Can we classify ampullary tumours better? Clinical, pathological and molecular features. Results of an AGEO study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Geraldine Perkins, Magali Svrcek, Cecile Bouchet-Doumenq, Thibault Voron, Orianne Colussi, Clotilde Debove, Fatiha Merabtene, Sylvie Dumont, Alain Sauvanet, Pascal Hammel, Jerome Cros, Thierry André, Jean-Baptiste Bachet, Armelle Bardier, Richard Douard, Tchao Meatchi, Frederique Peschaud, Jean-Francois Emile, Isabelle Cojean-Zelek, Pierre Laurent-Puig, Julien Taieb

ABSTRACT

BACKGROUND: Ampullary adenocarcinoma (AA) originates from either intestinal (INT) or pancreaticobiliary (PB) epithelium. Different prognostic factors of recurrence have been identified in previous studies. METHODS: In 91 AA patients of the AGEO retrospective multicentre cohort, we evaluated the centrally reviewed morphological classification, panel markers of Ang et al. including CK7, CK20, MUC1, MUC2 and CDX2, the 50-gene panel mutational analysis, and the clinicopathological AGEO prognostic score. RESULTS: Forty-three (47%) of the 91 tumours were Ang-INT, 29 (32%) were Ang-PB, 18 (20%) were ambiguous (Ang-AMB) and one could not be classified. Among these 90 tumours, 68.7% of INT tumours were Ang-INT and 78.2% of PB tumours were Ang-PB. MUC5AC expression was detected in 32.5% of the 86 evaluable cases. Among 71 tumours, KRAS, TP53, APC and PIK3CA were the most frequently mutated genes. The KRAS mutation was significantly more frequent in the PB subtype. In multivariate analysis, only AGEO prognostic score and tumour subtype were associated with relapse-free survival. Only AGEO prognostic score was associated with overall survival. CONCLUSIONS: Mutational analysis and MUC5AC expression provide no additional value in the prognostic evaluation of AA patients. Ang et al. classification and the AGEO prognostic score were confirmed as a strong prognosticator for disease recurrence. More... »

PAGES

1-6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41416-019-0415-8

DOI

http://dx.doi.org/10.1038/s41416-019-0415-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112543858

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30837681


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "French Institute of Health and Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.7429.8", 
          "name": [
            "Sorbonne Paris \u2013 Cit\u00e9, Paris Descartes University, Department of Gastroenterology and GI Oncology, Georges Pompidou European Hospital, Assistance Publique-H\u00f4pitaux de Paris, Paris, France", 
            "Centre de Recherche UMR-S 1147, M\u00e9decine Personnalis\u00e9e, Pharmacog\u00e9nomique, Optimisation Th\u00e9rapeutique, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Perkins", 
        "givenName": "Geraldine", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Sorbonne-Universit\u00e9, Department of Pathology, Saint-Antoine Hospital, Assistance Publique-H\u00f4pitaux de Paris, Paris, France", 
            "INSERM, UMR S 938, Sorbonne-Universit\u00e9, Universit\u00e9 Pierre et Marie Curie \u2013 Paris 6, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Svrcek", 
        "givenName": "Magali", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "French Institute of Health and Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.7429.8", 
          "name": [
            "Department of Gastrointestinal Surgery, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Paris, France", 
            "Centre de Recherche UMR-S 1147, M\u00e9decine Personnalis\u00e9e, Pharmacog\u00e9nomique, Optimisation Th\u00e9rapeutique, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bouchet-Doumenq", 
        "givenName": "Cecile", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Saint-Antoine", 
          "id": "https://www.grid.ac/institutes/grid.412370.3", 
          "name": [
            "Department of Gastrointestinal Surgery, Saint Antoine Hospital, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Voron", 
        "givenName": "Thibault", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Sorbonne Paris \u2013 Cit\u00e9, Paris Descartes University, Department of Gastroenterology and GI Oncology, Georges Pompidou European Hospital, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Colussi", 
        "givenName": "Orianne", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Saint-Antoine", 
          "id": "https://www.grid.ac/institutes/grid.412370.3", 
          "name": [
            "Department of Gastrointestinal Surgery, Saint Antoine Hospital, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Debove", 
        "givenName": "Clotilde", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "INSERM, UMR S 938, Sorbonne-Universit\u00e9, Universit\u00e9 Pierre et Marie Curie \u2013 Paris 6, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Merabtene", 
        "givenName": "Fatiha", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "INSERM, UMR S 938, Sorbonne-Universit\u00e9, Universit\u00e9 Pierre et Marie Curie \u2013 Paris 6, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dumont", 
        "givenName": "Sylvie", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Assistance Publique -Hopitaux De Paris", 
          "id": "https://www.grid.ac/institutes/grid.50550.35", 
          "name": [
            "Department of Digestive Surgery, H\u00f4pital Beaujon, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sauvanet", 
        "givenName": "Alain", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Research on Inflammation", 
          "id": "https://www.grid.ac/institutes/grid.462374.0", 
          "name": [
            "Department of Digestive Oncology, Beaujon University Hospital, Assistance Publique-H\u00f4pitaux de Paris, Clichy, France", 
            "Centre de Recherche sur l\u2019Inflammation (CRI), INSERM UMR 1149, University of Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hammel", 
        "givenName": "Pascal", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Beaujon Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411599.1", 
          "name": [
            "Centre de Recherche sur l\u2019Inflammation (CRI), INSERM UMR 1149, University of Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France", 
            "Department of Pathology, Beaujon University Hospital, Assistance Publique-H\u00f4pitaux de Paris, Clichy, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cros", 
        "givenName": "Jerome", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Sorbonne-Universit\u00e9, and department of Medical Oncology, Saint Antoine Hospital, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Andr\u00e9", 
        "givenName": "Thierry", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Piti\u00e9-Salp\u00eatri\u00e8re Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Centre de Recherche UMR-S 1147, M\u00e9decine Personnalis\u00e9e, Pharmacog\u00e9nomique, Optimisation Th\u00e9rapeutique, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Paris, France", 
            "Department of Hepato-Gastroenterology, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bachet", 
        "givenName": "Jean-Baptiste", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Piti\u00e9-Salp\u00eatri\u00e8re Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Surgical Pathology Department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bardier", 
        "givenName": "Armelle", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Paris Descartes University, Department of Digestive Surgery, Georges Pompidou European Hospital, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Douard", 
        "givenName": "Richard", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Paris Descartes University, Department of Pathology, Georges Pompidou European Hospital, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Meatchi", 
        "givenName": "Tchao", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Ambroise-Par\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.413756.2", 
          "name": [
            "Department of Surgery and Oncology, Ambroise Par\u00e9 Hospital, Assistance Publique-H\u00f4pitaux de Paris, Boulogne-Billancourt, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peschaud", 
        "givenName": "Frederique", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Versailles Saint-Quentin-en-Yvelines University", 
          "id": "https://www.grid.ac/institutes/grid.12832.3a", 
          "name": [
            "Department of Pathology, Ambroise Par\u00e9 Hospital, Assistance Publique-H\u00f4pitaux de Paris, Boulogne-Billancourt, France", 
            "EA4340, Biomarqueurs en Canc\u00e9rologie et Onco-H\u00e9matologie, UVSQ, Paris-Saclay University, Boulogne-Billancourt, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Emile", 
        "givenName": "Jean-Francois", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Medical Oncology, Diaconesses Hospital, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cojean-Zelek", 
        "givenName": "Isabelle", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "French Institute of Health and Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.7429.8", 
          "name": [
            "Centre de Recherche UMR-S 1147, M\u00e9decine Personnalis\u00e9e, Pharmacog\u00e9nomique, Optimisation Th\u00e9rapeutique, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Laurent-Puig", 
        "givenName": "Pierre", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Sorbonne Paris \u2013 Cit\u00e9, Paris Descartes University, Department of Gastroenterology and GI Oncology, Georges Pompidou European Hospital, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taieb", 
        "givenName": "Julien", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/sla.0000000000001999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002804961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0000000000001999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002804961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.10.9744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003740759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.surg.2014.08.092", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010189361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010619765", 
          "https://doi.org/10.1038/nature11252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2015.172", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011981731", 
          "https://doi.org/10.1038/bjc.2015.172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpa.0b013e31823cd9df", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012797887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpa.0b013e31823cd9df", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012797887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2015.11.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013016457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccell.2015.12.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017193344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jclinpath-2015-203337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017483614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2013.185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018345374", 
          "https://doi.org/10.1038/modpathol.2013.185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.09.2775", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026719751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/his.12693", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027481981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000278", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031437684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000278", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031437684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jso.24274", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037358948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2015.12.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038371101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.11156", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040163366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2016.124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040294280", 
          "https://doi.org/10.1038/modpathol.2016.124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2012.46.8868", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041247505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.surg.2013.12.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041304777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2014.04.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042726200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejso.2015.01.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042923054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jso.22090", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043909702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12876-015-0396-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045437840", 
          "https://doi.org/10.1186/s12876-015-0396-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpa.0000000000000112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047229051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpa.0000000000000112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047229051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048325127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048325127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00365521.2015.1046912", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051852667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085420097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085420097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccell.2017.07.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091212500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejso.2018.02.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101058005"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-04", 
    "datePublishedReg": "2019-04-01", 
    "description": "BACKGROUND: Ampullary adenocarcinoma (AA) originates from either intestinal (INT) or pancreaticobiliary (PB) epithelium. Different prognostic factors of recurrence have been identified in previous studies.\nMETHODS: In 91 AA patients of the AGEO retrospective multicentre cohort, we evaluated the centrally reviewed morphological classification, panel markers of Ang et al. including CK7, CK20, MUC1, MUC2 and CDX2, the 50-gene panel mutational analysis, and the clinicopathological AGEO prognostic score.\nRESULTS: Forty-three (47%) of the 91 tumours were Ang-INT, 29 (32%) were Ang-PB, 18 (20%) were ambiguous (Ang-AMB) and one could not be classified. Among these 90 tumours, 68.7% of INT tumours were Ang-INT and 78.2% of PB tumours were Ang-PB. MUC5AC expression was detected in 32.5% of the 86 evaluable cases. Among 71 tumours, KRAS, TP53, APC and PIK3CA were the most frequently mutated genes. The KRAS mutation was significantly more frequent in the PB subtype. In multivariate analysis, only AGEO prognostic score and tumour subtype were associated with relapse-free survival. Only AGEO prognostic score was associated with overall survival.\nCONCLUSIONS: Mutational analysis and MUC5AC expression provide no additional value in the prognostic evaluation of AA patients. Ang et al. classification and the AGEO prognostic score were confirmed as a strong prognosticator for disease recurrence.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41416-019-0415-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "120"
      }
    ], 
    "name": "Can we classify ampullary tumours better? Clinical, pathological and molecular features. Results of an AGEO study", 
    "pagination": "1-6", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "993be419607e6b67e7043138a4ed06f61e5895d503ee8e9c9bd3659112b17742"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30837681"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41416-019-0415-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112543858"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41416-019-0415-8", 
      "https://app.dimensions.ai/details/publication/pub.1112543858"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130814_00000006.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41416-019-0415-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41416-019-0415-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41416-019-0415-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41416-019-0415-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41416-019-0415-8'


 

This table displays all metadata directly associated to this object as RDF triples.

327 TRIPLES      21 PREDICATES      58 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41416-019-0415-8 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Nfc556e82998e4e79b1cafdb07a821ace
4 schema:citation sg:pub.10.1038/bjc.2015.172
5 sg:pub.10.1038/modpathol.2013.185
6 sg:pub.10.1038/modpathol.2016.124
7 sg:pub.10.1038/nature11252
8 sg:pub.10.1186/s12876-015-0396-x
9 https://doi.org/10.1002/jso.22090
10 https://doi.org/10.1002/jso.24274
11 https://doi.org/10.1016/j.ccell.2015.12.012
12 https://doi.org/10.1016/j.ccell.2017.07.007
13 https://doi.org/10.1016/j.celrep.2015.12.005
14 https://doi.org/10.1016/j.ejca.2014.04.007
15 https://doi.org/10.1016/j.ejso.2015.01.010
16 https://doi.org/10.1016/j.ejso.2018.02.008
17 https://doi.org/10.1016/j.humpath.2015.11.009
18 https://doi.org/10.1016/j.surg.2013.12.003
19 https://doi.org/10.1016/j.surg.2014.08.092
20 https://doi.org/10.1097/mpa.0000000000000112
21 https://doi.org/10.1097/mpa.0b013e31823cd9df
22 https://doi.org/10.1097/pas.0000000000000230
23 https://doi.org/10.1097/pas.0000000000000278
24 https://doi.org/10.1097/pas.0000000000000863
25 https://doi.org/10.1097/sla.0000000000001999
26 https://doi.org/10.1111/his.12693
27 https://doi.org/10.1136/jclinpath-2015-203337
28 https://doi.org/10.1200/jco.2006.09.2775
29 https://doi.org/10.1200/jco.2007.10.9744
30 https://doi.org/10.1200/jco.2012.46.8868
31 https://doi.org/10.18632/oncotarget.11156
32 https://doi.org/10.3109/00365521.2015.1046912
33 schema:datePublished 2019-04
34 schema:datePublishedReg 2019-04-01
35 schema:description BACKGROUND: Ampullary adenocarcinoma (AA) originates from either intestinal (INT) or pancreaticobiliary (PB) epithelium. Different prognostic factors of recurrence have been identified in previous studies. METHODS: In 91 AA patients of the AGEO retrospective multicentre cohort, we evaluated the centrally reviewed morphological classification, panel markers of Ang et al. including CK7, CK20, MUC1, MUC2 and CDX2, the 50-gene panel mutational analysis, and the clinicopathological AGEO prognostic score. RESULTS: Forty-three (47%) of the 91 tumours were Ang-INT, 29 (32%) were Ang-PB, 18 (20%) were ambiguous (Ang-AMB) and one could not be classified. Among these 90 tumours, 68.7% of INT tumours were Ang-INT and 78.2% of PB tumours were Ang-PB. MUC5AC expression was detected in 32.5% of the 86 evaluable cases. Among 71 tumours, KRAS, TP53, APC and PIK3CA were the most frequently mutated genes. The KRAS mutation was significantly more frequent in the PB subtype. In multivariate analysis, only AGEO prognostic score and tumour subtype were associated with relapse-free survival. Only AGEO prognostic score was associated with overall survival. CONCLUSIONS: Mutational analysis and MUC5AC expression provide no additional value in the prognostic evaluation of AA patients. Ang et al. classification and the AGEO prognostic score were confirmed as a strong prognosticator for disease recurrence.
36 schema:genre research_article
37 schema:inLanguage en
38 schema:isAccessibleForFree false
39 schema:isPartOf N1336b85deca14aa0a4f9dbaf83d198eb
40 N645c8c74fe664d799a54fa34da8a37d1
41 sg:journal.1017082
42 schema:name Can we classify ampullary tumours better? Clinical, pathological and molecular features. Results of an AGEO study
43 schema:pagination 1-6
44 schema:productId N11e950d2767f4fe5a0998475634bd12c
45 N8f2732af02344aa09b0edddf62a78f4f
46 N9bfa9be312994735be48e5216008873e
47 Nba2eb3b1c131478ca660a43a32588953
48 Neba4e671930548a5a0c9f314c1dc94da
49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112543858
50 https://doi.org/10.1038/s41416-019-0415-8
51 schema:sdDatePublished 2019-04-11T13:56
52 schema:sdLicense https://scigraph.springernature.com/explorer/license/
53 schema:sdPublisher Ndef27cd29b1e45b9ac45c7e9370b7835
54 schema:url https://www.nature.com/articles/s41416-019-0415-8
55 sgo:license sg:explorer/license/
56 sgo:sdDataset articles
57 rdf:type schema:ScholarlyArticle
58 N01f974d455e14bc491c7bac86f908e7d schema:affiliation N90da53ba5b334b70bec32441680d2fe2
59 schema:familyName Cojean-Zelek
60 schema:givenName Isabelle
61 rdf:type schema:Person
62 N0356ab02c73245b9b6c15e3b60529ee9 schema:affiliation https://www.grid.ac/institutes/grid.411599.1
63 schema:familyName Cros
64 schema:givenName Jerome
65 rdf:type schema:Person
66 N07baec18f4e149feae17c471381e537b rdf:first N0fa5f050b2c04c1891d0e8ed7782fbe5
67 rdf:rest N53b3aaf1fb85450ab15b2b61f16e3568
68 N07e156a7887c4e90b1cc1f6b566d9b6c schema:affiliation https://www.grid.ac/institutes/grid.412370.3
69 schema:familyName Voron
70 schema:givenName Thibault
71 rdf:type schema:Person
72 N09848b4112d3449785dd525515a36800 schema:name Paris Descartes University, Department of Pathology, Georges Pompidou European Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France
73 rdf:type schema:Organization
74 N0fa5f050b2c04c1891d0e8ed7782fbe5 schema:affiliation Ne1d101300b69406ba1710805086364f6
75 schema:familyName Merabtene
76 schema:givenName Fatiha
77 rdf:type schema:Person
78 N11e950d2767f4fe5a0998475634bd12c schema:name readcube_id
79 schema:value 993be419607e6b67e7043138a4ed06f61e5895d503ee8e9c9bd3659112b17742
80 rdf:type schema:PropertyValue
81 N1336b85deca14aa0a4f9dbaf83d198eb schema:volumeNumber 120
82 rdf:type schema:PublicationVolume
83 N1dcfcb30c79a4c42b5ed08a95c1f75c3 schema:affiliation https://www.grid.ac/institutes/grid.413756.2
84 schema:familyName Peschaud
85 schema:givenName Frederique
86 rdf:type schema:Person
87 N25846a578b994fa8aabc213abb16007e rdf:first N8369ec7631c444f0a1511929a8040745
88 rdf:rest N5c7682faf993489a85549f4a6a888d42
89 N2e7f11aba90c4e758d0bf79e080664a2 rdf:first N65307dcf729649cab5b7107adfccb21c
90 rdf:rest N07baec18f4e149feae17c471381e537b
91 N2f0d9e48b6a8458bbff99e0932eca29f rdf:first Nc9fc659c8dfe438b9a78f56ec6f3fe33
92 rdf:rest N38d246817c8342339159dea38e307648
93 N38d246817c8342339159dea38e307648 rdf:first N01f974d455e14bc491c7bac86f908e7d
94 rdf:rest N80605e95a9a242e49e4cd85c7e4dbf01
95 N3984a5775dc8484eb54e6ead1105d36b rdf:first N95250df0a0ff4d04a36a44a5fbe721ae
96 rdf:rest N25846a578b994fa8aabc213abb16007e
97 N418c9716193d44ed8869f71217a3ca11 schema:affiliation https://www.grid.ac/institutes/grid.411439.a
98 schema:familyName Bachet
99 schema:givenName Jean-Baptiste
100 rdf:type schema:Person
101 N4c362a40e1ef4c6aa0fad23f5568dcc4 schema:affiliation Nf698eb1fcdcf4326825fe41cbf1a5315
102 schema:familyName Colussi
103 schema:givenName Orianne
104 rdf:type schema:Person
105 N4ea05c7cbc91439abf635878bb0cf828 schema:name INSERM, UMR S 938, Sorbonne-Université, Université Pierre et Marie Curie – Paris 6, Paris, France
106 rdf:type schema:Organization
107 N52714274b41842b693bfce7a6126eff7 schema:name INSERM, UMR S 938, Sorbonne-Université, Université Pierre et Marie Curie – Paris 6, Paris, France
108 Sorbonne-Université, Department of Pathology, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France
109 rdf:type schema:Organization
110 N53b3aaf1fb85450ab15b2b61f16e3568 rdf:first Nd77a134e5fec47e3ae1dbd9235e85146
111 rdf:rest Nb04e32a3982d45ff9b5a5a19d26c9584
112 N5c7682faf993489a85549f4a6a888d42 rdf:first Ncc75d69c23b146f1a8e9b826e111b379
113 rdf:rest Nc37baa176228402f8ea4fead3c2a27e8
114 N5cbf548326bf48cd856b2ec47c7b7bcc schema:name Sorbonne-Université, and department of Medical Oncology, Saint Antoine Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France
115 rdf:type schema:Organization
116 N645c8c74fe664d799a54fa34da8a37d1 schema:issueNumber 7
117 rdf:type schema:PublicationIssue
118 N65307dcf729649cab5b7107adfccb21c schema:affiliation https://www.grid.ac/institutes/grid.412370.3
119 schema:familyName Debove
120 schema:givenName Clotilde
121 rdf:type schema:Person
122 N66c85b6cada749b88cb3023e986a7baf rdf:first N67e90520dfa54be098ccfbad3e03e5d1
123 rdf:rest N699818347b744d5aa0d0f2d65ccbe609
124 N67e90520dfa54be098ccfbad3e03e5d1 schema:affiliation https://www.grid.ac/institutes/grid.462374.0
125 schema:familyName Hammel
126 schema:givenName Pascal
127 rdf:type schema:Person
128 N699818347b744d5aa0d0f2d65ccbe609 rdf:first N0356ab02c73245b9b6c15e3b60529ee9
129 rdf:rest Nd637d1ce73924ca7bbb7e00d94182779
130 N6ef2a5973b65422aa8d88efb70f7f2d7 schema:affiliation https://www.grid.ac/institutes/grid.7429.8
131 schema:familyName Perkins
132 schema:givenName Geraldine
133 rdf:type schema:Person
134 N77aac99ddfac435883da5f50dce54f6f rdf:first N4c362a40e1ef4c6aa0fad23f5568dcc4
135 rdf:rest N2e7f11aba90c4e758d0bf79e080664a2
136 N7f5785a66a504dfaaa1e5524b47c45ff schema:affiliation N52714274b41842b693bfce7a6126eff7
137 schema:familyName Svrcek
138 schema:givenName Magali
139 rdf:type schema:Person
140 N80605e95a9a242e49e4cd85c7e4dbf01 rdf:first Nc5d5de1afa1c424c90156589f75afd4c
141 rdf:rest Ne4cf5a5e57f2437da73cf6c7fec9ab64
142 N8369ec7631c444f0a1511929a8040745 schema:affiliation Nff25014ed2a441faa463fe68afd3c828
143 schema:familyName Douard
144 schema:givenName Richard
145 rdf:type schema:Person
146 N8cc449a937e64d6599879f65da813bc0 rdf:first N07e156a7887c4e90b1cc1f6b566d9b6c
147 rdf:rest N77aac99ddfac435883da5f50dce54f6f
148 N8f2732af02344aa09b0edddf62a78f4f schema:name dimensions_id
149 schema:value pub.1112543858
150 rdf:type schema:PropertyValue
151 N90da53ba5b334b70bec32441680d2fe2 schema:name Department of Medical Oncology, Diaconesses Hospital, Paris, France
152 rdf:type schema:Organization
153 N934b21a1c1db4ad89576f8785d552037 schema:affiliation https://www.grid.ac/institutes/grid.7429.8
154 schema:familyName Bouchet-Doumenq
155 schema:givenName Cecile
156 rdf:type schema:Person
157 N95250df0a0ff4d04a36a44a5fbe721ae schema:affiliation https://www.grid.ac/institutes/grid.411439.a
158 schema:familyName Bardier
159 schema:givenName Armelle
160 rdf:type schema:Person
161 N9bfa9be312994735be48e5216008873e schema:name doi
162 schema:value 10.1038/s41416-019-0415-8
163 rdf:type schema:PropertyValue
164 N9f9f7b4b5541439eaa45f02c818b26fe rdf:first N7f5785a66a504dfaaa1e5524b47c45ff
165 rdf:rest Nd0dfc7c6f1784e85b42a1aded956a566
166 Na9ba0bbdf8194f81b16f125065192c4f schema:affiliation Nbfc79deb215d4060bc8b10997423e9ed
167 schema:familyName Taieb
168 schema:givenName Julien
169 rdf:type schema:Person
170 Nab5a6c3fcb3f4375a67e38654d2f75e3 schema:affiliation N5cbf548326bf48cd856b2ec47c7b7bcc
171 schema:familyName André
172 schema:givenName Thierry
173 rdf:type schema:Person
174 Nb04e32a3982d45ff9b5a5a19d26c9584 rdf:first Nb43ae7f362d241b88808d6a829ae44b9
175 rdf:rest N66c85b6cada749b88cb3023e986a7baf
176 Nb43ae7f362d241b88808d6a829ae44b9 schema:affiliation https://www.grid.ac/institutes/grid.50550.35
177 schema:familyName Sauvanet
178 schema:givenName Alain
179 rdf:type schema:Person
180 Nba2eb3b1c131478ca660a43a32588953 schema:name pubmed_id
181 schema:value 30837681
182 rdf:type schema:PropertyValue
183 Nbfc79deb215d4060bc8b10997423e9ed schema:name Sorbonne Paris – Cité, Paris Descartes University, Department of Gastroenterology and GI Oncology, Georges Pompidou European Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France
184 rdf:type schema:Organization
185 Nc37baa176228402f8ea4fead3c2a27e8 rdf:first N1dcfcb30c79a4c42b5ed08a95c1f75c3
186 rdf:rest N2f0d9e48b6a8458bbff99e0932eca29f
187 Nc5d5de1afa1c424c90156589f75afd4c schema:affiliation https://www.grid.ac/institutes/grid.7429.8
188 schema:familyName Laurent-Puig
189 schema:givenName Pierre
190 rdf:type schema:Person
191 Nc9fc659c8dfe438b9a78f56ec6f3fe33 schema:affiliation https://www.grid.ac/institutes/grid.12832.3a
192 schema:familyName Emile
193 schema:givenName Jean-Francois
194 rdf:type schema:Person
195 Ncc75d69c23b146f1a8e9b826e111b379 schema:affiliation N09848b4112d3449785dd525515a36800
196 schema:familyName Meatchi
197 schema:givenName Tchao
198 rdf:type schema:Person
199 Nd0dfc7c6f1784e85b42a1aded956a566 rdf:first N934b21a1c1db4ad89576f8785d552037
200 rdf:rest N8cc449a937e64d6599879f65da813bc0
201 Nd637d1ce73924ca7bbb7e00d94182779 rdf:first Nab5a6c3fcb3f4375a67e38654d2f75e3
202 rdf:rest Nfeed2be7528e437e97e5c0a01538c5b2
203 Nd77a134e5fec47e3ae1dbd9235e85146 schema:affiliation N4ea05c7cbc91439abf635878bb0cf828
204 schema:familyName Dumont
205 schema:givenName Sylvie
206 rdf:type schema:Person
207 Ndef27cd29b1e45b9ac45c7e9370b7835 schema:name Springer Nature - SN SciGraph project
208 rdf:type schema:Organization
209 Ne1d101300b69406ba1710805086364f6 schema:name INSERM, UMR S 938, Sorbonne-Université, Université Pierre et Marie Curie – Paris 6, Paris, France
210 rdf:type schema:Organization
211 Ne4cf5a5e57f2437da73cf6c7fec9ab64 rdf:first Na9ba0bbdf8194f81b16f125065192c4f
212 rdf:rest rdf:nil
213 Neba4e671930548a5a0c9f314c1dc94da schema:name nlm_unique_id
214 schema:value 0370635
215 rdf:type schema:PropertyValue
216 Nf698eb1fcdcf4326825fe41cbf1a5315 schema:name Sorbonne Paris – Cité, Paris Descartes University, Department of Gastroenterology and GI Oncology, Georges Pompidou European Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France
217 rdf:type schema:Organization
218 Nfc556e82998e4e79b1cafdb07a821ace rdf:first N6ef2a5973b65422aa8d88efb70f7f2d7
219 rdf:rest N9f9f7b4b5541439eaa45f02c818b26fe
220 Nfeed2be7528e437e97e5c0a01538c5b2 rdf:first N418c9716193d44ed8869f71217a3ca11
221 rdf:rest N3984a5775dc8484eb54e6ead1105d36b
222 Nff25014ed2a441faa463fe68afd3c828 schema:name Paris Descartes University, Department of Digestive Surgery, Georges Pompidou European Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France
223 rdf:type schema:Organization
224 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
225 schema:name Medical and Health Sciences
226 rdf:type schema:DefinedTerm
227 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
228 schema:name Oncology and Carcinogenesis
229 rdf:type schema:DefinedTerm
230 sg:journal.1017082 schema:issn 0007-0920
231 1532-1827
232 schema:name British Journal of Cancer
233 rdf:type schema:Periodical
234 sg:pub.10.1038/bjc.2015.172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011981731
235 https://doi.org/10.1038/bjc.2015.172
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/modpathol.2013.185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018345374
238 https://doi.org/10.1038/modpathol.2013.185
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/modpathol.2016.124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040294280
241 https://doi.org/10.1038/modpathol.2016.124
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/nature11252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010619765
244 https://doi.org/10.1038/nature11252
245 rdf:type schema:CreativeWork
246 sg:pub.10.1186/s12876-015-0396-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045437840
247 https://doi.org/10.1186/s12876-015-0396-x
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1002/jso.22090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043909702
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1002/jso.24274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037358948
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/j.ccell.2015.12.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017193344
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/j.ccell.2017.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091212500
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/j.celrep.2015.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038371101
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/j.ejca.2014.04.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042726200
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/j.ejso.2015.01.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042923054
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/j.ejso.2018.02.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101058005
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/j.humpath.2015.11.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013016457
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/j.surg.2013.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041304777
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/j.surg.2014.08.092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010189361
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1097/mpa.0000000000000112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047229051
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1097/mpa.0b013e31823cd9df schema:sameAs https://app.dimensions.ai/details/publication/pub.1012797887
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1097/pas.0000000000000230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048325127
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1097/pas.0000000000000278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031437684
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1097/pas.0000000000000863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085420097
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1097/sla.0000000000001999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002804961
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1111/his.12693 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027481981
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1136/jclinpath-2015-203337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017483614
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1200/jco.2006.09.2775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026719751
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1200/jco.2007.10.9744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003740759
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1200/jco.2012.46.8868 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041247505
292 rdf:type schema:CreativeWork
293 https://doi.org/10.18632/oncotarget.11156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040163366
294 rdf:type schema:CreativeWork
295 https://doi.org/10.3109/00365521.2015.1046912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051852667
296 rdf:type schema:CreativeWork
297 https://www.grid.ac/institutes/grid.12832.3a schema:alternateName Versailles Saint-Quentin-en-Yvelines University
298 schema:name Department of Pathology, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris, Boulogne-Billancourt, France
299 EA4340, Biomarqueurs en Cancérologie et Onco-Hématologie, UVSQ, Paris-Saclay University, Boulogne-Billancourt, France
300 rdf:type schema:Organization
301 https://www.grid.ac/institutes/grid.411439.a schema:alternateName Pitié-Salpêtrière Hospital
302 schema:name Centre de Recherche UMR-S 1147, Médecine Personnalisée, Pharmacogénomique, Optimisation Thérapeutique, Institut National de la Santé et de la Recherche Médicale, Paris, France
303 Department of Hepato-Gastroenterology, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France
304 Surgical Pathology Department, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France
305 rdf:type schema:Organization
306 https://www.grid.ac/institutes/grid.411599.1 schema:alternateName Beaujon Hospital
307 schema:name Centre de Recherche sur l’Inflammation (CRI), INSERM UMR 1149, University of Paris Diderot, Sorbonne Paris Cité, Paris, France
308 Department of Pathology, Beaujon University Hospital, Assistance Publique-Hôpitaux de Paris, Clichy, France
309 rdf:type schema:Organization
310 https://www.grid.ac/institutes/grid.412370.3 schema:alternateName Hôpital Saint-Antoine
311 schema:name Department of Gastrointestinal Surgery, Saint Antoine Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France
312 rdf:type schema:Organization
313 https://www.grid.ac/institutes/grid.413756.2 schema:alternateName Hôpital Ambroise-Paré
314 schema:name Department of Surgery and Oncology, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris, Boulogne-Billancourt, France
315 rdf:type schema:Organization
316 https://www.grid.ac/institutes/grid.462374.0 schema:alternateName Center for Research on Inflammation
317 schema:name Centre de Recherche sur l’Inflammation (CRI), INSERM UMR 1149, University of Paris Diderot, Sorbonne Paris Cité, Paris, France
318 Department of Digestive Oncology, Beaujon University Hospital, Assistance Publique-Hôpitaux de Paris, Clichy, France
319 rdf:type schema:Organization
320 https://www.grid.ac/institutes/grid.50550.35 schema:alternateName Assistance Publique -Hopitaux De Paris
321 schema:name Department of Digestive Surgery, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Paris, France
322 rdf:type schema:Organization
323 https://www.grid.ac/institutes/grid.7429.8 schema:alternateName French Institute of Health and Medical Research
324 schema:name Centre de Recherche UMR-S 1147, Médecine Personnalisée, Pharmacogénomique, Optimisation Thérapeutique, Institut National de la Santé et de la Recherche Médicale, Paris, France
325 Department of Gastrointestinal Surgery, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France
326 Sorbonne Paris – Cité, Paris Descartes University, Department of Gastroenterology and GI Oncology, Georges Pompidou European Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France
327 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...