Phase 1 trial of olaparib and oral cyclophosphamide in BRCA breast cancer, recurrent BRCA ovarian cancer, non-BRCA triple-negative breast cancer, ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02

AUTHORS

Chee Khoon Lee, Clare Scott, Geoffrey J. Lindeman, Anne Hamilton, Elizabeth Lieschke, Emma Gibbs, Rebecca Asher, Heath Badger, Robin Paterson, Lauren Macnab, Edmond Michael Kwan, Prudence A. Francis, Frances Boyle, Michael Friedlander

ABSTRACT

BACKGROUND: We conducted a Phase 1 study to evaluate safety and activity of olaparib tablets and oral cyclophosphamide. METHODS: Patients had metastatic breast cancer (BC) or recurrent high-grade serous ovarian cancer (HGSOC), performance status 0-2, and ≤3 lines of prior therapy. Patients were treated using a dose escalation strategy with cohort expansion once maximal tolerated dose (MTD) was determined. Dose level 1 (DL1): olaparib 300 mg bid, cyclophosphamide 50 mg on days 1, 3, and 5, weekly. DL2: olaparib 300 mg bid, cyclophosphamide 50 mg, days 1-5 weekly. RESULTS: Of 32 patients, 23 had HGSOC (germline BRCA mutation [gBRCAm] 70%) and 9 had BC (gBRCAm 67%). Four were treated at DL1 and 28 at DL2, the MTD. Haematological adverse events (AEs) were most common: grade 3/4 AEs: lymphopenia 75%, anaemia 31%, neutropenia 37%, thrombocytopenia 47%. Two permanently discontinued treatment due to haematological AEs. In BC, no objective response was reported. Unconfirmed objective response was 48% and 64% for all HGSOC and gBRCAm subset, respectively. CA125 responses were 70% (all HGSOC) and 92% (gBRCAm). CONCLUSIONS: In HGSOC and BC, olaparib 300 mg bid and cyclophosphamide 50 mg on days 1-5 weekly were tolerable and active, particularly in gBRCAm, and is worthy of further investigation. More... »

PAGES

279-285

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41416-018-0349-6

DOI

http://dx.doi.org/10.1038/s41416-018-0349-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111502385

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30655615


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Health and Medical Research Council", 
          "id": "https://www.grid.ac/institutes/grid.431143.0", 
          "name": [
            "St George Hospital, Sydney, NSW, Australia", 
            "National Health and Medical Research Council (NHMRC) Clinical Trials Centre, Sydney, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Chee Khoon", 
        "id": "sg:person.01230314310.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230314310.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Melbourne Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416153.4", 
          "name": [
            "Peter MacCallum Cancer Centre, Melbourne, VIC, Australia", 
            "Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia", 
            "The Royal Melbourne Hospital, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scott", 
        "givenName": "Clare", 
        "id": "sg:person.012473130017.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012473130017.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Melbourne Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416153.4", 
          "name": [
            "Peter MacCallum Cancer Centre, Melbourne, VIC, Australia", 
            "Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia", 
            "The Royal Melbourne Hospital, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lindeman", 
        "givenName": "Geoffrey J.", 
        "id": "sg:person.01265205546.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265205546.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peter MacCallum Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.1055.1", 
          "name": [
            "Peter MacCallum Cancer Centre, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hamilton", 
        "givenName": "Anne", 
        "id": "sg:person.0721217404.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721217404.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Walter and Eliza Hall Institute of Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.1042.7", 
          "name": [
            "Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lieschke", 
        "givenName": "Elizabeth", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Health and Medical Research Council", 
          "id": "https://www.grid.ac/institutes/grid.431143.0", 
          "name": [
            "National Health and Medical Research Council (NHMRC) Clinical Trials Centre, Sydney, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gibbs", 
        "givenName": "Emma", 
        "id": "sg:person.010244171321.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010244171321.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Health and Medical Research Council", 
          "id": "https://www.grid.ac/institutes/grid.431143.0", 
          "name": [
            "National Health and Medical Research Council (NHMRC) Clinical Trials Centre, Sydney, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Asher", 
        "givenName": "Rebecca", 
        "id": "sg:person.01276556535.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276556535.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Breast Cancer Trials Australia & New Zealand, Newcastle, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Badger", 
        "givenName": "Heath", 
        "id": "sg:person.01015522242.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015522242.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Breast Cancer Trials Australia & New Zealand, Newcastle, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paterson", 
        "givenName": "Robin", 
        "id": "sg:person.07720674417.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07720674417.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Breast Cancer Trials Australia & New Zealand, Newcastle, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Macnab", 
        "givenName": "Lauren", 
        "id": "sg:person.010640421130.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010640421130.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peter MacCallum Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.1055.1", 
          "name": [
            "Peter MacCallum Cancer Centre, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kwan", 
        "givenName": "Edmond Michael", 
        "id": "sg:person.0772025351.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772025351.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peter MacCallum Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.1055.1", 
          "name": [
            "Peter MacCallum Cancer Centre, Melbourne, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Francis", 
        "givenName": "Prudence A.", 
        "id": "sg:person.01202345760.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202345760.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Breast Cancer Trials Australia & New Zealand, Newcastle, NSW, Australia", 
            "The Mater Hospital, North Sydney, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boyle", 
        "givenName": "Frances", 
        "id": "sg:person.01103137672.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103137672.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Prince of Wales Hospital, Sydney and Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Friedlander", 
        "givenName": "Michael", 
        "id": "sg:person.01043610504.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043610504.70"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/annonc/mdf013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003073567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-12-2753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003639945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(14)71135-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005164599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(14)71135-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005164599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.12.1939", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007277658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1541-7786.mcr-15-0191-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009615434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(10)60893-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010088435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0806092105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012304925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/dju089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014725247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdj066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015926177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdj066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015926177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-14-2565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018304548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.26.9589", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020121676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.36.9215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020920540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-07-4953", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024438057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0900212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036199013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(11)70214-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037513376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(11)70214-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037513376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/92.18.1534", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038214940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/bcr3484", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040423249", 
          "https://doi.org/10.1186/bcr3484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pbc.24697", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044349792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11523-016-0435-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049466672", 
          "https://doi.org/10.1007/s11523-016-0435-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdu187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049886783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2014.56.2728", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064204398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/chromatography1020082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071267898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1706450", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085864115"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-02", 
    "datePublishedReg": "2019-02-01", 
    "description": "BACKGROUND: We conducted a Phase 1 study to evaluate safety and activity of olaparib tablets and oral cyclophosphamide.\nMETHODS: Patients had metastatic breast cancer (BC) or recurrent high-grade serous ovarian cancer (HGSOC), performance status 0-2, and \u22643 lines of prior therapy. Patients were treated using a dose escalation strategy with cohort expansion once maximal tolerated dose (MTD) was determined. Dose level 1 (DL1): olaparib 300\u2009mg bid, cyclophosphamide 50\u2009mg on days 1, 3, and 5, weekly. DL2: olaparib 300\u2009mg bid, cyclophosphamide 50\u2009mg, days 1-5 weekly.\nRESULTS: Of 32 patients, 23 had HGSOC (germline BRCA mutation [gBRCAm] 70%) and 9 had BC (gBRCAm 67%). Four were treated at DL1 and 28 at DL2, the MTD. Haematological adverse events (AEs) were most common: grade 3/4 AEs: lymphopenia 75%, anaemia 31%, neutropenia 37%, thrombocytopenia 47%. Two permanently discontinued treatment due to haematological AEs. In BC, no objective response was reported. Unconfirmed objective response was 48% and 64% for all HGSOC and gBRCAm subset, respectively. CA125 responses were 70% (all HGSOC) and 92% (gBRCAm).\nCONCLUSIONS: In HGSOC and BC, olaparib 300\u2009mg bid and cyclophosphamide 50\u2009mg on days 1-5 weekly were tolerable and active, particularly in gBRCAm, and is worthy of further investigation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41416-018-0349-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1017082", 
        "issn": [
          "0007-0920", 
          "1532-1827"
        ], 
        "name": "British Journal of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "120"
      }
    ], 
    "name": "Phase 1 trial of olaparib and oral cyclophosphamide in BRCA breast cancer, recurrent BRCA ovarian cancer, non-BRCA triple-negative breast cancer, and non-BRCA ovarian cancer", 
    "pagination": "279-285", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41416-018-0349-6"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d802c526e72a133bdb6f634ff13a65e0e5bee1fcbcff6e52a7423d562ac8c431"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111502385"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0370635"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30655615"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41416-018-0349-6", 
      "https://app.dimensions.ai/details/publication/pub.1111502385"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T08:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000374_0000000374/records_119717_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41416-018-0349-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41416-018-0349-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41416-018-0349-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41416-018-0349-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41416-018-0349-6'


 

This table displays all metadata directly associated to this object as RDF triples.

253 TRIPLES      21 PREDICATES      52 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41416-018-0349-6 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N0e9c9b5314cb4d7fafe0db1ea9801d1b
4 schema:citation sg:pub.10.1007/s11523-016-0435-8
5 sg:pub.10.1186/bcr3484
6 https://doi.org/10.1002/pbc.24697
7 https://doi.org/10.1016/s0140-6736(10)60893-8
8 https://doi.org/10.1016/s1470-2045(11)70214-5
9 https://doi.org/10.1016/s1470-2045(14)71135-0
10 https://doi.org/10.1056/nejmoa0900212
11 https://doi.org/10.1056/nejmoa1706450
12 https://doi.org/10.1073/pnas.0806092105
13 https://doi.org/10.1093/annonc/mdf013
14 https://doi.org/10.1093/annonc/mdj066
15 https://doi.org/10.1093/annonc/mdu187
16 https://doi.org/10.1093/jnci/92.18.1534
17 https://doi.org/10.1093/jnci/dju089
18 https://doi.org/10.1158/0008-5472.can-12-2753
19 https://doi.org/10.1158/1078-0432.ccr-07-4953
20 https://doi.org/10.1158/1078-0432.ccr-14-2565
21 https://doi.org/10.1158/1541-7786.mcr-15-0191-t
22 https://doi.org/10.1200/jco.2007.12.1939
23 https://doi.org/10.1200/jco.2009.26.9589
24 https://doi.org/10.1200/jco.2011.36.9215
25 https://doi.org/10.1200/jco.2014.56.2728
26 https://doi.org/10.3390/chromatography1020082
27 schema:datePublished 2019-02
28 schema:datePublishedReg 2019-02-01
29 schema:description BACKGROUND: We conducted a Phase 1 study to evaluate safety and activity of olaparib tablets and oral cyclophosphamide. METHODS: Patients had metastatic breast cancer (BC) or recurrent high-grade serous ovarian cancer (HGSOC), performance status 0-2, and ≤3 lines of prior therapy. Patients were treated using a dose escalation strategy with cohort expansion once maximal tolerated dose (MTD) was determined. Dose level 1 (DL1): olaparib 300 mg bid, cyclophosphamide 50 mg on days 1, 3, and 5, weekly. DL2: olaparib 300 mg bid, cyclophosphamide 50 mg, days 1-5 weekly. RESULTS: Of 32 patients, 23 had HGSOC (germline BRCA mutation [gBRCAm] 70%) and 9 had BC (gBRCAm 67%). Four were treated at DL1 and 28 at DL2, the MTD. Haematological adverse events (AEs) were most common: grade 3/4 AEs: lymphopenia 75%, anaemia 31%, neutropenia 37%, thrombocytopenia 47%. Two permanently discontinued treatment due to haematological AEs. In BC, no objective response was reported. Unconfirmed objective response was 48% and 64% for all HGSOC and gBRCAm subset, respectively. CA125 responses were 70% (all HGSOC) and 92% (gBRCAm). CONCLUSIONS: In HGSOC and BC, olaparib 300 mg bid and cyclophosphamide 50 mg on days 1-5 weekly were tolerable and active, particularly in gBRCAm, and is worthy of further investigation.
30 schema:genre research_article
31 schema:inLanguage en
32 schema:isAccessibleForFree false
33 schema:isPartOf N7b68f6723837448b8f4a9066905f8fb6
34 Nca4491e9ee9b48a4ada7568087cbdfd7
35 sg:journal.1017082
36 schema:name Phase 1 trial of olaparib and oral cyclophosphamide in BRCA breast cancer, recurrent BRCA ovarian cancer, non-BRCA triple-negative breast cancer, and non-BRCA ovarian cancer
37 schema:pagination 279-285
38 schema:productId N9644e243a87f49d283e76182e8f87e46
39 Na114e70b60c645a08a0df4945a1edb86
40 Na6f7a8fabc6d4749a3c032818e2464e1
41 Nf16e47b38ab0444aa21f425700a31bce
42 Nfde3476a4cb949a68076c3929912aa22
43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111502385
44 https://doi.org/10.1038/s41416-018-0349-6
45 schema:sdDatePublished 2019-04-15T08:48
46 schema:sdLicense https://scigraph.springernature.com/explorer/license/
47 schema:sdPublisher N8fc6b44fdf574ad692f5598237f427af
48 schema:url https://www.nature.com/articles/s41416-018-0349-6
49 sgo:license sg:explorer/license/
50 sgo:sdDataset articles
51 rdf:type schema:ScholarlyArticle
52 N005f7e1f59fe49ef8cff36fd56a84399 schema:name Breast Cancer Trials Australia & New Zealand, Newcastle, NSW, Australia
53 rdf:type schema:Organization
54 N037f58774fdb4eeaafefa356bf4843f6 rdf:first sg:person.01015522242.98
55 rdf:rest Na1bd42af80024d91b1d1377e9321c202
56 N0e9c9b5314cb4d7fafe0db1ea9801d1b rdf:first sg:person.01230314310.58
57 rdf:rest Ndc8c534936284bf083fb1e2b3f7104e4
58 N16fb190c217642858a93bd415f7b1ff8 schema:name Breast Cancer Trials Australia & New Zealand, Newcastle, NSW, Australia
59 rdf:type schema:Organization
60 N1b205c74b55c486a8f71a1e1a39b3764 schema:name Breast Cancer Trials Australia & New Zealand, Newcastle, NSW, Australia
61 The Mater Hospital, North Sydney, NSW, Australia
62 rdf:type schema:Organization
63 N3d60e0ab70bc40ca9aa66f403fcc02e7 schema:affiliation https://www.grid.ac/institutes/grid.1042.7
64 schema:familyName Lieschke
65 schema:givenName Elizabeth
66 rdf:type schema:Person
67 N49010fcb84f74783be6374fd7c025ec6 rdf:first sg:person.0721217404.64
68 rdf:rest Necbeda13ae394faab2cd772b7eb39dba
69 N576d322310c14c2ca47167c129c6611b rdf:first sg:person.01202345760.53
70 rdf:rest Nce9adf3cec1b46ed8754ecaa9ba3bb86
71 N7700b6ef65334759a20429a78f86c53c rdf:first sg:person.01276556535.28
72 rdf:rest N037f58774fdb4eeaafefa356bf4843f6
73 N7b68f6723837448b8f4a9066905f8fb6 schema:issueNumber 3
74 rdf:type schema:PublicationIssue
75 N81bf959214344370be37b8b15918d25b rdf:first sg:person.0772025351.85
76 rdf:rest N576d322310c14c2ca47167c129c6611b
77 N89f30b4c57ec459499f8b7ae68f7ef93 schema:name Breast Cancer Trials Australia & New Zealand, Newcastle, NSW, Australia
78 rdf:type schema:Organization
79 N8fc6b44fdf574ad692f5598237f427af schema:name Springer Nature - SN SciGraph project
80 rdf:type schema:Organization
81 N9644e243a87f49d283e76182e8f87e46 schema:name nlm_unique_id
82 schema:value 0370635
83 rdf:type schema:PropertyValue
84 N9b578f14e1774283a3963f6cac6ff2fe rdf:first sg:person.010640421130.05
85 rdf:rest N81bf959214344370be37b8b15918d25b
86 Na01174b3a1f247a6a2432bf1a44884f0 rdf:first sg:person.01265205546.72
87 rdf:rest N49010fcb84f74783be6374fd7c025ec6
88 Na114e70b60c645a08a0df4945a1edb86 schema:name doi
89 schema:value 10.1038/s41416-018-0349-6
90 rdf:type schema:PropertyValue
91 Na1bd42af80024d91b1d1377e9321c202 rdf:first sg:person.07720674417.39
92 rdf:rest N9b578f14e1774283a3963f6cac6ff2fe
93 Na6f7a8fabc6d4749a3c032818e2464e1 schema:name pubmed_id
94 schema:value 30655615
95 rdf:type schema:PropertyValue
96 Na9391f3571e443df940671b5759cb809 rdf:first sg:person.010244171321.93
97 rdf:rest N7700b6ef65334759a20429a78f86c53c
98 Nca4491e9ee9b48a4ada7568087cbdfd7 schema:volumeNumber 120
99 rdf:type schema:PublicationVolume
100 Nce9adf3cec1b46ed8754ecaa9ba3bb86 rdf:first sg:person.01103137672.45
101 rdf:rest Nd5f4940c37444436978470f658505f2d
102 Nd5f4940c37444436978470f658505f2d rdf:first sg:person.01043610504.70
103 rdf:rest rdf:nil
104 Ndc8c534936284bf083fb1e2b3f7104e4 rdf:first sg:person.012473130017.75
105 rdf:rest Na01174b3a1f247a6a2432bf1a44884f0
106 Ne148aaaa28b147f7a98d44e5b2d391a3 schema:name Prince of Wales Hospital, Sydney and Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia
107 rdf:type schema:Organization
108 Necbeda13ae394faab2cd772b7eb39dba rdf:first N3d60e0ab70bc40ca9aa66f403fcc02e7
109 rdf:rest Na9391f3571e443df940671b5759cb809
110 Nf16e47b38ab0444aa21f425700a31bce schema:name dimensions_id
111 schema:value pub.1111502385
112 rdf:type schema:PropertyValue
113 Nfde3476a4cb949a68076c3929912aa22 schema:name readcube_id
114 schema:value d802c526e72a133bdb6f634ff13a65e0e5bee1fcbcff6e52a7423d562ac8c431
115 rdf:type schema:PropertyValue
116 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
117 schema:name Medical and Health Sciences
118 rdf:type schema:DefinedTerm
119 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
120 schema:name Oncology and Carcinogenesis
121 rdf:type schema:DefinedTerm
122 sg:journal.1017082 schema:issn 0007-0920
123 1532-1827
124 schema:name British Journal of Cancer
125 rdf:type schema:Periodical
126 sg:person.01015522242.98 schema:affiliation N005f7e1f59fe49ef8cff36fd56a84399
127 schema:familyName Badger
128 schema:givenName Heath
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015522242.98
130 rdf:type schema:Person
131 sg:person.010244171321.93 schema:affiliation https://www.grid.ac/institutes/grid.431143.0
132 schema:familyName Gibbs
133 schema:givenName Emma
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010244171321.93
135 rdf:type schema:Person
136 sg:person.01043610504.70 schema:affiliation Ne148aaaa28b147f7a98d44e5b2d391a3
137 schema:familyName Friedlander
138 schema:givenName Michael
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043610504.70
140 rdf:type schema:Person
141 sg:person.010640421130.05 schema:affiliation N89f30b4c57ec459499f8b7ae68f7ef93
142 schema:familyName Macnab
143 schema:givenName Lauren
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010640421130.05
145 rdf:type schema:Person
146 sg:person.01103137672.45 schema:affiliation N1b205c74b55c486a8f71a1e1a39b3764
147 schema:familyName Boyle
148 schema:givenName Frances
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103137672.45
150 rdf:type schema:Person
151 sg:person.01202345760.53 schema:affiliation https://www.grid.ac/institutes/grid.1055.1
152 schema:familyName Francis
153 schema:givenName Prudence A.
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202345760.53
155 rdf:type schema:Person
156 sg:person.01230314310.58 schema:affiliation https://www.grid.ac/institutes/grid.431143.0
157 schema:familyName Lee
158 schema:givenName Chee Khoon
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230314310.58
160 rdf:type schema:Person
161 sg:person.012473130017.75 schema:affiliation https://www.grid.ac/institutes/grid.416153.4
162 schema:familyName Scott
163 schema:givenName Clare
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012473130017.75
165 rdf:type schema:Person
166 sg:person.01265205546.72 schema:affiliation https://www.grid.ac/institutes/grid.416153.4
167 schema:familyName Lindeman
168 schema:givenName Geoffrey J.
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265205546.72
170 rdf:type schema:Person
171 sg:person.01276556535.28 schema:affiliation https://www.grid.ac/institutes/grid.431143.0
172 schema:familyName Asher
173 schema:givenName Rebecca
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276556535.28
175 rdf:type schema:Person
176 sg:person.0721217404.64 schema:affiliation https://www.grid.ac/institutes/grid.1055.1
177 schema:familyName Hamilton
178 schema:givenName Anne
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721217404.64
180 rdf:type schema:Person
181 sg:person.0772025351.85 schema:affiliation https://www.grid.ac/institutes/grid.1055.1
182 schema:familyName Kwan
183 schema:givenName Edmond Michael
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772025351.85
185 rdf:type schema:Person
186 sg:person.07720674417.39 schema:affiliation N16fb190c217642858a93bd415f7b1ff8
187 schema:familyName Paterson
188 schema:givenName Robin
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07720674417.39
190 rdf:type schema:Person
191 sg:pub.10.1007/s11523-016-0435-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049466672
192 https://doi.org/10.1007/s11523-016-0435-8
193 rdf:type schema:CreativeWork
194 sg:pub.10.1186/bcr3484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040423249
195 https://doi.org/10.1186/bcr3484
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1002/pbc.24697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044349792
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/s0140-6736(10)60893-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010088435
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/s1470-2045(11)70214-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037513376
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/s1470-2045(14)71135-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005164599
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1056/nejmoa0900212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036199013
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1056/nejmoa1706450 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085864115
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1073/pnas.0806092105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012304925
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1093/annonc/mdf013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003073567
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1093/annonc/mdj066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015926177
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1093/annonc/mdu187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049886783
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1093/jnci/92.18.1534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038214940
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1093/jnci/dju089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014725247
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1158/0008-5472.can-12-2753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003639945
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1158/1078-0432.ccr-07-4953 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024438057
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1158/1078-0432.ccr-14-2565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018304548
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1158/1541-7786.mcr-15-0191-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1009615434
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1200/jco.2007.12.1939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007277658
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1200/jco.2009.26.9589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020121676
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1200/jco.2011.36.9215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020920540
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1200/jco.2014.56.2728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064204398
236 rdf:type schema:CreativeWork
237 https://doi.org/10.3390/chromatography1020082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071267898
238 rdf:type schema:CreativeWork
239 https://www.grid.ac/institutes/grid.1042.7 schema:alternateName Walter and Eliza Hall Institute of Medical Research
240 schema:name Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia
241 rdf:type schema:Organization
242 https://www.grid.ac/institutes/grid.1055.1 schema:alternateName Peter MacCallum Cancer Centre
243 schema:name Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
244 rdf:type schema:Organization
245 https://www.grid.ac/institutes/grid.416153.4 schema:alternateName Royal Melbourne Hospital
246 schema:name Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
247 The Royal Melbourne Hospital, Melbourne, VIC, Australia
248 Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia
249 rdf:type schema:Organization
250 https://www.grid.ac/institutes/grid.431143.0 schema:alternateName National Health and Medical Research Council
251 schema:name National Health and Medical Research Council (NHMRC) Clinical Trials Centre, Sydney, NSW, Australia
252 St George Hospital, Sydney, NSW, Australia
253 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...