Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-02

AUTHORS

Joseph Sarhan, Beiyun C. Liu, Hayley I. Muendlein, Chi G. Weindel, Irina Smirnova, Amy Y. Tang, Vladimir Ilyukha, Maxim Sorokin, Anton Buzdin, Katherine A. Fitzgerald, Alexander Poltorak

ABSTRACT

Interferons (IFNs) are critical determinants in immune-competence and autoimmunity, and are endogenously regulated by a low-level constitutive feedback loop. However, little is known about the functions and origins of constitutive IFN. Recently, lipopolysaccharide (LPS)-induced IFN was implicated as a driver of necroptosis, a necrotic form of cell death downstream of receptor-interacting protein (RIP) kinase activation and executed by mixed lineage kinase like-domain (MLKL) protein. We found that the pre-established IFN status of the cell, instead of LPS-induced IFN, is critical for the early initiation of necroptosis in macrophages. This pre-established IFN signature stems from cytosolic DNA sensing via cGAS/STING, and maintains the expression of MLKL and one or more unknown effectors above a critical threshold to allow for MLKL oligomerization and cell death. Finally, we found that elevated IFN-signaling in systemic lupus erythematosus (SLE) augments necroptosis, providing a link between pathological IFN and tissue damage during autoimmunity. More... »

PAGES

332-347

References to SciGraph publications

  • 2004-05. RIP1 is an essential mediator of Toll-like receptor 3–induced NF-κB activation in NATURE IMMUNOLOGY
  • 2008-02. TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines in NATURE
  • 2015-04. Ppm1b negatively regulates necroptosis through dephosphorylating Rip3 in NATURE CELL BIOLOGY
  • 2012-10. Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium in NATURE IMMUNOLOGY
  • 2007-07. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response in NATURE
  • 2014-11. Distinct roles of RIP1–RIP3 hetero- and RIP3–RIP3 homo-interaction in mediating necroptosis in CELL DEATH & DIFFERENTIATION
  • 2015-04. Mitochondrial DNA stress primes the antiviral innate immune response in NATURE
  • 2013-01. Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes in NATURE IMMUNOLOGY
  • 2016-03. CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3 in NATURE CELL BIOLOGY
  • 2015-11. TRAF2 is a biologically important necroptosis suppressor in CELL DEATH & DIFFERENTIATION
  • 2016-12. RIPK1 inhibits ZBP1-driven necroptosis during development in NATURE
  • 2008-04. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β in NATURE IMMUNOLOGY
  • 2003-03. Impaired response to interferon-α/β and lethal viral disease in human STAT1 deficiency in NATURE GENETICS
  • 2016-01. Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis in CELL DEATH & DIFFERENTIATION
  • 2014-01. Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis in NATURE CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41418-018-0122-7

    DOI

    http://dx.doi.org/10.1038/s41418-018-0122-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1104135678

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29786074


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Tufts University", 
              "id": "https://www.grid.ac/institutes/grid.429997.8", 
              "name": [
                "Medical Scientist Training Program (MSTP), Tufts University School of Medicine, 02111, Boston, MA, USA", 
                "Graduate Program in Immunology, Tufts University Sackler School of Biomedical Sciences, 02111, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sarhan", 
            "givenName": "Joseph", 
            "id": "sg:person.014547237216.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014547237216.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tufts University", 
              "id": "https://www.grid.ac/institutes/grid.429997.8", 
              "name": [
                "Graduate Program in Immunology, Tufts University Sackler School of Biomedical Sciences, 02111, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liu", 
            "givenName": "Beiyun C.", 
            "id": "sg:person.01365212054.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365212054.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tufts University", 
              "id": "https://www.grid.ac/institutes/grid.429997.8", 
              "name": [
                "Graduate Program in Genetics, Tufts University Sackler School of Biomedical Sciences, 02111, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Muendlein", 
            "givenName": "Hayley I.", 
            "id": "sg:person.012570741126.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012570741126.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Texas A&M Health Science Center", 
              "id": "https://www.grid.ac/institutes/grid.416970.d", 
              "name": [
                "Department of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, 77808, Bryan, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weindel", 
            "givenName": "Chi G.", 
            "id": "sg:person.0622633465.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622633465.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tufts University", 
              "id": "https://www.grid.ac/institutes/grid.429997.8", 
              "name": [
                "Department of Immunology, Tufts University School of Medicine, 02111, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Smirnova", 
            "givenName": "Irina", 
            "id": "sg:person.0737610324.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737610324.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tufts University", 
              "id": "https://www.grid.ac/institutes/grid.429997.8", 
              "name": [
                "Department of Immunology, Tufts University School of Medicine, 02111, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tang", 
            "givenName": "Amy Y.", 
            "id": "sg:person.014761262526.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014761262526.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Petrozavodsk State University", 
              "id": "https://www.grid.ac/institutes/grid.440717.1", 
              "name": [
                "Petrozavodsk State University, 185910, Petrozavodsk, Republic of Karelia, Russia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ilyukha", 
            "givenName": "Vladimir", 
            "id": "sg:person.01173364001.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173364001.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kurchatov Institute", 
              "id": "https://www.grid.ac/institutes/grid.18919.38", 
              "name": [
                "National Research Center, Kurchatov Institute, Moscow, Russian Federation"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sorokin", 
            "givenName": "Maxim", 
            "id": "sg:person.011000715021.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011000715021.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sechenov University", 
              "id": "https://www.grid.ac/institutes/grid.448878.f", 
              "name": [
                "National Research Center, Kurchatov Institute, Moscow, Russian Federation", 
                "I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Buzdin", 
            "givenName": "Anton", 
            "id": "sg:person.0777457272.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777457272.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Norwegian University of Science and Technology", 
              "id": "https://www.grid.ac/institutes/grid.5947.f", 
              "name": [
                "Program in Innate Immunity, University of Massachusetts Medical School, 01605, Worcester, MA, USA", 
                "Centre for Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, NTNU, 7491, Trondheim, Norway"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fitzgerald", 
            "givenName": "Katherine A.", 
            "id": "sg:person.013421321577.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013421321577.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Petrozavodsk State University", 
              "id": "https://www.grid.ac/institutes/grid.440717.1", 
              "name": [
                "Graduate Program in Immunology, Tufts University Sackler School of Biomedical Sciences, 02111, Boston, MA, USA", 
                "Graduate Program in Genetics, Tufts University Sackler School of Biomedical Sciences, 02111, Boston, MA, USA", 
                "Department of Immunology, Tufts University School of Medicine, 02111, Boston, MA, USA", 
                "Petrozavodsk State University, 185910, Petrozavodsk, Republic of Karelia, Russia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Poltorak", 
            "givenName": "Alexander", 
            "id": "sg:person.01036005044.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036005044.13"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/cdd.2015.70", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000242505", 
              "https://doi.org/10.1038/cdd.2015.70"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2015.02.051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000697611"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2015.01.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001943777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-med-051113-024537", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002179265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.05.037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002565336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2014.11.036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002618427"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2014.11.036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002618427"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1189/jlb.0307194", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004992042"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb3120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005204929", 
              "https://doi.org/10.1038/ncb3120"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0337679100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005749429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1124978", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007050874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1407068111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007320071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2016.05.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007481210"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m113.462341", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008787264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1116302108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009808720"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.06.048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013868051"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2013.06.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014115974"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2012.04.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015711939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2014.04.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015739544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2014.11.037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016083993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2883", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016989080", 
              "https://doi.org/10.1038/ncb2883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.1000361", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018859509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.13926", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019139822"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.171.8.4304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021123339"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2016.06.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024565472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1569", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032207157", 
              "https://doi.org/10.1038/ni1569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2015.12.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033032990"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033292640", 
              "https://doi.org/10.1038/nature06013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chom.2010.03.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035236958"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2397", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035728374", 
              "https://doi.org/10.1038/ni.2397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2475", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036331301", 
              "https://doi.org/10.1038/ni.2475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1501415", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037907435"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2014.03.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038841559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature20559", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039016302", 
              "https://doi.org/10.1038/nature20559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1061", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040607315", 
              "https://doi.org/10.1038/ni1061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1061", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040607315", 
              "https://doi.org/10.1038/ni1061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2014.77", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042389519", 
              "https://doi.org/10.1038/cdd.2014.77"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/sji.12335", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043005816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1400590", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045456696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1097", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046683769", 
              "https://doi.org/10.1038/ng1097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1097", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046683769", 
              "https://doi.org/10.1038/ng1097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.06.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046690609"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1312625", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048168435"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14156", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048355724", 
              "https://doi.org/10.1038/nature14156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1211521110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050470060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06537", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050557084", 
              "https://doi.org/10.1038/nature06537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb3314", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051782009", 
              "https://doi.org/10.1038/ncb3314"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m114.547547", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052170261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2015.35", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052535841", 
              "https://doi.org/10.1038/cdd.2015.35"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.181.9.6427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077798870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2017.02.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084064543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2017.03.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084524338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1701229", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100266137"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-02", 
        "datePublishedReg": "2019-02-01", 
        "description": "Interferons (IFNs) are critical determinants in immune-competence and autoimmunity, and are endogenously regulated by a low-level constitutive feedback loop. However, little is known about the functions and origins of constitutive IFN. Recently, lipopolysaccharide (LPS)-induced IFN was implicated as a driver of necroptosis, a necrotic form of cell death downstream of receptor-interacting protein (RIP) kinase activation and executed by mixed lineage kinase like-domain (MLKL) protein. We found that the pre-established IFN status of the cell, instead of LPS-induced IFN, is critical for the early initiation of necroptosis in macrophages. This pre-established IFN signature stems from cytosolic DNA sensing via cGAS/STING, and maintains the expression of MLKL and one or more unknown effectors above a critical threshold to allow for MLKL oligomerization and cell death. Finally, we found that elevated IFN-signaling in systemic lupus erythematosus (SLE) augments necroptosis, providing a link between pathological IFN and tissue damage during autoimmunity.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41418-018-0122-7", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2681766", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4730001", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2456371", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7171110", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6960000", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5244440", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4897329", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1112551", 
            "issn": [
              "1350-9047", 
              "1476-5403"
            ], 
            "name": "Cell Death & Differentiation", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "26"
          }
        ], 
        "name": "Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis", 
        "pagination": "332-347", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "7e3a1a88db84425742ee9020c7125f4151b3083718e180734ee0ba406a127422"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29786074"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9437445"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41418-018-0122-7"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1104135678"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41418-018-0122-7", 
          "https://app.dimensions.ai/details/publication/pub.1104135678"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:18", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78950_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41418-018-0122-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41418-018-0122-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41418-018-0122-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41418-018-0122-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41418-018-0122-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    341 TRIPLES      21 PREDICATES      79 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41418-018-0122-7 schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 schema:author Ndbbd9c0aea00490a8861d13efa7e2f17
    4 schema:citation sg:pub.10.1038/cdd.2014.77
    5 sg:pub.10.1038/cdd.2015.35
    6 sg:pub.10.1038/cdd.2015.70
    7 sg:pub.10.1038/nature06013
    8 sg:pub.10.1038/nature06537
    9 sg:pub.10.1038/nature14156
    10 sg:pub.10.1038/nature20559
    11 sg:pub.10.1038/ncb2883
    12 sg:pub.10.1038/ncb3120
    13 sg:pub.10.1038/ncb3314
    14 sg:pub.10.1038/ng1097
    15 sg:pub.10.1038/ni.2397
    16 sg:pub.10.1038/ni.2475
    17 sg:pub.10.1038/ni1061
    18 sg:pub.10.1038/ni1569
    19 https://doi.org/10.1016/j.cell.2009.05.037
    20 https://doi.org/10.1016/j.cell.2011.06.048
    21 https://doi.org/10.1016/j.cell.2012.06.019
    22 https://doi.org/10.1016/j.cell.2014.04.018
    23 https://doi.org/10.1016/j.cell.2014.11.036
    24 https://doi.org/10.1016/j.cell.2014.11.037
    25 https://doi.org/10.1016/j.cell.2015.12.032
    26 https://doi.org/10.1016/j.cell.2017.03.020
    27 https://doi.org/10.1016/j.celrep.2015.02.051
    28 https://doi.org/10.1016/j.celrep.2016.05.032
    29 https://doi.org/10.1016/j.celrep.2017.02.015
    30 https://doi.org/10.1016/j.chom.2010.03.006
    31 https://doi.org/10.1016/j.immuni.2012.04.011
    32 https://doi.org/10.1016/j.immuni.2013.06.018
    33 https://doi.org/10.1016/j.immuni.2015.01.012
    34 https://doi.org/10.1016/j.immuni.2016.06.007
    35 https://doi.org/10.1016/j.molcel.2014.03.003
    36 https://doi.org/10.1056/nejmoa1312625
    37 https://doi.org/10.1073/pnas.0337679100
    38 https://doi.org/10.1073/pnas.1116302108
    39 https://doi.org/10.1073/pnas.1211521110
    40 https://doi.org/10.1073/pnas.1407068111
    41 https://doi.org/10.1074/jbc.m113.462341
    42 https://doi.org/10.1074/jbc.m114.547547
    43 https://doi.org/10.1111/sji.12335
    44 https://doi.org/10.1126/science.1124978
    45 https://doi.org/10.1146/annurev-med-051113-024537
    46 https://doi.org/10.1189/jlb.0307194
    47 https://doi.org/10.1371/journal.pbio.1000361
    48 https://doi.org/10.18632/oncotarget.13926
    49 https://doi.org/10.4049/jimmunol.1400590
    50 https://doi.org/10.4049/jimmunol.1501415
    51 https://doi.org/10.4049/jimmunol.1701229
    52 https://doi.org/10.4049/jimmunol.171.8.4304
    53 https://doi.org/10.4049/jimmunol.181.9.6427
    54 schema:datePublished 2019-02
    55 schema:datePublishedReg 2019-02-01
    56 schema:description Interferons (IFNs) are critical determinants in immune-competence and autoimmunity, and are endogenously regulated by a low-level constitutive feedback loop. However, little is known about the functions and origins of constitutive IFN. Recently, lipopolysaccharide (LPS)-induced IFN was implicated as a driver of necroptosis, a necrotic form of cell death downstream of receptor-interacting protein (RIP) kinase activation and executed by mixed lineage kinase like-domain (MLKL) protein. We found that the pre-established IFN status of the cell, instead of LPS-induced IFN, is critical for the early initiation of necroptosis in macrophages. This pre-established IFN signature stems from cytosolic DNA sensing via cGAS/STING, and maintains the expression of MLKL and one or more unknown effectors above a critical threshold to allow for MLKL oligomerization and cell death. Finally, we found that elevated IFN-signaling in systemic lupus erythematosus (SLE) augments necroptosis, providing a link between pathological IFN and tissue damage during autoimmunity.
    57 schema:genre research_article
    58 schema:inLanguage en
    59 schema:isAccessibleForFree true
    60 schema:isPartOf N1fcec1e6a6824ac3b07c517b6991b878
    61 Na024b85711f5438f98910103d2470fb5
    62 sg:journal.1112551
    63 schema:name Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis
    64 schema:pagination 332-347
    65 schema:productId N143a081a7d8145a8b799b10d41b41ce9
    66 N68ada7dc5bce4d02887465773d2c9754
    67 N917668fae89f4ff58a616b03902a21a8
    68 N9613e28e39e342dea73233f60c11ce64
    69 Ne3c59615413745ed8321bc276966bc40
    70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104135678
    71 https://doi.org/10.1038/s41418-018-0122-7
    72 schema:sdDatePublished 2019-04-11T13:18
    73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    74 schema:sdPublisher Nb521023de67540e6a243d7977617084d
    75 schema:url https://www.nature.com/articles/s41418-018-0122-7
    76 sgo:license sg:explorer/license/
    77 sgo:sdDataset articles
    78 rdf:type schema:ScholarlyArticle
    79 N10446921713b486ab3fec1c6a83a1da7 rdf:first sg:person.013421321577.77
    80 rdf:rest Nb45b86bc806b4ff1bb10aa60c97acdc9
    81 N143a081a7d8145a8b799b10d41b41ce9 schema:name dimensions_id
    82 schema:value pub.1104135678
    83 rdf:type schema:PropertyValue
    84 N1fcec1e6a6824ac3b07c517b6991b878 schema:volumeNumber 26
    85 rdf:type schema:PublicationVolume
    86 N427c022f81554bb3959e8e4dfbf2d44b rdf:first sg:person.0777457272.21
    87 rdf:rest N10446921713b486ab3fec1c6a83a1da7
    88 N4962f2ad946e4369937c5e4b2c5ea2e2 rdf:first sg:person.014761262526.65
    89 rdf:rest Neb417a8b4110443ca20fa0bb688647c1
    90 N68a2f789b97a4c78a94063286fc414ac rdf:first sg:person.011000715021.57
    91 rdf:rest N427c022f81554bb3959e8e4dfbf2d44b
    92 N68ada7dc5bce4d02887465773d2c9754 schema:name pubmed_id
    93 schema:value 29786074
    94 rdf:type schema:PropertyValue
    95 N917668fae89f4ff58a616b03902a21a8 schema:name readcube_id
    96 schema:value 7e3a1a88db84425742ee9020c7125f4151b3083718e180734ee0ba406a127422
    97 rdf:type schema:PropertyValue
    98 N91ccf88ab24d43c2b984b1c24e3c9c3b rdf:first sg:person.01365212054.24
    99 rdf:rest N9bdbfdcd089a441f965d4034028ee452
    100 N9613e28e39e342dea73233f60c11ce64 schema:name nlm_unique_id
    101 schema:value 9437445
    102 rdf:type schema:PropertyValue
    103 N9bdbfdcd089a441f965d4034028ee452 rdf:first sg:person.012570741126.03
    104 rdf:rest Ne930454bfe7344c5b037a7916434384f
    105 Na024b85711f5438f98910103d2470fb5 schema:issueNumber 2
    106 rdf:type schema:PublicationIssue
    107 Nb45b86bc806b4ff1bb10aa60c97acdc9 rdf:first sg:person.01036005044.13
    108 rdf:rest rdf:nil
    109 Nb521023de67540e6a243d7977617084d schema:name Springer Nature - SN SciGraph project
    110 rdf:type schema:Organization
    111 Ndbbd9c0aea00490a8861d13efa7e2f17 rdf:first sg:person.014547237216.17
    112 rdf:rest N91ccf88ab24d43c2b984b1c24e3c9c3b
    113 Ne3c59615413745ed8321bc276966bc40 schema:name doi
    114 schema:value 10.1038/s41418-018-0122-7
    115 rdf:type schema:PropertyValue
    116 Ne930454bfe7344c5b037a7916434384f rdf:first sg:person.0622633465.84
    117 rdf:rest Nf4c9926914d34f87ad6f1112b688f2b3
    118 Neb417a8b4110443ca20fa0bb688647c1 rdf:first sg:person.01173364001.24
    119 rdf:rest N68a2f789b97a4c78a94063286fc414ac
    120 Nf4c9926914d34f87ad6f1112b688f2b3 rdf:first sg:person.0737610324.33
    121 rdf:rest N4962f2ad946e4369937c5e4b2c5ea2e2
    122 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    123 schema:name Biological Sciences
    124 rdf:type schema:DefinedTerm
    125 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    126 schema:name Biochemistry and Cell Biology
    127 rdf:type schema:DefinedTerm
    128 sg:grant.2456371 http://pending.schema.org/fundedItem sg:pub.10.1038/s41418-018-0122-7
    129 rdf:type schema:MonetaryGrant
    130 sg:grant.2681766 http://pending.schema.org/fundedItem sg:pub.10.1038/s41418-018-0122-7
    131 rdf:type schema:MonetaryGrant
    132 sg:grant.4730001 http://pending.schema.org/fundedItem sg:pub.10.1038/s41418-018-0122-7
    133 rdf:type schema:MonetaryGrant
    134 sg:grant.4897329 http://pending.schema.org/fundedItem sg:pub.10.1038/s41418-018-0122-7
    135 rdf:type schema:MonetaryGrant
    136 sg:grant.5244440 http://pending.schema.org/fundedItem sg:pub.10.1038/s41418-018-0122-7
    137 rdf:type schema:MonetaryGrant
    138 sg:grant.6960000 http://pending.schema.org/fundedItem sg:pub.10.1038/s41418-018-0122-7
    139 rdf:type schema:MonetaryGrant
    140 sg:grant.7171110 http://pending.schema.org/fundedItem sg:pub.10.1038/s41418-018-0122-7
    141 rdf:type schema:MonetaryGrant
    142 sg:journal.1112551 schema:issn 1350-9047
    143 1476-5403
    144 schema:name Cell Death & Differentiation
    145 rdf:type schema:Periodical
    146 sg:person.01036005044.13 schema:affiliation https://www.grid.ac/institutes/grid.440717.1
    147 schema:familyName Poltorak
    148 schema:givenName Alexander
    149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036005044.13
    150 rdf:type schema:Person
    151 sg:person.011000715021.57 schema:affiliation https://www.grid.ac/institutes/grid.18919.38
    152 schema:familyName Sorokin
    153 schema:givenName Maxim
    154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011000715021.57
    155 rdf:type schema:Person
    156 sg:person.01173364001.24 schema:affiliation https://www.grid.ac/institutes/grid.440717.1
    157 schema:familyName Ilyukha
    158 schema:givenName Vladimir
    159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173364001.24
    160 rdf:type schema:Person
    161 sg:person.012570741126.03 schema:affiliation https://www.grid.ac/institutes/grid.429997.8
    162 schema:familyName Muendlein
    163 schema:givenName Hayley I.
    164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012570741126.03
    165 rdf:type schema:Person
    166 sg:person.013421321577.77 schema:affiliation https://www.grid.ac/institutes/grid.5947.f
    167 schema:familyName Fitzgerald
    168 schema:givenName Katherine A.
    169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013421321577.77
    170 rdf:type schema:Person
    171 sg:person.01365212054.24 schema:affiliation https://www.grid.ac/institutes/grid.429997.8
    172 schema:familyName Liu
    173 schema:givenName Beiyun C.
    174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365212054.24
    175 rdf:type schema:Person
    176 sg:person.014547237216.17 schema:affiliation https://www.grid.ac/institutes/grid.429997.8
    177 schema:familyName Sarhan
    178 schema:givenName Joseph
    179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014547237216.17
    180 rdf:type schema:Person
    181 sg:person.014761262526.65 schema:affiliation https://www.grid.ac/institutes/grid.429997.8
    182 schema:familyName Tang
    183 schema:givenName Amy Y.
    184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014761262526.65
    185 rdf:type schema:Person
    186 sg:person.0622633465.84 schema:affiliation https://www.grid.ac/institutes/grid.416970.d
    187 schema:familyName Weindel
    188 schema:givenName Chi G.
    189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622633465.84
    190 rdf:type schema:Person
    191 sg:person.0737610324.33 schema:affiliation https://www.grid.ac/institutes/grid.429997.8
    192 schema:familyName Smirnova
    193 schema:givenName Irina
    194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737610324.33
    195 rdf:type schema:Person
    196 sg:person.0777457272.21 schema:affiliation https://www.grid.ac/institutes/grid.448878.f
    197 schema:familyName Buzdin
    198 schema:givenName Anton
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777457272.21
    200 rdf:type schema:Person
    201 sg:pub.10.1038/cdd.2014.77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042389519
    202 https://doi.org/10.1038/cdd.2014.77
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1038/cdd.2015.35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052535841
    205 https://doi.org/10.1038/cdd.2015.35
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1038/cdd.2015.70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000242505
    208 https://doi.org/10.1038/cdd.2015.70
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1038/nature06013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033292640
    211 https://doi.org/10.1038/nature06013
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1038/nature06537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050557084
    214 https://doi.org/10.1038/nature06537
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1038/nature14156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048355724
    217 https://doi.org/10.1038/nature14156
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1038/nature20559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039016302
    220 https://doi.org/10.1038/nature20559
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1038/ncb2883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016989080
    223 https://doi.org/10.1038/ncb2883
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1038/ncb3120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005204929
    226 https://doi.org/10.1038/ncb3120
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1038/ncb3314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051782009
    229 https://doi.org/10.1038/ncb3314
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1038/ng1097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046683769
    232 https://doi.org/10.1038/ng1097
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1038/ni.2397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035728374
    235 https://doi.org/10.1038/ni.2397
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1038/ni.2475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036331301
    238 https://doi.org/10.1038/ni.2475
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1038/ni1061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040607315
    241 https://doi.org/10.1038/ni1061
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1038/ni1569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032207157
    244 https://doi.org/10.1038/ni1569
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1016/j.cell.2009.05.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002565336
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1016/j.cell.2011.06.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013868051
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1016/j.cell.2012.06.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046690609
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1016/j.cell.2014.04.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015739544
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1016/j.cell.2014.11.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002618427
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1016/j.cell.2014.11.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016083993
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1016/j.cell.2015.12.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033032990
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1016/j.cell.2017.03.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084524338
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1016/j.celrep.2015.02.051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000697611
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1016/j.celrep.2016.05.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007481210
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1016/j.celrep.2017.02.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084064543
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1016/j.chom.2010.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035236958
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1016/j.immuni.2012.04.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015711939
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1016/j.immuni.2013.06.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014115974
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1016/j.immuni.2015.01.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001943777
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1016/j.immuni.2016.06.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024565472
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/j.molcel.2014.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038841559
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1056/nejmoa1312625 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048168435
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1073/pnas.0337679100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005749429
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1073/pnas.1116302108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009808720
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1073/pnas.1211521110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050470060
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1073/pnas.1407068111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007320071
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1074/jbc.m113.462341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008787264
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1074/jbc.m114.547547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052170261
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1111/sji.12335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043005816
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1126/science.1124978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007050874
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1146/annurev-med-051113-024537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002179265
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1189/jlb.0307194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004992042
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1371/journal.pbio.1000361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018859509
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.18632/oncotarget.13926 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019139822
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.4049/jimmunol.1400590 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045456696
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.4049/jimmunol.1501415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037907435
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.4049/jimmunol.1701229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100266137
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.4049/jimmunol.171.8.4304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021123339
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.4049/jimmunol.181.9.6427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077798870
    315 rdf:type schema:CreativeWork
    316 https://www.grid.ac/institutes/grid.18919.38 schema:alternateName Kurchatov Institute
    317 schema:name National Research Center, Kurchatov Institute, Moscow, Russian Federation
    318 rdf:type schema:Organization
    319 https://www.grid.ac/institutes/grid.416970.d schema:alternateName Texas A&M Health Science Center
    320 schema:name Department of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, 77808, Bryan, TX, USA
    321 rdf:type schema:Organization
    322 https://www.grid.ac/institutes/grid.429997.8 schema:alternateName Tufts University
    323 schema:name Department of Immunology, Tufts University School of Medicine, 02111, Boston, MA, USA
    324 Graduate Program in Genetics, Tufts University Sackler School of Biomedical Sciences, 02111, Boston, MA, USA
    325 Graduate Program in Immunology, Tufts University Sackler School of Biomedical Sciences, 02111, Boston, MA, USA
    326 Medical Scientist Training Program (MSTP), Tufts University School of Medicine, 02111, Boston, MA, USA
    327 rdf:type schema:Organization
    328 https://www.grid.ac/institutes/grid.440717.1 schema:alternateName Petrozavodsk State University
    329 schema:name Department of Immunology, Tufts University School of Medicine, 02111, Boston, MA, USA
    330 Graduate Program in Genetics, Tufts University Sackler School of Biomedical Sciences, 02111, Boston, MA, USA
    331 Graduate Program in Immunology, Tufts University Sackler School of Biomedical Sciences, 02111, Boston, MA, USA
    332 Petrozavodsk State University, 185910, Petrozavodsk, Republic of Karelia, Russia
    333 rdf:type schema:Organization
    334 https://www.grid.ac/institutes/grid.448878.f schema:alternateName Sechenov University
    335 schema:name I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
    336 National Research Center, Kurchatov Institute, Moscow, Russian Federation
    337 rdf:type schema:Organization
    338 https://www.grid.ac/institutes/grid.5947.f schema:alternateName Norwegian University of Science and Technology
    339 schema:name Centre for Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, NTNU, 7491, Trondheim, Norway
    340 Program in Innate Immunity, University of Massachusetts Medical School, 01605, Worcester, MA, USA
    341 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...