Uric acid: a potent molecular contributor to pluripotent stem cell cardiac differentiation via mesoderm specification View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-05

AUTHORS

Bingbing Ke, Yujie Zeng, Zhihong Zhao, Fusheng Han, Taoyan liu, Jingyi Wang, Anila Khalique, Wen-Jing Lu, James Chong, Feng Lan, Hua He

ABSTRACT

Congenital heart disease (CHD) is the most common cause of congenital anomaly and a leading cause of morbidity and mortality worldwide. Generation of cardiomyoctyes derived from pluripotent stem cells (PSCs) has opened new avenues for investigation of human cardiac development. Here we report that uric acid (UA), a physiologically abundant compound during embryonic development, can consistently and robustly enhance cardiac differentiation of human PSCs including hESCs and hiPSCs, in replacement of ascorbic acid (AA). We optimized treatment conditions and demonstrate that differentiation day 0-2, a period for specification of mesoderm cells, was a critical time for UA effects. This was further confirmed by UA-induced upregulation of mesodermal markers. Furthermore, we show that the developing mesoderm may be by directly promoted by SNAI pathway-mediated epithelial-mesenchymal transition (EMT) at 0-24 h and a lengthened G0/G1 phase by increasing the ubiquitination degradation in 24-48 h. These findings demonstrate that UA plays a critical role in mesoderm differentiation, and its level might be a useful indicator for CHD in early fetal ultrasound screening. More... »

PAGES

1-17

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41418-018-0157-9

DOI

http://dx.doi.org/10.1038/s41418-018-0157-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105765307

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30038385


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

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N-Triples is a line-based linked data format ideal for batch operations.

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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41418-018-0157-9'


 

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285 rdf:type schema:Organization
 




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