Ontology type: schema:ScholarlyArticle Open Access: True
2018-07
AUTHORSNa-Hee Lee, Ara Cho, Se-Ra Park, Jin Woo Lee, Park Sung Taek, Chan Hum Park, Yoon-Hyeong Choi, Soyi Lim, Min-Kwan Baek, Dong Young Kim, Mirim Jin, Hwa-Yong Lee, In-Sun Hong
ABSTRACTThe toxicological evaluation of potential drug candidates is very important in the preclinical phase of drug development. Toxic materials may cause serious decline in stem cell function and loss of stemness. Indeed, we found that toxic exposure more profoundly suppressed the growth of stem cells than terminally differentiated fibroblasts. Importantly, toxic exposure suppressed stem cell migration and multi-lineage differentiation potential in vitro and in vivo. Moreover, early-response genes involved in stem cell properties such as self-renewal and differentiation capabilities can be used as specific markers to predict toxicity. In the present study, we also identified a labile toxic response gene, SERPINB2, which is significantly increased in response to various toxic agents in human stem cells in vitro and in vivo. Consistently, self-renewal, migration, and multi-lineage differentiation potential were markedly decreased following SERPINB2 overexpression. To the best of our knowledge, this is the first study to focus on the functions of SERPINB2 on the regenerative potential of stem cells in response to various existing chemicals, and the findings will facilitate the development of promising toxicity test platforms for newly developed chemicals. More... »
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DOIhttp://dx.doi.org/10.1038/s41419-018-0748-x
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N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0748-x'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0748-x'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0748-x'
This table displays all metadata directly associated to this object as RDF triples.
296 TRIPLES
21 PREDICATES
70 URIs
21 LITERALS
9 BLANK NODES