SERPINB2 is a novel indicator of stem cell toxicity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-07

AUTHORS

Na-Hee Lee, Ara Cho, Se-Ra Park, Jin Woo Lee, Park Sung Taek, Chan Hum Park, Yoon-Hyeong Choi, Soyi Lim, Min-Kwan Baek, Dong Young Kim, Mirim Jin, Hwa-Yong Lee, In-Sun Hong

ABSTRACT

The toxicological evaluation of potential drug candidates is very important in the preclinical phase of drug development. Toxic materials may cause serious decline in stem cell function and loss of stemness. Indeed, we found that toxic exposure more profoundly suppressed the growth of stem cells than terminally differentiated fibroblasts. Importantly, toxic exposure suppressed stem cell migration and multi-lineage differentiation potential in vitro and in vivo. Moreover, early-response genes involved in stem cell properties such as self-renewal and differentiation capabilities can be used as specific markers to predict toxicity. In the present study, we also identified a labile toxic response gene, SERPINB2, which is significantly increased in response to various toxic agents in human stem cells in vitro and in vivo. Consistently, self-renewal, migration, and multi-lineage differentiation potential were markedly decreased following SERPINB2 overexpression. To the best of our knowledge, this is the first study to focus on the functions of SERPINB2 on the regenerative potential of stem cells in response to various existing chemicals, and the findings will facilitate the development of promising toxicity test platforms for newly developed chemicals. More... »

PAGES

724

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41419-018-0748-x

DOI

http://dx.doi.org/10.1038/s41419-018-0748-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104988744

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29925837


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0748-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0748-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0748-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0748-x'


 

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288 schema:name Department of Obstetrics and Gynecology, Gachon University Gil Medical Center, Incheon, Republic of Korea
289 Department of Otolaryngology-Head and Neck Surgery, Gil Medical Center, Gachon University School of Medicine, Incheon, Republic of Korea
290 rdf:type schema:Organization
291 https://www.grid.ac/institutes/grid.440940.d schema:alternateName Jungwon University
292 schema:name Department of Biomedical Science, Jungwon University, 85 Goesan-eup,Munmu-ro, 367-700, Goesan-gun, Chungcheongbuk-do, Republic of Korea
293 rdf:type schema:Organization
294 https://www.grid.ac/institutes/grid.477505.4 schema:alternateName Hallym University Kangnam Sacred Heart Hospital
295 schema:name Department of Obstetrics and Gynecology, Hallym University Kangnam Sacred Heart Hospital, Seoul, Republic of Korea
296 rdf:type schema:Organization
 




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