STIL balancing primary microcephaly and cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-02

AUTHORS

Dhruti Patwardhan, Shyamala Mani, Sandrine Passemard, Pierre Gressens, Vincent El Ghouzzi

ABSTRACT

Cell division and differentiation are two fundamental physiological processes that need to be tightly balanced to achieve harmonious development of an organ or a tissue without jeopardizing its homeostasis. The role played by the centriolar protein STIL is highly illustrative of this balance at different stages of life as deregulation of the human STIL gene expression has been associated with either insufficient brain development (primary microcephaly) or cancer, two conditions resulting from perturbations in cell cycle and chromosomal segregation. This review describes the recent advances on STIL functions in the control of centriole duplication and mitotic spindle integrity, and discusses how pathological perturbations of its finely tuned expression result in chromosomal instability in both embryonic and postnatal situations, highlighting the concept that common key factors are involved in developmental steps and tissue homeostasis. More... »

PAGES

65

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  • Journal

    TITLE

    Cell Death & Disease

    ISSUE

    2

    VOLUME

    9

    From Grant

  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41419-017-0101-9

    DOI

    http://dx.doi.org/10.1038/s41419-017-0101-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1100479099

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29352115


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