Clinical and genomic correlates of imatinib response in melanomas with KIT alterations View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-08-23

AUTHORS

Seungyeon Jung, Emma Armstrong, Alexander Z. Wei, Fei Ye, Aaron Lee, Matteo S. Carlino, Ryan J. Sullivan, Richard D. Carvajal, Alexander N. Shoushtari, Douglas B. Johnson

ABSTRACT

BackgroundImatinib is an active agent for some patients with melanoma harbouring c-KIT alterations. However, the genetic and clinical features that correlate with imatinib sensitivity are not well-defined.MethodsWe retrospectively evaluated 38 KIT-altered melanoma patients from five medical centres who received imatinib, and pooled data from prospective studies of imatinib in 92 KIT-altered melanoma patients. Baseline patient and disease characteristics, and clinical outcomes were assessed.ResultsIn the pooled analysis (N = 130), alterations in exons 11/13 had the highest response rates (38% and 33%); L576P (N = 23) and K642E (N = 12) mutations had ORR of 52% and 42%, respectively. ORR was 38% (mucosal), 25% (acral), and 8% (unknown-primary). PFS appeared longer in exon 11/13 vs. exon 17 alterations (median 4.3 and 4.5 vs. 1.1 months; p = 0.19), with similar superiority in OS (median 19.7 and 15.4 vs. 12.1 months; p = 0.20). By histology, median PFS was 4.5 months (mucosal), 2.7 (acral), and 5.0 (unknown-primary) [p = 0.36]. Median OS was 18.0 months (mucosal), 21.8 (acral), 11.5 (unknown-primary) [p = 0.26]. In multivariate analyses, mucosal melanoma was associated with higher PFS and exon 17 mutations were associated with reduced PFS.ConclusionThis multicenter study highlights KIT-alterations sensitive to imatinib and augments evidence for imatinib in subsets of KIT-altered melanoma. More... »

PAGES

1726-1732

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41416-022-01942-z

DOI

http://dx.doi.org/10.1038/s41416-022-01942-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1150426148

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35999272


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Imatinib Mesylate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-kit", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melanoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genomics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Vanderbilt University School of Medicine, Nashville, TN, USA", 
          "id": "http://www.grid.ac/institutes/grid.152326.1", 
          "name": [
            "Vanderbilt University School of Medicine, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jung", 
        "givenName": "Seungyeon", 
        "id": "sg:person.010771004514.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010771004514.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Armstrong", 
        "givenName": "Emma", 
        "id": "sg:person.016574407005.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016574407005.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.239585.0", 
          "name": [
            "Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wei", 
        "givenName": "Alexander Z.", 
        "id": "sg:person.011251642454.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011251642454.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA", 
          "id": "http://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ye", 
        "givenName": "Fei", 
        "id": "sg:person.01351200575.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351200575.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA", 
          "id": "http://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Aaron", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1013.3", 
          "name": [
            "Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carlino", 
        "givenName": "Matteo S.", 
        "id": "sg:person.01045737743.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045737743.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Massachusetts General Hospital, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.32224.35", 
          "name": [
            "Department of Medicine, Massachusetts General Hospital, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sullivan", 
        "givenName": "Ryan J.", 
        "id": "sg:person.0743410042.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743410042.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.239585.0", 
          "name": [
            "Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carvajal", 
        "givenName": "Richard D.", 
        "id": "sg:person.0726366600.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726366600.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shoushtari", 
        "givenName": "Alexander N.", 
        "id": "sg:person.01121172646.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121172646.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN, USA", 
          "id": "http://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Johnson", 
        "givenName": "Douglas B.", 
        "id": "sg:person.015122302157.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015122302157.06"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/bjc.2014.287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013468777", 
          "https://doi.org/10.1038/bjc.2014.287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2438", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005333082", 
          "https://doi.org/10.1038/nm.2438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature23291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090947343", 
          "https://doi.org/10.1038/nature23291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2009.116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007812587", 
          "https://doi.org/10.1038/modpathol.2009.116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41467-019-11107-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1118095273", 
          "https://doi.org/10.1038/s41467-019-11107-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13045-020-01026-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1134347467", 
          "https://doi.org/10.1186/s13045-020-01026-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41467-020-18988-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1131775868", 
          "https://doi.org/10.1038/s41467-020-18988-3"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2022-08-23", 
    "datePublishedReg": "2022-08-23", 
    "description": "BackgroundImatinib is an active agent for some patients with melanoma harbouring c-KIT alterations. However, the genetic and clinical features that correlate with imatinib sensitivity are not well-defined.MethodsWe retrospectively evaluated 38 KIT-altered melanoma patients from five medical centres who received imatinib, and pooled data from prospective studies of imatinib in 92 KIT-altered melanoma patients. Baseline patient and disease characteristics, and clinical outcomes were assessed.ResultsIn the pooled analysis (N\u2009=\u2009130), alterations in exons 11/13 had the highest response rates (38% and 33%); L576P (N\u2009=\u200923) and K642E (N\u2009=\u200912) mutations had ORR of 52% and 42%, respectively. ORR was 38% (mucosal), 25% (acral), and 8% (unknown-primary). PFS appeared longer in exon 11/13 vs. exon 17 alterations (median 4.3 and 4.5 vs. 1.1 months; p\u2009=\u20090.19), with similar superiority in OS (median 19.7 and 15.4 vs. 12.1 months; p\u2009=\u20090.20). By histology, median PFS was 4.5 months (mucosal), 2.7 (acral), and 5.0 (unknown-primary) [p\u2009=\u20090.36]. Median OS was 18.0 months (mucosal), 21.8 (acral), 11.5 (unknown-primary) [p\u2009=\u20090.26]. In multivariate analyses, mucosal melanoma was associated with higher PFS and exon 17 mutations were associated with reduced PFS.ConclusionThis multicenter study highlights KIT-alterations sensitive to imatinib and augments evidence for imatinib in subsets of KIT-altered melanoma.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41416-022-01942-z", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "127"
      }
    ], 
    "keywords": [
      "melanoma patients", 
      "KIT alterations", 
      "c-Kit alteration", 
      "high response rate", 
      "median PFS", 
      "baseline patient", 
      "median OS", 
      "mucosal melanoma", 
      "clinical features", 
      "clinical outcomes", 
      "prospective study", 
      "multicenter study", 
      "disease characteristics", 
      "pooled analysis", 
      "imatinib response", 
      "imatinib sensitivity", 
      "Medical Center", 
      "higher PFS", 
      "response rate", 
      "patients", 
      "multivariate analysis", 
      "PFS", 
      "imatinib", 
      "melanoma", 
      "genomic correlates", 
      "alterations", 
      "months", 
      "kit", 
      "active agents", 
      "BackgroundImatinib", 
      "OS", 
      "L576P", 
      "histology", 
      "MethodsWe", 
      "mutations", 
      "ResultsIn", 
      "similar superiority", 
      "outcomes", 
      "study", 
      "correlates", 
      "agents", 
      "subset", 
      "response", 
      "evidence", 
      "center", 
      "sensitivity", 
      "rate", 
      "analysis", 
      "data", 
      "ORR", 
      "features", 
      "characteristics", 
      "superiority"
    ], 
    "name": "Clinical and genomic correlates of imatinib response in melanomas with KIT alterations", 
    "pagination": "1726-1732", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1150426148"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41416-022-01942-z"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "35999272"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41416-022-01942-z", 
      "https://app.dimensions.ai/details/publication/pub.1150426148"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:44", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_943.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41416-022-01942-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41416-022-01942-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41416-022-01942-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41416-022-01942-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41416-022-01942-z'


 

This table displays all metadata directly associated to this object as RDF triples.

257 TRIPLES      21 PREDICATES      94 URIs      79 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41416-022-01942-z schema:about N2e75b6c0a61646b4b52bec68074807bc
2 N6dd1aa50f8c1433fad9cf7288847abe6
3 N6f349c1b5b4e4a86ab24c562398e501a
4 N7881244b4c5e43659776b3c55f16b69f
5 N9339d32d65864473a23eb0536440c7f5
6 Nb4f8f1967ebe4172a0b5548e00c3a1eb
7 Nbac12f6c5f6d4fe3bc1c7cd0e52d1993
8 Ndf5281f40c5a4a589790fb015ae82862
9 Nee3bd6236f544495ab7654c9deb191cb
10 anzsrc-for:11
11 anzsrc-for:1112
12 schema:author Nc7a50417633446a7a5da984f6fb910ae
13 schema:citation sg:pub.10.1038/bjc.2014.287
14 sg:pub.10.1038/modpathol.2009.116
15 sg:pub.10.1038/nature23291
16 sg:pub.10.1038/nm.2438
17 sg:pub.10.1038/s41467-019-11107-x
18 sg:pub.10.1038/s41467-020-18988-3
19 sg:pub.10.1186/s13045-020-01026-6
20 schema:datePublished 2022-08-23
21 schema:datePublishedReg 2022-08-23
22 schema:description BackgroundImatinib is an active agent for some patients with melanoma harbouring c-KIT alterations. However, the genetic and clinical features that correlate with imatinib sensitivity are not well-defined.MethodsWe retrospectively evaluated 38 KIT-altered melanoma patients from five medical centres who received imatinib, and pooled data from prospective studies of imatinib in 92 KIT-altered melanoma patients. Baseline patient and disease characteristics, and clinical outcomes were assessed.ResultsIn the pooled analysis (N = 130), alterations in exons 11/13 had the highest response rates (38% and 33%); L576P (N = 23) and K642E (N = 12) mutations had ORR of 52% and 42%, respectively. ORR was 38% (mucosal), 25% (acral), and 8% (unknown-primary). PFS appeared longer in exon 11/13 vs. exon 17 alterations (median 4.3 and 4.5 vs. 1.1 months; p = 0.19), with similar superiority in OS (median 19.7 and 15.4 vs. 12.1 months; p = 0.20). By histology, median PFS was 4.5 months (mucosal), 2.7 (acral), and 5.0 (unknown-primary) [p = 0.36]. Median OS was 18.0 months (mucosal), 21.8 (acral), 11.5 (unknown-primary) [p = 0.26]. In multivariate analyses, mucosal melanoma was associated with higher PFS and exon 17 mutations were associated with reduced PFS.ConclusionThis multicenter study highlights KIT-alterations sensitive to imatinib and augments evidence for imatinib in subsets of KIT-altered melanoma.
23 schema:genre article
24 schema:isAccessibleForFree false
25 schema:isPartOf N4da80ee017d14257aaf4b7705beed442
26 N9213130575a942f5a64879a9d7972512
27 sg:journal.1017082
28 schema:keywords BackgroundImatinib
29 KIT alterations
30 L576P
31 Medical Center
32 MethodsWe
33 ORR
34 OS
35 PFS
36 ResultsIn
37 active agents
38 agents
39 alterations
40 analysis
41 baseline patient
42 c-Kit alteration
43 center
44 characteristics
45 clinical features
46 clinical outcomes
47 correlates
48 data
49 disease characteristics
50 evidence
51 features
52 genomic correlates
53 high response rate
54 higher PFS
55 histology
56 imatinib
57 imatinib response
58 imatinib sensitivity
59 kit
60 median OS
61 median PFS
62 melanoma
63 melanoma patients
64 months
65 mucosal melanoma
66 multicenter study
67 multivariate analysis
68 mutations
69 outcomes
70 patients
71 pooled analysis
72 prospective study
73 rate
74 response
75 response rate
76 sensitivity
77 similar superiority
78 study
79 subset
80 superiority
81 schema:name Clinical and genomic correlates of imatinib response in melanomas with KIT alterations
82 schema:pagination 1726-1732
83 schema:productId N620ffadc4aea4c488feca4dad9ba1082
84 Ne70c1317a3b44843bbd1a191d4f167eb
85 Nef40313cde54492cae626c50f4d967b0
86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1150426148
87 https://doi.org/10.1038/s41416-022-01942-z
88 schema:sdDatePublished 2022-12-01T06:44
89 schema:sdLicense https://scigraph.springernature.com/explorer/license/
90 schema:sdPublisher Na01e555b99b641208251469e4a35582f
91 schema:url https://doi.org/10.1038/s41416-022-01942-z
92 sgo:license sg:explorer/license/
93 sgo:sdDataset articles
94 rdf:type schema:ScholarlyArticle
95 N2df701ec8a884725af52e56e2df298cd rdf:first Ne17ff2c4575242348d99601e3551e386
96 rdf:rest N3d97c4b434734830a8757c57768c0779
97 N2e75b6c0a61646b4b52bec68074807bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Antineoplastic Agents
99 rdf:type schema:DefinedTerm
100 N3d97c4b434734830a8757c57768c0779 rdf:first sg:person.01045737743.07
101 rdf:rest Nfce19a5a335247f0a8041f88befa810c
102 N4da80ee017d14257aaf4b7705beed442 schema:issueNumber 9
103 rdf:type schema:PublicationIssue
104 N620ffadc4aea4c488feca4dad9ba1082 schema:name pubmed_id
105 schema:value 35999272
106 rdf:type schema:PropertyValue
107 N6566dc1e04d1495383d69ddc1099a867 rdf:first sg:person.0726366600.25
108 rdf:rest Nc4f065b33e8247ddb95beb98e998a5c6
109 N6dd1aa50f8c1433fad9cf7288847abe6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Humans
111 rdf:type schema:DefinedTerm
112 N6f349c1b5b4e4a86ab24c562398e501a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Melanoma
114 rdf:type schema:DefinedTerm
115 N7881244b4c5e43659776b3c55f16b69f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Imatinib Mesylate
117 rdf:type schema:DefinedTerm
118 N9213130575a942f5a64879a9d7972512 schema:volumeNumber 127
119 rdf:type schema:PublicationVolume
120 N9339d32d65864473a23eb0536440c7f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Mutation
122 rdf:type schema:DefinedTerm
123 Na01e555b99b641208251469e4a35582f schema:name Springer Nature - SN SciGraph project
124 rdf:type schema:Organization
125 Na1270878f37544f5a4484a8b657d9522 rdf:first sg:person.016574407005.47
126 rdf:rest Nc0b2c163f36a483e81a9b4b9598ad65e
127 Nb4f8f1967ebe4172a0b5548e00c3a1eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Genomics
129 rdf:type schema:DefinedTerm
130 Nbac12f6c5f6d4fe3bc1c7cd0e52d1993 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Proto-Oncogene Proteins c-kit
132 rdf:type schema:DefinedTerm
133 Nc0b2c163f36a483e81a9b4b9598ad65e rdf:first sg:person.011251642454.11
134 rdf:rest Nf1d7669d6f7842fc981ccc7a3d36193e
135 Nc4f065b33e8247ddb95beb98e998a5c6 rdf:first sg:person.01121172646.82
136 rdf:rest Neb8683232ce5404092c95565f8fcc3bc
137 Nc7a50417633446a7a5da984f6fb910ae rdf:first sg:person.010771004514.46
138 rdf:rest Na1270878f37544f5a4484a8b657d9522
139 Ndf5281f40c5a4a589790fb015ae82862 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Prospective Studies
141 rdf:type schema:DefinedTerm
142 Ne17ff2c4575242348d99601e3551e386 schema:affiliation grid-institutes:grid.412807.8
143 schema:familyName Lee
144 schema:givenName Aaron
145 rdf:type schema:Person
146 Ne70c1317a3b44843bbd1a191d4f167eb schema:name doi
147 schema:value 10.1038/s41416-022-01942-z
148 rdf:type schema:PropertyValue
149 Neb8683232ce5404092c95565f8fcc3bc rdf:first sg:person.015122302157.06
150 rdf:rest rdf:nil
151 Nee3bd6236f544495ab7654c9deb191cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Retrospective Studies
153 rdf:type schema:DefinedTerm
154 Nef40313cde54492cae626c50f4d967b0 schema:name dimensions_id
155 schema:value pub.1150426148
156 rdf:type schema:PropertyValue
157 Nf1d7669d6f7842fc981ccc7a3d36193e rdf:first sg:person.01351200575.34
158 rdf:rest N2df701ec8a884725af52e56e2df298cd
159 Nfce19a5a335247f0a8041f88befa810c rdf:first sg:person.0743410042.57
160 rdf:rest N6566dc1e04d1495383d69ddc1099a867
161 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
162 schema:name Medical and Health Sciences
163 rdf:type schema:DefinedTerm
164 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
165 schema:name Oncology and Carcinogenesis
166 rdf:type schema:DefinedTerm
167 sg:journal.1017082 schema:issn 0007-0920
168 1532-1827
169 schema:name British Journal of Cancer
170 schema:publisher Springer Nature
171 rdf:type schema:Periodical
172 sg:person.01045737743.07 schema:affiliation grid-institutes:grid.1013.3
173 schema:familyName Carlino
174 schema:givenName Matteo S.
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045737743.07
176 rdf:type schema:Person
177 sg:person.010771004514.46 schema:affiliation grid-institutes:grid.152326.1
178 schema:familyName Jung
179 schema:givenName Seungyeon
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010771004514.46
181 rdf:type schema:Person
182 sg:person.01121172646.82 schema:affiliation grid-institutes:grid.51462.34
183 schema:familyName Shoushtari
184 schema:givenName Alexander N.
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121172646.82
186 rdf:type schema:Person
187 sg:person.011251642454.11 schema:affiliation grid-institutes:grid.239585.0
188 schema:familyName Wei
189 schema:givenName Alexander Z.
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011251642454.11
191 rdf:type schema:Person
192 sg:person.01351200575.34 schema:affiliation grid-institutes:grid.412807.8
193 schema:familyName Ye
194 schema:givenName Fei
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351200575.34
196 rdf:type schema:Person
197 sg:person.015122302157.06 schema:affiliation grid-institutes:grid.412807.8
198 schema:familyName Johnson
199 schema:givenName Douglas B.
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015122302157.06
201 rdf:type schema:Person
202 sg:person.016574407005.47 schema:affiliation grid-institutes:grid.51462.34
203 schema:familyName Armstrong
204 schema:givenName Emma
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016574407005.47
206 rdf:type schema:Person
207 sg:person.0726366600.25 schema:affiliation grid-institutes:grid.239585.0
208 schema:familyName Carvajal
209 schema:givenName Richard D.
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726366600.25
211 rdf:type schema:Person
212 sg:person.0743410042.57 schema:affiliation grid-institutes:grid.32224.35
213 schema:familyName Sullivan
214 schema:givenName Ryan J.
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743410042.57
216 rdf:type schema:Person
217 sg:pub.10.1038/bjc.2014.287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013468777
218 https://doi.org/10.1038/bjc.2014.287
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/modpathol.2009.116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007812587
221 https://doi.org/10.1038/modpathol.2009.116
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/nature23291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090947343
224 https://doi.org/10.1038/nature23291
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/nm.2438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005333082
227 https://doi.org/10.1038/nm.2438
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/s41467-019-11107-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1118095273
230 https://doi.org/10.1038/s41467-019-11107-x
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/s41467-020-18988-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1131775868
233 https://doi.org/10.1038/s41467-020-18988-3
234 rdf:type schema:CreativeWork
235 sg:pub.10.1186/s13045-020-01026-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1134347467
236 https://doi.org/10.1186/s13045-020-01026-6
237 rdf:type schema:CreativeWork
238 grid-institutes:grid.1013.3 schema:alternateName Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia
239 schema:name Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia
240 rdf:type schema:Organization
241 grid-institutes:grid.152326.1 schema:alternateName Vanderbilt University School of Medicine, Nashville, TN, USA
242 schema:name Vanderbilt University School of Medicine, Nashville, TN, USA
243 rdf:type schema:Organization
244 grid-institutes:grid.239585.0 schema:alternateName Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA
245 schema:name Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA
246 rdf:type schema:Organization
247 grid-institutes:grid.32224.35 schema:alternateName Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
248 schema:name Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
249 rdf:type schema:Organization
250 grid-institutes:grid.412807.8 schema:alternateName Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA
251 Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN, USA
252 schema:name Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA
253 Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN, USA
254 rdf:type schema:Organization
255 grid-institutes:grid.51462.34 schema:alternateName Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
256 schema:name Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
257 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...