Innate immune adaptor MyD88 deficiency prevents skin inflammation in SHARPIN-deficient mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Bhesh Raj Sharma, Rajendra Karki, Ein Lee, Qifan Zhu, Prajwal Gurung, Thirumala-Devi Kanneganti

ABSTRACT

Mice deficient in SHANK-associated RH domain-interacting protein (SHARPIN), a component of the linear ubiquitin chain assembly complex (LUBAC), develop a spontaneous inflammatory disorder with pathologic hallmarks similar to atopic dermatitis and psoriasis in humans. Previous studies identified the crucial role of components of the TNF and IL-1 signaling pathways in the progression of disease in SHARPIN-deficient mice. However, an innate immune adaptor or sensor that relates to the disease progression has remained unknown. In this study, we found that the genetic ablation of myeloid differentiation primary response 88 (MyD88) completely rescued skin inflammation in SHARPIN-deficient (Sharpincpdm) mice. Systemic inflammation and immune cell dysregulation were partially rescued. Fibroblasts derived from SharpincpdmMyd88-⁄- mice failed to provide protection against TNF-induced cell death. SharpincpdmMyd88-⁄- mice had reduced TNF production in their skin. Furthermore, depletion of the microbiota through the oral administration of antibiotics (ABX) partially rescued both the skin inflammation and systemic inflammation, demonstrating a role for the gut microbiota in SHARPIN-deficient mice. Our findings suggest a detrimental role for the innate immune adaptor MyD88 in instigating skin inflammation in Sharpincpdm mice. More... »

PAGES

741-750

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41418-018-0159-7

DOI

http://dx.doi.org/10.1038/s41418-018-0159-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105767857

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30038386


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