87b45e1541c1aeda793a08e75b80
157 N702291bc865444e9b36985de6367d73e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Female
159 rdf:type schema:DefinedTerm
160 N71b637f6e1444d0da9cc2a2ea64f7113 rdf:first sg:person.0774207002.15
161 rdf:rest N7ca4cf950ce647f39f24d08e6cb3555f
162 N74788301296940d592f9f340482f0165 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Gene Expression Regulation, Neoplastic
164 rdf:type schema:DefinedTerm
165 N79cddcbde1df44fba038c5388993f4c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Animals
167 rdf:type schema:DefinedTerm
168 N7c0e87b45e1541c1aeda793a08e75b80 rdf:first sg:person.01372162736.43
169 rdf:rest Nbe75ae475fba487a9d00cc1d95475dc8
170 N7c51973df2194a49a1976cd2a3e521e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Cell Line, Tumor
172 rdf:type schema:DefinedTerm
173 N7ca4cf950ce647f39f24d08e6cb3555f rdf:first sg:person.0765245215.48
174 rdf:rest N951d8e887a064f8886266af6f79bc2ba
175 N7cc3f414417f4b9099b90c3f85036e48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Mice
177 rdf:type schema:DefinedTerm
178 N7d469c0162984af7a802ee6e8c587504 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name RNA, Long Noncoding
180 rdf:type schema:DefinedTerm
181 N7e1d2dd48cff45438f91952c720e6b51 rdf:first sg:person.01371470771.31
182 rdf:rest N8f45ed37879045908f82c49eedd4d7b9
183 N803ed268f435440bb07a6467d3b95f1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Mice, Nude
185 rdf:type schema:DefinedTerm
186 N8a8c20a29f334051a823c54ce06fd407 rdf:first sg:person.0673122305.58
187 rdf:rest N7e1d2dd48cff45438f91952c720e6b51
188 N8f45ed37879045908f82c49eedd4d7b9 rdf:first sg:person.01365772160.10
189 rdf:rest Ne0813099b452417a9a8a6e41897119e6
190 N9268819fe451406dad555b28327a2a3b rdf:first sg:person.01064102140.08
191 rdf:rest N20afc91f4c484c77ac7b720da535b1b4
192 N951d8e887a064f8886266af6f79bc2ba rdf:first sg:person.0747516413.06
193 rdf:rest N4481baf7b6c54637b8539c52261d826d
194 Na7af003b03a34fe6bb8c01936a605912 schema:name pubmed_id
195 schema:value 30069008
196 rdf:type schema:PropertyValue
197 Nb5d82c53c0d94ce38939ed41733c0a60 schema:name doi
198 schema:value 10.1038/s41419-018-0893-2
199 rdf:type schema:PropertyValue
200 Nbe75ae475fba487a9d00cc1d95475dc8 rdf:first sg:person.01272777202.67
201 rdf:rest N5446da4d07294577b638086a27a6458f
202 Nc0aa10d902c84a61b420c0ad5bce21bf schema:issueNumber 8
203 rdf:type schema:PublicationIssue
204 Nc62a6d8a6880460b8506d72134d7c849 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Mouth Neoplasms
206 rdf:type schema:DefinedTerm
207 Ndf2d848012954669b7fc6369e8a4e9ac schema:name Springer Nature - SN SciGraph project
208 rdf:type schema:Organization
209 Ne0813099b452417a9a8a6e41897119e6 rdf:first sg:person.01317656760.00
210 rdf:rest N3318c2e46a39490ab264e776e408ed7d
211 Ne1ef4d2640da4b09b07da8f42c63ff0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Kaplan-Meier Estimate
213 rdf:type schema:DefinedTerm
214 Nfd3adafff7bc4493a6d4800f23fcf5df rdf:first sg:person.014315602124.12
215 rdf:rest rdf:nil
216 Nfd9ae10beec94b55b22ca8214d36c83d rdf:first sg:person.010336230435.31
217 rdf:rest N29f08429a8074bc18375e225adc6cf09
218 Nffbe74a9e2624af5bcc6bf7dff8edce4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Humans
220 rdf:type schema:DefinedTerm
221 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
222 schema:name Medical and Health Sciences
223 rdf:type schema:DefinedTerm
224 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
225 schema:name Oncology and Carcinogenesis
226 rdf:type schema:DefinedTerm
227 sg:grant.5866127 http://pending.schema.org/fundedItem sg:pub.10.1038/s41419-018-0893-2
228 rdf:type schema:MonetaryGrant
229 sg:grant.5882866 http://pending.schema.org/fundedItem sg:pub.10.1038/s41419-018-0893-2
230 rdf:type schema:MonetaryGrant
231 sg:grant.5912178 http://pending.schema.org/fundedItem sg:pub.10.1038/s41419-018-0893-2
232 rdf:type schema:MonetaryGrant
233 sg:grant.5914246 http://pending.schema.org/fundedItem sg:pub.10.1038/s41419-018-0893-2
234 rdf:type schema:MonetaryGrant
235 sg:grant.5924165 http://pending.schema.org/fundedItem sg:pub.10.1038/s41419-018-0893-2
236 rdf:type schema:MonetaryGrant
237 sg:grant.6534209 http://pending.schema.org/fundedItem sg:pub.10.1038/s41419-018-0893-2
238 rdf:type schema:MonetaryGrant
239 sg:grant.6834244 http://pending.schema.org/fundedItem sg:pub.10.1038/s41419-018-0893-2
240 rdf:type schema:MonetaryGrant
241 sg:grant.6834866 http://pending.schema.org/fundedItem sg:pub.10.1038/s41419-018-0893-2
242 rdf:type schema:MonetaryGrant
243 sg:grant.7534779 http://pending.schema.org/fundedItem sg:pub.10.1038/s41419-018-0893-2
244 rdf:type schema:MonetaryGrant
245 sg:grant.7542050 http://pending.schema.org/fundedItem sg:pub.10.1038/s41419-018-0893-2
246 rdf:type schema:MonetaryGrant
247 sg:grant.7544004 http://pending.schema.org/fundedItem sg:pub.10.1038/s41419-018-0893-2
248 rdf:type schema:MonetaryGrant
249 sg:journal.1042939 schema:issn 2041-4889
250 schema:name Cell Death & Disease
251 schema:publisher Springer Nature
252 rdf:type schema:Periodical
253 sg:person.01025415023.42 schema:affiliation grid-institutes:grid.263171.0
254 schema:familyName Kitajima
255 schema:givenName Hiroshi
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025415023.42
257 rdf:type schema:Person
258 sg:person.010336230435.31 schema:affiliation grid-institutes:grid.263171.0
259 schema:familyName Toyota
260 schema:givenName Mutsumi
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010336230435.31
262 rdf:type schema:Person
263 sg:person.010567305302.71 schema:affiliation grid-institutes:grid.263171.0
264 schema:familyName Nishiyama
265 schema:givenName Koyo
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010567305302.71
267 rdf:type schema:Person
268 sg:person.01064102140.08 schema:affiliation grid-institutes:grid.263171.0
269 schema:familyName Yamamoto
270 schema:givenName Eiichiro
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064102140.08
272 rdf:type schema:Person
273 sg:person.01073043060.92 schema:affiliation grid-institutes:grid.263171.0
274 schema:familyName Hiratsuka
275 schema:givenName Hiroyoshi
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073043060.92
277 rdf:type schema:Person
278 sg:person.01107207063.29 schema:affiliation grid-institutes:grid.263171.0
279 schema:familyName Igarashi
280 schema:givenName Tomohiro
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107207063.29
282 rdf:type schema:Person
283 sg:person.012451140051.65 schema:affiliation grid-institutes:grid.263171.0
284 schema:familyName Yorozu
285 schema:givenName Akira
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012451140051.65
287 rdf:type schema:Person
288 sg:person.01272777202.67 schema:affiliation grid-institutes:grid.263171.0
289 schema:familyName Tokino
290 schema:givenName Takashi
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272777202.67
292 rdf:type schema:Person
293 sg:person.013060476532.17 schema:affiliation grid-institutes:grid.263171.0
294 schema:familyName Sasaki
295 schema:givenName Yasushi
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013060476532.17
297 rdf:type schema:Person
298 sg:person.01317656760.00 schema:affiliation grid-institutes:grid.263171.0
299 schema:familyName Miyazaki
300 schema:givenName Akihiro
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317656760.00
302 rdf:type schema:Person
303 sg:person.01365772160.10 schema:affiliation grid-institutes:grid.263171.0
304 schema:familyName Dehari
305 schema:givenName Hironari
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365772160.10
307 rdf:type schema:Person
308 sg:person.01371470771.31 schema:affiliation grid-institutes:grid.263171.0
309 schema:familyName Ogi
310 schema:givenName Kazuhiro
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371470771.31
312 rdf:type schema:Person
313 sg:person.01372162736.43 schema:affiliation grid-institutes:grid.411790.a
314 schema:familyName Sugai
315 schema:givenName Tamotsu
316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372162736.43
317 rdf:type schema:Person
318 sg:person.014315602124.12 schema:affiliation grid-institutes:grid.263171.0
319 schema:familyName Suzuki
320 schema:givenName Hiromu
321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014315602124.12
322 rdf:type schema:Person
323 sg:person.016164640770.95 schema:affiliation grid-institutes:grid.263171.0
324 schema:familyName Hatanaka
325 schema:givenName Yui
326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016164640770.95
327 rdf:type schema:Person
328 sg:person.0673122305.58 schema:affiliation grid-institutes:grid.263171.0
329 schema:familyName Kobayashi
330 schema:givenName Jun-ichi
331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673122305.58
332 rdf:type schema:Person
333 sg:person.0747516413.06 schema:affiliation grid-institutes:grid.263171.0
334 schema:familyName Kai
335 schema:givenName Masahiro
336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747516413.06
337 rdf:type schema:Person
338 sg:person.0765245215.48 schema:affiliation grid-institutes:grid.263171.0
339 schema:familyName Niinuma
340 schema:givenName Takeshi
341 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765245215.48
342 rdf:type schema:Person
343 sg:person.0770307061.79 schema:affiliation grid-institutes:grid.263171.0
344 schema:familyName Idogawa
345 schema:givenName Masashi
346 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770307061.79
347 rdf:type schema:Person
348 sg:person.0774207002.15 schema:affiliation grid-institutes:grid.410807.a
349 schema:familyName Maruyama
350 schema:givenName Reo
351 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774207002.15
352 rdf:type schema:Person
353 sg:pub.10.1007/s10549-014-3012-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043385509
354 https://doi.org/10.1007/s10549-014-3012-9
355 rdf:type schema:CreativeWork
356 sg:pub.10.1038/bmt.2012.244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028358194
357 https://doi.org/10.1038/bmt.2012.244
358 rdf:type schema:CreativeWork
359 sg:pub.10.1038/nature08975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017276958
360 https://doi.org/10.1038/nature08975
361 rdf:type schema:CreativeWork
362 sg:pub.10.1038/nature11233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003047559
363 https://doi.org/10.1038/nature11233
364 rdf:type schema:CreativeWork
365 sg:pub.10.1038/ncomms13616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049727598
366 https://doi.org/10.1038/ncomms13616
367 rdf:type schema:CreativeWork
368 sg:pub.10.1038/nrc1391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023030962
369 https://doi.org/10.1038/nrc1391
370 rdf:type schema:CreativeWork
371 sg:pub.10.1038/nrm3679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037346264
372 https://doi.org/10.1038/nrm3679
373 rdf:type schema:CreativeWork
374 sg:pub.10.1038/sj.bjc.6601124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004110360
375 https://doi.org/10.1038/sj.bjc.6601124
376 rdf:type schema:CreativeWork
377 sg:pub.10.1038/sj.leu.2402551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037392906
378 https://doi.org/10.1038/sj.leu.2402551
379 rdf:type schema:CreativeWork
380 sg:pub.10.1038/sj.onc.1201643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001074134
381 https://doi.org/10.1038/sj.onc.1201643
382 rdf:type schema:CreativeWork
383 grid-institutes:grid.263171.0 schema:alternateName Department of Medical Genome Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan
384 Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan
385 Department of Oral Surgery, Sapporo Medical University School of Medicine, S1, W16, 060-8543, Chuo-ku, Sapporo, Japan
386 schema:name Department of Medical Genome Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan
387 Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, 060-8556, Chuo-ku, Sapporo, Japan
388 Department of Oral Surgery, Sapporo Medical University School of Medicine, S1, W16, 060-8543, Chuo-ku, Sapporo, Japan
389 rdf:type schema:Organization
390 grid-institutes:grid.410807.a schema:alternateName Project for Cancer Epigenomics, Cancer Institute, Japanese Foundation for Cancer Research, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan
391 schema:name Project for Cancer Epigenomics, Cancer Institute, Japanese Foundation for Cancer Research, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan
392 rdf:type schema:Organization
393 grid-institutes:grid.411790.a schema:alternateName Department of Molecular Diagnostic Pathology, School of Medicine, Iwate Medical University, Morioka, Japan
394 schema:name Department of Molecular Diagnostic Pathology, School of Medicine, Iwate Medical University, Morioka, Japan
395 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...