Repression of let-7a cluster prevents adhesion of colorectal cancer cells by enforcing a mesenchymal phenotype in presence of liver inflammation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-05

AUTHORS

Lipeng Cheng, Li Geng, Binghua Dai, Tao Zheng, Jun Fu, Liang Qiao, Wenchang Cai, Yue Wang, Jiamei Yang

ABSTRACT

The liver is the most common site of metastasis in patients with colorectal cancer, and colorectal cancer liver metastasis (CRLM) is associated with poor rates of survival. However, CRLM occurs infrequently in livers exhibiting signs of hepatitis or cirrhosis, suggesting a role for inflammation in attenuating CRLM. The molecular mechanisms driving this phenomenon remain unclear. The aim of this study was to confirm the mechanism by which liver inflammation inhibits CRLM. We used BALB/c animal models of inflammatory liver diseases to confirm that liver inflammation inhibits CRLM, and then elucidated the molecular mechanisms governing that process. Out data showed that liver inflammation induces IFN-γ expression, which then downregulates expression of the let-7a cluster through IRF-1 in colorectal cancer cells. Finally, we showed that modulation of let-7a expression regulated the epithelial-mesenchymal transition in colorectal cancer cell lines, and inhibited their capacity to metastasize in vivo. Cumulatively, we clarified the critical role played by the IFN-γ/IRF-1/let-7a cluster/EMT pathway in regulating the spread of circulating colorectal cancer cells to the liver, and highlighted the critical role that the hepatitis microenvironment plays in modulating that process. More... »

PAGES

489

References to SciGraph publications

  • 2014-12. Loss of miR-638 in vitro promotes cell invasion and a mesenchymal-like transition by influencing SOX2 expression in colorectal carcinoma cells in MOLECULAR CANCER
  • 2014-07. Impaired DICER1 function promotes stemness and metastasis in colon cancer in ONCOGENE
  • 2013-08. Hepatic steatosis is associated with lower incidence of liver metastasis from colorectal cancer in INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
  • 2008-10. NK cell-mediated targeting of human cancer and possibilities for new means of immunotherapy in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2010-12. Effect of ω-3 and ω-9 fatty acid rich oils on lipoxygenases and cyclooxygenases enzymes and on the growth of a mammary adenocarcinoma model in LIPIDS IN HEALTH AND DISEASE
  • 2013-11. Stat3-coordinated Lin-28–let-7–HMGA2 and miR-200–ZEB1 circuits initiate and maintain oncostatin M-driven epithelial–mesenchymal transition in ONCOGENE
  • 2003-02. A basal membrane-like structure surrounding tumour nodules may prevent intraepithelial leucocyte infiltration in colorectal cancer in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2000-02. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans in NATURE
  • 2015-12. Let-7a inhibits migration, invasion and epithelial-mesenchymal transition by targeting HMGA2 in nasopharyngeal carcinoma in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2008-08. Overlapping expression of microRNAs in human embryonic colon and colorectal cancer in CELL RESEARCH
  • 2009-04. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits in NATURE REVIEWS CANCER
  • 2012-04. Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis in ONCOGENE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41419-018-0477-1

    DOI

    http://dx.doi.org/10.1038/s41419-018-0477-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1103631158

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29695839


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Second Military Medical University", 
              "id": "https://www.grid.ac/institutes/grid.73113.37", 
              "name": [
                "Department of Special Treatment and Liver Transplantation, Shanghai Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 200438, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cheng", 
            "givenName": "Lipeng", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Second Military Medical University", 
              "id": "https://www.grid.ac/institutes/grid.73113.37", 
              "name": [
                "Department of Special Treatment and Liver Transplantation, Shanghai Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 200438, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Geng", 
            "givenName": "Li", 
            "id": "sg:person.01054744646.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054744646.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Second Military Medical University", 
              "id": "https://www.grid.ac/institutes/grid.73113.37", 
              "name": [
                "Department of Special Treatment and Liver Transplantation, Shanghai Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 200438, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dai", 
            "givenName": "Binghua", 
            "id": "sg:person.0624407672.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624407672.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of General Surgery, People\u2019s Liberation Army Nanjing General Hospital, 210002, Nanjing, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zheng", 
            "givenName": "Tao", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Xuzhou Central Hospital", 
              "id": "https://www.grid.ac/institutes/grid.452207.6", 
              "name": [
                "Department of Hepatobiliary Pancreatic and Spleen Surgery, Xuzhou Central Hospital, 221000, Xuzhou, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fu", 
            "givenName": "Jun", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Second Military Medical University", 
              "id": "https://www.grid.ac/institutes/grid.73113.37", 
              "name": [
                "Department of Special Treatment and Liver Transplantation, Shanghai Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 200438, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Qiao", 
            "givenName": "Liang", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Second Military Medical University", 
              "id": "https://www.grid.ac/institutes/grid.73113.37", 
              "name": [
                "Department of Special Treatment and Liver Transplantation, Shanghai Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 200438, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cai", 
            "givenName": "Wenchang", 
            "id": "sg:person.016014414555.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016014414555.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Second Military Medical University", 
              "id": "https://www.grid.ac/institutes/grid.73113.37", 
              "name": [
                "Research Center of Developmental Biology, Second Military Medical University, 200433, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Yue", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Second Military Medical University", 
              "id": "https://www.grid.ac/institutes/grid.73113.37", 
              "name": [
                "Department of Special Treatment and Liver Transplantation, Shanghai Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 200438, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yang", 
            "givenName": "Jiamei", 
            "id": "sg:person.01006222700.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006222700.26"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nrc2620", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000031106", 
              "https://doi.org/10.1038/nrc2620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molimm.2004.07.039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000273076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.clinre.2013.05.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001297695"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2011.04.074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001664537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2008.81", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003277282", 
              "https://doi.org/10.1038/cr.2008.81"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00384-013-1656-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004004225", 
              "https://doi.org/10.1007/s00384-013-1656-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2013.398", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004462354", 
              "https://doi.org/10.1038/onc.2013.398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00262-008-0492-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005994550", 
              "https://doi.org/10.1007/s00262-008-0492-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00262-008-0492-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005994550", 
              "https://doi.org/10.1007/s00262-008-0492-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/07357900902769749", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006201507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1440-1827.1975.tb00854.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006472908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.1960.03030040020006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007015652"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.sla.0000217629.94941.cf", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008912065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.sla.0000217629.94941.cf", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008912065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(10)60353-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008954947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2004-04-1422", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010370857"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcb.10142", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011337365"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2013.04.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012005862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(12)61728-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013705877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/meg.0b013e32831bc3d6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014313524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/meg.0b013e32831bc3d6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014313524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/meg.0b013e32831bc3d6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014313524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000441-195702000-00005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014854294"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000441-195702000-00005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014854294"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.20050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015847568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-13-2203", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016474746"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2014.12.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020098607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2006.01.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020260886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0142(19970615)79:12<2320::aid-cncr5>3.0.co;2-p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020837704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9610(01)00634-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021229258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.13.7556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022907036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2011.383", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025525510", 
              "https://doi.org/10.1038/onc.2011.383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12967-015-0462-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026693276", 
              "https://doi.org/10.1186/s12967-015-0462-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12967-015-0462-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026693276", 
              "https://doi.org/10.1186/s12967-015-0462-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12967-015-0462-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026693276", 
              "https://doi.org/10.1186/s12967-015-0462-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2012.573", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030198930", 
              "https://doi.org/10.1038/onc.2012.573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-04-0637", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030947986"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/cs20070328", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032969547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/cs20070328", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032969547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.biochem.67.1.227", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033786268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cancergen.2012.08.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035871068"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0142(20000201)88:3<577::aid-cncr13>3.0.co;2-v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036295371"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bjs.5278", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036508017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bjs.5278", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036508017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.clinbiochem.2016.07.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036571318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gutjnl-2011-301846", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036909369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2015.01.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037221827"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(13)61649-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038306846"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2012.11.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039440977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9610(99)00045-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039997050"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3322/caac.21208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041182772"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35002607", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047689840", 
              "https://doi.org/10.1038/35002607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35002607", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047689840", 
              "https://doi.org/10.1038/35002607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-511x-9-112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048278785", 
              "https://doi.org/10.1186/1476-511x-9-112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-4598-13-118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048557566", 
              "https://doi.org/10.1186/1476-4598-13-118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3748/wjg.v17.i13.1725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071367475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3748/wjg.v17.i6.804", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071368050"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.8.6.7907", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072300616"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5754/hge11259", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073100435"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5754/hge11747", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073100570"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5754/hge12564", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073100773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074539442", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00262-002-0363-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075240190", 
              "https://doi.org/10.1007/s00262-002-0363-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077070077", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077073281", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077099323", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077881322", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078132530", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3748/wjg.v17.i26.3092", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078447788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083131355", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-05", 
        "datePublishedReg": "2018-05-01", 
        "description": "The liver is the most common site of metastasis in patients with colorectal cancer, and colorectal cancer liver metastasis (CRLM) is associated with poor rates of survival. However, CRLM occurs infrequently in livers exhibiting signs of hepatitis or cirrhosis, suggesting a role for inflammation in attenuating CRLM. The molecular mechanisms driving this phenomenon remain unclear. The aim of this study was to confirm the mechanism by which liver inflammation inhibits CRLM. We used BALB/c animal models of inflammatory liver diseases to confirm that liver inflammation inhibits CRLM, and then elucidated the molecular mechanisms governing that process. Out data showed that liver inflammation induces IFN-\u03b3 expression, which then downregulates expression of the let-7a cluster through IRF-1 in colorectal cancer cells. Finally, we showed that modulation of let-7a expression regulated the epithelial-mesenchymal transition in colorectal cancer cell lines, and inhibited their capacity to metastasize in vivo. Cumulatively, we clarified the critical role played by the IFN-\u03b3/IRF-1/let-7a cluster/EMT pathway in regulating the spread of circulating colorectal cancer cells to the liver, and highlighted the critical role that the hepatitis microenvironment plays in modulating that process.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41419-018-0477-1", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.7016466", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1042939", 
            "issn": [
              "2041-4889"
            ], 
            "name": "Cell Death & Disease", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "Repression of let-7a cluster prevents adhesion of colorectal cancer cells by enforcing a mesenchymal phenotype in presence of liver inflammation", 
        "pagination": "489", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "cad90afb561d9c7c48baf5b014eea0af876047737691fdd048d5fe9d42f578f0"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29695839"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101524092"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41419-018-0477-1"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1103631158"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41419-018-0477-1", 
          "https://app.dimensions.ai/details/publication/pub.1103631158"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T16:51", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000566.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41419-018-0477-1"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0477-1'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0477-1'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0477-1'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41419-018-0477-1'


     

    This table displays all metadata directly associated to this object as RDF triples.

    312 TRIPLES      21 PREDICATES      89 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41419-018-0477-1 schema:about anzsrc-for:11
    2 anzsrc-for:1112
    3 schema:author Na0cb966bc4124b9e840a9b03470a5dc5
    4 schema:citation sg:pub.10.1007/s00262-002-0363-6
    5 sg:pub.10.1007/s00262-008-0492-7
    6 sg:pub.10.1007/s00384-013-1656-2
    7 sg:pub.10.1038/35002607
    8 sg:pub.10.1038/cr.2008.81
    9 sg:pub.10.1038/nrc2620
    10 sg:pub.10.1038/onc.2011.383
    11 sg:pub.10.1038/onc.2012.573
    12 sg:pub.10.1038/onc.2013.398
    13 sg:pub.10.1186/1476-4598-13-118
    14 sg:pub.10.1186/1476-511x-9-112
    15 sg:pub.10.1186/s12967-015-0462-8
    16 https://app.dimensions.ai/details/publication/pub.1074539442
    17 https://app.dimensions.ai/details/publication/pub.1077070077
    18 https://app.dimensions.ai/details/publication/pub.1077073281
    19 https://app.dimensions.ai/details/publication/pub.1077099323
    20 https://app.dimensions.ai/details/publication/pub.1077881322
    21 https://app.dimensions.ai/details/publication/pub.1078132530
    22 https://app.dimensions.ai/details/publication/pub.1083131355
    23 https://doi.org/10.1001/jama.1960.03030040020006
    24 https://doi.org/10.1002/(sici)1097-0142(19970615)79:12<2320::aid-cncr5>3.0.co;2-p
    25 https://doi.org/10.1002/(sici)1097-0142(20000201)88:3<577::aid-cncr13>3.0.co;2-v
    26 https://doi.org/10.1002/bjs.5278
    27 https://doi.org/10.1002/ijc.20050
    28 https://doi.org/10.1002/jcb.10142
    29 https://doi.org/10.1016/j.bbrc.2011.04.074
    30 https://doi.org/10.1016/j.cancergen.2012.08.003
    31 https://doi.org/10.1016/j.ccr.2006.01.025
    32 https://doi.org/10.1016/j.cell.2014.12.018
    33 https://doi.org/10.1016/j.cell.2015.01.023
    34 https://doi.org/10.1016/j.clinbiochem.2016.07.011
    35 https://doi.org/10.1016/j.clinre.2013.05.010
    36 https://doi.org/10.1016/j.molimm.2004.07.039
    37 https://doi.org/10.1016/s0002-9610(01)00634-1
    38 https://doi.org/10.1016/s0002-9610(99)00045-8
    39 https://doi.org/10.1016/s0140-6736(10)60353-4
    40 https://doi.org/10.1016/s0140-6736(12)61728-0
    41 https://doi.org/10.1016/s0140-6736(13)61649-9
    42 https://doi.org/10.1042/cs20070328
    43 https://doi.org/10.1053/j.gastro.2012.11.033
    44 https://doi.org/10.1053/j.gastro.2013.04.004
    45 https://doi.org/10.1073/pnas.95.13.7556
    46 https://doi.org/10.1097/00000441-195702000-00005
    47 https://doi.org/10.1097/01.sla.0000217629.94941.cf
    48 https://doi.org/10.1097/meg.0b013e32831bc3d6
    49 https://doi.org/10.1111/j.1440-1827.1975.tb00854.x
    50 https://doi.org/10.1136/gutjnl-2011-301846
    51 https://doi.org/10.1146/annurev.biochem.67.1.227
    52 https://doi.org/10.1158/0008-5472.can-04-0637
    53 https://doi.org/10.1158/0008-5472.can-13-2203
    54 https://doi.org/10.1182/blood-2004-04-1422
    55 https://doi.org/10.3109/07357900902769749
    56 https://doi.org/10.3322/caac.21208
    57 https://doi.org/10.3748/wjg.v17.i13.1725
    58 https://doi.org/10.3748/wjg.v17.i26.3092
    59 https://doi.org/10.3748/wjg.v17.i6.804
    60 https://doi.org/10.4161/cc.8.6.7907
    61 https://doi.org/10.5754/hge11259
    62 https://doi.org/10.5754/hge11747
    63 https://doi.org/10.5754/hge12564
    64 schema:datePublished 2018-05
    65 schema:datePublishedReg 2018-05-01
    66 schema:description The liver is the most common site of metastasis in patients with colorectal cancer, and colorectal cancer liver metastasis (CRLM) is associated with poor rates of survival. However, CRLM occurs infrequently in livers exhibiting signs of hepatitis or cirrhosis, suggesting a role for inflammation in attenuating CRLM. The molecular mechanisms driving this phenomenon remain unclear. The aim of this study was to confirm the mechanism by which liver inflammation inhibits CRLM. We used BALB/c animal models of inflammatory liver diseases to confirm that liver inflammation inhibits CRLM, and then elucidated the molecular mechanisms governing that process. Out data showed that liver inflammation induces IFN-γ expression, which then downregulates expression of the let-7a cluster through IRF-1 in colorectal cancer cells. Finally, we showed that modulation of let-7a expression regulated the epithelial-mesenchymal transition in colorectal cancer cell lines, and inhibited their capacity to metastasize in vivo. Cumulatively, we clarified the critical role played by the IFN-γ/IRF-1/let-7a cluster/EMT pathway in regulating the spread of circulating colorectal cancer cells to the liver, and highlighted the critical role that the hepatitis microenvironment plays in modulating that process.
    67 schema:genre research_article
    68 schema:inLanguage en
    69 schema:isAccessibleForFree true
    70 schema:isPartOf N7495845404534f40ba838dcaeaecea65
    71 Ncd3c9e37cebb427cab947f2020be3be8
    72 sg:journal.1042939
    73 schema:name Repression of let-7a cluster prevents adhesion of colorectal cancer cells by enforcing a mesenchymal phenotype in presence of liver inflammation
    74 schema:pagination 489
    75 schema:productId N03bca5b3dff740caac643ffff1a34d5f
    76 N137e1826c2b24686a63b4c844edf2beb
    77 N40a6118bc938488fa4ac40860d80ffcd
    78 N50d91d6f7c9a47c29782544b4dc356ac
    79 Na9dadf3aad544ba3b0283895b75fbbea
    80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103631158
    81 https://doi.org/10.1038/s41419-018-0477-1
    82 schema:sdDatePublished 2019-04-10T16:51
    83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    84 schema:sdPublisher N3a3fb717ddee4693bb811d9dfba93714
    85 schema:url https://www.nature.com/articles/s41419-018-0477-1
    86 sgo:license sg:explorer/license/
    87 sgo:sdDataset articles
    88 rdf:type schema:ScholarlyArticle
    89 N03bca5b3dff740caac643ffff1a34d5f schema:name nlm_unique_id
    90 schema:value 101524092
    91 rdf:type schema:PropertyValue
    92 N137e1826c2b24686a63b4c844edf2beb schema:name pubmed_id
    93 schema:value 29695839
    94 rdf:type schema:PropertyValue
    95 N15f88536df65485a8e8a168308b8c30e rdf:first N9ccd851c9f364be8addfe7c92120a8f6
    96 rdf:rest N6d44b38de2dd4ad2a5c0eed249d9570f
    97 N2a7c635e33a445cb97613380cac2245c rdf:first N2bcfbd18fb4b4718bb6fe704772c5afe
    98 rdf:rest Nb5a72198352941749f537b9ead169d4b
    99 N2bcfbd18fb4b4718bb6fe704772c5afe schema:affiliation N8e7610c259964d4ead34b81998c9ac60
    100 schema:familyName Zheng
    101 schema:givenName Tao
    102 rdf:type schema:Person
    103 N3a3fb717ddee4693bb811d9dfba93714 schema:name Springer Nature - SN SciGraph project
    104 rdf:type schema:Organization
    105 N40a6118bc938488fa4ac40860d80ffcd schema:name readcube_id
    106 schema:value cad90afb561d9c7c48baf5b014eea0af876047737691fdd048d5fe9d42f578f0
    107 rdf:type schema:PropertyValue
    108 N50d91d6f7c9a47c29782544b4dc356ac schema:name doi
    109 schema:value 10.1038/s41419-018-0477-1
    110 rdf:type schema:PropertyValue
    111 N61180df99a644db282c1a68afd40d78b rdf:first Nbce6c0d46ed24e31a5598ff9e1309c51
    112 rdf:rest Nfe3275aedf874490ae351df68c1e2fe0
    113 N6d44b38de2dd4ad2a5c0eed249d9570f rdf:first sg:person.016014414555.62
    114 rdf:rest N61180df99a644db282c1a68afd40d78b
    115 N7495845404534f40ba838dcaeaecea65 schema:volumeNumber 9
    116 rdf:type schema:PublicationVolume
    117 N81f021a866984dbba8eb09a553e2eb1c schema:affiliation https://www.grid.ac/institutes/grid.452207.6
    118 schema:familyName Fu
    119 schema:givenName Jun
    120 rdf:type schema:Person
    121 N8e7610c259964d4ead34b81998c9ac60 schema:name Department of General Surgery, People’s Liberation Army Nanjing General Hospital, 210002, Nanjing, China
    122 rdf:type schema:Organization
    123 N9ccd851c9f364be8addfe7c92120a8f6 schema:affiliation https://www.grid.ac/institutes/grid.73113.37
    124 schema:familyName Qiao
    125 schema:givenName Liang
    126 rdf:type schema:Person
    127 Na0cb966bc4124b9e840a9b03470a5dc5 rdf:first Nd4f588ea9f0c4305b06de6023f2cc39f
    128 rdf:rest Nd1e69d888e9f4f22804ce0847541a06a
    129 Na9dadf3aad544ba3b0283895b75fbbea schema:name dimensions_id
    130 schema:value pub.1103631158
    131 rdf:type schema:PropertyValue
    132 Nb5a72198352941749f537b9ead169d4b rdf:first N81f021a866984dbba8eb09a553e2eb1c
    133 rdf:rest N15f88536df65485a8e8a168308b8c30e
    134 Nbce6c0d46ed24e31a5598ff9e1309c51 schema:affiliation https://www.grid.ac/institutes/grid.73113.37
    135 schema:familyName Wang
    136 schema:givenName Yue
    137 rdf:type schema:Person
    138 Ncd3c9e37cebb427cab947f2020be3be8 schema:issueNumber 5
    139 rdf:type schema:PublicationIssue
    140 Nd1e69d888e9f4f22804ce0847541a06a rdf:first sg:person.01054744646.34
    141 rdf:rest Ned2311710d994bb3811a2ab17f0ef303
    142 Nd4f588ea9f0c4305b06de6023f2cc39f schema:affiliation https://www.grid.ac/institutes/grid.73113.37
    143 schema:familyName Cheng
    144 schema:givenName Lipeng
    145 rdf:type schema:Person
    146 Ned2311710d994bb3811a2ab17f0ef303 rdf:first sg:person.0624407672.12
    147 rdf:rest N2a7c635e33a445cb97613380cac2245c
    148 Nfe3275aedf874490ae351df68c1e2fe0 rdf:first sg:person.01006222700.26
    149 rdf:rest rdf:nil
    150 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    151 schema:name Medical and Health Sciences
    152 rdf:type schema:DefinedTerm
    153 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    154 schema:name Oncology and Carcinogenesis
    155 rdf:type schema:DefinedTerm
    156 sg:grant.7016466 http://pending.schema.org/fundedItem sg:pub.10.1038/s41419-018-0477-1
    157 rdf:type schema:MonetaryGrant
    158 sg:journal.1042939 schema:issn 2041-4889
    159 schema:name Cell Death & Disease
    160 rdf:type schema:Periodical
    161 sg:person.01006222700.26 schema:affiliation https://www.grid.ac/institutes/grid.73113.37
    162 schema:familyName Yang
    163 schema:givenName Jiamei
    164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006222700.26
    165 rdf:type schema:Person
    166 sg:person.01054744646.34 schema:affiliation https://www.grid.ac/institutes/grid.73113.37
    167 schema:familyName Geng
    168 schema:givenName Li
    169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054744646.34
    170 rdf:type schema:Person
    171 sg:person.016014414555.62 schema:affiliation https://www.grid.ac/institutes/grid.73113.37
    172 schema:familyName Cai
    173 schema:givenName Wenchang
    174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016014414555.62
    175 rdf:type schema:Person
    176 sg:person.0624407672.12 schema:affiliation https://www.grid.ac/institutes/grid.73113.37
    177 schema:familyName Dai
    178 schema:givenName Binghua
    179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624407672.12
    180 rdf:type schema:Person
    181 sg:pub.10.1007/s00262-002-0363-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075240190
    182 https://doi.org/10.1007/s00262-002-0363-6
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1007/s00262-008-0492-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005994550
    185 https://doi.org/10.1007/s00262-008-0492-7
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1007/s00384-013-1656-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004004225
    188 https://doi.org/10.1007/s00384-013-1656-2
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1038/35002607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047689840
    191 https://doi.org/10.1038/35002607
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1038/cr.2008.81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003277282
    194 https://doi.org/10.1038/cr.2008.81
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/nrc2620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000031106
    197 https://doi.org/10.1038/nrc2620
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/onc.2011.383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025525510
    200 https://doi.org/10.1038/onc.2011.383
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/onc.2012.573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030198930
    203 https://doi.org/10.1038/onc.2012.573
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/onc.2013.398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004462354
    206 https://doi.org/10.1038/onc.2013.398
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1186/1476-4598-13-118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048557566
    209 https://doi.org/10.1186/1476-4598-13-118
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1186/1476-511x-9-112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048278785
    212 https://doi.org/10.1186/1476-511x-9-112
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1186/s12967-015-0462-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026693276
    215 https://doi.org/10.1186/s12967-015-0462-8
    216 rdf:type schema:CreativeWork
    217 https://app.dimensions.ai/details/publication/pub.1074539442 schema:CreativeWork
    218 https://app.dimensions.ai/details/publication/pub.1077070077 schema:CreativeWork
    219 https://app.dimensions.ai/details/publication/pub.1077073281 schema:CreativeWork
    220 https://app.dimensions.ai/details/publication/pub.1077099323 schema:CreativeWork
    221 https://app.dimensions.ai/details/publication/pub.1077881322 schema:CreativeWork
    222 https://app.dimensions.ai/details/publication/pub.1078132530 schema:CreativeWork
    223 https://app.dimensions.ai/details/publication/pub.1083131355 schema:CreativeWork
    224 https://doi.org/10.1001/jama.1960.03030040020006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007015652
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1002/(sici)1097-0142(19970615)79:12<2320::aid-cncr5>3.0.co;2-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1020837704
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1002/(sici)1097-0142(20000201)88:3<577::aid-cncr13>3.0.co;2-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1036295371
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1002/bjs.5278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036508017
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1002/ijc.20050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015847568
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1002/jcb.10142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011337365
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1016/j.bbrc.2011.04.074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001664537
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1016/j.cancergen.2012.08.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035871068
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1016/j.ccr.2006.01.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020260886
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1016/j.cell.2014.12.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020098607
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1016/j.cell.2015.01.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037221827
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1016/j.clinbiochem.2016.07.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036571318
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1016/j.clinre.2013.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001297695
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1016/j.molimm.2004.07.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000273076
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1016/s0002-9610(01)00634-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021229258
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1016/s0002-9610(99)00045-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039997050
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1016/s0140-6736(10)60353-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008954947
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1016/s0140-6736(12)61728-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013705877
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1016/s0140-6736(13)61649-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038306846
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1042/cs20070328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032969547
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1053/j.gastro.2012.11.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039440977
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1053/j.gastro.2013.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012005862
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1073/pnas.95.13.7556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022907036
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1097/00000441-195702000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014854294
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1097/01.sla.0000217629.94941.cf schema:sameAs https://app.dimensions.ai/details/publication/pub.1008912065
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1097/meg.0b013e32831bc3d6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014313524
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1111/j.1440-1827.1975.tb00854.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006472908
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1136/gutjnl-2011-301846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036909369
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1146/annurev.biochem.67.1.227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033786268
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1158/0008-5472.can-04-0637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030947986
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1158/0008-5472.can-13-2203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016474746
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1182/blood-2004-04-1422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010370857
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.3109/07357900902769749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006201507
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.3322/caac.21208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041182772
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.3748/wjg.v17.i13.1725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071367475
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.3748/wjg.v17.i26.3092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078447788
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.3748/wjg.v17.i6.804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071368050
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.4161/cc.8.6.7907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072300616
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.5754/hge11259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073100435
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.5754/hge11747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073100570
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.5754/hge12564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073100773
    305 rdf:type schema:CreativeWork
    306 https://www.grid.ac/institutes/grid.452207.6 schema:alternateName Xuzhou Central Hospital
    307 schema:name Department of Hepatobiliary Pancreatic and Spleen Surgery, Xuzhou Central Hospital, 221000, Xuzhou, China
    308 rdf:type schema:Organization
    309 https://www.grid.ac/institutes/grid.73113.37 schema:alternateName Second Military Medical University
    310 schema:name Department of Special Treatment and Liver Transplantation, Shanghai Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 200438, Shanghai, China
    311 Research Center of Developmental Biology, Second Military Medical University, 200433, Shanghai, China
    312 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...