BPIFB1 (LPLUNC1) inhibits radioresistance in nasopharyngeal carcinoma by inhibiting VTN expression View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-03-22

AUTHORS

Fang Wei, Le Tang, Yi He, Yingfen Wu, Lei Shi, Fang Xiong, Zhaojian Gong, Can Guo, Xiayu Li, Qianjin Liao, Wenling Zhang, Qianxi Ni, Jia Luo, Xiaoling Li, Yong Li, Cong Peng, Xiang Chen, Guiyuan Li, Wei Xiong, Zhaoyang Zeng

ABSTRACT

Bactericidal/permeability-increasing-fold-containing family B member 1 (BPIFB1, previously named LPLUNC1) is highly expressed in the nasopharynx and significantly downregulated in nasopharyngeal carcinoma (NPC). Low expression is also associated with poor prognosis in patients with NPC. Radiotherapy is a routine treatment for NPC; however, radioresistance is a major cause of treatment failure. Thus, we aimed to investigate the role of BPIFB1 in the radioresponse of NPC. Colony formation and cell survival results showed that BPIFB1 sensitized NPC cells to ionizing radiation. VTN, a previously identified BPIFB1-binding protein, was shown to induce cell proliferation and survival, G2/M phase arrest, DNA repair, activation of the ATM-Chk2 and ATR-Chk1 pathways, and anti-apoptotic effects after exposure to radiation, facilitating NPC cell radioresistance. However, BPIFB1 inhibited this VTN-mediated radioresistance, ultimately improving NPC radiosensitivity. In conclusion, this study is the first to demonstrate the functions of BPIFB1 and VTN in the NPC radioresponse. Our findings indicated that promoting BPIFB1 expression and targeting VTN might represent new therapeutic strategies for NPC. More... »

PAGES

432

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41419-018-0409-0

    DOI

    http://dx.doi.org/10.1038/s41419-018-0409-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1101677161

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29568064


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