Alteration in tumoural PD-L1 expression and stromal CD8-positive tumour-infiltrating lymphocytes after concurrent chemo-radiotherapy for non-small cell lung cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-08-07

AUTHORS

Kazue Yoneda, Taiji Kuwata, Masatoshi Kanayama, Masataka Mori, Toshinori Kawanami, Kazuhiro Yatera, Takayuki Ohguri, Masanori Hisaoka, Toshiyuki Nakayama, Fumihiro Tanaka

ABSTRACT

BackgroundConsolidation treatment with an anti-PD-L1 antibody, durvalumab, following concurrent chemo-radiotherapy (cCRT) has become a new standard of care for locally advanced non-small cell lung cancer (NSCLC). The rationale of PD-L1 blockade after cCRT is based on preclinical evidence suggesting that chemotherapy and radiotherapy up-regulate tumoural PD-L1 expression, which has not been shown in clinical studies.MethodsTo examine alteration in tumoural PD-L1 expression (tumour proportion score, TPS) and density of stromal CD8-positive tumour-infiltrating lymphocytes (CD8 + TILs) after cCRT, paired NSCLC samples obtained before and after cCRT were reviewed in comparison with those obtained before and after drug therapy.ResultsPD-L1 expression was significantly up-regulated after cCRT (median TPS, 1.0 at baseline versus 48.0 after cCRT; P < 0.001), but not after drug therapy. There was no significant correlation between baseline TPS and post-cCRT TPS. CD8 + TIL density was significantly increased after cCRT (median, 10.6 versus 39.1; P < 0.001), and higher post-cCRT CD8 + TIL density was associated with a higher pathologic response and with a favourable survival (P = 0.019).ConclusionTumoural PD-L1 expression was up-regulated after cCRT, which provides pathologic rationale for PD-L1 blockade following cCRT to improve prognosis. Stromal CD8 + TIL density was also increased after cCRT, and higher post-cCRT CD8 + TIL density was a favourable prognostic indicator. More... »

PAGES

490-496

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41416-019-0541-3

DOI

http://dx.doi.org/10.1038/s41416-019-0541-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1120143588

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31388183


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