Considerations for the treatment of pancreatic cancer during the COVID-19 pandemic: the UK consensus position View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-07-08

AUTHORS

Christopher M. Jones, Ganesh Radhakrishna, Katharine Aitken, John Bridgewater, Pippa Corrie, Martin Eatock, Rebecca Goody, Paula Ghaneh, James Good, Derek Grose, Daniel Holyoake, Arabella Hunt, Nigel B. Jamieson, Daniel H. Palmer, Zahir Soonawalla, Juan W. Valle, Maria A. Hawkins, Somnath Mukherjee

ABSTRACT

The coronavirus disease 2019 (COVID-19) pandemic epicentre has moved to the USA and Europe, where it is placing unprecedented demands on healthcare resources and staff availability. These service constraints, coupled with concerns relating to an increased incidence and severity of COVID-19 among patients with cancer, should lead to re-consideration of the risk–benefit balance for standard treatment pathways. This is of particular importance to pancreatic cancer, given that standard diagnostic modalities such as endoscopy may be restricted, and that disease biology precludes significant delays in treatment. In light of this, we sought consensus from UK clinicians with an interest in pancreatic cancer for management approaches that would minimise patient risk and accommodate for healthcare service restrictions. The outcomes are described here and include recommendations for treatment prioritisation, strategies to bridge to later surgical resection in resectable disease and factors that modify the risk–benefit balance for treatment in the resectable through to the metastatic settings. Priority is given to strategies that limit hospital visits, including through the use of hypofractionated precision radiotherapy and chemoradiotherapy treatment approaches. More... »

PAGES

709-713

Journal

TITLE

British Journal of Cancer

ISSUE

5

VOLUME

123

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41416-020-0980-x

DOI

http://dx.doi.org/10.1038/s41416-020-0980-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1129058330

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32641867


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24 schema:description The coronavirus disease 2019 (COVID-19) pandemic epicentre has moved to the USA and Europe, where it is placing unprecedented demands on healthcare resources and staff availability. These service constraints, coupled with concerns relating to an increased incidence and severity of COVID-19 among patients with cancer, should lead to re-consideration of the risk–benefit balance for standard treatment pathways. This is of particular importance to pancreatic cancer, given that standard diagnostic modalities such as endoscopy may be restricted, and that disease biology precludes significant delays in treatment. In light of this, we sought consensus from UK clinicians with an interest in pancreatic cancer for management approaches that would minimise patient risk and accommodate for healthcare service restrictions. The outcomes are described here and include recommendations for treatment prioritisation, strategies to bridge to later surgical resection in resectable disease and factors that modify the risk–benefit balance for treatment in the resectable through to the metastatic settings. Priority is given to strategies that limit hospital visits, including through the use of hypofractionated precision radiotherapy and chemoradiotherapy treatment approaches.
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31 COVID-19 pandemic
32 Europe
33 UK clinicians
34 USA
35 approach
36 availability
37 balance
38 biology
39 cancer
40 clinicians
41 concern
42 consensus
43 consensus position
44 consideration
45 constraints
46 delay
47 demand
48 diagnostic modalities
49 disease
50 disease biology
51 endoscopy
52 epicenter
53 factors
54 healthcare resources
55 hospital visits
56 importance
57 incidence
58 interest
59 light
60 management approach
61 metastatic setting
62 modalities
63 outcomes
64 pancreatic cancer
65 pandemic
66 pandemic epicenter
67 particular importance
68 pathway
69 patient risk
70 patients
71 position
72 precision radiotherapy
73 prioritisation
74 priority
75 radiotherapy
76 recommendations
77 resectable disease
78 resection
79 resources
80 restriction
81 risk
82 risk-benefit balance
83 service constraints
84 service restrictions
85 setting
86 severity
87 significant delay
88 staff availability
89 standard diagnostic modality
90 standard treatment pathways
91 strategies
92 surgical resection
93 treatment
94 treatment approaches
95 treatment pathways
96 treatment prioritisation
97 unprecedented demand
98 use
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