Inhibition of the miR-192/215–Rab11-FIP2 axis suppresses human gastric cancer progression View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-07

AUTHORS

Xiaojing Zhang, Yin Peng, Yong Huang, Shiqi Deng, Xianling Feng, Gangqiang Hou, Huijuan Lin, Jian Wang, Ruibin Yan, Yanqiu Zhao, Xinmin Fan, Stephen J. Meltzer, Song Li, Zhe Jin

ABSTRACT

Less than a century ago, gastric cancer (GC) was the most common cancer throughout the world. Despite advances in surgical, chemotherapeutic, and radiotherapeutic treatment, GC remains the number 3 cancer killer worldwide. This fact highlights the need for better diagnostic biomarkers and more effective therapeutic targets. RAB11-FIP2, a member of the Rab11 family of interacting proteins, exhibits potential tumor suppressor function. However, involvement of RAB11-FIP2 in gastric carcinogenesis is yet to be elucidated. In this study, we demonstrated that RAB11-FIP2 was downregulated in GC tissues and constituted a target of the known onco-miRs, miR-192/215. We also showed that functionally, Rab11-FIP2 regulation by miR-192/215 is involved in GC-related biological activities. Finally, RAB11-FIP2 inhibition by miR-192/215 affected the establishment of cell polarity and tight junction formation in GC cells. In summary, this miR-192/215-Rab11-FIP2 axis appears to represent a new molecular mechanism underlying GC progression, while supplying a promising avenue of further research into diagnosis and therapy of GC. More... »

PAGES

778

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41419-018-0785-5

DOI

http://dx.doi.org/10.1038/s41419-018-0785-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105571990

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30006518


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HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0785-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0785-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0785-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0785-5'


 

This table displays all metadata directly associated to this object as RDF triples.

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