E2F1 inhibition mediates cell death of metastatic melanoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-05

AUTHORS

Florian Rouaud, Nedra Hamouda-Tekaya, Michaël Cerezo, Patricia Abbe, Joséphine Zangari, Veronique Hofman, Mickaël Ohanna, Baharia Mograbi, Najla El-Hachem, Zohra Benfodda, Alexandre Lebeau, Meri K. Tulic, Paul Hofman, Corine Bertolotto, Thierry Passeron, Jean-Sébastien Annicotte, Robert Ballotti, Stéphane Rocchi

ABSTRACT

Melanoma is one of the most lethal cancers when it reaches a metastatic stage. Despite advancements in targeted therapies (BRAF inhibitors) or immunotherapies (anti-CTLA-4 or anti-PD1), most patients with melanoma will need additional treatment. Thus, there is an urgent need to develop new therapeutical approaches to bypass resistance and achieve more prolonged responses. In this context, we were interested in E2F1, a transcription factor that plays a major role in the control of cell cycle under physiological and pathological conditions. Here we confirmed that E2F1 is highly expressed in melanoma cells. Inhibition of E2F1 activity further increased melanoma cell death and senescence, both in vitro and in vivo. Moreover, blocking E2F1 also induced death of melanoma cells resistant to BRAF inhibitors. In conclusion, our studies suggest that targeting the E2F1 signaling pathway may be therapeutically relevant for melanoma. More... »

PAGES

527

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41419-018-0566-1

DOI

http://dx.doi.org/10.1038/s41419-018-0566-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103886311

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29743521


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 C\u00f4te d'Azur", 
          "id": "https://www.grid.ac/institutes/grid.460782.f", 
          "name": [
            "INSERM, U1065, team 12, Study of molecular mechanisms involved in pigmentation and melanoma using translational approaches, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Nice, France", 
            "Universit\u00e9 Cote d\u2019azur, UFR de M\u00e9decine, Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rouaud", 
        "givenName": "Florian", 
        "id": "sg:person.0710030043.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710030043.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 C\u00f4te d'Azur", 
          "id": "https://www.grid.ac/institutes/grid.460782.f", 
          "name": [
            "INSERM, U1065, team 12, Study of molecular mechanisms involved in pigmentation and melanoma using translational approaches, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Nice, France", 
            "Universit\u00e9 Cote d\u2019azur, UFR de M\u00e9decine, Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hamouda-Tekaya", 
        "givenName": "Nedra", 
        "id": "sg:person.011623733165.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011623733165.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 C\u00f4te d'Azur", 
          "id": "https://www.grid.ac/institutes/grid.460782.f", 
          "name": [
            "INSERM, U1065, team 12, Study of molecular mechanisms involved in pigmentation and melanoma using translational approaches, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Nice, France", 
            "Universit\u00e9 Cote d\u2019azur, UFR de M\u00e9decine, Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cerezo", 
        "givenName": "Micha\u00ebl", 
        "id": "sg:person.01104713050.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104713050.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 C\u00f4te d'Azur", 
          "id": "https://www.grid.ac/institutes/grid.460782.f", 
          "name": [
            "INSERM, U1065, team 12, Study of molecular mechanisms involved in pigmentation and melanoma using translational approaches, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Nice, France", 
            "Universit\u00e9 Cote d\u2019azur, UFR de M\u00e9decine, Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abbe", 
        "givenName": "Patricia", 
        "id": "sg:person.01130457425.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130457425.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Research on Cancer and Aging in Nice", 
          "id": "https://www.grid.ac/institutes/grid.463830.a", 
          "name": [
            "Universit\u00e9 Cote d\u2019azur, UFR de M\u00e9decine, Nice, France", 
            "Institute of Research on Cancer and Ageing of Nice (IRCAN), CNRS UMR7284, INSERM U1081, 06107, Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zangari", 
        "givenName": "Jos\u00e9phine", 
        "id": "sg:person.01130564704.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130564704.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.464719.9", 
          "name": [
            "Universit\u00e9 Cote d\u2019azur, UFR de M\u00e9decine, Nice, France", 
            "Institute of Research on Cancer and Ageing of Nice (IRCAN), CNRS UMR7284, INSERM U1081, 06107, Nice, France", 
            "Laboratoire de pathologie clinique et exp\u00e9rimentale et Hospital-related biobank (BB-0033-00025), H\u00f4pital Pasteur, Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hofman", 
        "givenName": "Veronique", 
        "id": "sg:person.0752614471.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752614471.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 C\u00f4te d'Azur", 
          "id": "https://www.grid.ac/institutes/grid.460782.f", 
          "name": [
            "INSERM, U1065, team 12, Study of molecular mechanisms involved in pigmentation and melanoma using translational approaches, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Nice, France", 
            "Universit\u00e9 Cote d\u2019azur, UFR de M\u00e9decine, Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohanna", 
        "givenName": "Micka\u00ebl", 
        "id": "sg:person.01106765151.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106765151.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Research on Cancer and Aging in Nice", 
          "id": "https://www.grid.ac/institutes/grid.463830.a", 
          "name": [
            "Universit\u00e9 Cote d\u2019azur, UFR de M\u00e9decine, Nice, France", 
            "Institute of Research on Cancer and Ageing of Nice (IRCAN), CNRS UMR7284, INSERM U1081, 06107, Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mograbi", 
        "givenName": "Baharia", 
        "id": "sg:person.0576473004.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576473004.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 C\u00f4te d'Azur", 
          "id": "https://www.grid.ac/institutes/grid.460782.f", 
          "name": [
            "INSERM, U1065, team 12, Study of molecular mechanisms involved in pigmentation and melanoma using translational approaches, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Nice, France", 
            "Universit\u00e9 Cote d\u2019azur, UFR de M\u00e9decine, Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "El-Hachem", 
        "givenName": "Najla", 
        "id": "sg:person.012000142164.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012000142164.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of N\u00eemes", 
          "id": "https://www.grid.ac/institutes/grid.48959.39", 
          "name": [
            "Laboratoire de D\u00e9tection, \u00e9valuation gestion des risques \u00e9mergents et chroniques, Universit\u00e9 de Nimes, N\u00eemes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Benfodda", 
        "givenName": "Zohra", 
        "id": "sg:person.01050717727.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050717727.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of N\u00eemes", 
          "id": "https://www.grid.ac/institutes/grid.48959.39", 
          "name": [
            "Laboratoire de D\u00e9tection, \u00e9valuation gestion des risques \u00e9mergents et chroniques, Universit\u00e9 de Nimes, N\u00eemes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lebeau", 
        "givenName": "Alexandre", 
        "id": "sg:person.07407047721.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07407047721.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 C\u00f4te d'Azur", 
          "id": "https://www.grid.ac/institutes/grid.460782.f", 
          "name": [
            "INSERM, U1065, team 12, Study of molecular mechanisms involved in pigmentation and melanoma using translational approaches, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Nice, France", 
            "Universit\u00e9 Cote d\u2019azur, UFR de M\u00e9decine, Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tulic", 
        "givenName": "Meri K.", 
        "id": "sg:person.01252362324.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252362324.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.464719.9", 
          "name": [
            "Universit\u00e9 Cote d\u2019azur, UFR de M\u00e9decine, Nice, France", 
            "Institute of Research on Cancer and Ageing of Nice (IRCAN), CNRS UMR7284, INSERM U1081, 06107, Nice, France", 
            "Laboratoire de pathologie clinique et exp\u00e9rimentale et Hospital-related biobank (BB-0033-00025), H\u00f4pital Pasteur, Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hofman", 
        "givenName": "Paul", 
        "id": "sg:person.01200570232.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200570232.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Me\u0301diterrane\u0301en de Me\u0301decine Mole\u0301culaire", 
          "id": "https://www.grid.ac/institutes/grid.462370.4", 
          "name": [
            "Universit\u00e9 Cote d\u2019azur, UFR de M\u00e9decine, Nice, France", 
            "Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Team 1, INSERM U1065, Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bertolotto", 
        "givenName": "Corine", 
        "id": "sg:person.0623243524.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623243524.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Nice", 
          "id": "https://www.grid.ac/institutes/grid.410528.a", 
          "name": [
            "INSERM, U1065, team 12, Study of molecular mechanisms involved in pigmentation and melanoma using translational approaches, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Nice, France", 
            "Service de Dermatologie, H\u00f4pital Archet II, CHU de Nice, Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Passeron", 
        "givenName": "Thierry", 
        "id": "sg:person.0631551442.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631551442.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "CNRS, Institut Pasteur de Lille, UMR 8199\u2013EGID, Universit\u00e9 de Lille, 59000, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Annicotte", 
        "givenName": "Jean-S\u00e9bastien", 
        "id": "sg:person.01212445401.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212445401.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Me\u0301diterrane\u0301en de Me\u0301decine Mole\u0301culaire", 
          "id": "https://www.grid.ac/institutes/grid.462370.4", 
          "name": [
            "Universit\u00e9 Cote d\u2019azur, UFR de M\u00e9decine, Nice, France", 
            "Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Team 1, INSERM U1065, Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ballotti", 
        "givenName": "Robert", 
        "id": "sg:person.0724167354.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724167354.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 C\u00f4te d'Azur", 
          "id": "https://www.grid.ac/institutes/grid.460782.f", 
          "name": [
            "INSERM, U1065, team 12, Study of molecular mechanisms involved in pigmentation and melanoma using translational approaches, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), Nice, France", 
            "Universit\u00e9 Cote d\u2019azur, UFR de M\u00e9decine, Nice, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rocchi", 
        "givenName": "St\u00e9phane", 
        "id": "sg:person.01213637403.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213637403.54"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/0008-5472.can-08-0121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001507667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-12-1226-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001803226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/jid.2015.198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002066281", 
          "https://doi.org/10.1038/jid.2015.198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/med.21404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002627320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.12651", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011495105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-11-2575", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012614424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1002011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012824919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gks858", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014046893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200409187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016219784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2010.75", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016289898", 
          "https://doi.org/10.1038/cdd.2010.75"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2010.75", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016289898", 
          "https://doi.org/10.1038/cdd.2010.75"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11814", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017875293", 
          "https://doi.org/10.1038/nature11814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0905139106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027099936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/celldisc.2015.30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029629851", 
          "https://doi.org/10.1038/celldisc.2015.30"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cddis.2014.326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030314665", 
          "https://doi.org/10.1038/cddis.2014.326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-13-0074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033528952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-0683", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034102519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2011.277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036087824", 
          "https://doi.org/10.1038/onc.2011.277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2004.09.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036519688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-13-0143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037521958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/jid.2008.346", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038205777", 
          "https://doi.org/10.1038/jid.2008.346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccell.2016.04.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038935009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-09-2913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040839333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(13)60802-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043729077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.21.11.3616-3631.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044448081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djp458", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046705089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/jid.2014.202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047670123", 
          "https://doi.org/10.1038/jid.2014.202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1112302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051449373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.1420", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052066620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/msb.2010.5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052703550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/msb.2010.5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052703550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cbt.5.4.2512", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072294086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.8.24.10110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072300490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.290940.116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079394188"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-05", 
    "datePublishedReg": "2018-05-01", 
    "description": "Melanoma is one of the most lethal cancers when it reaches a metastatic stage. Despite advancements in targeted therapies (BRAF inhibitors) or immunotherapies (anti-CTLA-4 or anti-PD1), most patients with melanoma will need additional treatment. Thus, there is an urgent need to develop new therapeutical approaches to bypass resistance and achieve more prolonged responses. In this context, we were interested in E2F1, a transcription factor that plays a major role in the control of cell cycle under physiological and pathological conditions. Here we confirmed that E2F1 is highly expressed in melanoma cells. Inhibition of E2F1 activity further increased melanoma cell death and senescence, both in vitro and in vivo. Moreover, blocking E2F1 also induced death of melanoma cells resistant to BRAF inhibitors. In conclusion, our studies suggest that targeting the E2F1 signaling pathway may be therapeutically relevant for melanoma.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41419-018-0566-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1042939", 
        "issn": [
          "2041-4889"
        ], 
        "name": "Cell Death & Disease", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "E2F1 inhibition mediates cell death of metastatic melanoma", 
    "pagination": "527", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "da60dde2c1a8f7c408cac6b9811d33638590da6ebcc77d6aeda3e21a30bace1b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29743521"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101524092"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41419-018-0566-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1103886311"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41419-018-0566-1", 
      "https://app.dimensions.ai/details/publication/pub.1103886311"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T02:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000566.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41419-018-0566-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0566-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0566-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0566-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0566-1'


 

This table displays all metadata directly associated to this object as RDF triples.

314 TRIPLES      21 PREDICATES      61 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41419-018-0566-1 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N13c0b041417142709c12ace47763a0e5
4 schema:citation sg:pub.10.1038/cdd.2010.75
5 sg:pub.10.1038/cddis.2014.326
6 sg:pub.10.1038/celldisc.2015.30
7 sg:pub.10.1038/jid.2008.346
8 sg:pub.10.1038/jid.2014.202
9 sg:pub.10.1038/jid.2015.198
10 sg:pub.10.1038/nature11814
11 sg:pub.10.1038/onc.2011.277
12 https://doi.org/10.1002/med.21404
13 https://doi.org/10.1016/j.ccell.2016.04.013
14 https://doi.org/10.1016/j.molcel.2004.09.029
15 https://doi.org/10.1016/s0140-6736(13)60802-8
16 https://doi.org/10.1038/msb.2010.5
17 https://doi.org/10.1056/nejmoa1002011
18 https://doi.org/10.1056/nejmoa1112302
19 https://doi.org/10.1073/pnas.0905139106
20 https://doi.org/10.1083/jcb.200409187
21 https://doi.org/10.1093/jnci/djp458
22 https://doi.org/10.1093/nar/gks858
23 https://doi.org/10.1101/gad.290940.116
24 https://doi.org/10.1128/mcb.21.11.3616-3631.2001
25 https://doi.org/10.1158/0008-5472.can-08-0121
26 https://doi.org/10.1158/0008-5472.can-09-2913
27 https://doi.org/10.1158/0008-5472.can-11-2575
28 https://doi.org/10.1158/1078-0432.ccr-05-0683
29 https://doi.org/10.1158/1078-0432.ccr-13-0074
30 https://doi.org/10.1158/1078-0432.ccr-13-0143
31 https://doi.org/10.1158/1535-7163.mct-12-1226-t
32 https://doi.org/10.18632/oncotarget.12651
33 https://doi.org/10.18632/oncotarget.1420
34 https://doi.org/10.4161/cbt.5.4.2512
35 https://doi.org/10.4161/cc.8.24.10110
36 schema:datePublished 2018-05
37 schema:datePublishedReg 2018-05-01
38 schema:description Melanoma is one of the most lethal cancers when it reaches a metastatic stage. Despite advancements in targeted therapies (BRAF inhibitors) or immunotherapies (anti-CTLA-4 or anti-PD1), most patients with melanoma will need additional treatment. Thus, there is an urgent need to develop new therapeutical approaches to bypass resistance and achieve more prolonged responses. In this context, we were interested in E2F1, a transcription factor that plays a major role in the control of cell cycle under physiological and pathological conditions. Here we confirmed that E2F1 is highly expressed in melanoma cells. Inhibition of E2F1 activity further increased melanoma cell death and senescence, both in vitro and in vivo. Moreover, blocking E2F1 also induced death of melanoma cells resistant to BRAF inhibitors. In conclusion, our studies suggest that targeting the E2F1 signaling pathway may be therapeutically relevant for melanoma.
39 schema:genre research_article
40 schema:inLanguage en
41 schema:isAccessibleForFree true
42 schema:isPartOf N167071838f6a4c189b68cf021c7e7f24
43 Nb86067914d0546c6a382a39764c61617
44 sg:journal.1042939
45 schema:name E2F1 inhibition mediates cell death of metastatic melanoma
46 schema:pagination 527
47 schema:productId N302fa2fc667f4883a1814a1d0f4f6079
48 N41625a5e84d74d568f85cc50a36ea653
49 Ndd4258bdc361424ca8717744e36e93be
50 Nddc9278bed9a49f9b3c40f559d7cbdf8
51 Nefbcde6b527c4f78b5b29da6eca795cc
52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103886311
53 https://doi.org/10.1038/s41419-018-0566-1
54 schema:sdDatePublished 2019-04-11T02:23
55 schema:sdLicense https://scigraph.springernature.com/explorer/license/
56 schema:sdPublisher Ne7c8bd77dfa84a2eb4e50bd169a33347
57 schema:url https://www.nature.com/articles/s41419-018-0566-1
58 sgo:license sg:explorer/license/
59 sgo:sdDataset articles
60 rdf:type schema:ScholarlyArticle
61 N0d27bd6c94724cd7a396cbfe1a91cab5 rdf:first sg:person.01200570232.18
62 rdf:rest Nb7c8e1e675974afdb4bb1eccf9e0cf43
63 N13c0b041417142709c12ace47763a0e5 rdf:first sg:person.0710030043.25
64 rdf:rest N9d7d401592d54cb8994258943551212c
65 N167071838f6a4c189b68cf021c7e7f24 schema:issueNumber 5
66 rdf:type schema:PublicationIssue
67 N1e97532b6e0f4e3b8344cf1ee69a3a09 rdf:first sg:person.01130457425.71
68 rdf:rest N982c345f7369483e8420fa978e495348
69 N302fa2fc667f4883a1814a1d0f4f6079 schema:name dimensions_id
70 schema:value pub.1103886311
71 rdf:type schema:PropertyValue
72 N3c2edb80c4c84b60a3d256345667de90 rdf:first sg:person.01106765151.38
73 rdf:rest N8c244458ffab4f06815a920176d2b05b
74 N41625a5e84d74d568f85cc50a36ea653 schema:name readcube_id
75 schema:value da60dde2c1a8f7c408cac6b9811d33638590da6ebcc77d6aeda3e21a30bace1b
76 rdf:type schema:PropertyValue
77 N50b027be4e014f22b7f557c4a79a75ba rdf:first sg:person.01252362324.30
78 rdf:rest N0d27bd6c94724cd7a396cbfe1a91cab5
79 N515721cac2bb4a479d6e85824831459a rdf:first sg:person.012000142164.00
80 rdf:rest Nd02b7b2e07604617a30e1d02a8322748
81 N8c244458ffab4f06815a920176d2b05b rdf:first sg:person.0576473004.58
82 rdf:rest N515721cac2bb4a479d6e85824831459a
83 N9301e7ae4cfa44f6ac2535e6091c6305 rdf:first sg:person.01212445401.60
84 rdf:rest Nd2b3b97fd0994224975f135dad2de737
85 N982c345f7369483e8420fa978e495348 rdf:first sg:person.01130564704.71
86 rdf:rest Naa4fd47213e24e698c651383e61dc70b
87 N9d7d401592d54cb8994258943551212c rdf:first sg:person.011623733165.30
88 rdf:rest Nab3ced054ccf440b86f9a3822cd125e1
89 Naa4fd47213e24e698c651383e61dc70b rdf:first sg:person.0752614471.29
90 rdf:rest N3c2edb80c4c84b60a3d256345667de90
91 Nab3ced054ccf440b86f9a3822cd125e1 rdf:first sg:person.01104713050.65
92 rdf:rest N1e97532b6e0f4e3b8344cf1ee69a3a09
93 Nae2e1e4629334f4d932b03b1bff89091 rdf:first sg:person.0631551442.19
94 rdf:rest N9301e7ae4cfa44f6ac2535e6091c6305
95 Nb7c8e1e675974afdb4bb1eccf9e0cf43 rdf:first sg:person.0623243524.71
96 rdf:rest Nae2e1e4629334f4d932b03b1bff89091
97 Nb86067914d0546c6a382a39764c61617 schema:volumeNumber 9
98 rdf:type schema:PublicationVolume
99 Ncb636f369df84dc49b1cc2f766e21eec rdf:first sg:person.07407047721.18
100 rdf:rest N50b027be4e014f22b7f557c4a79a75ba
101 Nd02b7b2e07604617a30e1d02a8322748 rdf:first sg:person.01050717727.24
102 rdf:rest Ncb636f369df84dc49b1cc2f766e21eec
103 Nd2b3b97fd0994224975f135dad2de737 rdf:first sg:person.0724167354.34
104 rdf:rest Nfcec8c4a19604369a03eef8d7e268540
105 Ndd4258bdc361424ca8717744e36e93be schema:name nlm_unique_id
106 schema:value 101524092
107 rdf:type schema:PropertyValue
108 Nddc9278bed9a49f9b3c40f559d7cbdf8 schema:name doi
109 schema:value 10.1038/s41419-018-0566-1
110 rdf:type schema:PropertyValue
111 Ne7c8bd77dfa84a2eb4e50bd169a33347 schema:name Springer Nature - SN SciGraph project
112 rdf:type schema:Organization
113 Nefbcde6b527c4f78b5b29da6eca795cc schema:name pubmed_id
114 schema:value 29743521
115 rdf:type schema:PropertyValue
116 Nf9287970bd6b4e94b1c08055e3106046 schema:name CNRS, Institut Pasteur de Lille, UMR 8199–EGID, Université de Lille, 59000, Lille, France
117 rdf:type schema:Organization
118 Nfcec8c4a19604369a03eef8d7e268540 rdf:first sg:person.01213637403.54
119 rdf:rest rdf:nil
120 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
121 schema:name Medical and Health Sciences
122 rdf:type schema:DefinedTerm
123 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
124 schema:name Oncology and Carcinogenesis
125 rdf:type schema:DefinedTerm
126 sg:journal.1042939 schema:issn 2041-4889
127 schema:name Cell Death & Disease
128 rdf:type schema:Periodical
129 sg:person.01050717727.24 schema:affiliation https://www.grid.ac/institutes/grid.48959.39
130 schema:familyName Benfodda
131 schema:givenName Zohra
132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050717727.24
133 rdf:type schema:Person
134 sg:person.01104713050.65 schema:affiliation https://www.grid.ac/institutes/grid.460782.f
135 schema:familyName Cerezo
136 schema:givenName Michaël
137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104713050.65
138 rdf:type schema:Person
139 sg:person.01106765151.38 schema:affiliation https://www.grid.ac/institutes/grid.460782.f
140 schema:familyName Ohanna
141 schema:givenName Mickaël
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106765151.38
143 rdf:type schema:Person
144 sg:person.01130457425.71 schema:affiliation https://www.grid.ac/institutes/grid.460782.f
145 schema:familyName Abbe
146 schema:givenName Patricia
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130457425.71
148 rdf:type schema:Person
149 sg:person.01130564704.71 schema:affiliation https://www.grid.ac/institutes/grid.463830.a
150 schema:familyName Zangari
151 schema:givenName Joséphine
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130564704.71
153 rdf:type schema:Person
154 sg:person.011623733165.30 schema:affiliation https://www.grid.ac/institutes/grid.460782.f
155 schema:familyName Hamouda-Tekaya
156 schema:givenName Nedra
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011623733165.30
158 rdf:type schema:Person
159 sg:person.012000142164.00 schema:affiliation https://www.grid.ac/institutes/grid.460782.f
160 schema:familyName El-Hachem
161 schema:givenName Najla
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012000142164.00
163 rdf:type schema:Person
164 sg:person.01200570232.18 schema:affiliation https://www.grid.ac/institutes/grid.464719.9
165 schema:familyName Hofman
166 schema:givenName Paul
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200570232.18
168 rdf:type schema:Person
169 sg:person.01212445401.60 schema:affiliation Nf9287970bd6b4e94b1c08055e3106046
170 schema:familyName Annicotte
171 schema:givenName Jean-Sébastien
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212445401.60
173 rdf:type schema:Person
174 sg:person.01213637403.54 schema:affiliation https://www.grid.ac/institutes/grid.460782.f
175 schema:familyName Rocchi
176 schema:givenName Stéphane
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213637403.54
178 rdf:type schema:Person
179 sg:person.01252362324.30 schema:affiliation https://www.grid.ac/institutes/grid.460782.f
180 schema:familyName Tulic
181 schema:givenName Meri K.
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252362324.30
183 rdf:type schema:Person
184 sg:person.0576473004.58 schema:affiliation https://www.grid.ac/institutes/grid.463830.a
185 schema:familyName Mograbi
186 schema:givenName Baharia
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576473004.58
188 rdf:type schema:Person
189 sg:person.0623243524.71 schema:affiliation https://www.grid.ac/institutes/grid.462370.4
190 schema:familyName Bertolotto
191 schema:givenName Corine
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623243524.71
193 rdf:type schema:Person
194 sg:person.0631551442.19 schema:affiliation https://www.grid.ac/institutes/grid.410528.a
195 schema:familyName Passeron
196 schema:givenName Thierry
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631551442.19
198 rdf:type schema:Person
199 sg:person.0710030043.25 schema:affiliation https://www.grid.ac/institutes/grid.460782.f
200 schema:familyName Rouaud
201 schema:givenName Florian
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710030043.25
203 rdf:type schema:Person
204 sg:person.0724167354.34 schema:affiliation https://www.grid.ac/institutes/grid.462370.4
205 schema:familyName Ballotti
206 schema:givenName Robert
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724167354.34
208 rdf:type schema:Person
209 sg:person.07407047721.18 schema:affiliation https://www.grid.ac/institutes/grid.48959.39
210 schema:familyName Lebeau
211 schema:givenName Alexandre
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07407047721.18
213 rdf:type schema:Person
214 sg:person.0752614471.29 schema:affiliation https://www.grid.ac/institutes/grid.464719.9
215 schema:familyName Hofman
216 schema:givenName Veronique
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752614471.29
218 rdf:type schema:Person
219 sg:pub.10.1038/cdd.2010.75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016289898
220 https://doi.org/10.1038/cdd.2010.75
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/cddis.2014.326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030314665
223 https://doi.org/10.1038/cddis.2014.326
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/celldisc.2015.30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029629851
226 https://doi.org/10.1038/celldisc.2015.30
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/jid.2008.346 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038205777
229 https://doi.org/10.1038/jid.2008.346
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/jid.2014.202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047670123
232 https://doi.org/10.1038/jid.2014.202
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/jid.2015.198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002066281
235 https://doi.org/10.1038/jid.2015.198
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/nature11814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017875293
238 https://doi.org/10.1038/nature11814
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/onc.2011.277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036087824
241 https://doi.org/10.1038/onc.2011.277
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1002/med.21404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002627320
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/j.ccell.2016.04.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038935009
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/j.molcel.2004.09.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036519688
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/s0140-6736(13)60802-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043729077
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1038/msb.2010.5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052703550
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1056/nejmoa1002011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012824919
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1056/nejmoa1112302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051449373
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1073/pnas.0905139106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027099936
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1083/jcb.200409187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016219784
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1093/jnci/djp458 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046705089
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1093/nar/gks858 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014046893
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1101/gad.290940.116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079394188
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1128/mcb.21.11.3616-3631.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044448081
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1158/0008-5472.can-08-0121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001507667
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1158/0008-5472.can-09-2913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040839333
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1158/0008-5472.can-11-2575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012614424
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1158/1078-0432.ccr-05-0683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034102519
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1158/1078-0432.ccr-13-0074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033528952
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1158/1078-0432.ccr-13-0143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037521958
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1158/1535-7163.mct-12-1226-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1001803226
282 rdf:type schema:CreativeWork
283 https://doi.org/10.18632/oncotarget.12651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011495105
284 rdf:type schema:CreativeWork
285 https://doi.org/10.18632/oncotarget.1420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052066620
286 rdf:type schema:CreativeWork
287 https://doi.org/10.4161/cbt.5.4.2512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072294086
288 rdf:type schema:CreativeWork
289 https://doi.org/10.4161/cc.8.24.10110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072300490
290 rdf:type schema:CreativeWork
291 https://www.grid.ac/institutes/grid.410528.a schema:alternateName Centre Hospitalier Universitaire de Nice
292 schema:name INSERM, U1065, team 12, Study of molecular mechanisms involved in pigmentation and melanoma using translational approaches, Centre Méditerranéen de Médecine Moléculaire (C3M), Nice, France
293 Service de Dermatologie, Hôpital Archet II, CHU de Nice, Nice, France
294 rdf:type schema:Organization
295 https://www.grid.ac/institutes/grid.460782.f schema:alternateName Université Côte d'Azur
296 schema:name INSERM, U1065, team 12, Study of molecular mechanisms involved in pigmentation and melanoma using translational approaches, Centre Méditerranéen de Médecine Moléculaire (C3M), Nice, France
297 Université Cote d’azur, UFR de Médecine, Nice, France
298 rdf:type schema:Organization
299 https://www.grid.ac/institutes/grid.462370.4 schema:alternateName Centre Méditerranéen de Médecine Moléculaire
300 schema:name Centre Méditerranéen de Médecine Moléculaire (C3M), Team 1, INSERM U1065, Nice, France
301 Université Cote d’azur, UFR de Médecine, Nice, France
302 rdf:type schema:Organization
303 https://www.grid.ac/institutes/grid.463830.a schema:alternateName Institute of Research on Cancer and Aging in Nice
304 schema:name Institute of Research on Cancer and Ageing of Nice (IRCAN), CNRS UMR7284, INSERM U1081, 06107, Nice, France
305 Université Cote d’azur, UFR de Médecine, Nice, France
306 rdf:type schema:Organization
307 https://www.grid.ac/institutes/grid.464719.9 schema:alternateName Hôpital Pasteur
308 schema:name Institute of Research on Cancer and Ageing of Nice (IRCAN), CNRS UMR7284, INSERM U1081, 06107, Nice, France
309 Laboratoire de pathologie clinique et expérimentale et Hospital-related biobank (BB-0033-00025), Hôpital Pasteur, Nice, France
310 Université Cote d’azur, UFR de Médecine, Nice, France
311 rdf:type schema:Organization
312 https://www.grid.ac/institutes/grid.48959.39 schema:alternateName University of Nîmes
313 schema:name Laboratoire de Détection, évaluation gestion des risques émergents et chroniques, Université de Nimes, Nîmes, France
314 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...