Repression of let-7a cluster prevents adhesion of colorectal cancer cells by enforcing a mesenchymal phenotype in presence of liver inflammation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-05

AUTHORS

Lipeng Cheng, Li Geng, Binghua Dai, Tao Zheng, Jun Fu, Liang Qiao, Wenchang Cai, Yue Wang, Jiamei Yang

ABSTRACT

The liver is the most common site of metastasis in patients with colorectal cancer, and colorectal cancer liver metastasis (CRLM) is associated with poor rates of survival. However, CRLM occurs infrequently in livers exhibiting signs of hepatitis or cirrhosis, suggesting a role for inflammation in attenuating CRLM. The molecular mechanisms driving this phenomenon remain unclear. The aim of this study was to confirm the mechanism by which liver inflammation inhibits CRLM. We used BALB/c animal models of inflammatory liver diseases to confirm that liver inflammation inhibits CRLM, and then elucidated the molecular mechanisms governing that process. Out data showed that liver inflammation induces IFN-γ expression, which then downregulates expression of the let-7a cluster through IRF-1 in colorectal cancer cells. Finally, we showed that modulation of let-7a expression regulated the epithelial-mesenchymal transition in colorectal cancer cell lines, and inhibited their capacity to metastasize in vivo. Cumulatively, we clarified the critical role played by the IFN-γ/IRF-1/let-7a cluster/EMT pathway in regulating the spread of circulating colorectal cancer cells to the liver, and highlighted the critical role that the hepatitis microenvironment plays in modulating that process. More... »

PAGES

489

References to SciGraph publications

  • 2014-12. Loss of miR-638 in vitro promotes cell invasion and a mesenchymal-like transition by influencing SOX2 expression in colorectal carcinoma cells in MOLECULAR CANCER
  • 2014-07. Impaired DICER1 function promotes stemness and metastasis in colon cancer in ONCOGENE
  • 2013-08. Hepatic steatosis is associated with lower incidence of liver metastasis from colorectal cancer in INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
  • 2008-10. NK cell-mediated targeting of human cancer and possibilities for new means of immunotherapy in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2010-12. Effect of ω-3 and ω-9 fatty acid rich oils on lipoxygenases and cyclooxygenases enzymes and on the growth of a mammary adenocarcinoma model in LIPIDS IN HEALTH AND DISEASE
  • 2013-11. Stat3-coordinated Lin-28–let-7–HMGA2 and miR-200–ZEB1 circuits initiate and maintain oncostatin M-driven epithelial–mesenchymal transition in ONCOGENE
  • 2003-02. A basal membrane-like structure surrounding tumour nodules may prevent intraepithelial leucocyte infiltration in colorectal cancer in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2000-02. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans in NATURE
  • 2015-12. Let-7a inhibits migration, invasion and epithelial-mesenchymal transition by targeting HMGA2 in nasopharyngeal carcinoma in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2008-08. Overlapping expression of microRNAs in human embryonic colon and colorectal cancer in CELL RESEARCH
  • 2009-04. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits in NATURE REVIEWS CANCER
  • 2012-04. Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis in ONCOGENE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41419-018-0477-1

    DOI

    http://dx.doi.org/10.1038/s41419-018-0477-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1103631158

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29695839


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Second Military Medical University", 
              "id": "https://www.grid.ac/institutes/grid.73113.37", 
              "name": [
                "Department of Special Treatment and Liver Transplantation, Shanghai Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 200438, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cheng", 
            "givenName": "Lipeng", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Second Military Medical University", 
              "id": "https://www.grid.ac/institutes/grid.73113.37", 
              "name": [
                "Department of Special Treatment and Liver Transplantation, Shanghai Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 200438, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Geng", 
            "givenName": "Li", 
            "id": "sg:person.01054744646.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054744646.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Second Military Medical University", 
              "id": "https://www.grid.ac/institutes/grid.73113.37", 
              "name": [
                "Department of Special Treatment and Liver Transplantation, Shanghai Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 200438, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dai", 
            "givenName": "Binghua", 
            "id": "sg:person.0624407672.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624407672.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of General Surgery, People\u2019s Liberation Army Nanjing General Hospital, 210002, Nanjing, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zheng", 
            "givenName": "Tao", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Xuzhou Central Hospital", 
              "id": "https://www.grid.ac/institutes/grid.452207.6", 
              "name": [
                "Department of Hepatobiliary Pancreatic and Spleen Surgery, Xuzhou Central Hospital, 221000, Xuzhou, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fu", 
            "givenName": "Jun", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Second Military Medical University", 
              "id": "https://www.grid.ac/institutes/grid.73113.37", 
              "name": [
                "Department of Special Treatment and Liver Transplantation, Shanghai Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 200438, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Qiao", 
            "givenName": "Liang", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Second Military Medical University", 
              "id": "https://www.grid.ac/institutes/grid.73113.37", 
              "name": [
                "Department of Special Treatment and Liver Transplantation, Shanghai Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 200438, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cai", 
            "givenName": "Wenchang", 
            "id": "sg:person.016014414555.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016014414555.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Second Military Medical University", 
              "id": "https://www.grid.ac/institutes/grid.73113.37", 
              "name": [
                "Research Center of Developmental Biology, Second Military Medical University, 200433, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Yue", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Second Military Medical University", 
              "id": "https://www.grid.ac/institutes/grid.73113.37", 
              "name": [
                "Department of Special Treatment and Liver Transplantation, Shanghai Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 200438, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yang", 
            "givenName": "Jiamei", 
            "id": "sg:person.01006222700.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006222700.26"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nrc2620", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000031106", 
              "https://doi.org/10.1038/nrc2620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molimm.2004.07.039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000273076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.clinre.2013.05.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001297695"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2011.04.074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001664537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2008.81", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003277282", 
              "https://doi.org/10.1038/cr.2008.81"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00384-013-1656-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004004225", 
              "https://doi.org/10.1007/s00384-013-1656-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2013.398", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004462354", 
              "https://doi.org/10.1038/onc.2013.398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00262-008-0492-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005994550", 
              "https://doi.org/10.1007/s00262-008-0492-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00262-008-0492-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005994550", 
              "https://doi.org/10.1007/s00262-008-0492-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/07357900902769749", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006201507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1440-1827.1975.tb00854.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006472908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.1960.03030040020006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007015652"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.sla.0000217629.94941.cf", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008912065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.sla.0000217629.94941.cf", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008912065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(10)60353-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008954947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2004-04-1422", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010370857"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcb.10142", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011337365"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2013.04.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012005862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(12)61728-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013705877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/meg.0b013e32831bc3d6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014313524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/meg.0b013e32831bc3d6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014313524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/meg.0b013e32831bc3d6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014313524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000441-195702000-00005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014854294"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000441-195702000-00005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014854294"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.20050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015847568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-13-2203", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016474746"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2014.12.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020098607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2006.01.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020260886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0142(19970615)79:12<2320::aid-cncr5>3.0.co;2-p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020837704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9610(01)00634-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021229258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.13.7556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022907036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2011.383", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025525510", 
              "https://doi.org/10.1038/onc.2011.383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12967-015-0462-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026693276", 
              "https://doi.org/10.1186/s12967-015-0462-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12967-015-0462-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026693276", 
              "https://doi.org/10.1186/s12967-015-0462-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12967-015-0462-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026693276", 
              "https://doi.org/10.1186/s12967-015-0462-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2012.573", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030198930", 
              "https://doi.org/10.1038/onc.2012.573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-04-0637", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030947986"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/cs20070328", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032969547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/cs20070328", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032969547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.biochem.67.1.227", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033786268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cancergen.2012.08.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035871068"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0142(20000201)88:3<577::aid-cncr13>3.0.co;2-v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036295371"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bjs.5278", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036508017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bjs.5278", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036508017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.clinbiochem.2016.07.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036571318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gutjnl-2011-301846", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036909369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2015.01.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037221827"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(13)61649-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038306846"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2012.11.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039440977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9610(99)00045-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039997050"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3322/caac.21208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041182772"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35002607", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047689840", 
              "https://doi.org/10.1038/35002607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35002607", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047689840", 
              "https://doi.org/10.1038/35002607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-511x-9-112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048278785", 
              "https://doi.org/10.1186/1476-511x-9-112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-4598-13-118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048557566", 
              "https://doi.org/10.1186/1476-4598-13-118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3748/wjg.v17.i13.1725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071367475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3748/wjg.v17.i6.804", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071368050"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.8.6.7907", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072300616"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5754/hge11259", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073100435"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5754/hge11747", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073100570"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5754/hge12564", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073100773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074539442", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00262-002-0363-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075240190", 
              "https://doi.org/10.1007/s00262-002-0363-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077070077", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077073281", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077099323", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077881322", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078132530", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3748/wjg.v17.i26.3092", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078447788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083131355", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-05", 
        "datePublishedReg": "2018-05-01", 
        "description": "The liver is the most common site of metastasis in patients with colorectal cancer, and colorectal cancer liver metastasis (CRLM) is associated with poor rates of survival. However, CRLM occurs infrequently in livers exhibiting signs of hepatitis or cirrhosis, suggesting a role for inflammation in attenuating CRLM. The molecular mechanisms driving this phenomenon remain unclear. The aim of this study was to confirm the mechanism by which liver inflammation inhibits CRLM. We used BALB/c animal models of inflammatory liver diseases to confirm that liver inflammation inhibits CRLM, and then elucidated the molecular mechanisms governing that process. Out data showed that liver inflammation induces IFN-\u03b3 expression, which then downregulates expression of the let-7a cluster through IRF-1 in colorectal cancer cells. Finally, we showed that modulation of let-7a expression regulated the epithelial-mesenchymal transition in colorectal cancer cell lines, and inhibited their capacity to metastasize in vivo. Cumulatively, we clarified the critical role played by the IFN-\u03b3/IRF-1/let-7a cluster/EMT pathway in regulating the spread of circulating colorectal cancer cells to the liver, and highlighted the critical role that the hepatitis microenvironment plays in modulating that process.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41419-018-0477-1", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.7016466", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1042939", 
            "issn": [
              "2041-4889"
            ], 
            "name": "Cell Death & Disease", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "Repression of let-7a cluster prevents adhesion of colorectal cancer cells by enforcing a mesenchymal phenotype in presence of liver inflammation", 
        "pagination": "489", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "cad90afb561d9c7c48baf5b014eea0af876047737691fdd048d5fe9d42f578f0"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29695839"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101524092"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41419-018-0477-1"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1103631158"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41419-018-0477-1", 
          "https://app.dimensions.ai/details/publication/pub.1103631158"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T16:51", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000566.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41419-018-0477-1"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0477-1'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0477-1'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0477-1'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0477-1'


     

    This table displays all metadata directly associated to this object as RDF triples.

    312 TRIPLES      21 PREDICATES      89 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41419-018-0477-1 schema:about anzsrc-for:11
    2 anzsrc-for:1112
    3 schema:author Nb1374a590b5c4f4d8349339af60e19fe
    4 schema:citation sg:pub.10.1007/s00262-002-0363-6
    5 sg:pub.10.1007/s00262-008-0492-7
    6 sg:pub.10.1007/s00384-013-1656-2
    7 sg:pub.10.1038/35002607
    8 sg:pub.10.1038/cr.2008.81
    9 sg:pub.10.1038/nrc2620
    10 sg:pub.10.1038/onc.2011.383
    11 sg:pub.10.1038/onc.2012.573
    12 sg:pub.10.1038/onc.2013.398
    13 sg:pub.10.1186/1476-4598-13-118
    14 sg:pub.10.1186/1476-511x-9-112
    15 sg:pub.10.1186/s12967-015-0462-8
    16 https://app.dimensions.ai/details/publication/pub.1074539442
    17 https://app.dimensions.ai/details/publication/pub.1077070077
    18 https://app.dimensions.ai/details/publication/pub.1077073281
    19 https://app.dimensions.ai/details/publication/pub.1077099323
    20 https://app.dimensions.ai/details/publication/pub.1077881322
    21 https://app.dimensions.ai/details/publication/pub.1078132530
    22 https://app.dimensions.ai/details/publication/pub.1083131355
    23 https://doi.org/10.1001/jama.1960.03030040020006
    24 https://doi.org/10.1002/(sici)1097-0142(19970615)79:12<2320::aid-cncr5>3.0.co;2-p
    25 https://doi.org/10.1002/(sici)1097-0142(20000201)88:3<577::aid-cncr13>3.0.co;2-v
    26 https://doi.org/10.1002/bjs.5278
    27 https://doi.org/10.1002/ijc.20050
    28 https://doi.org/10.1002/jcb.10142
    29 https://doi.org/10.1016/j.bbrc.2011.04.074
    30 https://doi.org/10.1016/j.cancergen.2012.08.003
    31 https://doi.org/10.1016/j.ccr.2006.01.025
    32 https://doi.org/10.1016/j.cell.2014.12.018
    33 https://doi.org/10.1016/j.cell.2015.01.023
    34 https://doi.org/10.1016/j.clinbiochem.2016.07.011
    35 https://doi.org/10.1016/j.clinre.2013.05.010
    36 https://doi.org/10.1016/j.molimm.2004.07.039
    37 https://doi.org/10.1016/s0002-9610(01)00634-1
    38 https://doi.org/10.1016/s0002-9610(99)00045-8
    39 https://doi.org/10.1016/s0140-6736(10)60353-4
    40 https://doi.org/10.1016/s0140-6736(12)61728-0
    41 https://doi.org/10.1016/s0140-6736(13)61649-9
    42 https://doi.org/10.1042/cs20070328
    43 https://doi.org/10.1053/j.gastro.2012.11.033
    44 https://doi.org/10.1053/j.gastro.2013.04.004
    45 https://doi.org/10.1073/pnas.95.13.7556
    46 https://doi.org/10.1097/00000441-195702000-00005
    47 https://doi.org/10.1097/01.sla.0000217629.94941.cf
    48 https://doi.org/10.1097/meg.0b013e32831bc3d6
    49 https://doi.org/10.1111/j.1440-1827.1975.tb00854.x
    50 https://doi.org/10.1136/gutjnl-2011-301846
    51 https://doi.org/10.1146/annurev.biochem.67.1.227
    52 https://doi.org/10.1158/0008-5472.can-04-0637
    53 https://doi.org/10.1158/0008-5472.can-13-2203
    54 https://doi.org/10.1182/blood-2004-04-1422
    55 https://doi.org/10.3109/07357900902769749
    56 https://doi.org/10.3322/caac.21208
    57 https://doi.org/10.3748/wjg.v17.i13.1725
    58 https://doi.org/10.3748/wjg.v17.i26.3092
    59 https://doi.org/10.3748/wjg.v17.i6.804
    60 https://doi.org/10.4161/cc.8.6.7907
    61 https://doi.org/10.5754/hge11259
    62 https://doi.org/10.5754/hge11747
    63 https://doi.org/10.5754/hge12564
    64 schema:datePublished 2018-05
    65 schema:datePublishedReg 2018-05-01
    66 schema:description The liver is the most common site of metastasis in patients with colorectal cancer, and colorectal cancer liver metastasis (CRLM) is associated with poor rates of survival. However, CRLM occurs infrequently in livers exhibiting signs of hepatitis or cirrhosis, suggesting a role for inflammation in attenuating CRLM. The molecular mechanisms driving this phenomenon remain unclear. The aim of this study was to confirm the mechanism by which liver inflammation inhibits CRLM. We used BALB/c animal models of inflammatory liver diseases to confirm that liver inflammation inhibits CRLM, and then elucidated the molecular mechanisms governing that process. Out data showed that liver inflammation induces IFN-γ expression, which then downregulates expression of the let-7a cluster through IRF-1 in colorectal cancer cells. Finally, we showed that modulation of let-7a expression regulated the epithelial-mesenchymal transition in colorectal cancer cell lines, and inhibited their capacity to metastasize in vivo. Cumulatively, we clarified the critical role played by the IFN-γ/IRF-1/let-7a cluster/EMT pathway in regulating the spread of circulating colorectal cancer cells to the liver, and highlighted the critical role that the hepatitis microenvironment plays in modulating that process.
    67 schema:genre research_article
    68 schema:inLanguage en
    69 schema:isAccessibleForFree true
    70 schema:isPartOf Nabc2bd4521b94da39d24a3037b07356b
    71 Nb779eb555160463c8d1f3db078753650
    72 sg:journal.1042939
    73 schema:name Repression of let-7a cluster prevents adhesion of colorectal cancer cells by enforcing a mesenchymal phenotype in presence of liver inflammation
    74 schema:pagination 489
    75 schema:productId N415874d6292845ee8769a4586df4787f
    76 N47d6e4444139451ab2a29ce07f7ec802
    77 N7cb96fdc6b6440ccb68bb5005780c2d8
    78 N8e0fb7d34a08423ea7ea531e6fd6fcef
    79 Nf75f89ffa4b6452794e3cc984d835952
    80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103631158
    81 https://doi.org/10.1038/s41419-018-0477-1
    82 schema:sdDatePublished 2019-04-10T16:51
    83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    84 schema:sdPublisher N11534bf5d5d346948f63542a04167216
    85 schema:url https://www.nature.com/articles/s41419-018-0477-1
    86 sgo:license sg:explorer/license/
    87 sgo:sdDataset articles
    88 rdf:type schema:ScholarlyArticle
    89 N05a7e5d1312242fdba8178ea063ad97d rdf:first N0c908c6fc7ed442db33925d04b27f076
    90 rdf:rest N36161e65544a44e18590144eadb20a7b
    91 N0c908c6fc7ed442db33925d04b27f076 schema:affiliation https://www.grid.ac/institutes/grid.452207.6
    92 schema:familyName Fu
    93 schema:givenName Jun
    94 rdf:type schema:Person
    95 N11534bf5d5d346948f63542a04167216 schema:name Springer Nature - SN SciGraph project
    96 rdf:type schema:Organization
    97 N129786f5ed994c57bdf6b78e01fbd695 rdf:first sg:person.01054744646.34
    98 rdf:rest Ndc4e9815a63e472dadee2e161520f31a
    99 N36161e65544a44e18590144eadb20a7b rdf:first Nd71f841b2b1b418b8c9dfe41f30f65de
    100 rdf:rest Na22b861a7a11435898c636c538f1ead4
    101 N415874d6292845ee8769a4586df4787f schema:name nlm_unique_id
    102 schema:value 101524092
    103 rdf:type schema:PropertyValue
    104 N47d6e4444139451ab2a29ce07f7ec802 schema:name dimensions_id
    105 schema:value pub.1103631158
    106 rdf:type schema:PropertyValue
    107 N5a85a8e17eeb41a698ad90faed5611da rdf:first N768a7e91ccce4246b03d2e12acc4c434
    108 rdf:rest N05a7e5d1312242fdba8178ea063ad97d
    109 N5ce3e9111ffe4fdd9178d9f0c09c60cb schema:affiliation https://www.grid.ac/institutes/grid.73113.37
    110 schema:familyName Cheng
    111 schema:givenName Lipeng
    112 rdf:type schema:Person
    113 N62f3d970224d430ba7ed53bc1ae509da rdf:first Ne0a430fca930420fb1588a94d7b8c581
    114 rdf:rest Nf245004da95c4fe19e3f922b92316300
    115 N768a7e91ccce4246b03d2e12acc4c434 schema:affiliation N9af1bcdaa7e744fab9fbde881e6a58f0
    116 schema:familyName Zheng
    117 schema:givenName Tao
    118 rdf:type schema:Person
    119 N7cb96fdc6b6440ccb68bb5005780c2d8 schema:name pubmed_id
    120 schema:value 29695839
    121 rdf:type schema:PropertyValue
    122 N8e0fb7d34a08423ea7ea531e6fd6fcef schema:name doi
    123 schema:value 10.1038/s41419-018-0477-1
    124 rdf:type schema:PropertyValue
    125 N9af1bcdaa7e744fab9fbde881e6a58f0 schema:name Department of General Surgery, People’s Liberation Army Nanjing General Hospital, 210002, Nanjing, China
    126 rdf:type schema:Organization
    127 Na22b861a7a11435898c636c538f1ead4 rdf:first sg:person.016014414555.62
    128 rdf:rest N62f3d970224d430ba7ed53bc1ae509da
    129 Nabc2bd4521b94da39d24a3037b07356b schema:volumeNumber 9
    130 rdf:type schema:PublicationVolume
    131 Nb1374a590b5c4f4d8349339af60e19fe rdf:first N5ce3e9111ffe4fdd9178d9f0c09c60cb
    132 rdf:rest N129786f5ed994c57bdf6b78e01fbd695
    133 Nb779eb555160463c8d1f3db078753650 schema:issueNumber 5
    134 rdf:type schema:PublicationIssue
    135 Nd71f841b2b1b418b8c9dfe41f30f65de schema:affiliation https://www.grid.ac/institutes/grid.73113.37
    136 schema:familyName Qiao
    137 schema:givenName Liang
    138 rdf:type schema:Person
    139 Ndc4e9815a63e472dadee2e161520f31a rdf:first sg:person.0624407672.12
    140 rdf:rest N5a85a8e17eeb41a698ad90faed5611da
    141 Ne0a430fca930420fb1588a94d7b8c581 schema:affiliation https://www.grid.ac/institutes/grid.73113.37
    142 schema:familyName Wang
    143 schema:givenName Yue
    144 rdf:type schema:Person
    145 Nf245004da95c4fe19e3f922b92316300 rdf:first sg:person.01006222700.26
    146 rdf:rest rdf:nil
    147 Nf75f89ffa4b6452794e3cc984d835952 schema:name readcube_id
    148 schema:value cad90afb561d9c7c48baf5b014eea0af876047737691fdd048d5fe9d42f578f0
    149 rdf:type schema:PropertyValue
    150 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    151 schema:name Medical and Health Sciences
    152 rdf:type schema:DefinedTerm
    153 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    154 schema:name Oncology and Carcinogenesis
    155 rdf:type schema:DefinedTerm
    156 sg:grant.7016466 http://pending.schema.org/fundedItem sg:pub.10.1038/s41419-018-0477-1
    157 rdf:type schema:MonetaryGrant
    158 sg:journal.1042939 schema:issn 2041-4889
    159 schema:name Cell Death & Disease
    160 rdf:type schema:Periodical
    161 sg:person.01006222700.26 schema:affiliation https://www.grid.ac/institutes/grid.73113.37
    162 schema:familyName Yang
    163 schema:givenName Jiamei
    164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006222700.26
    165 rdf:type schema:Person
    166 sg:person.01054744646.34 schema:affiliation https://www.grid.ac/institutes/grid.73113.37
    167 schema:familyName Geng
    168 schema:givenName Li
    169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054744646.34
    170 rdf:type schema:Person
    171 sg:person.016014414555.62 schema:affiliation https://www.grid.ac/institutes/grid.73113.37
    172 schema:familyName Cai
    173 schema:givenName Wenchang
    174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016014414555.62
    175 rdf:type schema:Person
    176 sg:person.0624407672.12 schema:affiliation https://www.grid.ac/institutes/grid.73113.37
    177 schema:familyName Dai
    178 schema:givenName Binghua
    179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624407672.12
    180 rdf:type schema:Person
    181 sg:pub.10.1007/s00262-002-0363-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075240190
    182 https://doi.org/10.1007/s00262-002-0363-6
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1007/s00262-008-0492-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005994550
    185 https://doi.org/10.1007/s00262-008-0492-7
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1007/s00384-013-1656-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004004225
    188 https://doi.org/10.1007/s00384-013-1656-2
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1038/35002607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047689840
    191 https://doi.org/10.1038/35002607
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1038/cr.2008.81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003277282
    194 https://doi.org/10.1038/cr.2008.81
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/nrc2620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000031106
    197 https://doi.org/10.1038/nrc2620
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/onc.2011.383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025525510
    200 https://doi.org/10.1038/onc.2011.383
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/onc.2012.573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030198930
    203 https://doi.org/10.1038/onc.2012.573
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/onc.2013.398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004462354
    206 https://doi.org/10.1038/onc.2013.398
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1186/1476-4598-13-118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048557566
    209 https://doi.org/10.1186/1476-4598-13-118
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1186/1476-511x-9-112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048278785
    212 https://doi.org/10.1186/1476-511x-9-112
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1186/s12967-015-0462-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026693276
    215 https://doi.org/10.1186/s12967-015-0462-8
    216 rdf:type schema:CreativeWork
    217 https://app.dimensions.ai/details/publication/pub.1074539442 schema:CreativeWork
    218 https://app.dimensions.ai/details/publication/pub.1077070077 schema:CreativeWork
    219 https://app.dimensions.ai/details/publication/pub.1077073281 schema:CreativeWork
    220 https://app.dimensions.ai/details/publication/pub.1077099323 schema:CreativeWork
    221 https://app.dimensions.ai/details/publication/pub.1077881322 schema:CreativeWork
    222 https://app.dimensions.ai/details/publication/pub.1078132530 schema:CreativeWork
    223 https://app.dimensions.ai/details/publication/pub.1083131355 schema:CreativeWork
    224 https://doi.org/10.1001/jama.1960.03030040020006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007015652
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1002/(sici)1097-0142(19970615)79:12<2320::aid-cncr5>3.0.co;2-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1020837704
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1002/(sici)1097-0142(20000201)88:3<577::aid-cncr13>3.0.co;2-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1036295371
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1002/bjs.5278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036508017
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1002/ijc.20050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015847568
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1002/jcb.10142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011337365
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1016/j.bbrc.2011.04.074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001664537
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1016/j.cancergen.2012.08.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035871068
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1016/j.ccr.2006.01.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020260886
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1016/j.cell.2014.12.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020098607
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1016/j.cell.2015.01.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037221827
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1016/j.clinbiochem.2016.07.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036571318
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1016/j.clinre.2013.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001297695
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1016/j.molimm.2004.07.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000273076
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1016/s0002-9610(01)00634-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021229258
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1016/s0002-9610(99)00045-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039997050
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1016/s0140-6736(10)60353-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008954947
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1016/s0140-6736(12)61728-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013705877
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1016/s0140-6736(13)61649-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038306846
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1042/cs20070328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032969547
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1053/j.gastro.2012.11.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039440977
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1053/j.gastro.2013.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012005862
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1073/pnas.95.13.7556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022907036
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1097/00000441-195702000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014854294
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1097/01.sla.0000217629.94941.cf schema:sameAs https://app.dimensions.ai/details/publication/pub.1008912065
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1097/meg.0b013e32831bc3d6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014313524
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1111/j.1440-1827.1975.tb00854.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006472908
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1136/gutjnl-2011-301846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036909369
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1146/annurev.biochem.67.1.227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033786268
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1158/0008-5472.can-04-0637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030947986
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1158/0008-5472.can-13-2203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016474746
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1182/blood-2004-04-1422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010370857
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.3109/07357900902769749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006201507
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.3322/caac.21208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041182772
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.3748/wjg.v17.i13.1725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071367475
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.3748/wjg.v17.i26.3092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078447788
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.3748/wjg.v17.i6.804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071368050
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.4161/cc.8.6.7907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072300616
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.5754/hge11259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073100435
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.5754/hge11747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073100570
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.5754/hge12564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073100773
    305 rdf:type schema:CreativeWork
    306 https://www.grid.ac/institutes/grid.452207.6 schema:alternateName Xuzhou Central Hospital
    307 schema:name Department of Hepatobiliary Pancreatic and Spleen Surgery, Xuzhou Central Hospital, 221000, Xuzhou, China
    308 rdf:type schema:Organization
    309 https://www.grid.ac/institutes/grid.73113.37 schema:alternateName Second Military Medical University
    310 schema:name Department of Special Treatment and Liver Transplantation, Shanghai Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 200438, Shanghai, China
    311 Research Center of Developmental Biology, Second Military Medical University, 200433, Shanghai, China
    312 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...