TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-05

AUTHORS

Loïc Lionnard, Pauline Duc, Margs S. Brennan, Andrew J. Kueh, Martin Pal, Francesca Guardia, Barbara Mojsa, Maria-Alessandra Damiano, Stéphan Mora, Iréna Lassot, Ramya Ravichandran, Claude Cochet, Abdel Aouacheria, Patrick Ryan Potts, Marco J. Herold, Solange Desagher, Jérôme Kucharczak

ABSTRACT

BCL2A1 is an anti-apoptotic member of the BCL-2 family that contributes to chemoresistance in a subset of tumors. BCL2A1 has a short half-life due to its constitutive processing by the ubiquitin-proteasome system. This constitutes a major tumor-suppressor mechanism regulating BCL2A1 function. However, the enzymes involved in the regulation of BCL2A1 protein stability are currently unknown. Here, we provide the first insight into the regulation of BCL2A1 ubiquitination. We present evidence that TRIM28 is an E3 ubiquitin-ligase for BCL2A1. Indeed, endogenous TRIM28 and BCL2A1 bind to each other at the mitochondria and TRIM28 knock-down decreases BCL2A1 ubiquitination. We also show that TRIM17 stabilizes BCL2A1 by blocking TRIM28 from binding and ubiquitinating BCL2A1, and that GSK3 is involved in the phosphorylation-mediated inhibition of BCL2A1 degradation. BCL2A1 and its close relative MCL1 are thus regulated by common factors but with opposite outcome. Finally, overexpression of TRIM28 or knock-out of TRIM17 reduced BCLA1 protein levels and restored sensitivity of melanoma cells to BRAF-targeted therapy. Therefore, our data describe a molecular rheostat in which two proteins of the TRIM family antagonistically regulate BCL2A1 stability and modulate cell death. More... »

PAGES

1-16

References to SciGraph publications

  • 2012-01. BCL2A1: the underdog in the BCL2 family in CELL DEATH & DIFFERENTIATION
  • 2010-01-07. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival in NATURE
  • 2008-05. Physical and functional interactions between STAT3 and KAP1 in ONCOGENE
  • 2010-05. A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy in CELL DEATH & DISEASE
  • 2013-06. Clinical Utility of KAP-1 Expression in Thyroid Lesions in ENDOCRINE PATHOLOGY
  • 2013-02. Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons in CELL DEATH & DIFFERENTIATION
  • 2010-12. Trim17, a novel E3 ubiquitin-ligase, initiates neuronal apoptosis in CELL DEATH & DIFFERENTIATION
  • 2006-06. Upregulation of Bfl-1/A1 in leukemia cells undergoing differentiation by all-trans retinoic acid treatment attenuates chemotherapeutic agent-induced apoptosis in LEUKEMIA
  • 2007-09. Upregulation of bfl-1 is a potential mechanism of chemoresistance in B-cell chronic lymphocytic leukaemia in BRITISH JOURNAL OF CANCER
  • 2005-09. Constitutive proteasome-mediated turnover of Bfl-1/A1 and its processing in response to TNF receptor activation in FL5.12 pro-B cells convert it into a prodeath factor in CELL DEATH & DIFFERENTIATION
  • 2000-07. Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation in NATURE
  • 2007-08. Downregulation of Bfl-1 protein expression sensitizes malignant B cells to apoptosis in ONCOGENE
  • 2017-03. The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection in CELL DEATH & DIFFERENTIATION
  • 2017-03. Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment in CELL DEATH & DIFFERENTIATION
  • 2013-12. Clinical utility of measuring expression levels of KAP1, TIMP1 and STC2 in peripheral blood of patients with gastric cancer in WORLD JOURNAL OF SURGICAL ONCOLOGY
  • 2015-02. Control of neuronal apoptosis by reciprocal regulation of NFATc3 and Trim17 in CELL DEATH & DIFFERENTIATION
  • 2017-05. Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo in CELL DEATH & DIFFERENTIATION
  • 2010-03. KAP1 Is Associated With Peritoneal Carcinomatosis in Gastric Cancer in ANNALS OF SURGICAL ONCOLOGY
  • 2016. Using CRISPR/Cas9 Technology for Manipulating Cell Death Regulators in PROGRAMMED CELL DEATH
  • 2018-04. The BET bromodomain inhibitor CPI203 overcomes resistance to ABT-199 (venetoclax) by downregulation of BFL-1/A1 in in vitro and in vivo models of MYC+/BCL2+ double hit lymphoma in ONCOGENE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41418-018-0169-5

    DOI

    http://dx.doi.org/10.1038/s41418-018-0169-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1105777708

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30042493


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