Translating neural stem cells to neurons in the mammalian brain View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-09-24

AUTHORS

Siraj K. Zahr, David R. Kaplan, Freda D. Miller

ABSTRACT

The mammalian neocortex underlies our perception of sensory information, performance of motor activities, and higher-order cognition. During mammalian embryogenesis, radial glial precursor cells sequentially give rise to diverse populations of excitatory cortical neurons, followed by astrocytes and oligodendrocytes. A subpopulation of these embryonic neural precursors persists into adulthood as neural stem cells, which give rise to inhibitory interneurons and glia. Although the intrinsic mechanisms instructing the genesis of these distinct progeny have been well-studied, most work to date has focused on transcriptional, epigenetic, and cell-cycle control. Recent studies, however, have shown that posttranscriptional mechanisms also regulate the cell fate choices of transcriptionally primed neural precursors during cortical development. These mechanisms are mediated primarily by RNA-binding proteins and microRNAs that coordinately regulate mRNA translation, stability, splicing, and localization. Together, these findings point to an extensive network of posttranscriptional control and provide insight into both normal cortical development and disease. They also add another layer of complexity to brain development and raise important biological questions for future investigation. More... »

PAGES

2495-2512

References to SciGraph publications

  • 2013-04-24. Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4 in NATURE
  • 2005-07-20. A genome-wide in situhybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain in BMC DEVELOPMENTAL BIOLOGY
  • 2017-07-03. Fate and freedom in developing neocortical circuits in NATURE COMMUNICATIONS
  • 2009-03-29. A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2016-08-02. Essential role of the nuclear isoform of RBFOX1, a candidate gene for autism spectrum disorders, in the brain development in SCIENTIFIC REPORTS
  • 2010-09-05. A Pumilio-induced RNA structure switch in p27-3′ UTR controls miR-221 and miR-222 accessibility in NATURE CELL BIOLOGY
  • 2015-06-21. A critical role of RBM8a in proliferation and differentiation of embryonic neural progenitors in NEURAL DEVELOPMENT
  • 2017-04-25. The RNA-binding protein MARF1 promotes cortical neurogenesis through its RNase activity domain in SCIENTIFIC REPORTS
  • 2013-02-17. mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex in NATURE NEUROSCIENCE
  • 2019-08-28. Temporal plasticity of apical progenitors in the developing mouse neocortex in NATURE
  • 2015-10-16. Functional regulation of FoxO1 in neural stem cell differentiation in CELL DEATH & DIFFERENTIATION
  • 2013-10-09. Molecular logic of neocortical projection neuron specification, development and diversity in NATURE REVIEWS NEUROSCIENCE
  • 2010-04-04. The exon junction complex component Magoh controls brain size by regulating neural stem cell division in NATURE NEUROSCIENCE
  • 2018-06-06. Precise temporal regulation of alternative splicing during neural development in NATURE COMMUNICATIONS
  • 2001-02. Neurons derived from radial glial cells establish radial units in neocortex in NATURE
  • 2018-05-31. Ythdf2-mediated m6A mRNA clearance modulates neural development in mice in GENOME BIOLOGY
  • 2012-08-03. MicroRNAs tune cerebral cortical neurogenesis in CELL DEATH & DIFFERENTIATION
  • 2014-05-25. Cell cycle regulation of proliferation versus differentiation in the central nervous system in CELL AND TISSUE RESEARCH
  • 2018-03-14. A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex in NATURE
  • 2016-07-07. The RNA binding protein HuR determines the differential translation of autism-associated FoxP subfamily members in the developing neocortex in SCIENTIFIC REPORTS
  • 2009-03-15. miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche in NATURE NEUROSCIENCE
  • 2018-11-19. Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development in NATURE NEUROSCIENCE
  • 2014-11-17. FMRP regulates multipolar to bipolar transition affecting neuronal migration and cortical circuitry in NATURE NEUROSCIENCE
  • 2015-06-24. Novel function of PIWIL1 in neuronal polarization and migration via regulation of microtubule-associated proteins in MOLECULAR BRAIN
  • 2012-04-08. microRNA-9 regulates axon extension and branching by targeting Map1b in mouse cortical neurons in NATURE NEUROSCIENCE
  • 2018-01-01. Subtype Specification of Cerebral Cortical Neurons in Their Immature Stages in NEUROCHEMICAL RESEARCH
  • 2011-09. miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells in NATURE COMMUNICATIONS
  • 2014-10-16. MiR-29b controls fetal mouse neurogenesis by regulating ICAT-mediated Wnt/β-catenin signaling in CELL DEATH & DISEASE
  • 2019-01-30. Onset of differentiation is post-transcriptionally controlled in adult neural stem cells in NATURE
  • 2014-11-04. A census of human RNA-binding proteins in NATURE REVIEWS GENETICS
  • 2010-05-02. OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling in NATURE NEUROSCIENCE
  • 2013-02-25. MicroRNA let-7d regulates the TLX/microRNA-9 cascade to control neural cell fate and neurogenesis in SCIENTIFIC REPORTS
  • 2018-09-10. Persistent Lin28 Expression Impairs Neurite Outgrowth and Cognitive Function in the Developing Mouse Neocortex in MOLECULAR NEUROBIOLOGY
  • 2012-01-15. PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2 in NATURE NEUROSCIENCE
  • 2007-07. RNA regulons: coordination of post-transcriptional events in NATURE REVIEWS GENETICS
  • 2012-06-24. miR-7a regulation of Pax6 controls spatial origin of forebrain dopaminergic neurons in NATURE NEUROSCIENCE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41418-019-0411-9

    DOI

    http://dx.doi.org/10.1038/s41418-019-0411-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1121201756

    PUBMED

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