FHL3 links cell growth and self-renewal by modulating SOX4 in glioma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-05

AUTHORS

Wei Han, Peishan Hu, Fan Wu, Shanshan Wang, Yan Hu, Shanshan Li, Tao Jiang, Boqin Qiang, Xiaozhong Peng

ABSTRACT

Differentiation status significantly affects the properties of malignant glioma cells, with non-stem cells inducing tumor enlargement and stem-like cells driving tumor initiation and treatment resistance. It is not completely understood how the same protein can have a distinct role in these cell populations. Here, we report that four and a half LIM domain protein 3 (FHL3) has an inhibitory effect on proliferation in non-stem glioma cells and a non-proliferative effect in glioma stem cells (GSCs). In GSCs, we show that FHL3 interacts with the Smad2/3 protein complex at the SOX4 promoter region, inhibits SOX4 transcriptional activity by recruiting PPM1A phosphatase to Smad2/3, and then suppresses GSC tumor sphere formation and self-renewal in vitro and in vivo via downregulation of SOX2 expression. Altogether, these findings highlight the role of FHL3 as a stemness-suppressor in regulation of the Smad2/3-SOX4-SOX2 axis in glioma. More... »

PAGES

1-16

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41418-018-0152-1

    DOI

    http://dx.doi.org/10.1038/s41418-018-0152-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1105175424

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29955125


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    268 https://www.grid.ac/institutes/grid.411617.4 schema:alternateName Beijing Tian Tan Hospital
    269 schema:name Department of Neurosurgery, Beijing Tiantan Hospital, 100050, Beijing, China
    270 State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, 100005, Beijing, China
    271 rdf:type schema:Organization
     




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