RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-05

AUTHORS

Holly Anderton, Esther Bandala-Sanchez, Daniel S Simpson, James A Rickard, Ashley P Ng, Ladina Di Rago, Cathrine Hall, James E Vince, John Silke, Gianmaria Liccardi, Rebecca Feltham

ABSTRACT

RIPK1 is an essential downstream component of many pattern recognition and death receptors. RIPK1 can promote the activation of caspase-8 induced apoptosis and RIPK3-MLKL-mediated necroptosis, however, during development RIPK1 limits both forms of cell death. Accordingly, Ripk1-/- mice present with systemic cell death and consequent multi-organ inflammation, which is driven through the activation of both FADD-caspase-8 and RIPK3-MLKL signaling pathways causing perinatal lethality. TRADD is a death domain (DD) containing molecule that mediates signaling downstream of TNFR1 and the TLRs. Following the disassembly of the upstream receptor complexes either RIPK1 or TRADD can form a complex with FADD-caspase-8-cFLIP, via DD-DD interactions with FADD, facilitating the activation of caspase-8. We show that genetic deletion of Ripk1 licenses TRADD to complex with FADD-caspase-8 and activates caspase-8 during development. Deletion of Tradd provided no survival advantage to Ripk1-/- animals and yet was sufficient to reduce the systemic cell death and inflammation, rescue the intestinal and thymic histopathologies, reduce cleaved caspases in most tissues and rescue the anemia observed in Ripk1-/- neonates. Furthermore, deletion of Ripk3 is sufficient to rescue the neonatal lethality of Ripk1-/-Tradd-/- animals and delays but does not completely prevent early mortality. Although Ripk3 deletion provides a significant survival advantage, Ripk1-/-Tradd-/-Ripk3-/- animals die between 22 and 49 days, are runty compared to littermate controls and present with splenomegaly. These findings reveal a new mechanism by which RIPK1 limits apoptosis through blocking TRADD recruitment to FADD and preventing aberrant activation of caspase-8. More... »

PAGES

1-13

References to SciGraph publications

  • 2004-05. RIP1 is an essential mediator of Toll-like receptor 3–induced NF-κB activation in NATURE IMMUNOLOGY
  • 2013-01. TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1 in CELL DEATH & DISEASE
  • 2005-01. Recruitment of TRADD, FADD, and caspase 8 to double-stranded RNA-triggered death inducing signaling complexes (dsRNA-DISCs) in APOPTOSIS
  • 2008-09. Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses in NATURE IMMUNOLOGY
  • 2011-11. TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members in CELL DEATH & DISEASE
  • 2014-09. RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis in NATURE
  • 2014-09. RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis in NATURE
  • 2017-10. p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection in NATURE CELL BIOLOGY
  • 2016-12. RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation in NATURE
  • 2016-12. RIPK1 inhibits ZBP1-driven necroptosis during development in NATURE
  • 2017-03. Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways in CELL DEATH & DIFFERENTIATION
  • 2013-10. RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition in CELL DEATH & DIFFERENTIATION
  • 2015-07. The diverse role of RIP kinases in necroptosis and inflammation in NATURE IMMUNOLOGY
  • 2010-03. RIPK1 is not essential for TNFR1-induced activation of NF-κB in CELL DEATH & DIFFERENTIATION
  • 2016-05. Regulated necrosis: disease relevance and therapeutic opportunities in NATURE REVIEWS DRUG DISCOVERY
  • 2017-10. MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death in NATURE CELL BIOLOGY
  • 2008-09. The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors in NATURE IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41418-018-0166-8

    DOI

    http://dx.doi.org/10.1038/s41418-018-0166-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1106671362

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30185824


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