Glucose-6-phosphate dehydrogenase is indispensable in embryonic development by modulation of epithelial-mesenchymal transition via the NOX/Smad3/miR-200b axis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-01

AUTHORS

Yi-Hsuan Wu, Ying-Hsuan Lee, Hung-Yu Shih, Shih-Hsiang Chen, Yi-Chuan Cheng, Daniel Tsun-Yee Chiu

ABSTRACT

Glucose-6-phosphate dehydrogenase (G6PD) is a housekeeping enzyme involved in the pentose phosphate shunt for producing nicotinamide adenine dinucleotide phosphate (NADPH). Severe G6PD deficiency leads to embryonic lethality, but the underlying mechanism is unclear. In the current study, the effects of G6PD on epithelial-mesenchymal transition (EMT), especially during embryonic development, were investigated. The knockdown of G6PD induced morphological changes, accompanied by the suppression of epithelial markers, E-cadherin and β-catenin, in A549 and MDCK cells. Such modulation of EMT was corroborated by the enhancement of migration ability in G6PD-knockdown A549 cells. Zebrafish embryos with g6pd knockdown exhibited downregulation of the E-cadherin/β-catenin adhesion molecules and impaired embryonic development through reduction in epiboly rate and increase in cell shedding at the embryo surface. The dysregulation in zebrafish embryonic development caused by g6pd knockdown could be rescued through human G6PD or CDH1 (E-cadherin gene) cRNA coinjection. The Smad3/miR-200b axis was dysregulated upon G6PD knockdown, and the reconstitution of SMAD3 in G6PD-knockdown A549 cells restored the expression of E-cadherin/β-catenin. The inhibition of NADPH oxidase (NOX) activation through the loss of p22phox signaling was involved in the dysregulation of the Smad3/miR-200b axis upon G6PD knockdown. The reconstitution of G6PD led to the recovery of the regulation of NOX/Smad3/miR-200b signaling and increased the expression of E-cadherin/β-catenin in G6PD-knockdown cells. Thus, these results suggest that in the EMT process, G6PD plays an important regulatory role as an integral component of the NOX/Smad3/miR-200b axis. More... »

PAGES

10

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41419-017-0005-8

DOI

http://dx.doi.org/10.1038/s41419-017-0005-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100267667

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29317613


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Chang Gung University", 
          "id": "https://www.grid.ac/institutes/grid.145695.a", 
          "name": [
            "Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan", 
            "Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Yi-Hsuan", 
        "id": "sg:person.01050011641.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050011641.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chang Gung University", 
          "id": "https://www.grid.ac/institutes/grid.145695.a", 
          "name": [
            "Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Ying-Hsuan", 
        "id": "sg:person.013221162233.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013221162233.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chang Gung University", 
          "id": "https://www.grid.ac/institutes/grid.145695.a", 
          "name": [
            "Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shih", 
        "givenName": "Hung-Yu", 
        "id": "sg:person.01166307740.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166307740.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Linkou Chang Gung Memorial Hospital", 
          "id": "https://www.grid.ac/institutes/grid.454211.7", 
          "name": [
            "Department of Pediatric Hematology/Oncology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Shih-Hsiang", 
        "id": "sg:person.0724044477.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724044477.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Taoyuan Chang Gung Memorial Hospital", 
          "id": "https://www.grid.ac/institutes/grid.454210.6", 
          "name": [
            "Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan", 
            "Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou Medical Center, Taoyuan, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheng", 
        "givenName": "Yi-Chuan", 
        "id": "sg:person.0734417237.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734417237.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chang Gung University", 
          "id": "https://www.grid.ac/institutes/grid.145695.a", 
          "name": [
            "Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan", 
            "Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan", 
            "Department of Pediatric Hematology/Oncology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan", 
            "Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chiu", 
        "givenName": "Daniel Tsun-Yee", 
        "id": "sg:person.01227675726.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227675726.31"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.febslet.2012.03.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001717674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13238-014-0064-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002024790", 
          "https://doi.org/10.1007/s13238-014-0064-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0019394", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002054159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.136.5.1123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005497091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbamcr.2013.06.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006309234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2016.06.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006392606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2016/3912515", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008035233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2008.05.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008314667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2011.484", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010147130", 
          "https://doi.org/10.1038/onc.2011.484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.00328.2011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012583881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2009.02.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014661001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20100357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017712773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20100357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017712773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20100357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017712773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.00761.2012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018604437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cddis.2016.463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020399583", 
          "https://doi.org/10.1038/cddis.2016.463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200912134", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023203736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1521-1878(199912)22:1<1021::aid-bies6>3.0.co;2-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024295171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024922265", 
          "https://doi.org/10.1038/nature07441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1212769110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025535621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2008.07.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025684089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/v7122966", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026840011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.14348/molcells.2014.0244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027251209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.2009.113456", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027487256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.2009.113456", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027487256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0132566", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028033439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0132566", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028033439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2016.10.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029942718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10715762.2016.1223296", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031323128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000101315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032748834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0153462", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034178446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0153462", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034178446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bjh.12665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035059748"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cddis.2013.132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035265452", 
          "https://doi.org/10.1038/cddis.2013.132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1477-5956-10-53", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037033676", 
          "https://doi.org/10.1186/1477-5956-10-53"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvdy.20057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038287983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.exphem.2013.04.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039628670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(08)60073-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041111007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.cellbio.21.022404.142018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041742557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.cellbio.21.022404.142018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041742557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mod.2005.03.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042292289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.semcdb.2015.05.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042927413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/cdf426", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043101965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2016.147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043205554", 
          "https://doi.org/10.1038/modpathol.2016.147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/dbio.1999.9478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043567802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/stem.1352", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045366538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.123729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046261331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.123729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046261331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1385/endo:19:2:191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048615669", 
          "https://doi.org/10.1385/endo:19:2:191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gde.2005.12.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050626640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr4002959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056293450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m116.731216", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058215040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ars.2009.2728", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059231073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ars.2014.6142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059232471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db15-1033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070729692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fasebj.14.1.111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074573586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074967927", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074980667", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.180.10.6911", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077643989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078196733", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079878364", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080497048", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081730464", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082865628", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-01", 
    "datePublishedReg": "2018-01-01", 
    "description": "Glucose-6-phosphate dehydrogenase (G6PD) is a housekeeping enzyme involved in the pentose phosphate shunt for producing nicotinamide adenine dinucleotide phosphate (NADPH). Severe G6PD deficiency leads to embryonic lethality, but the underlying mechanism is unclear. In the current study, the effects of G6PD on epithelial-mesenchymal transition (EMT), especially during embryonic development, were investigated. The knockdown of G6PD induced morphological changes, accompanied by the suppression of epithelial markers, E-cadherin and \u03b2-catenin, in A549 and MDCK cells. Such modulation of EMT was corroborated by the enhancement of migration ability in G6PD-knockdown A549 cells. Zebrafish embryos with g6pd knockdown exhibited downregulation of the E-cadherin/\u03b2-catenin adhesion molecules and impaired embryonic development through reduction in epiboly rate and increase in cell shedding at the embryo surface. The dysregulation in zebrafish embryonic development caused by g6pd knockdown could be rescued through human G6PD or CDH1 (E-cadherin gene) cRNA coinjection. The Smad3/miR-200b axis was dysregulated upon G6PD knockdown, and the reconstitution of SMAD3 in G6PD-knockdown A549 cells restored the expression of E-cadherin/\u03b2-catenin. The inhibition of NADPH oxidase (NOX) activation through the loss of p22phox signaling was involved in the dysregulation of the Smad3/miR-200b axis upon G6PD knockdown. The reconstitution of G6PD led to the recovery of the regulation of NOX/Smad3/miR-200b signaling and increased the expression of E-cadherin/\u03b2-catenin in G6PD-knockdown cells. Thus, these results suggest that in the EMT process, G6PD plays an important regulatory role as an integral component of the NOX/Smad3/miR-200b axis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41419-017-0005-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1042939", 
        "issn": [
          "2041-4889"
        ], 
        "name": "Cell Death & Disease", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Glucose-6-phosphate dehydrogenase is indispensable in embryonic development by modulation of epithelial-mesenchymal transition via the NOX/Smad3/miR-200b axis", 
    "pagination": "10", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0578a70865c1e797a6c0b64551549b7b0688f18822093d49222e85f456ac94c4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29317613"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101524092"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41419-017-0005-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1100267667"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41419-017-0005-8", 
      "https://app.dimensions.ai/details/publication/pub.1100267667"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000493.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41419-017-0005-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41419-017-0005-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41419-017-0005-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41419-017-0005-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41419-017-0005-8'


 

This table displays all metadata directly associated to this object as RDF triples.

286 TRIPLES      21 PREDICATES      86 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41419-017-0005-8 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author N44647a438ac74a65a55ecea3687f8bd4
4 schema:citation sg:pub.10.1007/s13238-014-0064-x
5 sg:pub.10.1038/cddis.2013.132
6 sg:pub.10.1038/cddis.2016.463
7 sg:pub.10.1038/modpathol.2016.147
8 sg:pub.10.1038/nature07441
9 sg:pub.10.1038/onc.2011.484
10 sg:pub.10.1186/1477-5956-10-53
11 sg:pub.10.1385/endo:19:2:191
12 https://app.dimensions.ai/details/publication/pub.1074967927
13 https://app.dimensions.ai/details/publication/pub.1074980667
14 https://app.dimensions.ai/details/publication/pub.1078196733
15 https://app.dimensions.ai/details/publication/pub.1079878364
16 https://app.dimensions.ai/details/publication/pub.1080497048
17 https://app.dimensions.ai/details/publication/pub.1081730464
18 https://app.dimensions.ai/details/publication/pub.1082865628
19 https://doi.org/10.1002/(sici)1521-1878(199912)22:1<1021::aid-bies6>3.0.co;2-p
20 https://doi.org/10.1002/dvdy.20057
21 https://doi.org/10.1002/stem.1352
22 https://doi.org/10.1006/dbio.1999.9478
23 https://doi.org/10.1016/j.bbamcr.2013.06.026
24 https://doi.org/10.1016/j.bcp.2008.07.023
25 https://doi.org/10.1016/j.cell.2016.06.028
26 https://doi.org/10.1016/j.celrep.2016.10.027
27 https://doi.org/10.1016/j.devcel.2008.05.009
28 https://doi.org/10.1016/j.devcel.2009.02.012
29 https://doi.org/10.1016/j.exphem.2013.04.002
30 https://doi.org/10.1016/j.febslet.2012.03.023
31 https://doi.org/10.1016/j.gde.2005.12.007
32 https://doi.org/10.1016/j.mod.2005.03.008
33 https://doi.org/10.1016/j.semcdb.2015.05.002
34 https://doi.org/10.1016/s0140-6736(08)60073-2
35 https://doi.org/10.1021/pr4002959
36 https://doi.org/10.1042/bj20100357
37 https://doi.org/10.1073/pnas.1212769110
38 https://doi.org/10.1074/jbc.m116.731216
39 https://doi.org/10.1080/10715762.2016.1223296
40 https://doi.org/10.1083/jcb.136.5.1123
41 https://doi.org/10.1083/jcb.200912134
42 https://doi.org/10.1089/ars.2009.2728
43 https://doi.org/10.1089/ars.2014.6142
44 https://doi.org/10.1093/emboj/cdf426
45 https://doi.org/10.1096/fasebj.14.1.111
46 https://doi.org/10.1111/bjh.12665
47 https://doi.org/10.1136/thx.2009.113456
48 https://doi.org/10.1146/annurev.cellbio.21.022404.142018
49 https://doi.org/10.1152/ajpheart.00761.2012
50 https://doi.org/10.1152/ajprenal.00328.2011
51 https://doi.org/10.1155/2016/3912515
52 https://doi.org/10.1159/000101315
53 https://doi.org/10.1242/dev.123729
54 https://doi.org/10.1371/journal.pone.0019394
55 https://doi.org/10.1371/journal.pone.0132566
56 https://doi.org/10.1371/journal.pone.0153462
57 https://doi.org/10.14348/molcells.2014.0244
58 https://doi.org/10.2337/db15-1033
59 https://doi.org/10.3390/v7122966
60 https://doi.org/10.4049/jimmunol.180.10.6911
61 schema:datePublished 2018-01
62 schema:datePublishedReg 2018-01-01
63 schema:description Glucose-6-phosphate dehydrogenase (G6PD) is a housekeeping enzyme involved in the pentose phosphate shunt for producing nicotinamide adenine dinucleotide phosphate (NADPH). Severe G6PD deficiency leads to embryonic lethality, but the underlying mechanism is unclear. In the current study, the effects of G6PD on epithelial-mesenchymal transition (EMT), especially during embryonic development, were investigated. The knockdown of G6PD induced morphological changes, accompanied by the suppression of epithelial markers, E-cadherin and β-catenin, in A549 and MDCK cells. Such modulation of EMT was corroborated by the enhancement of migration ability in G6PD-knockdown A549 cells. Zebrafish embryos with g6pd knockdown exhibited downregulation of the E-cadherin/β-catenin adhesion molecules and impaired embryonic development through reduction in epiboly rate and increase in cell shedding at the embryo surface. The dysregulation in zebrafish embryonic development caused by g6pd knockdown could be rescued through human G6PD or CDH1 (E-cadherin gene) cRNA coinjection. The Smad3/miR-200b axis was dysregulated upon G6PD knockdown, and the reconstitution of SMAD3 in G6PD-knockdown A549 cells restored the expression of E-cadherin/β-catenin. The inhibition of NADPH oxidase (NOX) activation through the loss of p22<sub>phox</sub> signaling was involved in the dysregulation of the Smad3/miR-200b axis upon G6PD knockdown. The reconstitution of G6PD led to the recovery of the regulation of NOX/Smad3/miR-200b signaling and increased the expression of E-cadherin/β-catenin in G6PD-knockdown cells. Thus, these results suggest that in the EMT process, G6PD plays an important regulatory role as an integral component of the NOX/Smad3/miR-200b axis.
64 schema:genre research_article
65 schema:inLanguage en
66 schema:isAccessibleForFree true
67 schema:isPartOf N64bc4d0d89ce4d33a7b5d71b440abb1e
68 N9ba27622adb34b05bcd1cefefbbfb933
69 sg:journal.1042939
70 schema:name Glucose-6-phosphate dehydrogenase is indispensable in embryonic development by modulation of epithelial-mesenchymal transition via the NOX/Smad3/miR-200b axis
71 schema:pagination 10
72 schema:productId N33b9c44a2b9345d9aed606b54eefd71b
73 N3ed380a47d984031a72c91165adb56a9
74 Naca83161040644ccae6de3550bf34221
75 Nb377e719bc024ce2910a404ee12bdcee
76 Nfa5aa4a565254313a722813ac8514c90
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100267667
78 https://doi.org/10.1038/s41419-017-0005-8
79 schema:sdDatePublished 2019-04-10T14:05
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher N241123034afe40249a8a7cb466a34633
82 schema:url https://www.nature.com/articles/s41419-017-0005-8
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N224cc1015f6c4f18a766f8317a9a15d6 rdf:first sg:person.0734417237.69
87 rdf:rest Nb465a493a44a489b94423248b4deca41
88 N241123034afe40249a8a7cb466a34633 schema:name Springer Nature - SN SciGraph project
89 rdf:type schema:Organization
90 N326daafd61aa4225b5729f6d9e4b89d6 rdf:first sg:person.0724044477.86
91 rdf:rest N224cc1015f6c4f18a766f8317a9a15d6
92 N33b9c44a2b9345d9aed606b54eefd71b schema:name doi
93 schema:value 10.1038/s41419-017-0005-8
94 rdf:type schema:PropertyValue
95 N3ed380a47d984031a72c91165adb56a9 schema:name pubmed_id
96 schema:value 29317613
97 rdf:type schema:PropertyValue
98 N44647a438ac74a65a55ecea3687f8bd4 rdf:first sg:person.01050011641.72
99 rdf:rest Nb3ba28327ef24a90820cb3e7ed9115ef
100 N64bc4d0d89ce4d33a7b5d71b440abb1e schema:issueNumber 1
101 rdf:type schema:PublicationIssue
102 N9ba27622adb34b05bcd1cefefbbfb933 schema:volumeNumber 9
103 rdf:type schema:PublicationVolume
104 Naca83161040644ccae6de3550bf34221 schema:name readcube_id
105 schema:value 0578a70865c1e797a6c0b64551549b7b0688f18822093d49222e85f456ac94c4
106 rdf:type schema:PropertyValue
107 Nb377e719bc024ce2910a404ee12bdcee schema:name nlm_unique_id
108 schema:value 101524092
109 rdf:type schema:PropertyValue
110 Nb3ba28327ef24a90820cb3e7ed9115ef rdf:first sg:person.013221162233.79
111 rdf:rest Nc47d52771e2348a79a0001f2cf405e4e
112 Nb465a493a44a489b94423248b4deca41 rdf:first sg:person.01227675726.31
113 rdf:rest rdf:nil
114 Nc47d52771e2348a79a0001f2cf405e4e rdf:first sg:person.01166307740.65
115 rdf:rest N326daafd61aa4225b5729f6d9e4b89d6
116 Nfa5aa4a565254313a722813ac8514c90 schema:name dimensions_id
117 schema:value pub.1100267667
118 rdf:type schema:PropertyValue
119 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
120 schema:name Biological Sciences
121 rdf:type schema:DefinedTerm
122 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
123 schema:name Genetics
124 rdf:type schema:DefinedTerm
125 sg:journal.1042939 schema:issn 2041-4889
126 schema:name Cell Death & Disease
127 rdf:type schema:Periodical
128 sg:person.01050011641.72 schema:affiliation https://www.grid.ac/institutes/grid.145695.a
129 schema:familyName Wu
130 schema:givenName Yi-Hsuan
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050011641.72
132 rdf:type schema:Person
133 sg:person.01166307740.65 schema:affiliation https://www.grid.ac/institutes/grid.145695.a
134 schema:familyName Shih
135 schema:givenName Hung-Yu
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166307740.65
137 rdf:type schema:Person
138 sg:person.01227675726.31 schema:affiliation https://www.grid.ac/institutes/grid.145695.a
139 schema:familyName Chiu
140 schema:givenName Daniel Tsun-Yee
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227675726.31
142 rdf:type schema:Person
143 sg:person.013221162233.79 schema:affiliation https://www.grid.ac/institutes/grid.145695.a
144 schema:familyName Lee
145 schema:givenName Ying-Hsuan
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013221162233.79
147 rdf:type schema:Person
148 sg:person.0724044477.86 schema:affiliation https://www.grid.ac/institutes/grid.454211.7
149 schema:familyName Chen
150 schema:givenName Shih-Hsiang
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724044477.86
152 rdf:type schema:Person
153 sg:person.0734417237.69 schema:affiliation https://www.grid.ac/institutes/grid.454210.6
154 schema:familyName Cheng
155 schema:givenName Yi-Chuan
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734417237.69
157 rdf:type schema:Person
158 sg:pub.10.1007/s13238-014-0064-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002024790
159 https://doi.org/10.1007/s13238-014-0064-x
160 rdf:type schema:CreativeWork
161 sg:pub.10.1038/cddis.2013.132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035265452
162 https://doi.org/10.1038/cddis.2013.132
163 rdf:type schema:CreativeWork
164 sg:pub.10.1038/cddis.2016.463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020399583
165 https://doi.org/10.1038/cddis.2016.463
166 rdf:type schema:CreativeWork
167 sg:pub.10.1038/modpathol.2016.147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043205554
168 https://doi.org/10.1038/modpathol.2016.147
169 rdf:type schema:CreativeWork
170 sg:pub.10.1038/nature07441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024922265
171 https://doi.org/10.1038/nature07441
172 rdf:type schema:CreativeWork
173 sg:pub.10.1038/onc.2011.484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010147130
174 https://doi.org/10.1038/onc.2011.484
175 rdf:type schema:CreativeWork
176 sg:pub.10.1186/1477-5956-10-53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037033676
177 https://doi.org/10.1186/1477-5956-10-53
178 rdf:type schema:CreativeWork
179 sg:pub.10.1385/endo:19:2:191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048615669
180 https://doi.org/10.1385/endo:19:2:191
181 rdf:type schema:CreativeWork
182 https://app.dimensions.ai/details/publication/pub.1074967927 schema:CreativeWork
183 https://app.dimensions.ai/details/publication/pub.1074980667 schema:CreativeWork
184 https://app.dimensions.ai/details/publication/pub.1078196733 schema:CreativeWork
185 https://app.dimensions.ai/details/publication/pub.1079878364 schema:CreativeWork
186 https://app.dimensions.ai/details/publication/pub.1080497048 schema:CreativeWork
187 https://app.dimensions.ai/details/publication/pub.1081730464 schema:CreativeWork
188 https://app.dimensions.ai/details/publication/pub.1082865628 schema:CreativeWork
189 https://doi.org/10.1002/(sici)1521-1878(199912)22:1<1021::aid-bies6>3.0.co;2-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1024295171
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1002/dvdy.20057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038287983
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1002/stem.1352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045366538
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1006/dbio.1999.9478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043567802
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/j.bbamcr.2013.06.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006309234
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/j.bcp.2008.07.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025684089
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/j.cell.2016.06.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006392606
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/j.celrep.2016.10.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029942718
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/j.devcel.2008.05.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008314667
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.devcel.2009.02.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014661001
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.exphem.2013.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039628670
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.febslet.2012.03.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001717674
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/j.gde.2005.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050626640
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/j.mod.2005.03.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042292289
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/j.semcdb.2015.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042927413
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/s0140-6736(08)60073-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041111007
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1021/pr4002959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056293450
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1042/bj20100357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017712773
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1073/pnas.1212769110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025535621
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1074/jbc.m116.731216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058215040
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1080/10715762.2016.1223296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031323128
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1083/jcb.136.5.1123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005497091
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1083/jcb.200912134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023203736
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1089/ars.2009.2728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059231073
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1089/ars.2014.6142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059232471
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1093/emboj/cdf426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043101965
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1096/fasebj.14.1.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074573586
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1111/bjh.12665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035059748
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1136/thx.2009.113456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027487256
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1146/annurev.cellbio.21.022404.142018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041742557
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1152/ajpheart.00761.2012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018604437
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1152/ajprenal.00328.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012583881
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1155/2016/3912515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008035233
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1159/000101315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032748834
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1242/dev.123729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046261331
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1371/journal.pone.0019394 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002054159
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1371/journal.pone.0132566 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028033439
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1371/journal.pone.0153462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034178446
264 rdf:type schema:CreativeWork
265 https://doi.org/10.14348/molcells.2014.0244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027251209
266 rdf:type schema:CreativeWork
267 https://doi.org/10.2337/db15-1033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070729692
268 rdf:type schema:CreativeWork
269 https://doi.org/10.3390/v7122966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026840011
270 rdf:type schema:CreativeWork
271 https://doi.org/10.4049/jimmunol.180.10.6911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077643989
272 rdf:type schema:CreativeWork
273 https://www.grid.ac/institutes/grid.145695.a schema:alternateName Chang Gung University
274 schema:name Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan
275 Department of Pediatric Hematology/Oncology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan
276 Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan
277 Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan
278 Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan
279 rdf:type schema:Organization
280 https://www.grid.ac/institutes/grid.454210.6 schema:alternateName Taoyuan Chang Gung Memorial Hospital
281 schema:name Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan
282 Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou Medical Center, Taoyuan, Taiwan
283 rdf:type schema:Organization
284 https://www.grid.ac/institutes/grid.454211.7 schema:alternateName Linkou Chang Gung Memorial Hospital
285 schema:name Department of Pediatric Hematology/Oncology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan
286 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...