Ontology type: schema:ScholarlyArticle Open Access: True
2018-06
AUTHORSAlessandra Romagnoli, Elisa Petruccioli, Ivana Palucci, Serena Camassa, Elisabetta Carata, Linda Petrone, Stefania Mariano, Michela Sali, Luciana Dini, Enrico Girardi, Giovanni Delogu, Delia Goletti, Gian Maria Fimia
ABSTRACTMycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), has infected over 1.7 billion people worldwide and causes 1.4 million deaths annually. Recently, genome sequence analysis has allowed the reconstruction of Mycobacterium tuberculosis complex (MTBC) evolution, with the identification of seven phylogeographic lineages: four referred to as evolutionarily "ancient", and three "modern". The MTBC strains belonging to "modern" lineages appear to show enhanced virulence that may have warranted improved transmission in humans over ancient lineages through molecular mechanisms that remain to be fully characterized. To evaluate the impact of MTBC genetic diversity on the innate immune response, we analyzed intracellular bacterial replication, inflammatory cytokine levels, and autophagy response in human primary macrophages infected with MTBC clinical isolates belonging to the ancient lineages 1 and 5, and the modern lineage 4. We show that, when compared to ancient lineage 1 and 5, MTBC strains belonging to modern lineage 4 show a higher rate of replication, associated to a significant production of proinflammatory cytokines (IL-1β, IL-6, and TNF-α) and induction of a functional autophagy process. Interestingly, we found that the increased autophagic flux observed in macrophages infected with modern MTBC is due to an autocrine activity of the proinflammatory cytokine IL-1β, since autophagosome maturation is blocked by an interleukin-1 receptor antagonist. Unexpectedly, IL-1β-induced autophagy is not disadvantageous for the survival of modern Mtb strains, which reside within Rab5-positive phagosomal vesicles and avoid autophagosome engulfment. Altogether, these results suggest that autophagy triggered by inflammatory cytokines is compatible with a high rate of intracellular bacilli replication and may therefore contribute to the increased pathogenicity of the modern MTBC lineages. More... »
PAGES624
http://scigraph.springernature.com/pub.10.1038/s41419-018-0640-8
DOIhttp://dx.doi.org/10.1038/s41419-018-0640-8
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1104158452
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29795378
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Immunology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Istituti di Ricovero e Cura a Carattere Scientifico",
"id": "https://www.grid.ac/institutes/grid.414603.4",
"name": [
"Department of Epidemiology and Preclinical Research, National Institutes for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149, Rome, Italy"
],
"type": "Organization"
},
"familyName": "Romagnoli",
"givenName": "Alessandra",
"id": "sg:person.01130437467.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130437467.18"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Istituti di Ricovero e Cura a Carattere Scientifico",
"id": "https://www.grid.ac/institutes/grid.414603.4",
"name": [
"Department of Epidemiology and Preclinical Research, National Institutes for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149, Rome, Italy"
],
"type": "Organization"
},
"familyName": "Petruccioli",
"givenName": "Elisa",
"id": "sg:person.01316222666.31",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316222666.31"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Catholic University of the Sacred Heart",
"id": "https://www.grid.ac/institutes/grid.8142.f",
"name": [
"Institute of Microbiology, Universita\u2019 Cattolica del Sacro Cuore \u2013 Fondazione Policlinico Gemelli, 00168, Rome, Italy"
],
"type": "Organization"
},
"familyName": "Palucci",
"givenName": "Ivana",
"id": "sg:person.01161317047.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161317047.40"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Catholic University of the Sacred Heart",
"id": "https://www.grid.ac/institutes/grid.8142.f",
"name": [
"Institute of Microbiology, Universita\u2019 Cattolica del Sacro Cuore \u2013 Fondazione Policlinico Gemelli, 00168, Rome, Italy"
],
"type": "Organization"
},
"familyName": "Camassa",
"givenName": "Serena",
"id": "sg:person.01026771172.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026771172.24"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Salento",
"id": "https://www.grid.ac/institutes/grid.9906.6",
"name": [
"Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, University of Salento, 73100, Lecce, Italy"
],
"type": "Organization"
},
"familyName": "Carata",
"givenName": "Elisabetta",
"id": "sg:person.01346531721.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346531721.17"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Istituti di Ricovero e Cura a Carattere Scientifico",
"id": "https://www.grid.ac/institutes/grid.414603.4",
"name": [
"Department of Epidemiology and Preclinical Research, National Institutes for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149, Rome, Italy"
],
"type": "Organization"
},
"familyName": "Petrone",
"givenName": "Linda",
"id": "sg:person.0755160366.91",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755160366.91"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Salento",
"id": "https://www.grid.ac/institutes/grid.9906.6",
"name": [
"Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, University of Salento, 73100, Lecce, Italy"
],
"type": "Organization"
},
"familyName": "Mariano",
"givenName": "Stefania",
"id": "sg:person.01202453300.95",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202453300.95"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Catholic University of the Sacred Heart",
"id": "https://www.grid.ac/institutes/grid.8142.f",
"name": [
"Institute of Microbiology, Universita\u2019 Cattolica del Sacro Cuore \u2013 Fondazione Policlinico Gemelli, 00168, Rome, Italy"
],
"type": "Organization"
},
"familyName": "Sali",
"givenName": "Michela",
"id": "sg:person.01006361171.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006361171.07"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Salento",
"id": "https://www.grid.ac/institutes/grid.9906.6",
"name": [
"Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, University of Salento, 73100, Lecce, Italy"
],
"type": "Organization"
},
"familyName": "Dini",
"givenName": "Luciana",
"id": "sg:person.01064477442.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064477442.53"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Istituti di Ricovero e Cura a Carattere Scientifico",
"id": "https://www.grid.ac/institutes/grid.414603.4",
"name": [
"Department of Epidemiology and Preclinical Research, National Institutes for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149, Rome, Italy"
],
"type": "Organization"
},
"familyName": "Girardi",
"givenName": "Enrico",
"id": "sg:person.01222655205.82",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222655205.82"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Catholic University of the Sacred Heart",
"id": "https://www.grid.ac/institutes/grid.8142.f",
"name": [
"Institute of Microbiology, Universita\u2019 Cattolica del Sacro Cuore \u2013 Fondazione Policlinico Gemelli, 00168, Rome, Italy"
],
"type": "Organization"
},
"familyName": "Delogu",
"givenName": "Giovanni",
"id": "sg:person.01367573522.56",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367573522.56"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Istituti di Ricovero e Cura a Carattere Scientifico",
"id": "https://www.grid.ac/institutes/grid.414603.4",
"name": [
"Department of Epidemiology and Preclinical Research, National Institutes for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149, Rome, Italy"
],
"type": "Organization"
},
"familyName": "Goletti",
"givenName": "Delia",
"id": "sg:person.01200446072.99",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200446072.99"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Salento",
"id": "https://www.grid.ac/institutes/grid.9906.6",
"name": [
"Department of Epidemiology and Preclinical Research, National Institutes for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149, Rome, Italy",
"Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, University of Salento, 73100, Lecce, Italy"
],
"type": "Organization"
},
"familyName": "Fimia",
"givenName": "Gian Maria",
"id": "sg:person.0741346170.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741346170.03"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/j.tibs.2016.09.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001955790"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.052548299",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002264494"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrd4696",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002419266",
"https://doi.org/10.1038/nrd4696"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2012.06.040",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002482019"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0962-8479(98)80002-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002788217"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pntd.0000744",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003790163"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/srep16320",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004656238",
"https://doi.org/10.1038/srep16320"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/imr.12264",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005426927"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.chom.2016.11.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006566918"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pbio.0060311",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007027373"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0150800",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007715846"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0952-7915(03)00075-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007780283"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0952-7915(03)00075-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007780283"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev-immunol-020711-074948",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007945977"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1600-065x.2007.00547.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009533622"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.chom.2015.05.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010362763"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cyto.2011.08.022",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010407494"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncomms11290",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010683868",
"https://doi.org/10.1038/ncomms11290"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4161/auto.20881",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011631725"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.smim.2014.09.012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012226072"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/mi.2011.14",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013828195",
"https://doi.org/10.1038/mi.2011.14"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1098/rstb.2011.0316",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013839053"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/iai.00602-06",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015834769"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature02837",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017834156",
"https://doi.org/10.1038/nature02837"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature02837",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017834156",
"https://doi.org/10.1038/nature02837"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/82_2013_332",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020601145",
"https://doi.org/10.1007/82_2013_332"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.immuni.2012.04.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020606164"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.tim.2012.06.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022002944"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri3532",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022777012",
"https://doi.org/10.1038/nri3532"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1183/13993003.01012-2016",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023521447"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1183/13993003.01012-2016",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023521447"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1183/13993003.01012-2016",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023521447"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.tube.2015.02.019",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024051091"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10875-014-0103-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025325690",
"https://doi.org/10.1007/s10875-014-0103-7"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10875-014-0103-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025325690",
"https://doi.org/10.1007/s10875-014-0103-7"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.ppat.1000988",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025705796"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ni.3273",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025859742",
"https://doi.org/10.1038/ni.3273"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.ppat.1000160",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026873394"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20151570",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026971461"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.molcel.2013.12.014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027948350"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/infdis/jis226",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028332722"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/iai.00561-06",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029290139"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1472-9792(02)00054-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029518054"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1472-9792(02)00054-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029518054"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.smim.2014.09.011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030791145"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.mib.2013.05.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031401456"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature16451",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033165191",
"https://doi.org/10.1038/nature16451"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/jcm.00498-14",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033620541"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/mbio.00250-13",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037782575"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.ppat.1005809",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040126353"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.coi.2011.10.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040136477"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2011.10.026",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040436255"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci73945",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041742494"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.chom.2012.06.010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043261915"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/srep23089",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043291608",
"https://doi.org/10.1038/srep23089"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0043170",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045591187"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.1202688",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045650577"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.immuni.2007.07.022",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046529230"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0023870",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046781705"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2004.11.038",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049070577"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cytogfr.2013.01.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049154364"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.ppat.1001307",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050316131"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.chom.2015.05.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050325728"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.chom.2015.05.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050325728"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1155/2015/854507",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050711021"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.1210500109",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051292375"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.immuni.2006.04.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051689852"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev-cellbio-092910-154005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052438773"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3389/fimmu.2014.00180",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053487970"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074469644",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082783632",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082881533",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083091586",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/eji.201646562",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083404260"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.molimm.2017.05.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1085411104"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrd.2017.162",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1091891119",
"https://doi.org/10.1038/nrd.2017.162"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/joim.12714",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1095858462"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrmicro.2018.8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1101104614",
"https://doi.org/10.1038/nrmicro.2018.8"
],
"type": "CreativeWork"
}
],
"datePublished": "2018-06",
"datePublishedReg": "2018-06-01",
"description": "Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), has infected over 1.7 billion people worldwide and causes 1.4 million deaths annually. Recently, genome sequence analysis has allowed the reconstruction of Mycobacterium tuberculosis complex (MTBC) evolution, with the identification of seven phylogeographic lineages: four referred to as evolutionarily \"ancient\", and three \"modern\". The MTBC strains belonging to \"modern\" lineages appear to show enhanced virulence that may have warranted improved transmission in humans over ancient lineages through molecular mechanisms that remain to be fully characterized. To evaluate the impact of MTBC genetic diversity on the innate immune response, we analyzed intracellular bacterial replication, inflammatory cytokine levels, and autophagy response in human primary macrophages infected with MTBC clinical isolates belonging to the ancient lineages 1 and 5, and the modern lineage 4. We show that, when compared to ancient lineage 1 and 5, MTBC strains belonging to modern lineage 4 show a higher rate of replication, associated to a significant production of proinflammatory cytokines (IL-1\u03b2, IL-6, and TNF-\u03b1) and induction of a functional autophagy process. Interestingly, we found that the increased autophagic flux observed in macrophages infected with modern MTBC is due to an autocrine activity of the proinflammatory cytokine IL-1\u03b2, since autophagosome maturation is blocked by an interleukin-1 receptor antagonist. Unexpectedly, IL-1\u03b2-induced autophagy is not disadvantageous for the survival of modern Mtb strains, which reside within Rab5-positive phagosomal vesicles and avoid autophagosome engulfment. Altogether, these results suggest that autophagy triggered by inflammatory cytokines is compatible with a high rate of intracellular bacilli replication and may therefore contribute to the increased pathogenicity of the modern MTBC lineages.",
"genre": "research_article",
"id": "sg:pub.10.1038/s41419-018-0640-8",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1042939",
"issn": [
"2041-4889"
],
"name": "Cell Death & Disease",
"type": "Periodical"
},
{
"issueNumber": "6",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "9"
}
],
"name": "Clinical isolates of the modern Mycobacterium tuberculosis lineage 4 evade host defense in human macrophages through eluding IL-1\u03b2-induced autophagy",
"pagination": "624",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"90aef010242bd36eb494d2ee6943537bbaae11ecd1fc3bdfc0ba48475c9b78b3"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"29795378"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101524092"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41419-018-0640-8"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1104158452"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41419-018-0640-8",
"https://app.dimensions.ai/details/publication/pub.1104158452"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T18:28",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000566.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41419-018-0640-8"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0640-8'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0640-8'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0640-8'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0640-8'
This table displays all metadata directly associated to this object as RDF triples.
381 TRIPLES
21 PREDICATES
100 URIs
21 LITERALS
9 BLANK NODES